共查询到19条相似文献,搜索用时 171 毫秒
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透明质酸是一种广泛分布于人体各组织器官中的黏多糖,是细胞外基质的主要成分之一。因其具有良好的生物相容性、抗黏附以及结构易修饰等特点,目前透明质酸已被公认为是生物医学领域中新生物材料开发的重要基石。本文对基于透明质酸设计的新型抗菌制剂及其应用进行综述,探讨透明质酸在抗菌制剂中的作用,指出透明质酸在抗菌制剂中应用的局限性与挑战性,并提出展望。 相似文献
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透明质酸是一种天然的线性黏多糖,具有特殊生理功能.本文简介透明质酸的功能、各种制备方法以及在医学方面的进展. 相似文献
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透明质酸衍生物研究进展 总被引:5,自引:3,他引:5
透明质酸因具有黏弹性、生物相容性及可降解性等,在医药领域获得广泛应用。但它对强酸、强碱、热、自由基及透明质酸酶敏感,容易发生降解,因而限制了其应用。为克服这些缺点及获得新的功能,有必要对透明质酸进行结构修饰。此文简介了透明质酸的修饰方法,包括酯化、交联、接枝、与金属形成配合物等。 相似文献
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透明质酸是一种广泛存在于细胞基质中的大分子酸性黏多糖,是一种重要的细胞外基质成分,具有良好的生物相容性和力学特性,体内可自行降解,同时通过与细胞表面受体结合,直接影响组织构建,促进细胞迁移以及胞外基质重构。研究表明透明质酸具有影响体外培养干细胞的黏附、迁移、增殖、老化及分化的能力。本文对透明质酸用于干细胞培养的最新研究进展进行综述。 相似文献
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透明质酸是一种酸性黏多糖,其作为优良的药物载体,具有生物相容性良好,生物可降解的特性,同时可与肿瘤细胞表面富含的CD44、RHAMM等受体结合,目前已成为抗肿瘤药物递送载体研究的主要热点。本综述主要通过查阅近年文献,对透明质酸在紫杉醇新型给药系统中的应用进行综述。 相似文献
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透明质酸钠预防手屈指肌腱黏连临床应用 总被引:1,自引:0,他引:1
目的:评价透明质酸钠防治手屈指肌腱术后黏连的有效性和给药方法。方法:50例71指手屈指肌腱损伤者随机分成2组,A组在肌腱损伤修复部鞘内或局部分别置管并注入透明质酸钠凝胶制剂。B组不用透明质酸钠。其他治疗两组相同。术后4,8,12周测定相关部位的功能、疼痛、肿胀情况,按关节功能、握拳功能评价透明质酸钠预防黏连的效果。结果:50例经平均12个月随访,A组最佳疗效率87.2%,无明显不良反应,B组最佳疗效率为59.4%。两组比较差异有显著性(P<0.05)。结论:透明质酸钠凝胶有预防术后屈指肌腱黏连作用,使用安全。 相似文献
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多糖是一类生物相容性好、无毒、非免疫原性的生物材料,现已广泛应用于药物传递系统。综述海藻酸盐、几丁质、葡聚糖、透明质酸和肝素等多糖及其衍生物的理化和生物学特性以及在药物传递系统中的应用进展。 相似文献
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Gangliang Huang 《Drug delivery》2018,25(1):766-772
Hyaluronic acid has good biocompatibility, biodegradability, and nonimmunogenicity. In addition, it has the ability to recognize specific receptors that are overexpressed on the surface of tumor cells, and cancer drugs can be targeted to the tumor cells to better kill them. Therefore, hyaluronic acid has attracted much attention as drug delivery vehicle. Herein, the application of hyaluronic acid as carrier in drug delivery was analyzed and summarized in detail. It showed that hyaluronic acid would have broad prospects for drug delivery. 相似文献
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Cho KY Chung TW Kim BC Kim MK Lee JH Wee WR Cho CS 《International journal of pharmaceutics》2003,260(1):83-91
Recently, in situ gel formation has extensively been studied to enhance ocular bioavailability and duration of the drug activity. In this study, we report grafting of poloxamer onto the hyaluronic acid for application of tissue engineering oriented ophthalmic drug delivery system. Graft copolymers were prepared by coupling mono amine-terminated poloxamer (MATP) with hyaluronic acid (HA) backbone using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxylsuccinimide (NHS) as coupling agents. The coupling of MATP with HA was clarified by 1H NMR and FT-IR spectroscopy. The gelation temperature of graft copolymers was dependent on the content of HA and the concentration of poloxamer. From drug release studies in vitro, ciprofloxacin was sustainedly released from the poloxamer-g-hyaluronic acid hydrogel due to the in situ gel formation of the copolymer and viscous properties of HA. 相似文献
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Silvia Rossi Marzia Marciello Giuseppina Sandri Franca Ferrari Maria Cristina Bonferoni Adele Papetti 《Pharmaceutical development and technology》2013,18(4):415-422
