共查询到20条相似文献，搜索用时 31 毫秒
1.
Nadim Jiwa Alon Abraham Vera Bril Hans D. Katzberg Leif E. Lovblom Carolina Barnett Ari Breiner 《Clinical neurophysiology》2018,129(11):2239-2244
Objective
To investigate the use of a sonographic median-to-ulnar cross-sectional area ratio (MUR) in diagnosis of carpal tunnel syndrome (CTS); and to compare the MUR with currently used sonographic parameters, and electrophysiology.Methods
Subjects with CTS and healthy volunteers underwent ultrasound studies of the median and ulnar nerves in the wrist and forearm. Various sonographic parameters and ratios were calculated, and compared between CTS patients and controls. The sensitivity and specificity of the different parameters were compared by plotting receiver operator characteristic curves. Correlations of sonographic results with electrophysiologic studies were calculated.Results
The MUR was increased in patients with CTS, in comparison with controls. A cut-point of >2.09 yielded a sensitivity of 86% and specificity of 84%. This was comparable to the currently used ultrasound metrics for CTS. The MUR also correlated with electrophysiologic severity.Conclusions
The MUR is an effective means of diagnosing CTS and correlates with electrophysiologic severity.Significance
This report provides support for the use of the MUR in the sonographic diagnosis of CTS. 相似文献2.
Amandine Sevy Aude-Marie Grapperon Emmanuelle Salort Campana Emilien Delmont Shahram Attarian 《Clinical neurophysiology》2018,129(1):127-132
Objective
Current diagnostic electrophysiological criteria can miss the early stages of Guillain–Barré syndrome (GBS). We evaluated the diagnostic efficiency of the triple stimulation technique (TST) in highlighting proximal conduction blocks (CBs) in patients who do not meet the electrophysiological criteria for GBS.Methods
All patients with a diagnosis of clinical GBS referred to our center between September 2014 and January 2016 were included in the study. For patients who did not fulfill the electrophysiological criteria of GBS, we performed the TST examination.Results
Among the 44 included patients, 86% fulfilled the electrophysiological criteria of GBS during the initial nerve conduction study (NCS). The six remaining patients had proximal CBs revealed by TST examination. Therefore, a combination of a conventional NCS and the TST allowed 100% of the patients to be electrophysiologically diagnosed.Conclusions
TST is useful for the diagnosis of GBS in association with NCS, particularly in the early stages of the disease.Significance
TST is a useful tool for GBS diagnosis at the early stages of the disease. 相似文献3.
Mustafa Aykut Kural Páll Karlsson Kirsten Pugdahl Baris Isak Anders Fuglsang-Frederiksen Hatice Tankisi 《Clinical neurophysiology》2017,128(9):1590-1595
Objective
The electrodiagnosis of polyneuropathy (PNP) may benefit from examination using near-nerve needle technique (NNT) and from inclusion of distal nerves. This study compared the diagnostic utility of distal nerve conduction studies (NCS) and NNT recording.Methods
Bilateral NNT and surface recording of the sural nerve and surface recording of the dorsal sural and medial plantar nerves were prospectively done in 91 patients with clinically suspected PNP. Distal NCS were additionally done in 37 healthy controls. Diagnostic reference standard was the final clinical diagnosis retrieved from the patients medical records after 1–4 years.Results
The clinical follow-up diagnosis confirmed PNP in 68 patients. Equally high sensitivities of the dorsal sural (72%), medial plantar (75%), and sural nerve with NNT recording (77%) were seen, while the sensitivity of conventional surface recording of the sural nerve was lower (60%). Sural NCS with both NNT and surface recording and dorsal sural NCS showed high specificities (85–95%) and positive predictive values (94–98%), while a lower specificity was seen for the medial plantar nerve (68%).Conclusion
NCS of distal nerves, especially the dorsal sural nerve, have high diagnostic power equalling sural NNT recording.Significance
The electrodiagnostic evaluation of patients with suspected PNP benefits from NCS of distal nerves. 相似文献4.
