Sorbents for thin-layer chromatography in pharmaceutical analysis

Compounds contained in medicinal plant raw material and DL-tryptophan have been separated by thin-layer chromatography using various sorbents including cellulose, RP-modified silica gel, chiral precoated plates, and plates with a concentrating zone.     

反相薄层色谱法在药物分析中的应用研究进展

目的本文简要概述了反相薄层色谱法在药物分析中的应用研究进展。方法通过查阅国内外相关文献资料,对反相薄层色谱的原理及应用研究加以综述。结果反相薄层色谱法可用于中药材鉴别、有关物质检查和手性药物分离。结论反相薄层色谱法具有设备简单,操作简便等特点,可广泛应用于药物分析中。     

Determination of lidocaine in pharmaceutical preparations using thin-layer chromatographic densitometry

A thin-layer chromatographic (TLC)—UV-densitometric method has been developed for the analysis of lidocaine in ointments, suppositories and gels. The method is quantitative, rapid and able to separate lidocaine from other components in the pharmaceutical dosage forms investigated without preliminary extraction. The method gave precise and reproducible results.     

Evaluation of the purity of vitamin a oil-based preparations by thin-layer chromatography

An important stage in pharmaceutical analysis is the estimation of the degree of purity of parent substances and related preparations. There is currently a need to develop simple, economic, and accessible methods for rapid analysis. One such method is thin-layer chromatography (TLC). In the present work, the possibility of using TLC for monitoring the content of impurities in oil-based vitamin A preparations and for their separation and identification is considered. Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 12, pp. 47–49, December, 2008.     

Determination of nitrofurazone in some pharmaceutical preparations

A simple, selective and accurate paper chromatographic method for the determination of nitrofurazone in some dosage forms has been described. The method was based on impregnation of the chromatographic paper with pH 4.0 buffer containing 10% (w/v) urea. The percentage recovery of nitrofurazone obtained by the developed method indicated the accuracy of the prescribed method. The analytical results obtained compared favourably with those given for the official methods.