Nursing of advanced colorectal cancer patients treated with Cetuximab combined with chemotherapy

Cetuximab is a new medication that has recently been approved for the treatment of advanced colorectal cancer. To date we have had little experience in using this targeted agent. Eleven patients in our hospital with advanced colorectal cancer were treated with cetuximab and chemotherapy. Based on the curative effect of this combination therapy, we have concluded that the following nursing practices make an important contribution to the patients'prognosis and wellbeing: to establish a good nurse-patient relationship, to increase patient understanding of the side effects, to standardize the medications, to observe and to deal with the side effects of the medications(for example skin reaction, neutropenia, and diarrhea), and to provide continuous mental health care support and education.     

Phototherapeutic Keratectomy Combined with Photorefractive Keratecto-my for Treatment of Myopia with Corneal Scars

Phototherapeutickeratectomy(PTK)hasbeenawel1--establishedmethodforthetreatmentofkeratOPathy['--']andphotorefractivekeratectomy(PRK)hasbeenprovedeffectiveinthetreatmentofmyopia.ButnoreportswereavailableonPTKcom-binedwithPRKtotreatmyopicpatientswithcornealscars.1PATIENTSANDMETHODSFromJune,l996toMay,l998,24myopiccas-es(30eyes)withcornealscarswerelncludedinthestudy.Meanagewas32.7years(agerangingfrom17to60y).Theyincluded10men(l2eyes)andl4women(18eyes).Meancourseofdiseasewasll.3y(rangi…     

Preliminary observation on treatment of patients with Japanese B encephalitis with monoclonal antibody

The monoclonat antibodies(McAbs)against Japanese B encephalitis virus for clinicaluse were prepared according to the standards of Food and Drug Administration(FDA,USA).Immediately after the diagnosis,the patients were given 10 mg of McAbs(IgG)in normal salineby intravenous drip plus intramuscular injection.The average febrifugal days of the McAb treat-ment group(55 cases),symptomatic treatment group(12 cases),ribavirin treatment group(17cases)and thymus peptides treatment group(7 cases)were 2.86,6.20,7.16 and 9.11d,respec-tively(P<0.05 or P<0.01).It is necessary to take the skin test before use of the McAbs andto give dexamethasone during the McAb treatment.     

Clinical Observation of Patients with Hematologic Malignancies Treated with Hematopoietic Stem Cell Transplantation

HSCTincludingauto HSCT ,myeloablativeallo HSCTandnonmyeloablativeallo HSCTwhichdevel opedrecently ,isthebesttherapeusisforhematologicmalignanciesnowadays .FromApril 1996toApril2 0 0 4 30patientswithhematologicmalignanciesun derwentHSCTinourhospital ,asrep…     

Back pain associated with osteoporosis

ＢａｃｋｐａｉｎａｓｓｏｃｉａｔｅｄｗｉｔｈｏｓｔｅｏｐｏｒｏｓｉｓＤａｉＬｉｙａｎｇ（戴力扬）；ＪｉａＬｉａｎｓｈｕｎ（贾连顺）（ＤｅｐａｒｔｍｅｎｔｏｆＯｒｔｈｏｐａｅｄｉｃｓ，ＣｈａｎｇｚｈｅｎｇＨｏｓｐｉｔａｌ，ＳｅｃｏｎｄＭｉｌｉｔａｒｙＭ...     

Cutaneous Sporotrichosis Treated with Terbinafine

ＣｕｔａｎｅｏｕｓＳｐｏｒｏｔｒｉｃｈｏｓｉｓＴｒｅａｔｅｄｗｉｔｈＴｅｒｂｉｎａｆｉｎｅＷｕＳｈａｏｘｉ吴绍熙；ＧｕｏＮｉｎｇｒｕ郭宁如ａｎｄＬｕＧｕｉｘｉａ吕桂霞（ＩｎｓｔｉｔｕｔｅｏｆＤｅｒｍａｔｏｌｏｇｙ，ＣＡＭＳ＆ＰＵＭＣ，Ｎａｎｊｉｎｇ２...     

Nine Cases of Herpes Zoster with HIVInfection Treated with Rhubarb Powder

ＦｒｏｍＭａｙ１９９７ｔｏＭａｙ１９９８,ｗｈｉｌｅｔｈｅａｕｔｈｏｒｓｔｒｅａｔｅｄＨＩＶｉｎｆｅｃｔｅｄｐａｔｉｅｎｔｓｗｉｔｈｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅｍｅｄｉｃｉｎｅ（ＴＣＭ）ｉｎＴａｎｚａｎｉａ,９ｃａｓｅｓｏｆｈｅｒｐｅｓｚｏｓｔｅｒｗｉｔｈＨＩＶｉｎｆｅｃｔｉｏｎｗｅｒｅｔｒｅａｔｅｄｗｉｔｈｔｈｅｐｏｗｄｅｒｏｆＲａｄｉｘｅｔＲｈｉｚｏｍａＲｈｅｉ（ＲＲＲ）．ＭＥＴＨＯＤＳＣｌｉｎｉｃａｌＤａｔａ　　ＮｉｎｅｃａｓｅｓｗｅｒｅｄｉａｇｎｏｓｅｄＨＩＶｐｏｓｉｔｉ…     

