腺样体肥大儿童合并慢性鼻窦炎的临床调查及相关性分析

目的　了解本地区腺样体肥大儿童合并慢性鼻窦炎的发病情况,并分析两者之间的相关性。方法　对178例确诊腺样体肥大患儿进行鼻窦CT三围扫描,明确合并慢 性鼻窦炎,进行判定,收集相关数据,行统计学分析。结果  178例腺样体肥大患儿,男107例,女71例,平均年龄7.3±2.5岁。合并慢性鼻窦炎者60例,占33.71%,二者在平均年龄、发病年龄及病程间比较均无显著性差异（P＞0.05）。鼻窦炎CT评分与A/N比值各等级之间比较,差异有统计学意义（r =0.435,P <0.05）。结论　腺样体肥大与慢性鼻窦炎CT评分之间有明显相关性,针对腺样体肥大治疗可明显减缓慢性鼻窦炎病情。     

腺样体肥大儿童合并慢性鼻-鼻窦炎的临床调查及相关性分析

目的了解腺样体肥大儿童合并慢性鼻-鼻窦炎的情况,计算腺样体肥大儿童中慢性鼻-鼻窦炎的发生率,并分析腺样体肥大与慢性鼻-鼻窦炎的相关性。方法调查128例确诊为腺样体肥大儿童,详细了解其临床表现及治疗现状,收集相关数据并对数据进行统计学分析。结果128例腺样体肥大儿童,年龄3~16岁,平均(8.1±3.5)岁,其中男85例,女43例。并发慢性鼻-鼻窦炎54例(42.2%,54/128),年龄3~16岁,平均(8.4±3.9)岁,各鼻窦受累情况为上颌窦54例,前组筛窦24例,后组筛窦8例,额窦14例,蝶窦6例。54例儿童腺样体肥大程度与鼻-鼻窦炎Lund-Mackay CT评分的秩相关系数为0.485。结论腺样体肥大儿童合并慢性鼻-鼻窦炎的发生率为42.2%,腺样体肥大堵塞鼻咽部并影响鼻腔正常引流是慢性鼻-鼻窦炎的发病机制之一,对于儿童慢性鼻-鼻窦炎合并腺样体肥大者,优先考虑行腺样体切除手术治疗。     

合并腺样体肥大儿童慢性鼻窦炎的诊治体会

儿童慢性鼻窦炎常合并腺样体肥大,国外有研究表明儿童慢性鼻窦炎合并腺样体肥大的发病率为69%[1],且易延误治疗,使儿童慢性鼻窦炎迁延不愈,增加了鼻内镜手术治疗难度.     

儿童鼻窦炎与腺样体肥大的关系

儿童鼻窦炎发病率高,腺样体肥大是导致儿童鼻窦炎发病的重要原因之一。腺样体肥大可通过影响鼻腔发育、阻碍鼻腔引流和不断释放致病菌而持续影响鼻窦炎的发生发展,鼻窦炎则可通过炎症刺激导致腺样体肥大增生。变态反应因素可同时影响到鼻窦炎和腺样体炎症,是治疗儿童鼻窦炎和腺样体肥大时需要考虑的重要治疗靶点。腺样体与儿童鼻窦炎关系密切互为因果,而腺样体切除术可作为儿童鼻窦炎保守治疗效果不好时的首选外科治疗方案。     

儿童腺样体肥大合并慢性鼻窦炎对分泌性中耳炎发生率的影响

目的探讨儿童腺样体肥大(AH)合并慢性鼻窦炎(CRS)对分泌性中耳炎(OME)发生率的影响。方法对我院2017年至2018年行腺样体切除术或腺样体扁桃体切除术的腺样体肥大患者的临床资料进行统计和分析,包括病史和体征,电子鼻咽镜检查,声阻抗测试以评估腺样体肥大患者分泌性中耳炎和慢性鼻窦炎的患病情况。并使用统计软件SPSS 24.0进行统计分析。结果在208例AH儿童中,有分泌性中耳炎的50例(24%),在学龄儿童(6~12岁)腺样体肥大患者中分泌性中耳炎的发生率最高。腺样体肥大组和腺样体肥大合并慢性鼻窦炎组之间分泌性中耳炎的发生率在统计学上有差异(P=0.001)。结论患有慢性鼻窦炎的腺样体肥大儿童患分泌性中耳炎的风险相应增加,而学龄期的腺样体肥大儿童分泌性中耳炎发生率最高。     

腺样体切除术治疗儿童鼻窦炎20例

儿童鼻窦炎较为常见，近年来发病率日趋升高，颇受社会重视。其中有相当一部分与腺样体肥大同时存在，其病因与腺样体有很大关系。我科近2年来以切除腺样体作为治疗儿童鼻窦炎的一种方式，取得了良好疗效，现报告如下。     

