Tumor de células de Sertoli-Leydig ovárico

We present the rare case of a 62-year-old woman who developed an ovarian tumor associated with severe hirsutism, hypertension, renal insufficiency, and hyperparathyroidism. Hormone evaluation showed high plasma testosterone and estradiol values, with suppressed gonadotropins. Ultrasound examination and computed tomography revealed a large pelvic tumor. Differential diagnosis with a Sertoli-like endometrioid carcinoma of the ovary was contemplated, but inhibin-positive expression established the diagnosis of Sertoli-Leydig cell tumor. Postsurgical outcome was favorable, with normal plasma values of sexual steroids and an increase of gonadotropins to within the normal postmenopausal range.     

Recurrencia del tumor ovárico de las células de la granulosa

We present the case of a 79-year-old woman who was misdiagnosed with an ovarian fibroma 5 years previously. The patient presented with pain in the right iliac fossa with leukocytosis and was diagnosed with diverticulitis. A mass was incidentally found in the anterior abdominal wall, which was later confirmed as metastasis from a granulosa cell tumor of the ovary.We provide a literature review, focussing on the clinical findings and treatment of this tumor. Few reports have been published of this uncommon entity, characterized by a long natural history and tendency to recur years after the initial diagnosis.     

Tumor virilizante de células esteroideas del ovario

Steroid cell tumors account for 0.1% of ovarian tumors and are classified within the group of stromal tumors, also known as sex cord tumors. These neoplasms can appear at any age but are more common in menopausal women and are associated with endocrine syndromes. The most significant clinical findings are hirsutism and virilization. Management should be individualized according to histological findings, surgical stage and the woman's reproductive wishes.     

Endometriosis cervical. Presentación de un caso

We report a case of cervical endometriosis in a 33-year-old patient who was diagnosed by means of colposcopy and histopathological study of directed neck biopsy and who was attended in the lower genital tract clinic of the Mariana Grajales de Santa Clara Provincial Maternity Hospital, in Villa Clara. The patient underwent diathermy loop conization of the uterine neck, which gave the diagnosis of cervical endometriosis. Outcome was satisfactory.     

Linfoma primario no Hodgkin difuso de células grandes B de vagina

Advanced lymphoma and leukemia can infiltrate the uterus and vagina. However, primary lymphomas affecting the female reproductive system are extremely uncommon (representing 1% of non-nodal tumors). We present a case of primary non-Hodgkin’s lymphoma of the vagina, diffuse large B cell type, stage IE according to the Ann-Arbor staging system. Complete remission was obtained after treatment with chemotherapy and radiotherapy. Five years after diagnosis, the patient is disease free.     

Tumor ovárico virilizante mixto de células de Sertoli-Leydig/granulosa (ginandroblastoma) en adolescente de 15 años

Sertoli-Leydig cell tumors constitute less than 5% of ovarian tumors. We report the case of a 15-year-old girl with virilization, amenorrhea, and abdominal pain, who was diagnosed with a left annexal tumor. Laboratory investigations revealed isolated testosterone elevation. Because the tumor was unilateral, the capsule was intact, and the patient wished to preserve her fertility, left salpingooophorectomy was performed. Histopathological examination revealed a mixed Sertoli-Leydig/juvenile granulosa cell tumor with a cartilaginous heterologous component, which could be considered a gynandroblastoma. Symptoms of virilization progressively improved.     

Carcinoma de células pequeñas neuroendocrino de cérvix uterino

We report a case of a neuroendocrine small-cell carcinoma of the cervix seen in our Gynaecology Department. This is a rare diagnosis and is of interest. Small-cell carcinoma of the cervix is a rare tumour with poor prognosis and high aggressiveness. Optimal treatment has not been established due to the rarity of the tumour.     

Metástasis vaginal del carcinoma de células renales

Renal cell carcinoma behaves unpredictably, with a strong tendency to produce metastasis, which can affect the vagina, leading to genital bleeding. Treatment is based on wide local excision of the lesion.     

Carcinoma de células pequeñas de mama

Oat cell breast cancer is a rare and aggressive form of cancer. Because only a few cases have been described in the literature, there is no standard treatment. We report the case of a 64-year-old woman who attended our unit for investigation of a node in her left breast that was diagnosed as infiltrative oat-cell breast carcinoma.     