In the present work wound dressings, based on chitosan hydrochloride (HCS), 5-methyl-pyrrolidinone chitosan (MPC), and their mixtures with an anionic polymer, hyaluronic acid (HA), were prepared by freeze-drying. Chlorhexidine diacetate (CX) was used as an antimicrobic drug. The mechanical properties of the wound dressings were investigated. In particular, the wound dressings were subjected to dynamic hydration measurements to evaluate their capability to absorb wound exudate and to rheological analysis to investigate their resistance to mechanical stresses on hydration. The wound dressings were also characterized for drug release properties. The antioxidant and antimicrobial activities of medicated and non-medicated wound dressings were also investigated. All the wound dressings are characterized by mechanical resistance suitable for skin application. The addition of hyaluronic acid to chitosans leads to a reduction in wound dressing hydration properties and a modulation of drug release. The wound dressing based on MPC is characterized by the highest elastic properties and by the best scavenger activity. Antimicrobial activity against bacteria and C. albicans is shown by the dressing based on chitosan also in absence of chlorhexidine. 相似文献
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Peng Sun Haoliang Wu Hao He Liwei Zhang Yuanfeng Liu Cong Zhang Chunyang Lou Jingan Li Hualong Bai 《Drug delivery》2022,29(1):1994
Neointimal hyperplasia is a complex process after vascular interventions, acute platelet deposition and smooth muscle cell proliferation both contributed to this process. There are still no perfect solutions to solve this problem. Rivaroxaban is a novel anticoagulant that has been widely used in clinic, it has a good pharmacological effects both in vivo and in vitro. Chitosan microparticle rapamycin (MP-rapa) was fabricated, interspaces of polyglycolic acid (PGA) scaffold were used as a reservoir of MP-rapa, and the scaffold was coated with hyaluronic acid rivaroxaban (MP-rapa-riva). Scanning electronic microscopy (SEM) photographs were taken and water contact angles were measured, rat inferior vena cava (IVC) patch venoplasty model was used; patches were harvested at day 14 and examined by immunohistochemistry and immunofluorescence. SEM photographs showed the microparticles rapamycin were inside the interspace of the scaffold, hyaluronic acid rivaroxaban was also successfully coated onto the surface of the scaffold. There was a thinner neointima, fewer proliferating cell nuclear antigen (PCNA) positive cells, fewer macrophages in the MP-rapa and MP-rapa-riva grafts compared to the control PGA graft. The result showed that this scaffold with dual anticoagulation and antiproliferation functions can effectively inhibit venous neointimal hyperplasia, although this is an animal experiment, it showed promising potential clinical application in the future. 相似文献
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Wound dressings based on chitosans and hyaluronic acid for the release of chlorhexidine diacetate in skin ulcer therapy 总被引:2,自引:0,他引:2
Rossi S Marciello M Sandri G Ferrari F Bonferoni MC Papetti A Caramella C Dacarro C Grisoli P 《Pharmaceutical development and technology》2007,12(4):415-422
In the present work wound dressings, based on chitosan hydrochloride (HCS), 5-methyl-pyrrolidinone chitosan (MPC), and their mixtures with an anionic polymer, hyaluronic acid (HA), were prepared by freeze-drying. Chlorhexidine diacetate (CX) was used as an antimicrobic drug. The mechanical properties of the wound dressings were investigated. In particular, the wound dressings were subjected to dynamic hydration measurements to evaluate their capability to absorb wound exudate and to rheological analysis to investigate their resistance to mechanical stresses on hydration. The wound dressings were also characterized for drug release properties. The antioxidant and antimicrobial activities of medicated and non-medicated wound dressings were also investigated. All the wound dressings are characterized by mechanical resistance suitable for skin application. The addition of hyaluronic acid to chitosans leads to a reduction in wound dressing hydration properties and a modulation of drug release. The wound dressing based on MPC is characterized by the highest elastic properties and by the best scavenger activity. Antimicrobial activity against bacteria and C. albicans is shown by the dressing based on chitosan also in absence of chlorhexidine. 相似文献