儿童腺样体肥大110例分析

近几年，由于儿童分泌性中耳炎、鼻窦炎、睡眠打鼾的病例逐渐增多，腺样体肥大引起的危害性引起了人们重视。我科3年来收治腺样体肥大患儿110例，并进行了手术治疗，效果满意，报告如下。     

儿童鼻窦炎与腺样体肥大

儿童鼻窦炎与腺样体肥大之间有一定的相关性。急性鼻炎、急性鼻窦炎和急性扁桃体炎反复发作,可造成腺样体迅速增生肥大,加重鼻阻塞,阻碍鼻腔引流;鼻炎鼻窦炎分泌物又刺激腺样体使之继续增生,形成互为因果的恶性循环。     

儿童慢性扁桃体炎腺样体肥大切除202例

对２０２例慢性扁桃体炎腺样体肥大的患儿行手术切除，随访１８０例，治愈率９０％。对其中４０例伴有明确睡眠呼吸暂停病史的患儿手术前后进行了血气分析，结果（ｘ±ｓ）表明：术前ｐＨ７．３３４±０．０１３、Ｐｃｏ２（ｋＰａ）６．０４±０．２６、Ｐｏ２（ｋＰａ）１０３８±０２０，术后ｐＨ７３８８±００１８、Ｐｃｏ２５３７±０１９、Ｐｏ２１２４１±０２４，统计学处理各项指标均有显著性差异（Ｐ＜０．０１）。作者认为慢性扁桃体炎腺样体肥大如有睡眠性呼吸暂停临床症状及并发症者应早期手术治疗。     

腺样体切除对治疗儿童鼻窦炎疗效的影响

目的观察腺样体切除对治疗儿童鼻窦炎疗效的影响.方法儿童慢性鼻窦炎伴腺样体肥大168例,分为两组,治疗组在药物治疗的同时切除肥大的腺样体,对照组单纯药物治疗.结果1月后治疗组有效率94.8%,对照组有效率84.7 %,两者差异无显著性意义(P＞0.05).6月后治疗组有效率85.4%,对照组有效率61.1%,两者差异有显著性意义(P＜0.01).结论治疗儿童鼻窦炎的同时,切除肥大的腺样体可提高疗效,尤其以远期疗效更为显著.     

Adenoid hypertrophy and chronic rhinosinusitis: Helicobacter pylori on antral lavages,adenoid tissue and salival inmunoglobuline A on paediatric patients

ObjectiveTo determine Helicobacter pylori presence on antral lavages, adenoids and salival inmunoglobuline A on paediatric patients with chronic rhinosinusitis without nasal polyps (CRSsNP) and adenoid hypertrophy.MethodsAdenoid tissue, liquid obtained from antral lavages and saliva from 28 children diagnosed with CRSsNP, from the paediatric otorhinolaryngology practice of “Dr. Domingo Luciani” Hospital was taken and processed by means of polymerase chain reaction (PCR) using cagA, vacA and babA primers, also anatomopathological examination using Giemsa stain of the adenoids, determination of salivary specific secretory inmunoglobuline A (sIgA), socio-economic condition using the Graffar scale and associated gastrointestinal symptoms were assessed.ResultsNo evidence of Helicobacter pylori neither in antral lavages liquid nor adenoid tissue was found using PCR and Giemsa stain. sIgA was present in 28.6% of the subjects. The most frequently found symptoms were, diarrhea in 17.9%, distension and abdominal pain in 10.7%, 64.3% of the patients were in working (28.6%) and low middle (35.7%) classes.ConclusionsHelicobacter pylori is not present neither in maxillary sinuses nor adenoid tissue of the evaluated patients, sIgA it is a non-invasive method for assessment of immunologic challenge with the bacteria, not the presence of acute or chronic infection.     

Prevalence and associated factors of pulmonary hypertension in Kenyan children with adenoid or adenotonsillar hypertrophy

Objectives

Adenotonsillar hypertrophy is a common condition in childhood, whose serious complications of pulmonary hypertension and cor pulmonale are devastating but local prevalence is unknown. This study determined the prevalence and associated factors of pulmonary hypertension in children with adenoid or adenotonsillar hypertrophy at Kenyatta National Hospital, Kenya.

Methods

This was a cross sectional hospital based survey conducted among children below 12 years of age with clinical and radiological adenoid hypertrophy attending the ear, nose and throat (ENT) outpatient clinic and general pediatric wards. Doppler echocardiography was used to determine pulmonary hypertension defined as a mean pulmonary arterial pressure (mPAP) of ≥25 mm Hg using the Chemla equation. Children with mPAP of ≥25 mm Hg were compared to those with lower pressures and clinical and radiological factors associated with pulmonary hypertension determined using multivariate logistic regression analysis.