Closed Anesthesia with Nitrous Oxide

ＣｌｏｓｅｄＡｎｅｓｔｈｅｓｉａｗｉｔｈＮｉｔｒｏｕｓＯｘｉｄｅＬＩＳｈｉｔｏｎｇ（李士通）；ＷＡＮＧＺｈｅｎｇｐｉｎｇ（汪正平）；ＺＥＮＧＢａｎｇｘｉｏｎｇ（曾邦雄）；ＬＩＵＪｕｎｊｉｅ（刘俊杰）（ＤｅｐａｒｔｍｅｎｔｏｆＡｎｅｓｔｈｅｓｉｏｌｏｇ...     

Association of defective HLA-Ⅰ expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer

Background It has been confirmed that defective expression of human leukocyte antigen class Ⅰ (HLA-Ⅰ) molecules can contribute to the immune evasion of cancer cells in some types of cancer. The aim of this study was to examine the expression of HLA class Ⅰ antigen and the antigen-processing machinery (APM) components in esophageal squamous cell carcinoma (ESCC) and their role in high risk human papillomavirus (HPV) infection, and to analyze their association with histopathological characteristics in the Kazak ethnic group.Methods A total of 50 formalin-fixed, paraffin-embedded ESCC lesions were collected from the First Affiliated Hospital of Xinjiang Medical University, China. The expression levels of HLA-Ⅰ antigen and APM components were determined by immunohistochemistry; the HPV DNA were detected using polymerase chain reaction (PCR).Results A high frequency of down-regulation or loss of expression of HLA and APM components were found in esophageal cancer in Kazak people. HLA-Ⅰ, TAP1, CNX, LMP7, Erp57, Tapasin and ERAP1 were down-regulated in 68%,44%, 48%, 40%, 52%, 32% and 20% of ESCC lesions then, respectively. The loss of expression of HLA-Ⅰ antigen was significantly correlated with part of the APM components and positively correlated with high risk HPV16 infection. TAP1,CNX, LMP7, Erp57 and Tapasin loss were significantly associated with tumor grading, lymph node metastasis and depth of invasion (P＜0.05).Conclusion Our results suggest that APM component defects are a mechanism underlying HLA-Ⅰ antigen down-regulation in ESCC lesions, and indicate that the loss expression of HLA-Ⅰ and APM components will become an important marker of ESCC and analysis of HLA-Ⅰ and APM component expression can provide useful prognostic information for patients with ESCC from the Kazak ethnic group.     

Oncol2012: Association of salivary α-amylase activity with pain relieving scale in cancer patients with bone metastasis treated with radiotherapy

Background Subjective assessment tools such as visual analog scale (VAS) or pain score are commonly used to evaluate chronic cancer-induced pain intensity. However, they are limited value. We have determined the changes of VAS and salivary α-amylase (sAA ) activity in cancer patients with bone metastasis during radiotherapy in order to discuss the correlation between them. Methods 30 patients suffering from bone metastasis were enrolled in a single institution from June 2010 to March 2011. All cases with cancer-induced bone pain received radiation therapy (RT) at the same dose (30 Gy) and fractionation (3 Gy/fraction, 5 days/week) for palliative pain relief. Heart rate(HR), Systolic vs diastolic blood pressure blood pressure(DBP/SBP), VAS of the cases were assessed before (d0), after 5 fractions (d5) and 10 fractions (d10) of the irradiation. sAA activity and salivary cortisol (SC) were respectively measured using a portable analyzer and automated chemiluminescence analyzer. Results The radiotherapy markedly decreased the VAS pain scale from 82.93?9.29 to 31.43?16.73mm (P<0.001) and sAA activity from 109.40?26.38 to 36.03?19.40U/ml (P <0.001).Moreover, there is a significant correlation between the two indices (P <0.01, r=0.541). HR decreased by 6.5% after radiotherapy, but was not associated with VAS (P >0.05). In addition, SC and BP didn’t change significantly in the study (P >0.05). Conclusion Since there was a significant correlation between sAA activity and VAS pain scale, these preliminary results suggest that this biomarker may be a valuable, noninvasive and sensitive index for the objective assessment of pain intensity in patients with cancer-induced bone pain.     

Association of T regulatory cells with natural course and response to treatment with interferon-α in patients with chronic hepatitis B infection

Background  Regulatory T cell populations, particularly CD4⁺CD25⁺ T regulatory cells, have been implicated in the persistence of hepatitis B virus (HBV) infection. However, no clear relationship has been established between the frequency of CD4⁺CD25⁺ T regulatory cells in the peripheral blood and either the disease phases in the natural history of chronic HBV infection or in the response to interferon-α therapy.

