女性心理障碍与中介变量之间关系

目的探讨女性心理障碍与中介变量之间的相互关系。方法采用症状自评量表(SCL-90)、领悟社会支持量表(PSSS)、特质应对方式问卷(TCSQ)、自我接纳问卷(SAQ)、一般自我效能感量表(GSES)、被他人所容纳量表(ATOS)对女性进行调查,女性心理障碍与中介变量之间相互作用关系采用多元回归分析。结果家庭支持对女性心理障碍严重程度有正向预测作用(Beta=0.297,P<0.01),家庭支持主要影响抑郁情绪(Beta=0.307,P<0.01)和精神病性症状(Beta=0.302,P<0.01)。SCL-90总分对中介变量无显著的预测作用,人际关系敏感对社会支持(Beta=0.170,P<0.05)有正向预测作用,精神病性症状对社会支持(Beta=0.226,P<0.01)和积极应对(Beta=0.209,P<0.01)有正向预测作用。结论中介变量丧失心理健康的保护作用是女性心理障碍的重要因素之一。心理障碍对中介变量无显著影响,人际关系敏感和精神病性症状能增加社会支持,精神病性症状还能增加积极应对。     

医学院校大学生就业状况与人口学变量

目的探讨影响医学院校大学生就业的人口学变量。方法采用人口学问卷,对368名医学院校大学毕业生的就业状况进行调查。结果①专业、是否学生干部、是否党员、家庭经济状况在就业状况上的差异有统计学意义(χ2=38.596,P0.000;χ2=12.923,P0.012;χ2=26.684,P0.000;χ2=21.253,P0.007);②就业状况在性别、生源地上的差异没有统计学意义(χ2=7.330,P0.119;χ2=9.145,P0.058)。结论专业、是否学生干部、是否党员、家庭经济状况等变量影响医学院校大学生的就业状况;性别、生源地不影响其就业状况。     

Quantitation of Bacteria in Blood of Typhoid Fever Patients and Relationship between Counts and Clinical Features, Transmissibility, and Antibiotic Resistance

Salmonella typhi was isolated from 369 and Salmonella paratyphi A was isolated from 6 of 515 Vietnamese patients with suspected enteric fever. Compared with conventional broth culture of blood, direct plating of the buffy coat had a diagnostic sensitivity of 99.5% (95% confidence interval [CI], 97.1 to 100%). Blood bacterial counts were estimated by the pour plate method. The median S. typhi count in blood was 1 CFU/ml (range, <0.3 to 387 CFU/ml), of which a mean of 63% (95% CI, 58 to 67%) were intracellular. The mean number of bacteria per infected leukocyte was 1.3 (interquartile range [IQR], 0.7 to 2.4) CFU/cell (n = 81). Children (<15 years old; n = 115) had higher median blood bacterial counts than adults (n = 262): 1.5 (range, <0.3 to 387) versus 0.6 (range, <0.3 to 17.7) CFU/ml (P = 0.008), and patients who excreted S. typhi in feces had higher bacteremias than those who did not: a median of 3 (range, <0.3 to 32) versus 1 (range, <0.3 to 68) CFU/ml (P = 0.02). Blood bacterial counts declined with increasing duration of illness (P = 0.002) and were higher in infections caused by multidrug-resistant S. typhi (1.3 [range, <0.3 to 387] CFU/ml; n = 313) than in infections caused by antibiotic-sensitive S. typhi (0.5 [range, <0.3 to 32] CFU/ml; n = 62) (P = 0.006). In a multivariate analysis this proved to be an independent association, suggesting a relationship between antibiotic resistance and virulence in S. typhi.     

