4%与1%吲哚美辛乳膏的镇痛抗炎作用比较

目的:观察4%与1%吲哚美辛乳膏的镇痛抗炎作用.方法:以1%吲哚美辛乳膏为对比,对几种炎症、疼痛模型考察4%吲哚美辛乳膏的治疗作用.结果:4%吲哚美辛乳膏对甲醛致小鼠足部疼痛、热板法致小鼠足部疼痛、大鼠尾部压痛均有明显镇痛效果,对卡拉胶致大鼠足肿胀和二甲致小鼠耳肿胀有明显抗炎效果.结论:4%吲哚美辛乳膏具有明显的镇痛抗炎药效,优于1%吲哚美辛乳膏.     

小鼠鞘内注射吲哚美辛的镇痛作用与5-羟色胺的关系

目的研究小鼠鞘内注射吲哚美辛的镇痛机制与５．羟色胺的关系。方法采用温浴法观察动物痛阈变化;荧光测定法测定脊髓组织５－羟色胺、５－羟吲哚乙酸含量变化。结果小鼠鞘内注射（ｉｔｈ）吲哚美辛 １．８ ｍｇ·ｋｇ－１具有明显的镇痛作用,其作用可被ｉｔｈ 噻庚啶拮抗,该剂量的吲哚美辛可升高脊髓组织内的５－羟吲哚乙酸水平,前列腺素对此无影响。结论 吲哚美辛可通过促进脊髓内 ５－ＨＴ的释放发挥脊髓镇痛作用,该作用与其前列腺素抑制作用无明显关系。     

吲哚拉新搽剂的抗炎镇痛作用研究

目的研究吲哚拉新搽剂的抗炎镇痛作用。方法镇痛作用试验采用小白鼠扭体法及大白鼠光辐射热甩尾法 ;抗炎作用试验采用鼠耳肿胀法和大白鼠足爪肿胀法。结果吲哚拉新搽剂( 1 5 %)对冰醋酸致小鼠扭体反应数及光幅射大白鼠尾的镇痛作用均优于同体积市售吲哚美辛搽剂 ( 1 0 %) ;对卡拉胶致大鼠足肿胀的抑制作用与吲哚美辛搽剂相似 ,对二甲苯致小白鼠耳肿胀的抗炎作用与吲哚美辛搽剂相当。结论吲哚拉新搽剂具有较强的抗炎镇痛作用。     

吲哚美辛原料及肠溶片剂质量再评价

吲哚美辛原料及肠溶片剂质量再评价中国药品生物制品检定所１０００５０王维王瑾吲哚美辛（Ｉｎｄｏｍｅｔｈａｃｉｎ），异名消炎痛，是前列腺素合成抑制药，对炎症性疼痛作用显著，对痛风性关节炎及骨关节炎疗效较好．不良反应主要表现为胃肠反应，对胃刺激性较强．故现...     

不同剂量吲哚美辛对小鼠胚泡着床的影响

吲哚美辛是一种非选择性的前列腺素合成酶抑制剂,国外已有吲哚美辛影响动物着床的报道,在此,进一步观察不同剂量吲哚美辛对小鼠着床的影响,为下一步建立吲哚美辛致小鼠胚泡着床障碍模型奠定基础.     

吲哚美辛凝胶稳定性研究

目的:考察吲哚美辛凝胶的稳定性.方法:将包装和脱包装的吲哚美辛样品置于高温、高湿、强光环境下,考察其含量变化情况.结果:强光时脱包装吲哚美辛凝胶含量略为下降,高温时(80℃)吲哚美辛凝胶含量下降明显,高湿对吲哚美辛凝胶含量无影响.结论:吲哚美辛凝胶对高温不稳定,对强光略为不稳定,对高湿稳定,提示吲哚美辛凝胶应采用低温避光保存.     

