经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经闭孔无张力尿道中段悬吊术治疗女性压力性尿失禁的临床观察

Objective To evaluate the efficacy and safety of the transobturator tension-free vaginal tape (TVT-O) surgery, a minimally invasive surgery for treating patients with the stress urinary incontinence (SUI). Methods 28 cases with female stress uri-nary incontinence treated by TVT-O procedure from April 2006 to June 2008 were retrospectively analyzed. The follow-up time is from 4 to 24 months. Results The mean operation time was 23 min (rang 10～30 min) and the mean intraoperative bleeding was 24 ml (range 15～40 ml). An indwelling catheter had been used for 3 d because of urinary retention in 3 cases. 24 patients(85.7%)reached complete control after the surgery,effective control in 4 patients(14.35%). Conclusions TVT-O surgery is an effective, safe, minimally invasive management to treat the stress urinary incontinence.     

经尿道等离子汽化电切术治疗浅表膀胱肿瘤57例效果观察

Objective To evaluate the clinical efficacy of the bipolar plasmakinetic system in transurethral resection for bladder tumors (TURBt). Methods 57 patients aged 38 to 82 (42 male and 15 female; mean age, 58.2 years) with bladder tumors were treated by the bipolar plasmakinetic system. Single tumor was noted in 38 patients and multiple tumors in 19. Results All the patients received only one TURBt. The mean operation time was 22 min and mean hospital stay was( 5 ± 0.36 )days. 55 patients were followed up and 2 were lost. 12 patients relapsed within 24 months of follow-up. 8 had to receive second transurethral resection and 4 required radical cystectomy. Conclusions The bipolar plasmakinetic system in TURBt is minimally invasive, effective and safe.     

经尿道等离子汽化电切术治疗浅表膀胱肿瘤57例效果观察

Objective To evaluate the clinical efficacy of the bipolar plasmakinetic system in transurethral resection for bladder tumors (TURBt). Methods 57 patients aged 38 to 82 (42 male and 15 female; mean age, 58.2 years) with bladder tumors were treated by the bipolar plasmakinetic system. Single tumor was noted in 38 patients and multiple tumors in 19. Results All the patients received only one TURBt. The mean operation time was 22 min and mean hospital stay was( 5 ± 0.36 )days. 55 patients were followed up and 2 were lost. 12 patients relapsed within 24 months of follow-up. 8 had to receive second transurethral resection and 4 required radical cystectomy. Conclusions The bipolar plasmakinetic system in TURBt is minimally invasive, effective and safe.     

宫颈环形电切术治疗宫颈糜烂疗效观察

Objective To observe the clinical curative effect of cervical loop electrosurgical excision procedure in treatment of patients with cervical erosion by LEEP.Methods 268 patients whose cervical erosions were above Ⅱ°were treated by LEEP,and the length of operation time,bleeding volume in the operation, amount of vaginal discharge after the operation,the length of bleeding time and cervical repair were observed.Results Follow-up was 12 weeks.262 cases (97.76% ) were cured, 6 cases (2.24% ) were effective.The bleeding amount was less than 10ml.The average surgery time was(2.62 ±0.58) minutes.18 cases(6.71% ) had the colporrhagia.No infectious case was found.Conclusion The curative effect of LEEP for cervical erosion was significant,and operation was simple and safe.LEEP was a well treatment method of cervical erosion.     

经尿道前列腺汽化电切术治疗高危前列腺增生症的疗效观察

Objective To investigate the clinical efficacy and safety of transurthral electrovaporization of the prostate(TUVP) for benign prostatic hyperplasia( BPH) at high risk.Methods Forty-eight patients with BPH at high risk were treated with transurthral electrovaporization of the prostate(TUVP).The clinical data and therapeutic results were measured.Results All patients went through the perioperiative period safely and had been followed up for 3 to 14 months.Postvoid residual ( PVR) , the International Prostate Symptom Score (IPSS) and quality of life (QOL) before operations were (97.5 ± 16.9) ml, ( 28.4 ± 2.3 ) score and (5.5 ±0.6) score respectively.Three months after operation ,PVR ,IPSS and QOL were( 30.2 ± 12.3 ) ml, (8.2 ± 1.3 ) score and( 1.9 ±0.5) score respectively,there was significant difference between them(t =22.31,53.16,31.94,all P<0.05).Conclusion TUVP is an effective and safe method in treating BPH patients at high risk.     