Tumor de células epitelioides perivasculares en cuerpo uterino asociado a complejo de esclerosis tuberosa en mujer de 18 años

Perivascular epithelioid cell tumors (PEComa) are an uncommon group of neoplasms, distinguished by epithelioid-like cells, with perivascular disposition. These tumors express myogenic and melanocytic markers, for which there is no known equivalent counterpart in non-neoplastic cells.     

Linfoma cervical primario: presentación de un caso y revisión de la literatura

Primary lymphoma of the uterine cervix is extremely rare and the clinical presentation is similar to that of carcinoma of the cervix. Diagnosis is made with a deep cervical biopsy because smear tests can show false negative results. The standard treatment has not yet been established but used to be radiotherapy. Currently, combination chemotherapy is used with or without surgery. We report a case of cervical lymphoma that needed several biopsies to establish the diagnosis and was successfully treated with neoadjuvant chemotherapy and surgery.     

Tumor de la granulosa coexistente con cistoadenoma mucinoso en el ovario contralateral

We present the case of a 57-year-old woman with mucinous cystoadenoma in one ovary and granulosa tumor as an incidental finding in the other. The patient reported primary amenorrhea, and clinical presentation consisted of metrorrhagia and an abdominal mass.     

Tumor filodes maligno: a propósito de un caso y revisión de la literatura

Phyllodes tumor of the breast is a rare neoplasm, representing less than 1% of all breast tumors. The definitive diagnosis of these fibroepithelial tumors is histologic. Local recurrence occurs in 20% of cases. Although uncommon, these tumors can metastasize to other organs. Treatment is surgical with wide excision and disease-free margins. We present the case of a patient with phyllodes tumor who developed lung involvement.     

Carcinoma verrugoso de vagina. Presentación de un caso

Verrucous carcinoma of the vagina is a rare neoplasm. This entity is a slow-growing, locally invasive but generally nonmetastasizing neoplasm, with a characteristic gross and microscopic appearance.We report a case of verrucous carcinoma of the vagina in a postmenopausal woman diagnosed 4 years after transvaginal hysterectomy for grade 4 uterine prolapse. We also discuss the differential diagnosis and treatment.Verrucous carcinoma of the vagina is a rare neoplasm. The differential diagnosis includes typical squamous cell carcinoma, warty carcinoma, and condyloma acuminatum. Surgery remains the most effective treatment.     

Adenoma de células de Sertoli bilateral en paciente con síndrome de insensibilidad a los andrógenos

Androgen insensitivity syndrome is characterized by the presence of a female phenotype, masculine gonads, and 46,XY karyotype. This syndrome is the most common cause of masculine pseudohermaphroditism and is the third most frequent cause of primary amenorrhea after gonadal dysgenesis and congenital absence of the vagina. The importance of this entity lies in its early diagnosis in puberty because of the risk of testicular tumors. In this article, we present a case of late diagnosis of androgen insensitivity syndrome related to Sertoli cell adenoma.     

Hidroadenoma papilífero vulvar. Presentación de un caso

Hidroadenoma papilliferum (HP) is a rare benign tumor of the vulva that grows mainly in the skin of the anogenital region of adult women. The differential diagnosis between this neoplasm and Bartholin cysts and abscesses, lipoma and some premalignant and malignant vulvar lesions can be difficult. HP may arise from mammary-like glands located in the vulvar and perineal region of women.     

Citología con atipias en células glandulares. Evaluación,tratamiento y resultados

Objective

To study the frequency of a cytological result of atypical glandular cells of unknown significance/atypical glandular cells, not otherwise specified (AGUS/GAC-NOS) in the pap smear and the final diagnosis in patients with this result.

Subjects and methods

We retrospectively analyzed data from three hospitals in three provinces of the Basque Country: Txagorritxu in Vitoria, Basurto in Bilbao and Donostia Hospital in San Sebastian. Cytological studies with a diagnosis of AGUS/GAC-NOS were gathered and the results in these patients were analyzed.

Results

Of the total number of cases of AGUS/GAC-NOS in the three hospitals, 44.02% were pathological, 23.65% were high-grade squamous intraepithelial lesions and 20.37% corresponded to malignant disease: squamous carcinoma in 5.37% and adenocarcinoma in 15%.

Conclusions

These data show that, although cases of AGUS/GAC-NOS are infrequent, a high percentage shows pathological findings. Consequently, meticulous initial investigation and long-term monitoring are required since these patients are at high risk.