Ingrid J.T. Herraets H. Stephan Goedee Johan A. Telleman Jan-Thies H. van Asseldonk Leo H. Visser W. Ludo van der Pol Leonard H. van den Berg 《Clinical neurophysiology》2018,129(1):232-237
Objective
Wartenberg’s migrant sensory neuritis (WMSN) is a rare, patchy, pure sensory neuropathy of unknown etiology. High-resolution ultrasonography (HRUS) is an emerging diagnostic technique for neuropathies, but it has not been applied in WMSN. In this study we aimed to determine HRUS abnormalities in WMSN.Methods
We performed a case-control study of 8 newly diagnosed patients with WMSN and 22 treatment-naive disease controls (16 patients with pure sensory axonal neuropathy and 6 with pure sensory chronic inflammatory demyelinating polyneuropathy (CIDP) or Lewis-Sumner syndrome (LSS)). All patients underwent routine diagnostic evaluations and a predefined HRUS protocol.Results
We found multifocal nerve enlargement in all 8 WMSN patients. The median nerve in the upper arm and the sural nerve were significantly larger in WMSN than in axonal controls (p?=?0.01 and p?=?0.04). In CIDP/LSS, sonographic enlargement was more extensive. Furthermore we found brachial plexus involvement in 3 of 8 (38%) WMSN patients.Conclusion
HRUS showed enlargement of multiple nerves in all WMSN patients even if clinical testing and NCS were normal.Significance
The feature of multifocal nerve enlargement may be of additional value in establishing the diagnosis of WMSN and may support the suggestion of an auto-immune etiology. 相似文献5.
Objective
The aim of the study was to investigate the electrophysiological parameters in phrenic nerve conduction studies (NCS) that sensitively reflect latent respiratory insufficiency present in amyotrophic lateral sclerosis (ALS).Method
Forty-nine patients with ALS were examined, and after exclusion, 21 patients with ALS and their phrenic NCS results were reviewed. The patients were divided into two groups according to their respiratory sub-score in the ALS functional rating scale - revised (Group A, sub-score 12 vs. Group B, sub-score 11). We compared the parameters of phrenic NCS between the two groups.Results
There were no significant differences in the clinical characteristics between the two groups. Using a multivariate model, we found that the terminal latency of the phrenic nerve was the only parameter that was associated with early symptoms of respiratory insufficiency (p < 0.05). The optimal cutoff value for the terminal latency of the phrenic nerve was 7.65 ms (sensitivity 80%, specificity 68.2%).Conclusion
The significantly prolonged terminal latency of the phrenic nerve in our study may reflect a profound distal motor axonal dysfunction of the phrenic nerve in patients with ALS in the early stage of respiratory insufficiency that can be used as a sensitive electrophysiological marker reflecting respiratory symptoms in ALS.Significance
The terminal latency of the phrenic nerve is useful for early detection of respiratory insufficiency in patients with ALS. 相似文献6.
Agnese Suppiej Ambra Cappellari Giacomo Talenti Elisa Cainelli Matteo Di Capua Augusta Janes Daniela Longo Rodica Mardari Cristina Marinaccio Stefano Pro Paola Sciortino Daniele Trevisanuto Roberta Vittorini Renzo Manara 《Clinical neurophysiology》2018,129(1):95-100
Objective
The introduction of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy calls for reevaluation of the prognostic role of somatosensory evoked potentials (SEPs).Methods
Among 80 consecutive neonates undergoing hypothermia for hypoxic-ischemic encephalopathy, 58 performed SEPs and MRI at 4–14?days of life and were recruited in this multicenter study. SEPs were scored as: 0 (bilaterally/unilaterally recorded N20) or 1 (bilaterally absent N20). The severity of brain injury was scored using MRI.Results
Bilaterally absent N20 was observed in 10/58 neonates (17%); all had moderate/severe MRI abnormalities; 36/48 neonates (75%) with score 0 at SEPs had normal MRI. The positive predictive value of SEPs on MRI outcome was of 1.00, while the negative predictive value 0.72, sensitivity 0.48, specificity 1.00, with an accuracy of 0.78 (p?<?.001).Conclusions
Bilateral absence of cortical SEPs predicts moderate/severe MRI pattern of injury.Significance
Therapeutic hypothermia does not seem to significantly affect prognostic reliability of SEPs. 相似文献7.