高效液相色谱法测定尿中美芬妥英及代谢产物4'-羟基美芬妥英

A simple, sensitive and reproducible HPLC assay is described for the determination of mephenytoin and 4'-hydroxymephenytoin in human urine. Phenobarbital was used as an internal standard.The compounds were separated on a U-Bondapack RP-C₁₈ column using a mobile phase of and the UV detectou was set at 210 nm. Calibration curves in the range 0.05～1.00ug/ml for mephenytoin and 0.5～100.0ug/ml for 4'-hydroxymephenytoin were linear (r=0.9998and r=0.9992,respectivesy). The average recovery was 95.10±2。95%,and the relative standard devia- tion within day and day to day was less than 10%。The detection limit for mephenytoin was 25mg/ml and 4‘-hydroxymephenytoin was 50mg。ml。The method was used to study the metabolism of S-mephenytoin 4'-hydroxylatoin in 10healthy volunteers.The 12 h urinary metabolic ratio (MR)and hydroxylation index(HI)were calculated to express interindividual variation in metabolism. Two of them exhibited defective 4'-hydroxylation of S-mephenytoin as poor metabllizers (HI:1349.18 and 409.57;MR:105.29 and 8.25).In the remaining 8 subjects, the ranged from 1.68 to 6.71 and the MR ranged from 0.002 to 0.014,as extensive metabolizers of S-mephenytoin.     

反相高效液相色谱法测定人血浆中阿昔洛韦浓度

A RP-HPLC method was developed for the determination of aeyclovir (ACV) in human plasma. ACV was extracted from plasma using ODS, obtained from Sep-Pak C₁₈ cartridge (Waters associates) and reinstalled in a self-made glass tube suitable for extraction of solutes from small volume plasma samples. After extraction, and rinsing the ODS extract with water to remove hydrophilic impurities, ACV was recovered with methanol and chromatographed on YWG C₁₈H₃₇ column, and detected at 254 mm. The mobile phase was 5.0% (v/v) methanol/water. The average recovery of ACV was 73. 5%; the minimum detection concentration of ACV in plasma was 20 ng/ml with a plasma volume of 0. 2 ml and S/N value of 2. A good linear relationship between the peak area ratios and ACV concentrations was found at the ACV concentrations ranging from 0. 2 to 1.0 μg/ml, C_ACV=0. 840 A_ACV/A_is+0.002, r=0.9969.     

108例腹腔镜全腹膜外疝修补术的临床分析

Objective To investigate the clinical value of laparoscopic totally extraperitioneal inguinal hernia repair. Methods One hundred and eight patients who suffered from inguinal hcmia were treated with laparoscopic totally extraperitioneal inguinal hernia repair. The operation time, wound pain, postoperative recovery of independent function, complications and recurrence rate were studied. Results One hundred and five cases of inguinal hernia were performed the operation successfully, while three cases were converted to open surgery. The operating time was 55～110 minutes for unilateral hemioplasty, and 90～140 minutes for bilateral hemioplasty. Losing blood volume was 15～60 ml. Postoperative complications include 5 cases of hematoma of scrotum and 4 cases of seroma of scrotum. The average postoperative stay was 3～5 days. The follow-up period ranged from 2 to 50 months and no recurrence was observed. None of the follow-up patients complained long-term discomfort. Conclusions Laparoscopic totally extraperitioneal inguinal hernia repair is safe with less complications, low recurrence rate and excellent therapeutic effect.     