罗夏测验攻击变量与外显攻击敌意的关系

目的:探索国内提出的罗夏测验攻击变量与外显的攻击敌意行为的关系。方法:按照CCMD-3标准选择30名病人施测罗夏测验,做简明精神病量表的评定。结果:①攻击变量的克伦巴赫α系数均在0.78以上;②因素分析将攻击变量归纳为3个因子:攻击行为(28.91)、攻击主体(23.95)、被攻击的结果(23.11),总方差贡献率为76%;③攻击变量中:攻击性内容、潜在的攻击、攻击性情绪、心理伤害和攻击变量总分与简明精神病量表的敌对猜疑因子显著相关,攻击性内容和攻击变量总分在敌对猜疑因子的高低分组上差异显著。结论:部分支持使用罗夏测验攻击变量测量攻击,但还需要进一步研究完善。     

Clinical Trial of Hyposensitisation in Hay Fever: Two Methods of Relating Symptom Scores to Daily Pollen Counts

Two methods of relating daily pollen counts to patients' symptom scores in clinical trials of hyposensitisation in hay fever are described. The problems involved in comparing results from different centres and years of a trial are discussed with particular reference to symptoms which are not pollen related. The Normalised Regression method is a powerful technique, but often the Pollen Interval method is preferable on the grounds of simplicity of communication and calculation.     

Correlation between Peripheral White Blood Cell Counts and Hyperglycemic Emergencies

Objective: To determine the correlation between differential leukocyte counts and hyperglycemic emergencies.Methods: Fifty patients with diabetic ketoacidosis (DKA), 50 patients with diabetic ketosis (DK), 50 non-DK diabetic patients with stable glycemic control, and 50 normal controls were enrolled. Their total and differential leukocyte counts were measured and evaluated at admission and after treatment.Results: The patients with DKA and DK had higher plasma glucose levels (20.84±6.73 mmol/L, 15.55±2.6 mmol/L, respectively) and more median leukocytes (13325/mm³ and 6595/mm³, respectively) and median neutrophils (11124 /mm³ and 4125/mm³, respectively) but fewer median eosinophils (28/mm³ and 72/mm³, respectively) compared to non-DK and control groups (all p < 0.05). Acute infection increased the elevating extent. The median leukocyte counts in DK and non-DK patients (6595/mm³ and 6008/mm³, respectively) were within the normal range. The counts of total leukocytes and neutrophils were significantly higher but eosinophils lower in severe DKA cases than in mild/moderate cases (p < 0.05). When the DKA and DK and infection resolved, total leukocytes and neutrophils fell, but eosinophils increased. The counts of total leukocytes, neutrophils, and monocytes were negatively correlated with arterial pH levels (r = -0.515, r = -0.510, r = -0.517, all p < 0.001, respectively) and positively correlated with plasma glucose levels (r = 0.722, r = 0.733, r = 0.632, all p < 0.05, respectively) in DKA patients. The arterial pH level was the most significant factor affecting total leukocytes in DKA (β = 0.467, p = 0.003). The diagnosis analysis showed that higher total leukocyte and neutrophil counts and lower eosinophil counts had a significant ability to reflect the presence of hyperglycemic emergencies.Conclusion: More total leukocytes and neutrophils but fewer eosinophils was significantly correlated with DKA and DK. Leukocyte counts can add valuable information to reflect the presence of hyperglycemic crisis and acute infection.     

人格特征与罗夏测验攻击变量的相关性研究

目的 探讨人格特征与罗夏测验攻击变量的相关性.方法 使用艾森克个性问卷(EPQ)和罗夏测验在225名中国人样本中进行测试.结果 EPQ中各维度与大部分罗夏测验攻击变量的相关不显著(P＞0.05),与AgC等攻击变量相关显著(P＜0.05),但相关值均较低(0.008～0.265).结论 罗夏测验攻击变量与个体的人格特征存在一定的相关性.     