Fabrice Giraudet Perrine Charles Thierry Mom Odile Boespflug-Tanguy Alexandra Dürr Paul Deltenre Paul Avan 《Clinical neurophysiology》2018,129(6):1121-1129
Objectives
In patients with Friedreich ataxia (FRDA), mitochondrial failure leads to impaired cellular energetics. Since many FRDA patients have impaired hearing in noise, we investigated the objective consequences on standard auditory brainstem-evoked responses (ABRs).Methods
In 37 FRDA patients, among whom 34 with abnormal standard ABRs, hearing sensitivity, speech-in-noise intelligibility and otoacoustic emissions were controlled. ABR recordings were split into four consecutive segments of the total time frame used for data collection, thus allowing the dynamics of ABR averaging to be observed.Results
Most ears showed features of an auditory neuropathy spectrum disorder with flattened ABRs and impaired speech-in-noise intelligibility contrasting with near-normal hearing sensitivity and normal preneural responses. Yet split-ABRs revealed short-lived wave patterns in 26 out of 68 ears with flattened standard ABRs (38%). While averaging went on, the pattern of waves shifted so that interwave latencies increased by 35% on average.Conclusions
In FRDA, the assumption of stationarity used for extracting standard ABRs is invalid. The preservation of early split-ABRs indicates no short-term dyssynchrony of action potentials. A large decrease in conduction velocity along auditory neurons occurs within seconds, attributed to fast energetic failure.Significance
This model of metabolic sensory neuropathy warns against exposure of metabolically-impaired patients to sustained auditory stimulation. 相似文献8.
Sara Yagüe Misericordia Veciana Carlos Casasnovas Montserrat Ruiz Jordi Pedro Josep Valls-Solé Aurora Pujol 《Clinical neurophysiology》2018,129(3):507-515
Objective
Patients with adrenomyeloneuropathy may have dysfunctions of visual, auditory, motor and somatosensory pathways. We thought on examining the nociceptive pathways by means of laser evoked potentials (LEPs), to obtain additional information on the pathophysiology of this condition.Methods
In 13 adrenomyeloneuropathic patients we examined LEPs to leg, arm and face stimulation. Normative data were obtained from 10 healthy subjects examined in the same experimental conditions. We also examined brainstem auditory evoked potentials (BAEPs), pattern reversal full-field visual evoked potentials (VEPs), motor evoked potentials (MEPs) and somatosensory evoked potentials (SEPs).Results
Upper and lower limb MEPs and SEPs, as well as BAEPs, were abnormal in all patients, while VEPs were abnormal in 3 of them (23.1%). LEPs revealed abnormalities to stimulation of the face in 4 patients (30.7%), the forearm in 4 patients (30.7%) and the leg in 10 patients (76.9%).Conclusions
The pathologic process of adrenomyeloneuropathy is characterized by a preferential involvement of auditory, motor and somatosensory tracts and less severely of the visual and nociceptive pathways. This non-inflammatory distal axonopathy preferably damages large myelinated spinal tracts but there is also partial involvement of small myelinated fibres.Significance
LEPs studies can provide relevant information about afferent pain pathways involvement in adrenomyeloneuropathic patients. 相似文献9.
Objectives
To evaluate whether the task-specific neural coupling mechanism during the performance of cooperative hand movements is preserved in tetraplegic subjects.Methods
Recordings of ipsilateral and contralateral electromyographic reflex responses in activated forearm muscles and bilateral somatosensory potentials (SSEP) to unilateral ulnar nerve stimulations during rest, cooperative and non-cooperative hand movements.Results
Contralateral reflex responses were present in almost all patients during cooperative hand movements but small in amplitude when hand function was severely impaired. Ipsilateral SSEP potentials were enhanced during both cooperative and, in contrast to healthy subjects, also non-cooperative bimanual movements.Conclusions
Both results indicate a strong involvement of ipsilateral non-damaged cervical tracts and hemispheres in the control of bimanual hand movements in tetraplegic subjects.Significance
This study on the neural control of bimanual movements in patients suffering a cervical injury allows designing therapeutic approaches for the improvement of hand function that are based on physiological insights. 相似文献10.
Michael B.H. Hall Ida A. Nissen Elisabeth C.W. van Straaten Paul L. Furlong Caroline Witton Elaine Foley Stefano Seri Arjan Hillebrand 《Clinical neurophysiology》2018,129(6):1221-1229
Objective
Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients.Methods
We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting. Virtual electrodes were placed in the kurtosis volumetric peaks and visually inspected to select a candidate source. The candidate sources were compared to the ECD localizations and resection areas.Results
The kurtosis beamformer produced interpretable localizations in 18/22 patients, of which the candidate source coincided with the resection lobe in 9/13 seizure-free patients and in 3/5 patients with persistent seizures. The sublobar accuracy of the kurtosis beamformer with respect to the resection zone was higher than ECD (56% and 50%, respectively), however, ECD resulted in a higher lobar accuracy (75%, 67%).Conclusions
Kurtosis beamforming may provide additional value when spikes are not clearly discernible on the sensors and support ECD localizations when dipoles are scattered.Significance
Kurtosis beamforming should be integrated with existing clinical protocols to assist in localizing the epileptogenic zone. 相似文献11.
