共查询到20条相似文献，搜索用时 31 毫秒
1.
Joachim Bas Emilien Delmont Farzad Fatehi Emmanuelle Salort-Campana Annie Verschueren Jean Pouget Marie-Noëlle Lefebvre Aude-Marie Grapperon Shahram Attarian 《Clinical neurophysiology》2018,129(7):1390-1396
Objective
The aim of this study was to assess the usefulness of motor unit number index (MUNIX) technique in Charcot-Marie-Tooth disease and test the correlation between MUNIX and clinical impairment.Methods
MUNIX technique was performed in the abductor pollicis brevis (APB), the abductor digiti minimi (ADM) and the tibialis anterior (TA) muscles in the nondominant side. A MUNIX sum score was calculated by adding the MUNIX of these 3 muscles. Muscle strength was measured using the MRC (medical research council) scale. Disability was evaluated using several functional scales, including CMT neuropathy score version 2 (CMTNSv2) and overall neuropathy limitation scale (ONLS).Results
A total of 56 CMT patients were enrolled. The MUNIX scores of the ADM, APB and TA muscles correlated with the MRC score of the corresponding muscle (p?<?0.01). The MUNIX sum score correlated with the clinical scales CMTNSv2 (r??=???0.65, p?<?0.01) and ONLS (r??=???0.57, p?<?0.01).Conclusion
MUNIX correlates with muscle strength and clinical measurements of disability in patients with CMT disease.Significance
The MUNIX technique evaluates motor axonal loss and correlates with disability. The MUNIX sum score may be a useful outcome measure of disease progression in CMT. 相似文献2.
Giorgia Querin Timothée Lenglet Rabab Debs Tanya Stojkovic Anthony Behin François Salachas Nadine Le Forestier Maria del Mar Amador Lucette Lacomblez Vincent Meininger Gaelle Bruneteau Pascal Laforêt Sophie Blancho Véronique Marchand-Pauvert Peter Bede Jean-Yves Hogrel Pierre-François Pradat 《Clinical neurophysiology》2018,129(11):2333-2340
Objective
Objective of this study is the comprehensive characterisation of motor unit (MU) loss in type III and IV Spinal Muscular Atrophy (SMA) using motor unit number index (MUNIX), and evaluation of compensatory mechanisms based on MU size indices (MUSIX).Methods
Nineteen type III and IV SMA patients and 16 gender- and age-matched healthy controls were recruited. Neuromuscular performance was evaluated by muscle strength testing and functional scales. Compound motor action potential (CMAP), MUNIX and MUSIX were studied in the abductor pollicis brevis (APB), abductor digiti minimi (ADM), deltoid, tibialis anterior and trapezius muscles. A composite MUNIX score was also calculated.Results
SMA patients exhibited significantly reduced MUNIX values (p?<?0.05) in all muscles, while MUSIX was increased, suggesting active re-innervation. Significant correlations were identified between MUNIX/MUSIX and muscle strength. Similarly, composite MUNIX scores correlated with disability scores. Interestingly, in SMA patients MUNIX was much lower in the ADM than in the ABP, a pattern which is distinctly different from that observed in Amyotrophic Lateral Sclerosis.Conclusions
MUNIX is a sensitive measure of MU loss in adult forms of SMA and correlates with disability.Significance
MUNIX evaluation is a promising candidate biomarker for longitudinal studies and pharmacological trials in adult SMA patients. 相似文献3.
