ESOPHAGEAL LICHEN PLANUS: A CASE REPORT AND REVIEW OF LITERATURE

Lichen planus is a rare cause of esophagitis and esophageal stricture. It is invariably associated with oral mucosal involvement and the diagnosis has to be considered in these patients who present with dysphagia. We present a case of esophageal stricture secondary to lichen planus.     

CUTANEOUS PANCREATIC METASTASIS: A CASE REPORT AND REVIEW OF LITERATURE

Pancreatic cancer is one of the most dangerous human cancers and will continue to be a major unsolved health problem as we enter the 21^st century. This is the case despite advances in imaging technology and surgical management. Indeed, 80% to 90% of pancreatic cancers are diagnosed either at the locally advanced or metastatic stage. Cutaneous metastases originating from pancreatic cancer are relatively rare. The most common site of cutaneous metastasis is the umbilicus, and this is known as the Sister Joseph''s nodule. Very few patients have been reported with cutaneous lesions disclosing a pancreatic carcinoma at sites other than the umbilical area. To the best of our knowledge, there have been no previous reports on cutaneous pancreatic metastasis in Egypt. This is a report on a patient with cutaneous pancreatic metastases at the neck and review of reported non-umbilical cutaneous metastases from pancreatic carcinoma in the literatures.     

MULTIPLE SMOOTH MUSCLE HAMARTOMA: CASE REPORT AND REVIEW OF THE LITERATURE

Smooth muscle hamartoma (SMH) is a proliferative disorder of cells originating from muscle cells. It is a benign tumoral mass that usually presents as a single congenital skin-colored and hypertrichotic plaque involving the trunk and extremities. Multiple SMHs have rarely been reported in the literature. We describe the case of a seven-month-old girl with multiple SMHs located over the back and arm areas. The diagnosis was confirmed by biopsy and immunohistochemical (IHC) staining. She had no cerebral or skeletal abnormalities and her growth and development were normal.     

NORWEGIAN SCABIES IN A MALE MONGOLOID: REPORT OF A CASE AND A REVIEW OF THE LITERATURE

Norwegian scabies, caused by Sarcoptes scabiei, is a rare disease. It is often seen in the mentally deficient and the mentally retarded, especially in male mongoloids. The eleventh U. S. case is presented with an extensive bibliography.     

SOLITARY LYMPHOCYTOMA CUTIS: REPORT OF A CASE AND BRIEF REVIEW OF LITERATURE

A case report of solitary lymphocytoma cutis of the nose and its treatment in a 35-year-old woman is presented. Biopsy is necessary in establishing a definitive diagnosis as lymphocytoma cutis is commonly confused with other cutaneous lesions. A possible pathogenesis is discussed.     

CASE PRESENTATION AND REVIEW OF THE LITERATURE

All reported cases of Hætnophilus influenzæ cellulitis are reviewed and compared. A typical patient is a male between the ages of 1–3 years. He is acutely ill with a red-blue cellulitis of the face. Swelling of the involved area is massive and rapid in onset. Both temperature and the number of leukocytes are markedly elevated, Hæmophilus influenzæ type B can usually be isolated from cultures of the blood or nasopharynx. Appropriate antibiotic therapy produces prompt remission of both signs and symptoms.     

TREATMENT OF BASAL CELL CARCINOMA WITH INTRALESIONAL INTERFERON ALPHA: A CASE REPORT AND LITERATURE REVIEW

We report the case of a 76 year old man with three ulcerated basal cell carcinomas on his lower limbs. He was considered unsuitable for surgical therapy and was treated by intralesional interferon alpha-2b (Intron A) injections. Twenty months post therapy two of the three treatment sites remain clinically cured. Recurrence occurred at the site which received the smallest total dose of interferon. A review of the therapeutic trials of interferon alpha for basal cell carcinoma is presented. We conclude that interferon alpha-2b is a useful agent for treatment of basal cell carcinoma in selected patients.     

SEZARY'S SYNDROME: A CASE REPORT INCLUDING ULTRASTRUCTURAL AND IMMUNOHISTO-CHEMICAL CHARACTERIZATION OF THE CELLULAR INFILTRATES

A case of a 77-year-old male with Sézary's syndrome (SS) is reported, including ultrastructural and immunohistochemical characterization of the cellular infiltrates. Atypical lymphocytes in the skin were evaluated at stages of both clinical exacerbation and improvement. During both stages, skin specimens revealed essentially similar findings. They were diffusely infiltrated by atypical lymphocytes with a characteristic nuclear convolution. The infiltrating cells exhibited T-cell markers which cross-reacted with the T-cells of the lymph nodes. Atypical convoluted cells in the peripheral blood were PAS positive and peroxidase negative. The morphological and functional characteristics of the cellular infiltrates in SS and its clinical independence from mycosis fungoides were discussed.     

BULLOUS PEMPHIGOID IN CHILDHOOD: REPORT OF THREE CASES AND A REVIEW OF LITERATURE

Three proven cases of bullous pemphigoid in childhood which responded to dapsone are reported. The clinical and immunological criteria for diagnosis were similar to those in the aged. This report emphasizes that the condition is a distinctive clinical entity and entirely different from dermatitis herpetiformis and benign chronic bullous dermatosis of childhood.     

CONTACT DERMATITIS DUE TO BUDESONIDE: REPORT OF FIVE CASES AND REVIEW OF THE JAPANESE LITERATURE

Background. Contact allergy to corticosteroids has recently gained increased attention. Methods. Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described. The Japanese literature was reviewed for reports on this allergy, and the occurrence due to budesonide was compared with that of other dermocorticosteroids. Results. Budesonide use can cause contact dermatitis. Conclusions. Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.     

ROTHMUND-THOMSON SYNDROME: A CASE REPORT*

A patient demonstrating many of the changes seen in the Rothmund-Thomson syndrome is presented. In particular, she shows early solar skin damage and it is probable that further skin cancers¹ will develop.