吲哚美辛对大鼠胃功能的影响及作用机制研究

目的 研究吲哚美辛对大鼠胃酸分泌及胃蛋白酶活力的影响及其作用机制。方法 大鼠分为对照组和吲哚美辛低、中、高剂量组。测定各组大鼠胃酸分泌量及胃蛋白酶活力,测定血清胃泌素含量。结果 吲哚美辛可显著增加胃酸分泌量、增加胃酸分泌速度及增加胃蛋白酶活力,促进胃泌素分泌。结论 吲哚美辛可显著促进胃酸分泌,增加胃蛋白酶活力,这与其促进胃秘素分泌有关。     

吲哚美辛栓引起的全身性过敏反应

吲哚美辛栓具有解热、镇痛及非特异性抗炎作用。其最常见的不良反应是胃刺激和头痛。过敏反应较为罕见。吲哚美辛栓可避免胃肠道刺激,使用方便、副作用少。但在我院对症治疗的同时,就2000年7～8月份在妇产科出现吲哚美辛栓致全身性过敏反应的人数达5人以上,其中最为严重的1例现报道如下。     

新癀片中药组分对吲哚美辛的减毒作用

目的探讨新癀片中的中药组分对化学药成分吲哚美辛的减毒作用。方法采用急性毒性实验。给ICR小鼠分别ig不同剂量的新癀片、化学药成分吲哚美辛,记录各组小鼠的死亡数、毒性症状,用Bliss法分别计算LD50。同时另设新癀片中药组分组,确定其最大给药量,并观察毒性反应。结果新癀片中药组分对小鼠的1日最大给药量为18.2g/kg。吲哚美辛的LD50为18.31mg/kg,新癀片的LD50为1217.83mg/kg,由于吲哚美辛在新癀片中的质量分数为2.478%,因此折算成新癀片中吲哚美辛的LD50为30.16mg/kg。结论新癀片中中药组分对吲哚美辛具有减毒作用。     

对两种胚泡着床障碍小鼠模型围着床期子宫内膜形态结构的比较研究

目的比较研究米非司酮、吲哚美辛诱导的两种胚泡着床障碍小鼠模型围着床期子宫内膜形态结构。方法将成年♀昆明小鼠交配后随机分为对照组、米非司酮组和吲哚美辛组,于妊娠d8观察小鼠胚泡着床率及平均着床胚泡数,利用光镜和电镜观察子宫内膜的形态结构。结果与对照组相比,米非司酮组和吲哚美辛组其着床率和平均着床胚泡数均降低;米非司酮模型小鼠子宫内膜的发育明显受抑制,吲哚美辛模型小鼠子宫内膜的血管形成受阻。结论米非司酮和吲哚美辛通过对围着床期子宫内膜形态结构不同的影响而复制小鼠胚泡着床障碍模型。     

壮骨1号方镇痛抗炎作用研究

目的 观察壮骨1 号方的镇痛抗炎作用,为临床研究提供科学依据。方法 采用小鼠热板、醋酸扭体两种镇痛实验方法,观察壮骨1 号方的镇痛作用;采用小鼠二甲苯耳肿模型和大鼠棉球肉芽肿模型,观察壮骨1 号方的抗炎作用。结果 壮骨1 号方能有效地缓解由外界热刺激和化学性刺激引起的机体的疼痛,具有较好的镇痛作用,尤以高、中剂量效果显著;能有效的降低小鼠、大鼠的急性炎症和慢性炎症的发生,具有较好的抗炎效果。结论 壮骨1 号方具有显著的镇痛和抗炎效果。     

新癀片皮肤外涂给药抗炎镇痛实验研究

目的：观察新癀片外涂给药的抗炎镇痛作用。方法：制作炎症及镇痛模型,观察新癀片外涂给药的抗炎镇痛作用。结果：新癀片外涂给药对小鼠耳肿、大鼠角叉菜胶足肿、棉球肉芽肿等急、慢性炎症有非常显著的抑制作用;对大、小鼠水浴甩尾、小鼠醋酸扭体等温热刺激、化学刺激引起的疼痛有非常显著的镇痛作用,且在相同剂量下,外涂给药和ig给药的作用无明显差异。结论：新癀片外涂给药同ig给药一样,对各种肿痛均有较好的治疗作用。     

