共查询到20条相似文献,搜索用时 406 毫秒
1.
Letizia Penolazzi Ilaria Lampronti Monica Borgatti Mahmud Tareq Hassan Khan Margherita Zennaro Roberta Piva Roberto Gambari 《BMC complementary and alternative medicine》2008,8(1):59
Background
Osteoclasts (OCs) are involved in rheumatoid arthritis and in several pathologies associated with bone loss. Recent results support the concept that some medicinal plants and derived natural products are of great interest for developing therapeutic strategies against bone disorders, including rheumatoid arthritis and osteoporosis. In this study we determined whether extracts of Emblica officinalis fruits display activity of possible interest for the treatment of rheumatoid arthritis and osteoporosis by activating programmed cell death of human primary osteoclasts. 相似文献2.
Objective
To investigate nano-hydroxyapatite (nHA) pellets as carriers for vancomycin in the treatment of chronic osteomyelitis and bone defects due to methicillin-resistant Staphylococcus aureus (MRSA) strains. 相似文献3.
Edílson Damke Joyce K Tsuzuki Diógenes AG Cortez Izabel CP Ferreira Thâmara A Bertoni Márcia R Batista Lucélia Donati Terezinha IE Svidzinski Márcia EL Consolaro 《BMC complementary and alternative medicine》2011,11(1):35
Background
Study of in vivo antifungal activity of the hydroalcoholic extract (HE) and n-BuOH extract (BUTE) of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida spp. 相似文献4.
Bardia A Tiwari SK Gunisetty S Anjum F Nallari P Habeeb MA Khan AA 《Inflammation research》2012,61(4):359-365
Objective
The present study was designed to investigate the role of X-ray cross-complementing group 1 (XRCC1) and apurinic/apyrimidinic endonuclease 1 (APE1) polymorphisms in apoptosis and the risk of ulcerative colitis (UC). 相似文献5.
Background
Rhizoma Curculiginis (Xianmao) and Rhizoma Drynariae (Gusuibu) are 'Yang-tonifying' traditional Chinese herbal medicines used to strengthen bones. This investigation aims to assess the systemic effect of extracts of Rhizoma Curculiginis and Rhizoma Drynariae on bone histomorphology and formation, and their local effect on bone healing. 相似文献6.
Sevjidmaa Baasanjav Aleksander Jamsheer Mateusz Kolanczyk Denise Horn Tomasz Latos Katrin Hoffmann Anna Latos-Bielenska Stefan Mundlos 《BMC medical genetics》2010,11(1):110
Background
Osteopoikilosis is a rare autosomal dominant genetic disorder, characterised by the occurrence of the hyperostotic spots preferentially localized in the epiphyses and metaphyses of the long bones, and in the carpal and tarsal bones [1]. Heterozygous LEMD3 gene mutations were shown to be the primary cause of the disease [2]. Association of the primarily asymptomatic osteopokilosis with connective tissue nevi of the skin is categorized as Buschke-Ollendorff syndrome (BOS) [3]. Additionally, osteopoikilosis can coincide with melorheostosis (MRO), a more severe bone disease characterised by the ectopic bone formation on the periosteal and endosteal surface of the long bones [4–6]. However, not all MRO affected individuals carry germ-line LEMD3 mutations [7]. Thus, the genetic cause of MRO remains unknown. Here we describe a familial case of osteopoikilosis in which a novel heterozygous LEMD3 mutation coincides with a novel mutation in EXT1, a gene involved in aetiology of multiple exostosis syndrome. The patients affected with both LEMD3 and EXT1 gene mutations displayed typical features of the osteopoikilosis. There were no additional skeletal manifestations detected however, various non-skeletal pathologies coincided in this group. 相似文献7.
Objective
The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms confer susceptibility to ankylosing spondylitis (AS). 相似文献8.
José A Riancho Carmen Valero María T Zarrabeitia María T García-Unzueta José A Amado Jesús González-Macías 《BMC medical genetics》2008,9(1):112
Background
Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influence of common polymorphisms of the SHBG gene on serum SHBG, bone mineral density (BMD), and osteoporotic fractures. 相似文献9.
María-José Ariza Miguel-Ángel Sánchez-Chaparro Francisco-Javier Barón Ana-María Hornos Eva Calvo-Bonacho José Rioja Pedro Valdivielso José-Antonio Gelpi Pedro González-Santos 《BMC medical genetics》2010,11(1):66
Background
Hypertriglyceridemia (HTG) is a well-established independent risk factor for cardiovascular disease and the influence of several genetic variants in genes related with triglyceride (TG) metabolism has been described, including LPL, APOA5 and APOE. The combined analysis of these polymorphisms could produce clinically meaningful complementary information. 相似文献10.