Methods  In the present study, three different common markers of CD4⁺CD25⁺ T regulatory cells were used to determine the numbers of T regulatory cells in healthy controls and in patients with chronic HBV infection.

Results  No significant difference was found when samples were gated for CD25^hi and CD25⁺FoxP3⁺ T cells. A significant correlation was found between the number of CD4⁺ Treg cells that gated with CD25⁺FoxP3⁺ and CD25⁺CD127^low/- in healthy controls and in patients with chronic hepatitis B (CHB) (r=0.67, 0.59; P <0.01). The percentages of Treg cells were (8.56±2.01)% in asymptomatic carriers (Asc), (8.74±3.04)% in inactive HBsAg carriers, (10.7±2.93)% in CHB and (7.42±1.28)% in healthy controls (F=11.1, P <0.001). The percentage of Treg cells in patients with CHB was higher than in asymptomatic HBV patients, inactive HBsAg carriers, or healthy controls (P <0.01). The proportion of CD4⁺CD25⁺CD127^low/- T cells in patients who responded to interferon-α was (11.9±3.3)%, (9.1±2.4)% and (9.0±2.9)% at baseline, week 12 and week 24 after treatment, respectively (Z=2.42, P <0.05; Z=2.67, P <0.01).

Conclusions  These results suggest that the proportion of the CD4⁺CD25⁺ regulatory T cells might be affected by the application of different markers in process to detect T regulatory cells. The frequency of Treg cells was increased in patients with CHB, which might be associated with the disease activity of these patients and contribute to prevention of extensive liver damage. A decline in Treg cells at week 12 of treatment might be associated with a better response to treatment with interferon-α.

     

Therapeutic effect of taurine with hypertonic saline on rat hemorrhagic shock complicated with hypernatremia

ＴｈｅｒａｐｅｕｔｉｃｅｆｅｃｔｏｆｔａｕｒｉｎｅｗｉｔｈｈｙｐｅｒｔｏｎｉｃｓａｌｉｎｅｏｎｒａｔｈｅｍｏｒｒｈａｇｉｃｓｈｏｃｋｃｏｍｐｌｉｃａｔｅｄｗｉｔｈｈｙｐｅｒｎａｔｒｅｍｉａＹａｎｇＪｕｎ杨军，ＣｈａｎｇＹｉｎｇｚｉ常英姿，ＬｉｕＸｉｕ...     

Pericardial devascularization combined with Latarjet’s innervation in the treatment of patients with

Ｈｅｍｏｒｈａｇｅｆｒｏｍｅｓｏｐｈａｇｅａｌｖａｒｉｃｅｓｉｓａｆａｔａｌｃｏｍｐｌｉｃａｔｉｏｎｉｎｃｉｒｈｏｔｉｃｐａｔｉｅｎｔｓ，ｗｉｔｈａｍｏｒｔａｌｉｔｙｕｐｔｏ６３％．Ｃｏｎｔｒｏｌｉｎｇｂｌｅｅｄｉｎｇｉｎｔｒｅａｔｉｎｇｐｏｒｔ...     

Treatment of Prolapse of Rectum with Acupuncture Combined with TCM Drugs in 38 Cases

Prolapse of rectum is usually seen in children and seniorcitizens.By means of acupuncture combined with TCM drugs,the authors have treated 38 cases of the disorder,and achievedgood therapeutic effects.This is reported as follows.Clinical DataOf the 38 cases in this series,20 cases were male and 18female,ranging from 6 to 70 years in age.Of them,12 casesaged 6-10 years,22 cases 50-70 years,and only 4 cases 10-50years.     

Cardiac protection by long-term treatment with captopril in patients with acute myocardial infarction.

ＣａｒｄｉａｃｐｒｏｔｅｃｔｉｏｎｂｙｌｏｎｇｔｅｒｍｔｒｅａｔｍｅｎｔｗｉｔｈｃａｐｔｏｐｒｉｌｉｎｐａｔｉｅｎｔｓｗｉｔｈａｃｕｔｅｍｙｏｃａｒｄｉａｌｉｎｆａｒｃｔｉｏｎＳｈｅｎＷｅｉｆｅｎｇ沈卫峰，ＬｉＭｉｎｇｚｈｏｕ李明洲，ＨｕＨｏｕｄａ...     

Clinical Study of Suddern Deafness Treated with Method of Integrated Traditional Chinese with Western Medicine

Ｃｌｉｎｉｃａｌ　Ｓｔｕｄｙ　ｏｆ　Ｓｕｄｄｅｒｎ　Ｄｅａｆｎｅｓｓ　Ｔｒｅａｔｅｄ　ｗｉｔｈ　Ｍｅｔｈｏｄ　ｏｆ　Ｉｎｔｅｇｒａｔｅｄ　Ｔｒａｄｉｔｉｏｎａｌ　Ｃｈｉｎｅｓｅ　ｗｉｔｈ　Ｗｅｓｔｅｒｎ　ＭｅｄｉｃｉｎｅＺＨＡＮＧＸｉａｎｇ－ｙａｎｇ...