Relationships between Actin Regulatory Mechanisms and Measurable State Variables

In this report we extend our recent mathematical formulation of the actin cycle model [Bindschadler et al. Biophys. J. 86 (2004) 2720] to predict the influence of key regulatory mechanisms on network-scale state variables estimable in live cell experiments. Specifically, we examine the influence of regulation by cofilin, profilin, capping protein and proteins that adjust filament number through nucleation and/or filament severing, on the higher order variables of average filament length, polymer fraction, and filament turnover rate. Importantly, we find that severing/nucleation, the acceleration of ADP-subunit disassembly by cofilin, and the catalytic and shuttle functions of profilin have ‘signature’ effects on the higher order state variables. In this way, measurement of the state variables in live cells can allow inference of regulatory mechanism(s) underlying changes in cell state. Our results compare favorably to published data for endothelial cells undergoing a transition from non-motile confluent cells to highly motile subconfluent cells. The extension of our model to higher order state variables allows us to investigate other important issues such as the distinction between basic and higher order measures of filament dynamics, the influence of thymosin β4 on network state variables, the interplay between thymosin β4 and profilin, and the synergystic effects of cofilin and profilin.     

The Relationship of Early Family Variables to Children's Subsequent Behavioral Adjustment

Examined the relative strength of the relation between early family functioning variables and subsequent (41/2 years later) child adjustment. Five clusters of family variables were examined: child's gender, life-stress events, child characteristics, maternal characteristics, and spousal support. The criterion variables were mother, father, and teacher ratings of the target child's adjustment. Hierarchical regression analyses were used to identify the best models for the prediction of child adjustment. No significant models were found when the independent criteria of father- or teacher-rated behavior were used. The models for the prediction of children's total adjustment, conduct disorders, social aggression, attention problems, and anxiety-withdrawal, as rated by the mother, indicated that the early family variables of life stress, child characteristics, and maternal characteristics are key in subsequent child functioning, with spousal support playing an apparently minor role.     

Correlation of Variables between the Dominant and Non-dominant Eyes in Healthy Young People

Objective: To investigate the correlation of variables between dominant and non-dominant eyes in healthy young people. Methods: 300 cases(600 eyes) of healthy young volunteers recruited in our hospital from March 2020 to February 2022were selected as the research objects. The general data of the volunteers were collected and the dominant eye, diopter, biological parameters and retinal blood flow density were detected. We compared all the test indexes of volunteers with different dominant eyes, a...     

Sex Differences in Physiological Reactions to Real Life Stress and Their Relationship to Psychological Variables

The present experiment investigates whether there are sex differences in physiological reactions to real life stress and whether these reactions are differentially related to psychological variables in males and females. In 29 male and 23 female students physiological measurements were taken on the day of an examination and on a normal routine day. Behavioral characteristics were measured using questionnaires. Serum cholesterol level, systolic blood pressure, and heart rate were found to be higher on the examination day. These reactions did not differ between the sexes. Males showed a larger increase of urine-adrenaline excretion than did females. In males, cholesterol level and response were related to achievement motivation. Ambulatory monitored HR during the exam correlated with state anxiety and state depression in females, but not in males. The analysis of sex specific expression of behavioral traits in physiological parameters, including the CHD risk factors, is of potential value for a better understanding of mechanisms mediating between behavior and CHD risk.     

大学生的人际关系与自我和谐的关系

目的:了解大学生的人际关系困扰与自我和谐的关系,为大学生人际关系的改善及自我和谐水平的提高提供参考。方法:选取贵州省大学生554名,用人际关系综合诊断量表和自我和谐量表(SCCS)进行测查。结果:按SCCS得分将大学生分为3组,即低分组、中间组和高分组,3组大学生在人际关系各因子及总量表上的得分差异均具有统计学意义(F=39.73,29.48,24.09,18.15,55.67;P0.001)。人际关系及其4个因子得分与SCCS的3个因子得分的相关均具有统计学意义(r=-0.09~0.54,P0.05)。回归分析显示,自我与经验不和谐得分对人际关系总分具有正向预测作用(β=0.59,P0.001),自我灵活性得分对人际关系总分具有负向预测作用(β=-0.16,P0.01)。路径分析显示,自我与经验不和谐和自我灵活性到人际关系各因子的路径系数均有统计学意义(P0.05)。结论:自我与经验不和谐和自我的灵活性可能是影响大学生人际关系的重要因素。     