Christoph Neuwirth Nathalie Braun Kristl G. Claeys Robert Bucelli Christina Fournier Mark Bromberg Susanne Petri Stephan Goedee Timothée Lenglet Ron Leppanen Antonio Canosa Ira Goodman Muhammad Al-Lozi Takuya Ohkubo Annemarie Hübers Nazem Atassi Agessandro Abrahao Andreas Funke Markus Weber 《Clinical neurophysiology》2018,129(8):1756-1762
Objective
Motor Unit Number Index (MUNIX) is a quantitative neurophysiological method that reflects loss of motor neurons in Amyotrophic Lateral Sclerosis (ALS) in longitudinal studies. It has been utilized in one natural history ALS study and one drug trial (Biogen USA) after training and qualification of raters.Methods
Prior to testing patients, evaluators had to submit test-retest data of 4 healthy volunteers. Twenty-seven centres with 36 raters measured MUNIX in 4 sets of 6 different muscles twice. Coefficient of variation of all measurements had to be <20% to pass the qualification process. MUNIX COV of the first attempt, number of repeated measurements and muscle specific COV were evaluated.Results
COV varied considerably between raters. Mean COV of all raters at the first measurements was 12.9%?±?13.5 (median 8.7%). Need of repetitions ranged from 0 to 43 (mean 10.7?±?9.1, median 8). Biceps and first dorsal interosseus muscles showed highest repetition rates. MUNIX variability correlated considerably with variability of compound muscle action potential.Conclusion
MUNIX revealed generally good reliability, but was rater dependent and ongoing support for raters was needed.Significance
MUNIX can be implemented in large clinical trials as an outcome measure after training and a qualification process. 相似文献4.
Marcio Luiz Escorcio-Bezerra Agessandro Abrahao Denizart Santos-Neto Nadia Iandoli de Oliveira Braga Acary Souza Bulle Oliveira Gilberto Mastrocola Manzano 《Clinical neurophysiology》2017,128(12):2392-2396
Objective
To assess the impact of averaging multiple MUNIX trials on the follow-up of patients with amyotrophic lateral sclerosis (ALS).Methods
We determined the percent relative change (%RC) of MUNIX, in healthy subjects and patients with ALS, by subtracting the MUNIX value in the second visit from the first. Both the mean of a set of three MUNIX (mean-MUNIX) and the first MUNIX sample (single-MUNIX) were evaluated. Then, we studied the sensitivity to detect relative changes over time and the statistical dispersion of the %RC from these two parameters.Results
We found that the mean-MUNIX %RC has lower mean coefficient of variation than the single-MUNIX %RC in all muscles. The mean-MUNIX also resulted in more ALS patients with significant %RC, i.e., outside reference limits.Conclusion
The mean-MUNIX resulted in less dispersed values of %RC in patients with ALS and thus, increased the precision of the technique. The mean-MUNIX resulted also in an increase in the sensitivity to track changes over time in these patients.Significance
The mean-MUNIX should be considered in any ALS follow-up study as a more reliable approach and as a way of potentially reducing the sample size needed for the study. 相似文献5.
Mathilde Duchesne Laurence Richard Jean-Michel Vallat Laurent Magy 《Clinical neurophysiology》2018,129(7):1341-1348
Objective
Sudoscan provides a rapid assessment of sudomotor function based on the measurement of electrochemical skin conductance (ESC), which is thought to be proportional to small nerve fibres innervating the sweat glands. However, the relationship between ESC and small nerve fibre density on skin biopsy remains unclear.Methods
In a retrospective single-centre study, we compared ESC measurements with autonomic sweat gland nerve fibre density (SGNFD) and somatic intraepidermal nerve fibre density (IENFD) in patients with polyneuropathy.Results
63 patients were included (mean age: 60.6?±?13.3?years). ESC was more strongly correlated with SGNFD (r?=?0.49; p?=?0.0005) than with IENFD (r?=?0.42; p?=?0.0005). Foot ESC was lower in patients with abnormal SGNFD (1.0?±?0.3 µS/kg versus 0.7?±?0.4 µS/kg; p?=?0.0419) or abnormal IENFD (1.1?±?0.3 µS/kg versus 0.8?±?0.3 µS/kg; p?=?0.0425).Conclusion
ESC measurement is a novel method of potential value for assessing sudomotor function. More studies are required to define its place beside ancient well-established techniques.Significance
The weak correlation of ESC with skin biopsy results suggests that mechanisms other than the loss of innervating fibres may be responsible for sweat gland dysfunction in polyneuropathies. 相似文献6.
