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RP-HPLC法测定玉屏风口服液中黄芪甲苷的含量 总被引:3,自引:0,他引:3
目的建立玉屏风口服液的含量测定方法。方法采用十八烷基硅烷键合硅胶柱,流动相为乙腈一水(35:65),检测波长为203nm。结果浓度0.5~15.0μg范围内线性关系良好。结论本方法灵敏、准确,可用于玉屏风口服液的质量控制。 相似文献
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HPLC-ELSD法测定玉屏风口服液中黄芪甲苷的含量 总被引:3,自引:0,他引:3
目的 建立玉屏风口服液中黄芪甲苷的含量测定方法。方法 采用HPLC-ELSD法,Kromasil-C18(250mm×4.6mm,5μm)色谱柱;流动相为甲醇-水(74∶26);流量为0.8ml·min-1;柱温为30℃;ELSD检测器检测;ELSD漂移管温度为90℃;气体流量1.48L·min-1。结果 平均加样回收率为99.1%,RSD为2.76%。结论 方法准确、可靠,可用于玉屏风口服液的质量控制。 相似文献
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罗苑苑 《现代食品与药品杂志》2004,14(3):10-11
目的 建立玉屏风口服液的含量测定方法。方法 采用十八烷基硅烷键合硅胶柱,流动相为乙腈—水(35:65),检测波长为203nm。结果 浓度0.5~15.0μg范围内线性关系良好。结论 本方法灵敏、准确,可用于玉屏风口服液的质量控制。 相似文献
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目的建立玉屏风口服液的含量测定方法. 方法采用十八烷基硅烷键合硅胶柱,流动相为乙腈-水(35∶65),检测波长为203 nm. 结果浓度0.5~15.0 μg范围内线性关系良好.结论本方法灵敏、准确,可用于玉屏风口服液的质量控制. 相似文献
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目的建立玉屏风口服液中黄芪甲苷的含量测定方法。方法采用HPLCELSD法,KromasilC18(250mm×4.6mm,5μm)色谱柱;流动相为甲醇水(74∶26);流量为0.8ml·min-1;柱温为30℃;ELSD检测器检测;ELSD漂移管温度为90℃;气体流量1.48L·min-1。结果平均加样回收率为99.1%,RSD为2.76%。结论方法准确、可靠,可用于玉屏风口服液的质量控制。 相似文献
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溪黄草口服液制备工艺研究 总被引:2,自引:0,他引:2
目的:制备质量稳定,澄清的溪黄草口服液。方法:以口服液中总黄酮含量为指标,用正交试验优选撮提取工艺,用甲壳质与乙醇作澄清工艺比较优选澄清工艺。结果:溪黄草加水15倍,提取3次,每次1h,用350ppm浓度甲壳质吸附澄清,总黄酮含量高、稳定性好。结论:用水提聚、甲壳质吸附澄制备的口服液质量稳定、澄明度好。 相似文献
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Chen J Zhu H Chu VM Jang YS Son JY Kim YH Son CG Seol IC Kang JS 《Journal of pharmaceutical and biomedical analysis》2011,55(1):206-210
Two methods based on high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) were developed for the quality control of "samgiumgagambang" (SGMX), a new herbal medicinal preparation containing 14 herbs. Nine components from SGMX were selected as markers: 5-hydroxymethylfuraldehyde, geniposidic acid, chlorogenic acid, paeoniflorin, 20-hydroxyecdysone, coptisine, berberine, luteolin, and glycyrrhizic acid. The markers were identified and analyzed using HPLC coupled with a UV-diode-array detector and monitored at 250nm with a gradient elution of acetonitrile and water containing formic acid on a C(18) analytical column or using CE with a 70mM borate buffer (pH 9.5) containing 10% methanol on a 60-cm fused silica capillary monitored at 230nm. The marker components in SGMX were well separated using both methods and were readily determined within 60min using HPLC or 13min using CE with good precision and accuracy. 相似文献
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目的优选术后排气口服液的制备工艺。方法以处方中所含有效成分柚皮苷含量为评价指标,采用L9(3^4)正交试验。对影响煮提效果的诸因素(加水量、煎煮时间、煎煮次数)进行了优选,最后确定提取工艺。结果优选术后排气口服液以加水9倍,煎煮1次,每次时间为60min提取效果最好。结论该提取工艺可行,试验结果为确定术后排气口服液的提取工艺提供了实验依据。 相似文献
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于莉 《中国生化药物杂志》2004,25(4):238-239
目的观察乌鳖口服液对脾虚小鼠的影响。方法分别给模型组小鼠灌胃生脉液、乌鳖口服液进行观察实验。结果乌鳖口服液 2 7.5、5 5 .0ml/kg剂量组能明显延长脾虚小鼠的游泳时间和断头后张口喘气时间 ,张口喘气次数明显增多 ,与模型对照组比较具有显著差异。结论乌鳖口服液是一理想滋肾健脾的口服制剂。 相似文献