Crossover Counts and Likelihood in Multipoint Linkage Analysis

For large numbers of genetic loci, jointly tested to determinetheir order along a chromosome, liklihood methods become unfeasibleowing to the very large numbers of discrete alternative hypotheses(locus orderings) whose liklihoods must be separetly evaluated.A mehtod to order loci according to the criterion of minimizingthe obligatory crossover count is therefore proposed. A branch-and-boundalgorithm implementing this proposal has been programmed; theproperties of this algorithm are investigated. The statisticalproperties of the proposed method are also considered. It isshown to be consistent under wide conditions, including arbitarylocus spacings, variable amounts of inforation per locus, andsome patterns of interference. The relationship between theminimum crossover order and the maximum likelihood order isdiscussed. For fully informative gametes, and tight linkage,there is a virtual equivalence of the two criteria. For looserlinkage, ther remains a close relatinships.     

洛夏测验的一些变量与智力的相关研究

本研究目的是用经验性的方法来研究洛夏测验的一些变量与智力的关系。将６０名正常人的洛夏测验和中国修订韦氏成人智力量表的测试结果，进行相关研究时发现，洛夏测验反应总数，人的运动，反应内容，组合反应频数，组合反应总和，发展质量，常见反应，惯常纯形状，惯常形状，混合反应，整体反应，歪曲形状与智商有轻到中度相关。多元回归表明，洛夏测验中涉及知觉组织和知觉精确性的变量对智力影响较大。本文对这些发现进行了讨论。     

大学生同伴信任与关系型自我构念的关系

目的:探究大学生同伴信任与关系型自我构念之间的关系。方法:以随机整群抽样的方式向上海市具有代表性的5所高校发放调查问卷564份;以信任量表(TS)和关系型自我构念量表(RISC)为测评工具,探讨两者之间的相关与回归效应。结果:男生的同伴信任(t=-4.83,P0.01)和关系型自我构念得分低于女生(t=-4.00,P0.01),大一学生的同伴信任(t=-2.32,P0.05)和关系型自我构念得分低于大二学生(t=-2.57,P0.05);信任量表与关系型自我构念量表的相关有统计学意义(r=0.571,P0.001);关系型自我构念能够预测同伴信任32.6%的变异量(r=0.571,R2=0.326,R2adj=0.325,F=272.02,P0.001)。结论:大学生关系型自我构念能够显著预测同伴信任。     

Natural Killer Cell Counts Are Not Different between Patients with Post-Lyme Disease Syndrome and Controls