108例腹腔镜全腹膜外疝修补术的临床分析

Objective To investigate the clinical value of laparoscopic totally extraperitioneal inguinal hernia repair. Methods One hundred and eight patients who suffered from inguinal hcmia were treated with laparoscopic totally extraperitioneal inguinal hernia repair. The operation time, wound pain, postoperative recovery of independent function, complications and recurrence rate were studied. Results One hundred and five cases of inguinal hernia were performed the operation successfully, while three cases were converted to open surgery. The operating time was 55～110 minutes for unilateral hemioplasty, and 90～140 minutes for bilateral hemioplasty. Losing blood volume was 15～60 ml. Postoperative complications include 5 cases of hematoma of scrotum and 4 cases of seroma of scrotum. The average postoperative stay was 3～5 days. The follow-up period ranged from 2 to 50 months and no recurrence was observed. None of the follow-up patients complained long-term discomfort. Conclusions Laparoscopic totally extraperitioneal inguinal hernia repair is safe with less complications, low recurrence rate and excellent therapeutic effect.     

108例腹腔镜全腹膜外疝修补术的临床分析

Objective To investigate the clinical value of laparoscopic totally extraperitioneal inguinal hernia repair. Methods One hundred and eight patients who suffered from inguinal hcmia were treated with laparoscopic totally extraperitioneal inguinal hernia repair. The operation time, wound pain, postoperative recovery of independent function, complications and recurrence rate were studied. Results One hundred and five cases of inguinal hernia were performed the operation successfully, while three cases were converted to open surgery. The operating time was 55～110 minutes for unilateral hemioplasty, and 90～140 minutes for bilateral hemioplasty. Losing blood volume was 15～60 ml. Postoperative complications include 5 cases of hematoma of scrotum and 4 cases of seroma of scrotum. The average postoperative stay was 3～5 days. The follow-up period ranged from 2 to 50 months and no recurrence was observed. None of the follow-up patients complained long-term discomfort. Conclusions Laparoscopic totally extraperitioneal inguinal hernia repair is safe with less complications, low recurrence rate and excellent therapeutic effect.     

108例腹腔镜全腹膜外疝修补术的临床分析

Objective To investigate the clinical value of laparoscopic totally extraperitioneal inguinal hernia repair. Methods One hundred and eight patients who suffered from inguinal hcmia were treated with laparoscopic totally extraperitioneal inguinal hernia repair. The operation time, wound pain, postoperative recovery of independent function, complications and recurrence rate were studied. Results One hundred and five cases of inguinal hernia were performed the operation successfully, while three cases were converted to open surgery. The operating time was 55～110 minutes for unilateral hemioplasty, and 90～140 minutes for bilateral hemioplasty. Losing blood volume was 15～60 ml. Postoperative complications include 5 cases of hematoma of scrotum and 4 cases of seroma of scrotum. The average postoperative stay was 3～5 days. The follow-up period ranged from 2 to 50 months and no recurrence was observed. None of the follow-up patients complained long-term discomfort. Conclusions Laparoscopic totally extraperitioneal inguinal hernia repair is safe with less complications, low recurrence rate and excellent therapeutic effect.     

108例腹腔镜全腹膜外疝修补术的临床分析

Objective To investigate the clinical value of laparoscopic totally extraperitioneal inguinal hernia repair. Methods One hundred and eight patients who suffered from inguinal hcmia were treated with laparoscopic totally extraperitioneal inguinal hernia repair. The operation time, wound pain, postoperative recovery of independent function, complications and recurrence rate were studied. Results One hundred and five cases of inguinal hernia were performed the operation successfully, while three cases were converted to open surgery. The operating time was 55～110 minutes for unilateral hemioplasty, and 90～140 minutes for bilateral hemioplasty. Losing blood volume was 15～60 ml. Postoperative complications include 5 cases of hematoma of scrotum and 4 cases of seroma of scrotum. The average postoperative stay was 3～5 days. The follow-up period ranged from 2 to 50 months and no recurrence was observed. None of the follow-up patients complained long-term discomfort. Conclusions Laparoscopic totally extraperitioneal inguinal hernia repair is safe with less complications, low recurrence rate and excellent therapeutic effect.