Christoph Neuwirth Paul E. Barkhaus Christian Burkhardt José Castro David Czell Mamede de Carvalho Sanjeev Nandedkar Erik Stålberg Markus Weber 《Clinical neurophysiology》2017,128(3):495-500
Objective
Motor Unit Number Index (MUNIX) is a quantitative neurophysiological measure that provides an index of the number of lower motor neurons supplying a muscle. It reflects the loss of motor neurons in patients with Amyotrophic Lateral Sclerosis (ALS). However, it is unclear whether MUNIX also detects motor unit loss in strong, non-wasted muscles.Methods
Three centres measured MUNIX in 49 ALS patients every three months in six different muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis, abductor hallucis) on the less affected side. The decline of MUNIX in initially non-wasted, clinically strong muscles (manual muscle testing, MMT grade 5) was analysed before and after onset of weakness.Results
In 49 subjects, 151 clinically strong muscles developed weakness and were included for analysis. The average monthly relative loss of MUNIX was 5.0% before and 5.6% after onset of weakness. This rate of change was significantly higher compared to ALS functional rating scale (ALSFRS-R) and compound muscle action potential (CMAP) change over 12 months prior to the onset of muscle weakness (p = 0.024).Conclusion
MUNIX is an electrophysiological marker that detects lower motor neuron loss in ALS, before clinical weakness becomes apparent by manual muscle testing.Significance
This makes MUNIX a good biomarker candidate for disease progression and possibly pharmacodynamics responds. 相似文献7.
Manon Philibert Aude-Marie Grapperon Emilien Delmont Shahram Attarian 《Clinical neurophysiology》2017,128(1):235-240
Objective
To determine whether motor unit number index (MUNIX) is pertinent to monitor the effect of intravenous immunoglobulins (IVIg) in multifocal motor neuropathy (MMN).Methods
MUNIX was assessed longitudinally in 7 MMN patients and 17 healthy controls in the abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles. A MUNIX sum-score and a compound muscle action potential (CMAP) sum-score were calculated by summing up the scores of APB and ADM. MMN patients were evaluated on the first day of IVIg infusion, 5 MMN patients were evaluated 22 days after IVIg infusion, and 3 MMN patients were evaluated 1 month after two IVIg infusions.Results
Intraclass correlation coefficient of the MUNIX sum-score in healthy controls was 0.85, showing good test–retest reproducibility. MUNIX and CMAP sum-scores were lower in MMN patients than in healthy controls (p < 0.01 and 0.02, respectively). MUNIX sum-score improved in three of the five patients 22 days after IVIg infusion and in two of the three patients 1 month after 2 IVIg infusions, whereas CMAP sum-score improved in only one patient in both evaluations.Conclusions
In this preliminary study, MUNIX seems to be a reliable and sensitive tool to monitor the short-term efficiency of IVIg in MMN.Significance
MUNIX can help monitor IVIg treatment in MMN. 相似文献8.
Objective
To evaluate the repeatability of (Motor Unit Number Index) MUNIX under repeatability conditions, specify the origin of variations and provide strategies for quality control.Methods
MUNIX calculations were performed on the bicep brachii muscles of eight healthy subjects. Negative effect of suboptimal electrode positions on MUNIX accuracy was eliminated by employing the high-density surface electromyography technique. MUNIX procedures that utilized a variety of surface interferential pattern (SIP) epoch recruitment strategies (including the original MUNIX procedure, two proposed improvement strategies and their combinations) were described. For each MUNIX procedure, ten thousands of different SIP pools were constructed by randomly recruiting necessary SIP epochs from a large SIP epoch pool (3 datasets, 9 independent electromyography recordings at different contraction levels per dataset and 10 SIP epochs per recording) and implemented for MUNIX calculation. The repeatability of each MUNIX procedure was assessed by summarizing the resulting MUNIX distribution and compared to investigate the effect of SIP epoch selection strategy on repeatability performance.Results
SIP epochs selected at lower contraction levels have a stronger influence on the repeatability of MUNIX than those selected at higher contraction levels. MUNIX under repeatability conditions follows a normal distribution and the standard deviation can be significantly reduced by introducing more epochs near the MUNIX definition line.Conclusions
The MUNIX technique shows an inherent variation attributable to SIP epochs at low contraction levels. It is recommended that more epochs should be sampled at these low contraction levels to improve the repeatability.Significance
The present study thoroughly documented the inherent variation of MUNIX and the causes, and offered practical solutions to improve the repeatability of MUNIX. 相似文献9.