Results

Of the 123 eligible children in the study, 27 had pulmonary hypertension giving a prevalence of 21.9% (95% CI 14.64%–29.27%). Independent factors associated with pulmonary hypertension included nasal obstruction (OR = 3.0 [95% CI 1.08–8.44] p = 0.035) and hyperactivity on history (OR = 0.2 [95% CI 0.07–0.59] p = 0.003) and adenoid-nasopharyngeal ratio (ANR) >0.825 on lateral neck radiography (OR = 5.0 [95% CI 1.01–24.37] p = 0.048).

Conclusion

One in five children with adenoid or adenotonsillar hypertrophy had pulmonary hypertension with a 3-fold and 5-fold increased odds in those with nasal obstruction on history and ANR >0.825 on lateral neck radiography respectively and an 80% reduced odds in reportedly hyperactive children.     

Assessment of pulmonary function and nasal flow in children with adenoid hypertrophy

OBJECTIVE: Adenotonsillar hypertrophy is the most common cause of upper airways obstruction in children. The consequences of this disorder were analyzed by many researchers. The aim of the study was the assessment of pulmonary function and nasal flow in children with adenoid hypertrophy. METHODS: The study group covered 30 children treated surgically due to adenoid hypertrophy. Nasometric and spirometric tests were performed before and after surgery. RESULTS: The results revealed statistically significant differences between pre- and post-operative values of nasometric flows and the following spirometric parameters: VC, FVC, PEF, FEV1/PEF and FEV1/FVC. CONCLUSION: The influence of adenoid hypertrophy on pulmonary function in children has been confirmed on the basis of the conducted research.     

替牙期扁桃体伴腺样体肥大患儿过敏因素与颌面畸形的相关性

目的 研究替牙期扁桃体伴腺样体肥大患儿过敏因素与颌面部畸形的相关性.方法 对2018-2021年在山东大学齐鲁医院耳鼻咽喉科住院行扁桃体及腺样体切除术的替牙期(6-12岁)儿童207例行过敏原检测,收集患儿一般资料、临床资料及头影测量指标,组间比较采用t检验或非参数检验,相关分析使用Pearson或Spearman相关...     

腺样体肥大患儿血清特异性及总IgE检测结果分析

目的 初步分析腺样体肥大患儿血清特异性IgE分布及总IgE水平,探讨特异性IgE及总IgE水平与腺样体大小的关系.方法 回顾性分析2018年8月16日-2020年10月19日进行腺样体手术的186例腺样体肥大患儿的血清特异性IgE、总IgE检测结果,分析腺样体肥大患儿血清IgE分布情况,并比较患儿腺样体肥大程度与血清特...     

舌下含服粉尘螨滴剂治疗儿童变应性鼻炎合并腺样体肥大的疗效观察

目的 探讨舌下特异性免疫治疗对儿童变应性鼻炎及腺样体肥大的治疗效果。方法 将诊断为变应性鼻炎合并腺样体肥大的92例患儿随机分为两组,研究组应用舌下含服粉尘螨滴剂治疗,对照组采用常规抗过敏药物治疗,研究组观察3、6个月,对照组观察3个月,采用VAS评分记录患者鼻过敏和睡眠打鼾症状的变化,采用鼻内镜检查及鼻咽侧位片A/N比检测患儿腺样体大小的改变。结果 ①两组患者治疗后鼻过敏症状、睡眠打鼾症状VAS评分均低于治疗前;②常规抗过敏药物治疗组睡眠打鼾症状VAS评分低于舌下含服组,差异均有显著性统计学意义;③两组治疗后腺样体A/N比率均小于治疗前,且常规抗过敏药物治疗组小于舌下含服组（P<0.05）。结论 舌下特异性免疫治疗可有效控制儿童变应性鼻炎合并腺样体肥大患儿的过敏症状、睡眠打鼾症状及腺样体大小,可作为非手术干预治疗变应性鼻炎伴腺样体肥大的有效方法。     

Innate immunity gene expression by epithelial cells of upper respiratory tract in children with adenoid hypertrophy

Background

A major role of the innate immunity in the defence of mucosal tissue is well established. However, a balance between the main components of the immunity such as toll-like receptors (TLRs) and defensins in the pathology of upper respiratory tract in children has not been addressed yet. Our aim was to investigate the gene expression of some TLRs as well as alpha and beta-defensins in children suffered from adenoid hyperthrophy in comparison with healthy children.