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In the literature, solubility values of itraconazole complexed with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were found which were still much too low to obtain the target concentration of 1 g itraconazole/100 ml, the concentration of the marketed itraconazole formulation Sporanox (Janssen Pharmaceutica). Therefore, we compared two preparation methods: the classical and the dissolving method to investigate if the method of preparation can have an influence on the solubility of itraconazole complexed with cyclodextrin (CD). With the classical method, the active compound and the CDs are jointly dissolved with a co-solvent, propylene glycol, in water. With the dissolving method, the active compound is first dissolved separately in a solvent in which it dissolves well, while the CDs are dissolved in water, before mixing. Three different CDs were used and compared for their complexing capacity with itraconazole. The complex formation of itraconazole with HP-beta-CD, sulfobutylether-7-beta-cyclodextrin (SBE-7-beta-CD) and maltosyl-beta-cyclodextrin (malt-beta-CD) was investigated at pH 2, in the presence of 10% propylene glycol for an oral solution. These three CDs were chosen as they can also serve in formulations for parenteral use. The method of preparation had an important influence on the complex formation. With the dissolving method, a much higher solubility of itraconazole was obtained using the same CD concentration than with the classical method. Inclusion capacity obtained with the dissolving method was comparable for HP-beta-CD and SBE-7-beta-CD: 1 g itraconazole/100 ml of 25% HP-beta-CD or of 30% SBE-7-beta-CD. In 100 ml of 40% malt-beta-CD only about 500 mg of itraconazole could be dissolved. With the classical method only around 160 mg itraconazole could be dissolved with 100 ml 40 % HP-beta-CD or SBE-7-beta-CD. Due to the fast preparation, once the CD amount is known by pretests, the dissolving method shows also an advantage for industrial production. 相似文献
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药用缓释材料聚乳酸-乙醇酸共聚物的研制 总被引:1,自引:0,他引:1
目的:合成药用聚乳酸-乙醇酸高分子缓释材料,用于某些生物药物缓、控释剂型的制备;同时探讨聚合反应条件的影响因素以及优化工艺。方法:在一定的温度和压力下,采用配位-插入聚合法通过交酯开环合成聚乳酸-乙醇酸共聚物缓释材料。结果:本研制合成的聚乳酸-乙醇酸共聚物(PLGA75/25和PLGA50/50)经采用多种鉴定手段表征化学结构正确,力学性能良好,玻璃转化温度为33.7℃,分子量为27000~70000,分子量分布为1.4~1.6,产品最终产率可达70%以上。结论:通过制备工艺条件的控制和优化,在一定范围内,不仅可以得到分子量大小不等和单体比例不同的聚乳酸-乙醇酸缓释材料,而且每批次之间所得分子量重现性良好,合成工艺稳定、可靠。 相似文献
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目的 建立麦芪口服液的最优工艺.方法 用正交设计方法 ,对制备工艺进行优化.结果 工艺条件为加水量每次为药材重的12倍,煎煮3次,每次60min,浓缩至含生药量2g·mL-1,壳聚糖净化处理,离心,调整总量至每毫升1.2g生药.结论 本研究获得了制备含可溶性多糖的中药口服液较满意的工艺. 相似文献
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葡萄糖酸钙口服溶液系补钙药,能促进骨骼和牙齿的钙化,维持神经与肌肉的正常兴奋性,降低毛细血管通透性,治疗缺钙症及过敏性疾患。中国药典2000年版二部收载了葡萄糖酸钙口服溶液处方及质量标准,其处方组成为:葡萄糖酸钙100g,乳酸5g,氢氧化钙0.5g,蔗糖200g,香精适量,水加至1000mL。因本品系葡萄糖酸钙的过饱和溶液, 相似文献
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目的制备护肝口服液,并建立该制剂的质控方法。方法用薄层色谱法对该处方中的丹参、白芍进行鉴别,以双波长薄层扫描仪测定丹参中原儿茶醛含量,作为质控标准。结果原儿茶醛在0.32-1.27mg/ml浓度范围内,浓度与峰面积呈线性关系,r=0.9990,RSD=1.37%;加样回收率为97.90%,n=5。结论该制剂制备工艺简单,质量控制方法可靠。 相似文献