Objective
Gait imbalance in patients with bilateral-vestibular-deficiency (BVD) was linked to increased variability in perceived direction of gravity while upright. We hypothesized this to be true also when roll-tilted. Moreover, as utricular input is essential for spatial orientation, we predicted the variability of perceived vertical to correlate inversely with utricular function.Methods
Subjective visual vertical (SVV) and haptic vertical (SHV) were measured in various roll-orientations (0°/±45°/±90°) and postural adjustments along earth-vertical/earth-horizontal were collected in patients with partial BVD (n?=?10) and healthy controls (n?=?11). Patients with bilaterally-absent bone-conducted ocular vestibular-evoked myogenic-potentials (oVEMPs) were compared to those with (partially) preserved oVEMPs.Results
For the SVV (p?<?0.001) and SHV (p?=?0.004) variability was larger in patients than controls. Compared to those with (partially) preserved oVEMPs, patients with bilaterally-absent oVEMPs had higher SVV (p?=?0.024) and SHV (p?=?0.006) variability. Self-positioning along earth-horizontal was more variable in BVD-patients compared to controls (p?<?0.001). Again, variability was higher in those with bilaterally-absent oVEMPs (p?=?0.032). SVV/SHV-variability was correlated (R2?=?0.61, slope?=?1.06 [95%-CI?=?0.80–1.54]) in BVD-patients.Conclusion
With variability correlating amongst the different paradigms and with oVEMP-responses, this emphasizes the role of bilaterally intact utricular input for precise perception of gravity.Significance
In BVD-patients with bilaterally-absent oVEMPs intensified vestibular rehabilitation should be considered. 相似文献10.
Farzad Fatehi Emilien Delmont Aude-Marie Grapperon Emmanuelle Salort-Campana Amandine Sévy Annie Verschueren José Boucraut Shahram Attarian 《Clinical neurophysiology》2017,128(7):1264-1269
Objective
To investigate the relationship between Motor Unit Number Index (MUNIX) and functional scales in patients with anti-Myelin Associated Glycoprotein (MAG) neuropathy and to know if MUNIX is modify after rituximab (RTX) therapy.Methods
17 patients were enrolled, of whom 6 were prospectively evaluated during one year after RTX treatment. MUNIX technique was assessed in abductor digiti mini (ADM), abductor pollicis brevi (APB) and tibialis anterior (TA) muscles. MUNIX sum score was calculated by adding the results of ADM, APB and TA muscles.Results
MUNIX sum score was correlated with overall neuropathy limitation scale (ONLS) (r = ?0.55, p = 0.02), grip strength in dominant hand (r = 0.63, p = 0.01) MRC testing (r = 0.71, p < 0.001) and CMAP sum score (r = 0.71, p = 0.001). Twelve months after RTX, four patients improved their disability measured on the ONLS score, five patients had improved MUNIX sum score with a median increase of 37% compared to initial evaluation.Conclusions
MUNIX is related to motor impairment and disability in anti-MAG neuropathy and MUNIX is modified after immunosuppressive treatment.Significance
Considering its advantages, MUNIX may be a suitable test to evaluate anti-MAG neuropathy in clinical trials. 相似文献11.