Aleksandra Vuckovic Vicente Jose Ferrer Gallardo Mohammed Jarjees Mathew Fraser Mariel Purcell 《Clinical neurophysiology》2018,129(8):1605-1617
Objectives
To create a classifier based on electroencephalography (EEG) to identify spinal cord injured (SCI) participants at risk of developing central neuropathic pain (CNP) by comparing them with patients who had already developed pain and with able bodied controls.Methods
Multichannel EEG was recorded in the relaxed eyes opened and eyes closed states in 10 able bodied participants and 31 subacute SCI participants (11 with CNP, 10 without NP and 10 who later developed pain within 6?months of the EEG recording). Up to nine EEG band power features were classified using linear and non-linear classifiers.Results
Three classifiers (artificial neural networks ANN, support vector machine SVM and linear discriminant analysis LDA) achieved similar average performances, higher than 85% on a full set of features identifying patients at risk of developing pain and achieved comparably high performance classifying between other groups. With only 10 channels, LDA and ANN achieved 86% and 83% accuracy respectively, identifying patients at risk of developing CNP.Conclusion
Transferable learning classifier can detect patients at risk of developing CNP. EEG markers of pain appear before its physical symptoms. Simple and complex classifiers have comparable performance.Significance
Identify patients to receive prophylaxic treatment of CNP. 相似文献12.
Ewa Zalewska Anna Kaminska Biruta Kierdaszuk Elżbieta Szmidt-Salkowska Małgorzata Gawel 《Clinical neurophysiology》2018,129(8):1595-1604
Objective
The aim was to compare muscle fiber diameters obtained from standard muscle biopsy and from computer simulations based on recorded motor unit potentials (MUPs).Methods
Electromyography (EMG) and muscle biopsy were performed in 14 patients with a suspicion of a neuromuscular disorder. Histograms of the simulated muscle fiber diameters (SMFDs) were compared with those from the biopsyResults
The values of the SMFDs were similar to those in the muscle biopsy for the same patient (p?=?0.05) in all 14 cases.Conclusions
Comprehensive evaluation of EMG and biopsy findings supported by computer simulations may help resolve the discrepancy between the assessment of muscle by EMG and biopsy by explaining different results obtained with these two methods.Significance
Evaluation of the SMFDs that are comparable to biopsy findings extends the amount of information available from EMG. 相似文献13.
Johannes Koren Gerhard Gritsch Susanne Pirker Johannes Herta Hannes Perko Tilmann Kluge Christoph Baumgartner 《Clinical neurophysiology》2018,129(6):1291-1299
Objective
To test the diagnostic accuracy of a new automatic algorithm for ictal onset source localization (IOSL) during routine presurgical epilepsy evaluation following STARD (Standards for Reporting of Diagnostic Accuracy) criteria.Methods
We included 28 consecutive patients with refractory focal epilepsy (25 patients with temporal lobe epilepsy (TLE) and 3 with extratemporal epilepsy) who underwent resective epilepsy surgery. Ictal EEG patterns were analyzed with a novel automatic IOSL algorithm. IOSL source localizations on a sublobar level were validated by comparison with actual resection sites and seizure free outcome 2?years after surgery.Results
Sensitivity of IOSL was 92.3% (TLE: 92.3%); specificity 60% (TLE: 50%); positive predictive value 66.7% (TLE: 66.7%); and negative predictive value 90% (TLE: 85.7%). The likelihood ratio was more than ten times higher for concordant IOSL results as compared to discordant results (p?=?0.013).Conclusions
We demonstrated the clinical feasibility of our IOSL approach yielding reasonable high performance measures on a sublobar level.Significance
Our IOSL method may contribute to a correct localization of the seizure onset zone in temporal lobe epilepsy and can readily be used in standard epilepsy monitoring settings. Further studies are needed for validation in extratemporal epilepsy. 相似文献14.