栀黄巴布剂抗炎镇痛作用的实验研究

目的研究栀黄巴布剂的抗炎镇痛作用。方法采用醋酸所致小鼠腹膜炎引起疼痛的扭体反应观察栀黄巴布剂的镇痛作用;采用二甲苯所致的小鼠急性炎症、大鼠棉球肉芽肿慢性炎症观察栀黄巴布剂的抗炎作用。结果栀黄巴布剂对实验鼠具有明显的镇痛及抗炎作用,与模型组比较有显著性差异(P<0.01)。结论栀黄巴布剂具有镇痛、抗炎作用。     

退烧颗粒抗炎镇痛作用研究

目的研究退烧颗粒镇痛抗炎的药理活性,为临床用药提供指导。方法采用醋酸扭体法和热板法实验研究退烧颗粒的镇痛作用;采用二甲苯致小鼠耳肿胀法、鸡蛋清致大鼠足肿胀法考察退烧颗粒的抗炎作用。结果与模型组及对照组相比,退烧颗粒能够显著延长小鼠的疼痛潜伏期,明显提高小鼠痛阈值,减少扭体次数;抗炎作用研究表明,退烧颗粒对二甲苯致小鼠耳肿胀和蛋清致大鼠足肿胀有显著抑制作用。结论退烧颗粒具有显著抗炎、镇痛作用,对感冒引起的发炎、疼痛等症状具有良好治疗作用。     

金胆片浸膏的主要药效学研究

目的观察金胆片浸膏对小鼠的镇痛、抗炎作用以及对大鼠的利胆作用。方法采用二甲苯致炎剂,观察金胆片浸膏对由此而产生耳廓肿胀作用的影响;观察金胆片浸膏对醋酸刺激所致疼痛的影响;观察金胆片浸膏对大鼠胆汁流量的影响。结果金胆片浸膏对二甲苯所致的小鼠耳肿胀有明显的抑制作用,对醋酸所致小鼠扭体反应也有明显抑制作用,能明显增加大鼠胆汁流量。结论金胆片浸膏具有镇痛、抗炎、利胆作用。     

Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal ants Polyrhachis lamellidens

The ethanol extract of Chinese medicinal ants Polyrhachis lamelliden was evaluated for its analgesic and anti-inflammatory activities in mice. It was shown that the extract significantly inhibited acetic acid-induced writhing response and increased hot-plate pain threshold of mice at doses of 1.5 and 3.0 g crude drug/kg. Meanwhile, the extract significantly inhibited the increase in vascular permeability induced by acetic acid and in ear edema induced by xylene in mice. However, it had no obvious effect on leukocyte migration induced by carboxymethylcellulose sodium (CMC-Na). The ethanol extract suspended in water was partitioned with diethyl ether, ethyl acetate and n-butanol successively to yield four fractions including water fraction. Among these fractions, diethyl ether and ethyl acetate fractions were found to increase hot-plate pain threshold and to inhibit acetic acid-induced writhing response in mice. Water fractions markedly inhibited acetic acid-induced writhing response and reduced the dye leakage to the peritoneal cavity induced by acetic acid and ear edema induced by xylene. These results suggest that P. lamellidens presents remarkable analgesic and anti-inflammatory activity, which supported the traditional use of the medicinal ants in the treatment of various diseases associated with inflammation. The diethyl ether fraction has greater contribution to the overall analgesic activity, whereas the water fraction showed the greatest anti-inflammatory and peripheral analgesic activities.     