Jun Tsugawa Thanuja Dharmadasa Yan Ma William Huynh Steve Vucic Matthew C. Kiernan 《Clinical neurophysiology》2018,129(10):2149-2154
Objective
To investigate the association between the frequency and intensity of fasciculations with clinical measures of disease progression in amyotrophic lateral sclerosis (ALS).Methods
Twenty-four consecutive patients with ALS underwent clinical review and neuromuscular ultrasound assessment to detect intensity of fasciculations. Results were correlated with clinical markers of disease severity, as measured by the ALS Functional Rating Scale-revised (ALSFRS-R) and rate of disease progression (ΔFS), in addition to assessment of cortical motor function.Results
Disease duration negatively correlated (R?=??0.530, p?<?0.01) with fasciculation intensity, while the ΔFS positively correlated with the fasciculation number (R?=?0.626, p?<?0.01). In terms of potential central contributions to ectopic impulse generation, patients were classified into cohorts based on their fasciculation intensity and short interval intracortical inhibition (SICI). ΔFS was significantly higher in patients with established hyperexcitability (low SICI) with high fasciculation intensity compared to those patients with minimal SICI change.Conclusions
Fasciculation intensity appears linked to disease progression and separately to markers of cortical dysfunction, specifically the advent of cortical hyperexcitability.Significance
Assessment of the intensity of patient fasciculations is a noninvasive approach that may provide further insight disease pathophysiology in ALS. 相似文献12.
Rossella Spataro Alexander Heilinger Brendan Allison Domenico De Cicco Santino Marchese Cesare Gregoretti Vincenzo La Bella Christoph Guger 《Clinical neurophysiology》2018,129(6):1130-1136
Objective
To assess somatosensory discrimination and command following using a vibrotactile P300-based Brain-Computer Interface (BCI) in Unresponsive Wakefulness Syndrome (UWS), and investigate the predictive role of this cognitive process on the clinical outcomes.Methods
Thirteen UWS patients and six healthy controls each participated in two experimental runs in which they were instructed to count vibrotactile stimuli delivered to the left or right wrist. A BCI determined each subject’s task performance based on EEG measures. All of the patients were followed up six months after the BCI assessment, and correlations analysis between accuracy rates and clinical outcome were investigated.Results
Four UWS patients demonstrated clear EEG-based indices of task following in one or both paradigms, which did not correlate with clinical factors. The efficacy of somatosensory discrimination strongly correlated (VT2: R?=?0.89, p?=?0.0000002, VT3: R?=?0.81, p?=?0.002) with the clinical outcome at 6-months. The BCI system also yielded the expected results with healthy controls.Conclusions
Neurophysiological correlates of somatosensory discrimination can be detected in clinically unresponsive patients and are associated with recovery of behavioural responsiveness at six months.Significance
Quantitative measurements of somatosensory discrimination may increase the diagnostic accuracy of persons with DOCs and provide useful prognostic information. 相似文献13.
Aleksandra Vučković Mohammed Jarjees Muhammad Abul Hasan Makoto Miyakoshi Matthew Fraser 《Clinical neurophysiology》2018,129(8):1669-1679
Objectives
Spinal Cord Injured (SCI) persons with and without Central Neuropathic Pain (CNP) show different oscillatory brain activities during imagination of movement. This study investigates whether they also show differences in movement related cortical potentials (MRCP).Methods
SCI paraplegic patients with no CNP (n?=?8), with CNP in their lower limbs (n?=?8), and healthy control subjects (n?=?10) took part in the study. EEG clustering involved independent component analysis, equivalent current dipole fitting, and Measure Projection to define cortical domains that have functional modularity during the motor imagery task.Results
Three domains were identified: limbic system, sensory-motor cortex and visual cortex. The MRCP difference between the groups of SCI with and without CNP was reflected in a domain located in the limbic system, while the difference between SCI patients and control subjects was in the sensorimotor domain. Differences in MRCP morphology between patients and healthy controls were visible for both paralysed and non paralysed limbs.Conclusion
SCI but not CNP affects the movement preparation, and both SCI and CNP affect sensory processes.Significance
Rehabilitation strategies of SCI patients based on MRCP should take into account the presence of CNP. 相似文献14.