Luciana Pelosi Dominic Ming Yin Tse Eoin Mulroy Andrew M. Chancellor Michael R. Boland 《Clinical neurophysiology》2018,129(10):2155-2161
Objective
To systematically study demographic, clinical, electrophysiological and nerve ultrasound characteristics of ulnar neuropathy with abnormal non-localizing electrophysiology (NL-UN) and further define the utility of ultrasound over and above the conventional electro-diagnostic approach.Method
NL-UNs were prospectively identified from 113 consecutive referrals with suspected ulnar neuropathy. All received electro-diagnostic tests and ulnar nerve ultrasound. NL-UN severity was graded using clinical and electrophysiological scales.Results
In 64 of 113 referrals, an ulnar mono- neuropathy was confirmed by electrophysiology. Sixteen of these 64 (25%) had NL-UN, predominantly males (14 out of 16 patients) with severe or moderate clinical and electrophysiological ratings. Ultrasound showed focal ulnar neuropathy at the elbow in 13 out of 16, and diffuse ulnar nerve abnormality in three, and identified a likely or possible causative mechanism in 11.Conclusion
A significant proportion (a quarter) of ulnar neuropathies with abnormal electrophysiology were NL-UN, of heterogeneous etiology; the majority were males with significant disability and axonal loss. Ultrasound had a significant role in localization and classification that facilitated management.Significance
To our knowledge, this is the first systematic prospective study that analyzes the demographic, clinical, electrophysiological and ultrasound characteristics of NL-UN in a routine clinical neurophysiology setting. 相似文献15.
Amir G. Baroumand Pieter van Mierlo Gregor Strobbe Lars H. Pinborg Martin Fabricius Guido Rubboli Anne-Mette Leffers Peter Uldall Bo Jespersen Jannick Brennum Otto Mølby Henriksen Sándor Beniczky 《Clinical neurophysiology》2018,129(11):2403-2410
Objective
To evaluate the accuracy of automated EEG source imaging (ESI) in localizing epileptogenic zone.Methods
Long-term EEG, recorded with the standard 25-electrode array of the IFCN, from 41 consecutive patients with focal epilepsy who underwent resective surgery, were analyzed blinded to the surgical outcome. The automated analysis comprised spike-detection, clustering and source imaging at the half-rising time and at the peak of each spike-cluster, using individual head-models with six tissue-layers and a distributed source model (sLORETA). The fully automated approach presented ESI of the cluster with the highest number of spikes, at the half-rising time. In addition, a physician involved in the presurgical evaluation of the patients, evaluated the automated ESI results (up to four clusters per patient) in clinical context and selected the dominant cluster and the analysis time-point (semi-automated approach). The reference standard was location of the resected area and outcome one year after operation.Results
Accuracy was 61% (95% CI: 45–76%) for the fully automated approach and 78% (95% CI: 62–89%) for the semi-automated approach.Conclusion
Automated ESI has an accuracy similar to previously reported neuroimaging methods.Significance
Automated ESI will contribute to increased utilization of source imaging in the presurgical evaluation of patients with epilepsy. 相似文献16.
Giampietro Zanette Gian Maria Fabrizi Federica Taioli Matteo Francesco Lauriola Andrea Badari Moreno Ferrarini Tiziana Cavallaro Stefano Tamburin 《Clinical neurophysiology》2018,129(11):2259-2267
Objective
Ulnar/median motor nerve conduction velocity (MNCV) is ≤38?m/s in demyelinating Charcot-Marie-Tooth disease (CMT). Previous nerve high resolution ultrasound (HRUS) studies explored demyelinating CMT assuming it as a homogeneous genetic/pathological entity or focused on CMT1A.Methods
To explore the spectrum of nerve HRUS findings in demyelinating CMTs, we recruited patients with CMT1A (N?=?44), CMT1B (N?=?9), CMTX (N?=?8) and CMT4C (N?=?4). They underwent nerve conduction study (NCS) and HRUS of the median, ulnar, peroneal nerve, and the brachial plexus.Results
Median, ulnar and peroneal MNCV significantly differed across CMT subtypes. Cross sectional area (CSA) was markedly and diffusely enlarged at all sites, except entrapment ones, in CMT1A, while it was slightly enlarged or within normal range in the other CMTs. No significant right-to-left difference was found. Age had limited effect on CSA. CSAs of some CMT1A patients largely overlapped with those of other demyelinating CMTs. A combination of three median CSA measures could separate CMT1A from other demyelinating CMTs.Conclusions
Nerve HRUS findings are heterogeneous in demyelinating CMTs.Significance
Nerve HRUS may separate CMT1A from other demyelinating CMTs. The large demyelinating CMTs HRUS spectrum may be related to its pathophysiological variability. 相似文献17.