前列宁片抗前列腺增生与抗炎镇痛实验研究

目的:研究前列宁片抗前列腺增生及抗炎镇痛作用。方法:采用小鼠实验性前列腺增生模型,二甲苯致耳廓肿胀法、角叉菜、5-HT致炎法、热板法、扭体法等多种模型。结果:前列宁片对小鼠实验性前列腺增生有预防和治疗作用;对二甲苯引起的耳廓肿胀及角叉菜、5-HT所致的大鼠足肿胀有抑制作用;可抑制5-HT和组胺所致大鼠毛细血管通透性增加;对小鼠热板法和醋酸扭体法诱发的疼痛有明显的抑制作用。结论:前列宁片具有抗前列腺增生及抗炎镇痛作用     

福司福沙的初步药理学研究

福司福沙在小鼠醋酸扭体法和热板刺激法中具有相似的镇痛作用；在二甲苯所致小鼠耳肿胀试验和醋酸诱发小鼠急性渗出试验中也有相似的抗炎作用。其镇痛、抗炎作用与阿司匹林均无显著差异，但对胃刺激性比阿司匹林小。小鼠口服的ＬＤ５０为１８７５ｍｇ／ｋｇ。     

Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models

Objectives Friedelin was isolated from Azima tetracantha Lam. leaves collected from Kallakurichi, Villuppuram district, Tamil Nadu, India. The anti‐inflammatory, analgesic and antipyretic activities of friedelin have been investigated in Wistar rats and mice. Methods Friedelin was isolated from the hexane extract of leaves of A. tetracantha using column chromatography. The effects of friedelin on inflammation were studied by using carrageenan‐induced hind paw oedema, croton oil‐induced ear oedema, acetic acid‐induced vascular permeability, cotton pellet‐induced granuloma and adjuvant‐induced arthritis. The analgesic effect of friedelin was evaluated using the acetic acid‐induced abdominal constriction response, formalin‐induced paw licking response and the hot‐plate test. The antipyretic effect of friedelin was evaluated using the yeast‐induced hyperthermia test in rats. Key findings In the acute phase of inflammation, maximum inhibitions of 52.5 and 68.7% (P < 0.05) were noted with 40 mg/kg friedelin in carrageenan‐induced paw oedema and croton oil‐induced ear oedema, respectively. Administration of friedelin (40 mg/kg) significantly (P < 0.05) decreased the formation of granuloma tissue induced by cotton pellet at a rate of 36.3%. In the adjuvant‐induced arthritis test friedelin inhibited 54.5% of paw thickness. Friedelin inhibited acetic acid‐induced vascular permeability in mice. Friedelin also produced significant (P < 0.05) analgesic activity in the acetic acid‐induced abdominal constriction response and formalin‐induced paw licking response. In the hot‐plate test, friedelin did not show any significant results when compared with control. Treatment with friedelin showed a significant (P < 0.05) dose‐dependent reduction in pyrexia in rats. Conclusions The results suggested that friedelin possessed potent anti‐inflammatory, analgesic and antipyretic activities.     

Anti-inflammatory Properties of Entada abyssinica. Leaves

Abstract

The effects of the defatted methanol extract of Entada abyssinica. Steud. ex A. Rich leaves on some models of inflammation were investigated. The analgesic property of the plant extract was also tested on acetic acid–induced writhing, as well as formalin-induced paw licking, in mice. The antipyretic effect was evaluated using yeast-induced hyperpyrexia in mice. At doses of 50–200 mg/kg, the extract produced significant (p < 0.05) inhibition of leukocyte migration after intraperitoneal injection of carrageenan in rats. A topical anti-inflammatory effect was produced by 20 mg/ear of the extract, as demonstrated by inhibition of croton oil–induced ear edema in mice. The analgesic property of the plant extract was observed by inhibition of acetic acid–induced writhing and paw licking induced by formalin in mice. The extract, however, exhibited no antipyretic activity. This study further established the anti-inflammatory activity of E. abyssinica., in addition to its analgesic effect.