Objectives
To measure changes in the visual interpretation of the EEG by the human expert for neonatal seizure detection when reducing the number of recording electrodes.Methods
EEGs were recorded from 45 infants admitted to the neonatal intensive care unit (NICU). Three experts annotated seizures in EEG montages derived from 19, 8 and 4 electrodes. Differences between annotations were assessed by comparing intra-montage with inter-montage agreement (K).Results
Three experts annotated 4464 seizures across all infants and montages. The inter-expert agreement was not significantly altered by the number of electrodes in the montage (p?=?0.685, n?=?43). Reducing the number of EEG electrodes altered the seizure annotation for all experts. Agreement between the 19-electrode montage (K19,19?=?0.832) was significantly higher than the agreement between 19 and 8-electrode montages (dK?=?0.114; p?<?0.001, n?=?42) or 19 and 4-electrode montages (dK?=?0.113, p?<?0.001, n?=?43). Seizure burden and number were significantly underestimated by the 4 and 8-electrode montage (p?<?0.001). No significant difference in agreement was found between 8 and 4-electrode montages (dK?=?0.002; p?=?0.07, n?=?42).Conclusions
Reducing the number of EEG electrodes from 19 electrodes resulted in slight but significant changes in seizure detection.Significance
Four-electrode montages for routine EEG monitoring are comparable to eight electrodes for seizure detection in the NICU. 相似文献15.
Marisa Blanquet Jens A. Petersen Antonella Palla Dorothe Veraguth Konrad P. Weber Dominik Straumann Alexander A. Tarnutzer Hans H. Jung 《Clinical neurophysiology》2018,129(4):863-873
Objective
We aimed to quantify peripheral-vestibular deficits that may contribute to imbalanced stance/gait in patients with inflammatory neuropathies.Methods
Twenty-one patients (58?±?15?y [mean age?±?1SD]; chronic-inflammatory-demyelinating-polyneuropathy?=?10, Guillain-Barré Syndrome?=?5, Anti-MAG peripheral neuropathy?=?2, multifocal-motor-neuropathy?=?4) were compared with 26 healthy controls. All subjects received video-head-impulse testing (vHIT), caloric irrigation and cervical/ocular vestibular-evoked myogenic-potentials (VEMPs). The Yardley vertigo-symptom-scale (VSS) was used to rate vertigo/dizziness. Postural stability was assessed using the functional gait-assessment (FGA). Pure-tone audiograms (n?=?18), otoacoustic emissions (n?=?12) and auditory brainstem responses were obtained (n?=?12).Results
Semicircular-canal hypofunction was noted in 9/21 (43%) patients (vHIT?=?6; caloric irrigation?=?5), whereas otolith function was impaired in 12/21 (57%) (oVEMPs?=?8; cVEMPs?=?5), resulting in vestibular impairment of at least one sensor in 13/21 (62%). On average, 2.4?±?1.1 vestibular end organs (each side: anterior/posterior/horizontal canal, utriculus, sacculus; total?=?10) were affected. The VSS-scores were higher in patients (16.8?±?8.6 vs. 9.5?±?6.2, p?=?0.002) but did not correlate with the number of affected organs. Auditory neuropathy was found in 1/12 (8%) patients.Conclusion
Impairment of one or more vestibular end organs was frequent, but usually mild, possibly contributing to imbalance of stance/gait in inflammatory neuropathies.Significance
While our data does not support routine vestibular testing in inflammatory neuropathies, this may be considered in selected cases. 相似文献16.
Pedro Monsalve Sandy Ren Hong Jiang Jianhua Wang Maja Kostic Philip Gordon Vittorio Porciatti 《Clinical neurophysiology》2018,129(9):1813-1818
Objective
To assess residual retinal ganglion cell (RGC) function in patients with recovered optic neuritis (ON) and multiple sclerosis (MS).Methods
Age-matched controls (C, n?=?32) and MS patients (n?=?17) with history of ON in one eye but normal visual acuity and color vision were tested with steady-state Pattern Electroretinogram (PERG). Light Emitting Diodes (LED)-generated bar gratings, robust signal averaging and Fourier analysis were used to assess response amplitude and latency.Results
PERG amplitude was similar for C, ON and fellow eyes (FE) (P?=?0.4), but PERG latency was shortened in ON by 3.2?ms (P?=?0.002) and in FE by 2.0?ms (P?=?0.02) and was correlated (P?<?0.01) with both Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell Inner Plexiform Layer (GCIPL) thicknesses. PERG latency shortening could be simulated in control subjects (n?=?8) by dioptrically blurring the edges of gratings (high spatial frequencies), which reduced activity of parvocellular RGCs with smaller/slower axons. The blurred PERG latency was shorter than baseline by 2.9?ms (P?=?0.01).Conclusions
PERG latency is shortened in both eyes of MS patients with recovered unilateral ON, suggesting relative dysfunction of RGCs with slower axons and sparing of RGCs with faster axons.Significance
Assessment of PERG latency in MS and ON may help identifying and monitoring RGC dysfunction. PERG latency shortening in FE suggests primary retinopathy in MS. 相似文献17.