Steven Hageman Maria O. Kovalchuk Boudewijn T.H.M. Sleutjes Leonard J. van Schelven Leonard H. van den Berg Hessel Franssen 《Clinical neurophysiology》2018,129(4):809-814
Objective
Sodium-potassium pump dysfunction in peripheral nerve is usually assessed by determining axonal hyperpolarization following maximal voluntary contraction (MVC) or maximal electrical nerve stimulation. As MVC may be unreliable and maximal electrical stimulation too painful, we assessed if hyperpolarization can also be induced by submaximal electrical nerve stimulation.Methods
In 8 healthy volunteers different submaximal electrical stimulus trains were given to the median nerve at the wrist, followed by 5 min assessment of thresholds for compound muscle action potentials of 20%, 40% or 60% of maximal.Results
Threshold increase after submaximal electrical nerve stimulation was most prominent after an 8?Hz train of at least 5 min duration evoking submaximal CMAPs of 60%. It induced minimal discomfort and was not painful. Threshold increase after MVC was not significantly higher than this stimulus train.Conclusions
Submaximal electrical stimulation evokes activity dependent hyperpolarization in healthy test subjects without causing significant discomfort.Significance
Sodium-potassium pump function may be assessed using submaximal electrical stimulation. 相似文献18.
Ana Catarina Franco Olympia Kremmyda Jan Rémi Soheyl Noachtar 《Clinical neurophysiology》2018,129(5):952-955
Objective
Positive interictal epileptiform discharges (IEDs) are rarely recorded from surface EEG, due to the orientation of the cortex and its neurons. Their frequency and significance in adults is unknown, and has only been studied as a phenomenon of the neonatal period and childhood. We aimed to evaluate the frequency and characteristics of positive epileptiform discharges in a large cohort of patients.Methods
We retrospectively reviewed 24,178 reports from 18,060 patients of non-invasively recorded EEGs for various indications.Results
Positive IEDs were recorded in six patients (eight EEGs – 0.033%), all of which had epileptic seizures. Brain surgery was the most common reason for recording positive and not negative IEDs. Cortical malformation was the most probable etiology in the remaining patients.Conclusions
Positive IEDs seem to be of lower frequency in adults than in children and are highly associated with epilepsy. They appear more often, but not exclusively, in adult patients with skull defects.Significance
This is the first adult series reported. Positive IEDs must be identified for the correct diagnosis and clearly differentiated from normal variants. 相似文献19.
Felice T. Sun Sharanya Arcot Desai Thomas K. Tcheng Martha J. Morrell 《Clinical neurophysiology》2018,129(3):676-686
Objective
Subacute and long-term electrocorticographic (ECoG) changes in ambulatory patients with depth and cortical strip electrodes were evaluated in order to determine the length of the implant effect.Methods
ECoG records were assessed in patients with medically intractable epilepsy who had depth and/or strip leads implanted in order to be treated with brain-responsive stimulation. Changes in total spectral power, band-limited spectral power, and spike rate were assessed.Results
121 patients participating in trials of the RNS® System had a total of 93994 ECoG records analyzed. Significant changes in total spectral power occurred from the first to second months after implantation, involving 55% of all ECoG channels (68% of strip and 47% of depth lead channels). Significant, but less pronounced, changes continued over the 2nd to 5th post-implant months, after which total power became more stable. Similar patterns of changes were observed within frequency bands and spike rate.Conclusions
ECoG spectral power and spike rates are not stable in the first 5?months after implantation, presumably due to neurophysiological and electrode-tissue interface changes.Significance
ECoG data collected in the first 5?months after implantation of intracranial electrodes may not be fully representative of chronic cortical electrophysiology. 相似文献20.
Seunghoon Lee Sang-Ku Park Jeong-A Lee Byung-Euk Joo Doo-Sik Kong Dae-Won Seo Kwan Park 《Clinical neurophysiology》2018,129(7):1490-1495