It has been reported that patients with “chronic Lyme disease” have a decreased number of natural killer cells, as defined by the CD57 marker. We performed immunophenotyping in 9 individuals with post-Lyme disease syndrome, 12 who recovered from Lyme disease, and 9 healthy volunteers. The number of natural killer cells was not significantly different between the groups.Lyme disease, the most common vector-borne illness in the United States, is caused by Borrelia burgdorferi and transmitted by the bite of the Ixodes sp. tick (the deer tick). The disease usually begins with erythema migrans, an expanding skin lesion at the site of the tick bite. Within several days or weeks, there is hematogenous dissemination of the spirochetes, and patients may present with dermatologic, neurological, cardiac, and rheumatologic involvement (7). “Chronic Lyme disease” is a controversial term applied to a broad spectrum of patients, including individuals with Lyme disease and those with post-Lyme disease syndrome (PLDS), as well as patients with no evidence of current or past B. burgdorferi infection (5, 6). PLDS is defined as the persistence or relapse of nonspecific symptoms (such as fatigue, musculoskeletal pain, and cognitive complaints) in patients who have had Lyme disease and have received an adequate course of antibiotic therapy.It has been reported that patients diagnosed with chronic Lyme disease have a decreased number of natural killer cells, as defined by the CD57 marker, and that the changes in the number of CD57⁺ cells can be monitored as evidence of response to therapy (8-10). CD57 was initially used as a marker for NK cells, but it is not expressed by all NK cells and is also expressed by T-cell subpopulations. It is thought that CD57 is a marker of terminally differentiated cells (4). Currently, the most common approach for identifying NK cells utilizes a combination of CD56 and CD16 surface markers used together with CD3 to exclude T cells expressing NK markers (NK T cells). The CD57 test is offered in some clinical laboratories and is being used by some health practitioners to evaluate and follow patients diagnosed with chronic Lyme disease. To further evaluate the utility of NK cell numbers in evaluating and/or monitoring this patient group, we performed immunophenotyping in 9 patients with PLDS, 12 individuals who recovered from Lyme disease, and 9 healthy volunteers.Patients with PLDS had a past history of Lyme disease according to the Centers for Disease Control and Prevention clinical definition (1, 2), a prior positive serologic analysis confirmed by immunoglobulin G Western blotting (3), received at least one course of recommended antibiotic therapy (11), and had persistent or intermittent symptoms for at least 6 months after appropriate antibiotic therapy for Lyme disease. Common symptoms included widespread musculoskeletal pain and fatigue, memory and/or concentration impairment, and radicular pain, paresthesias, or dysesthesias. The onset of symptoms was coincident with or within 6 months of initial B. burgdorferi infection, symptoms were severe enough to interfere with daily life activities, and other causes were excluded. Individuals who recovered from Lyme disease also had a past history of Lyme disease according to the Centers for Disease Control and Prevention clinical definition and received recommended antibiotic therapy but had no complaints attributed to the disease. Controls included healthy volunteers from areas of endemicity (n = 9) with no previous history compatible with Lyme disease and who were seronegative for B. burgdorferi. The study was approved by the National Institute of Allergy and Infectious Diseases Institutional Review Board, and all individuals signed informed consent forms.Peripheral blood specimens were obtained by phlebotomy on site. Anticoagulated (EDTA) samples were stained using the whole-blood lysis method and analyzed concurrently on a dual-laser FACSCalibur (BD Biosciences) using CellQuest software (BD Biosciences). Directly conjugated mouse anti-human monoclonal antibodies against CD3, CD4, CD8, CD20, CD16, CD56, and CD57 were used. Irrelevant, directly conjugated, mouse anti-human monoclonal antibodies were used to define background staining. All monoclonal antibodies were obtained from BD Biosciences and Beckman Coulter and used as recommended by the manufacturers. Lymphocytes were identified by forward and side scatter, and the lymphocyte gate was confirmed using the CD45/CD14 LeucoGate reagent (BD Biosciences). To calculate the absolute numbers of each lymphocyte subset, the percentage of positive cells was multiplied by the absolute peripheral blood lymphocyte count obtained using an automated hematology instrument on the same blood sample. Results were compared by Kruskal-Wallis test or Mann-Whitney test. The Spearman rank correlation coefficient was used to calculate quantitative correlations. All P values were two sided and regarded as statistically significant if P was <0.05.There were six women and three men in the PLDS group, six women and six men in the recovered group, and four women and five men in the healthy volunteer group. All participants were Caucasian. The median ages in the PLDS, recovered, and healthy volunteer groups were 52, 59, and 52 years, respectively. The initial presentation of the disease was a single erythema migrans lesion in two patients, a flu-like illness in one, multiple erythema migrans lesions in one, and neurological disease in five patients in the PLDS group. In the recovered group, three patients presented with a single erythema migrans lesion, four patients presented with multiple erythema migrans lesions, and five presented with neurological disease. The time that elapsed from the initial presentation of the disease to the date of lymphocyte phenotyping was longer in the PLDS group (mean, 84 months) than for the recovered group (mean, 50 months), but the difference did not reach statistical significance (P = 0.095).There was no significant difference between the three groups regarding the number of CD3⁻ CD57⁺ (P = 0.68) or CD16⁺ or CD56⁺ CD3⁻ cells (P = 0.65) (Fig. ​(Fig.1).1). There was also no difference between the groups regarding the numbers of CD3⁻ CD8⁺ CD57⁺ (P = 0.54), CD3⁻ CD56⁺ CD57⁺ (P = 0.75), and CD3⁻ CD56⁻ CD57⁺ cells (P = 0.13). Very few cells were CD3⁻ CD56⁻ CD57⁺, and the Spearman rank-order correlation coefficient between CD3⁻ CD57⁺ and CD3⁻ CD56⁺ CD57⁺ cells was 0.98 (P < 0.0001). We conclude that the numbers of NK cells do not differ between patients with PLDS, individuals who have recovered from Lyme disease, and healthy volunteers and that the number of CD57⁺ non-T (CD3⁻) cells is not helpful in evaluation or management of these patients.Open in a separate windowFIG. 1.Natural killer cell numbers (CD16⁺ or CD56⁺ CD3⁻) and CD3⁻ CD57⁺ cell numbers do not differ between PLDS patients, individuals who have recovered from Lyme disease (REC), and healthy volunteers (HV).     