A.B. Jacobsen R.S. Kristensen A. Witt A.G. Kristensen L. Duez S. Beniczky A. Fuglsang-Frederiksen H. Tankisi 《Clinical neurophysiology》2018,129(3):646-653
Objective
To compare the diagnostic utility of motor unit number estimation (MUNE) methods to motor unit potential (MUP) analysis in amyotrophic lateral sclerosis (ALS).Methods
Twenty-five patients (1 definite, 11 probable, 9 possible ALS and 4 progressive muscular atrophy) and 22 healthy controls were prospectively included. Quantitative MUP analysis and three MUNE methods; Multiple Point Stimulation MUNE (MPS), Motor Unit Number Index (MUNIX) and MScanFit MUNE (MScan) were done in abductor pollicis brevis muscle. The sensitivities were compared by McNemar chi-square test. MUNE, MUP and revised ALS Functional Rating Scale (ALSFRS-R) parameters were correlated by regression analysis.Results
The sensitivities of MPS (76%) and MScan (68%) were higher than MUP duration (36%) and amplitude (40%) in detecting motor unit loss (p?<?0.05). MUNE methods increased the categorical probability from possible to probable ALS in 4 patients (16%). There was only significant correlation between ALSFRS-R and MScan (r?=?0.443, p?=?0.027) among the electrophysiological tests. MUNE methods did not correlate to MUP parameters.Conclusions
MUNE methods are more sensitive in showing abnormality than MUP analysis.Significance
MUNE methods, in particular MScan, may have the potential to be implemented in the clinical practice for diagnosis and follow-up of neuromuscular disorders particularly ALS. 相似文献18.
Tomoyuki Fumuro Masao Matsuhashi Riki Matsumoto Kiyohide Usami Akihiro Shimotake Takeharu Kunieda Takayuki Kikuchi Kazumichi Yoshida Ryosuke Takahashi Susumu Miyamoto Akio Ikeda 《Clinical neurophysiology》2018,129(9):1884-1890
Objective
Neuro-feedback (NFB) training by the self-regulation of slow potentials (SPs) <0.5?Hz recorded from the vertex scalp has been applied for seizure suppression in patients with epilepsy. However, SP is highly susceptible to artifact contamination, such as the galvanic skin response (GSR). This study aimed to evaluate the correlation between SPs recorded from the scalp and intracranial electroencephalography (EEG) by event-related coherence analysis.Methods
The scalp and subdural SPs were simultaneously recorded during NFB training by the DC-EEG machine while undergoing invasive recordings before epilepsy surgery in 10 patients with refractory partial epilepsy. The SPs at the vertex electrode were used as a reference for coherence analysis.Results
The coherence of SPs negatively correlated with the distance between the subdural and scalp electrodes. A significant negative correlation was noted between the linear subdural–scalp electrode distance and the coherence value (r?=????0.916, p?<?0.001).Conclusion
Scalp-recorded SPs from the vertex area primarily reflect the cortical activity of high lateral convexity.Significance
Our results strongly suggest that SPs in NFB recorded from the vertex scalp electrode is derived from the cortices of high lateral convexity but not from the artifacts, such as GSR. 相似文献19.
Eleonora Tobaldini Edgar Toschi-Dias Pietro Davide Trimarchi Nicola Brena Angela Comanducci Silvia Casarotto Nicola Montano Guya Devalle 《Clinical neurophysiology》2018,129(5):1083-1089