Objective
The aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations. 相似文献11.
Introduction
We aimed to determine the neutralization of Neisseria meningitidis outer membrane vesicles (blebs) by humoral and cellular elements of whole blood. 相似文献12.
Objective and design
Leflunomide (LEF) is effective not only in different animal models of autoimmune diseases and the therapy of patients with rheumatoid arthritisbut also in graft rejection. The effect of LEF on CD4+CD25+T regulatory cells (Treg) was determined in a mouse model of allogeneic bone marrow transplantation. 相似文献13.
James RiddellIV Daniel R Kaul Petros C Karakousis Joel E Gallant Jennifer Mitty Powel H Kazanjian 《Journal of translational medicine》2007,5(1):50
Background
To describe long term outcomes of Mycobacterium avium complex (MAC) immune reconstitution inflammatory syndrome (IRIS). 相似文献14.
Yunping Qiu Minjun Chen Mingming Su Guoxiang Xie Xin Li Mingmei Zhou Aihua Zhao Jian Jiang Wei Jia 《Chinese medicine》2008,3(1):3
Background
Herba Cistanches (Roucongrong) is effective in treating Shenxu Zheng ('kidney-deficiency syndrome'). However, the mechanisms and systemic metabolic responses to the herbal intervention are unclear. 相似文献15.
Objective and design
To determine whether exposure to E. coli lipopolysaccharide (LPS) modulates adenosine A1 receptor-induced increase in plasma exudation from the intact hamster cheek pouch microcirculation. 相似文献16.
《Scandinavian journal of immunology》2018,88(3)
Rationale
Sufficient levels of vitamin D seem to be essential for proper immune function, and low levels might be associated to disease activity in Rheumatoid Arthritis (RA ). Most studies investigate only 25OHD and not the physiologically active vitamin D metabolite, 1,25(OH )2D.Objective
To investigate associations between serum level of vitamin D metabolites and disease activity parameters in 160 inflammatory active and treatment naïve early RA patients. Serum level of vitamin D metabolites (25OHD 2, 25OHD 3 and 1,25(OH )2D) was measured by isotope dilution mass spectrometry and radio‐immunoassays at baseline. Disease characteristics were gender, number of tender joints, number of swollen joints, DAS 28‐CRP , HAQ , VAS ‐scores, CRP , erosive status (Total Sharp Score; TSS ), ACPA and IgM‐RF ‐status. Associations were evaluated using Spearman's and Wilcoxon rank‐sum tests. The study was registered in clinical trials; trial registration number: NCT 00209859.Findings
Statistically significant inverse associations were found between the active metabolite 1,25(OH )2D and DAS 28‐CRP (P = 0.004, rho = −0.23), HAQ (P = 0.005, rho = −0.22), CRP (P = 0.001, rho = −0.25), VAS patient‐pain (P = 0.008, rho = −0.21), and a positive association was found to ACPA ‐status (P = 0.04).Conclusion
The vitamin D metabolite 1,25(OH )2D was inversely associated with disease activity and positively associated with ACPA in treatment naïve and inflammatory active early RA . The results indicate that in RA , both the degree of inflammatory activity, and the diagnostic sensitivity and specificity might affect—or might be affected by the level of vitamin 1,25(OH )2D.17.
Objective
To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). 相似文献18.
Qing Liu Yao Tong Stephen ChoWing Sze Wing Keung Liu Lam Lam Ellie ShihngMeir Chu Christine MiuNgan Yow 《Chinese medicine》2010,5(1):25
Background
Tian Xian Liquid (TXL) is a Chinese medicine decoction and has been used as an anticancer dietary supplement. The present study aims to investigate the effects of TXL on the apoptosis of HT-29 cells and tumor growth in vivo. 相似文献19.
Hossein Hosseinzadeh Azar Hosseini Marjan Nassiri-Asl Hamid-Reza Sadeghnia 《BMC complementary and alternative medicine》2007,7(1):23
Background
Salvia leriifolia have been shown to decrease ischemia-reperfusion (I/R) injury in brain tissues. In this study, the effects of S. leriifolia aqueous and ethanolic extracts were evaluated on an animal model of I/R injury in the rat hind limb. 相似文献20.
Philipp Ehlermann Dieter Weichenhan Jörg Zehelein Henning Steen Regina Pribe Raphael Zeller Stephanie Lehrke Christian Zugck Boris T Ivandic Hugo A Katus 《BMC medical genetics》2008,9(1):95