Relationship between anti-A and anti-Forssman

Antibodies that detect a spectrum of A antigenic specificities have been demonstrated in human anti-A sera. Some sera contain antibodies that detect a specificity common to human A red cells and buccal cells, sheep R, r and i red cells, pig A red cells as well as guinea-pig kidney cells. Antibodies reacting with the A determinant on pig A red cells may be absent from some sera. Another antibody detects an antigenic specificity present on human A red cells and buccal cells, pig A and sheep R red cells, and perhaps also on guinea-pig kidney, but absent from sheep r or i red cells. Other antibodies detect an A antigen present only on human A red cells.     

The Relationship between Adult Attachment and Internersonal Relationship of Undergraduates

目的 研究成人依恋和人际交往的状况,并探讨了两者之间的关系,为促进大学生的心理健康提供参考依据.方法 采用成人亲密关系体验调查问卷(ECR)和人际关系综合诊断量表对172名大学生进行调查,分析大学生的成人依恋的状况及其与人际交往状况之间的相关.结果 ①大学生的成人依恋类型分布不均衡.其中比重最大的是惧怕型(47.7％),其次是冷漠型(24.4％),专注型和安全型的比重较小(分别为16.3％,11.6％);②不同生源地的大学生在依恋的回避维度和人际交往的交谈维度存在显著的差异(F=5.770,2.745,P＜0.05);③除待人接物与回避维度相关不显著外(r=0.050,P＞0.05),交谈、交际与交友和异性交往均与依恋回避显著相关(r=0.305,0.287,0.349,P＜0.01),且依恋焦虑与人际交往的各个维度均显著相关(r=0.234,0.331.0.433,0.250,P＜0.01);④成人依恋对人际交往有一定的预测作用(R2=0.29,P＜0.001).结论 大学生的成人依恋与人际交往有着密切的关系,可以在充分了解自己的依恋风格的基础上提高自己的人际交往的能力.     

军校新生人际关系与心理健康相关性分析

目的:探讨军校新生人际关系与心理健康的关系,为军校大学生心理教育提供理论依据和实践指导。方法:以方便抽样法,采用人际关系综合诊断量表、症状自评量表(SCL-90)及一般状况问卷,对某军校591名新生进行问卷调查。结果:1该军校新生中有23.7%存在不同程度的人际关系困扰;22.2%可能存在较严重的心理问题,19.8%可能存在轻度的心理问题;3人际关系总分及其各维度与SCL-90总分及其各因子均存在统计学正相关(r=0.200~0.551,P0.001)。结论:军校大学生存在一定程度的人际关系困扰和心理问题,且人际关系与心理健康密切相关,改善军校新生的人际关系有助于提高其心理健康水平。     

Relationship between bacteria and IgE

In this preliminary report, we describe our inability to induce IgE antibody to a well-characterized bacterial component, the membrane proteoglycan of Klebsiella pneumoniae and its major protein fraction FIII-B in BALB/c mice. In contrast, an immunomodulatory effect of membrane proteoglycan of K. pneumoniae on the IgE and IgG antibody responses to ovalbumin could be demonstrated.