Eyelid involvement in paracoccidioidomycosis

PURPOSE: To describe a series of patients with eyelid lesions caused by paracoccidioidomycosis and to estimate the prevalence of eyelid involvement in this disease METHODS: The medical records of 439 patients with paracoccidioidomycosis admitted to our hospital from 1992 to 2002 were reviewed. Age, sex, and clinical forms of the disease were recorded. All patients with eyelid involvement had a skin biopsy positive for paracoccidioidomycosis and were examined by an ophthalmologist with oculoplastic training. RESULTS: Of 439 patients with acute, subacute, or chronic paracoccidioidomycosis, 11 (2.5%) had eyelid involvement. Active lesions ranged from erythematous patches of madarosis to frank destructive ulcers indistinguishable from malignancies. Healed lesions were characterized by a high degree of fibrosis. Cicatricial changes induced eyelid malpositions (entropion or ectropion) and fusion of eyelid tissues to the globe. Madarosis was a constant finding in the inactive lesions. CONCLUSIONS: The prevalence of eyelid involvement in paracoccidioidomycosis is low. Isolated active lesions are usually diagnosed as malignant tumors. Cicatricial changes are characterized by a high degree of fibrosis. If not treated, the mycosis can destroy the eyelid.     

Ocular involvement in pemphigus

PURPOSE: To report the occurrence of ocular involvement in the setting of pemphigus and discuss its relationship with disease activity and prognostic significance. DESIGN: Retrospective case reports. METHODS: Five patients, aged 38 to 65 years, diagnosed with pemphigus according to clinical, histopathologic, and immunopathologic criteria (n = 4 pemphigus vulgaris; n = 1 superficial pemphigus) developed ocular symptoms and signs consistent with the disease, ranging from mild conjunctivitis to blisters and prominent erosions of the bulbar/palpebral conjunctiva or at the eyelid margin. RESULTS: Ocular involvement in our series mostly followed skin disease or represented the stigmata of quiescent localized pemphigus. One of five patients had fatal outcome from myocardial infarction, whereas in the remaining cases significant improvement was achieved with oral prednisolone. CONCLUSIONS: Ocular pemphigus is probably underdiagnosed and its frequency appears underestimated. It does not seem to correlate with disease severity, but may persist chronically after healing of cutaneous lesion.     

Conjunctival involvement in paraneoplastic pemphigus.

Paraneoplastic pemphigus is a recently described autoimmune inflammatory mucocutaneous disease associated with an underlying neoplasm. Although histopathologic and direct immunofluorescence findings of involved skin and mucous membranes are consistent with pemphigus vulgaris, indirect immunofluorescence and immunoprecipitation study results are unique. We treated two patients with non-Hodgkin's lymphoma and paraneoplastic pemphigus. Both patients had bilateral bulbar conjunctival hyperemia and diffuse papillary tarsal conjunctival reactions. One patient had sloughing of conjunctival epithelium and the other had tarsal conjunctival cicatrization and forniceal shortening. Histopathologic findings of conjunctivae obtained from both patients were consistent with pemphigus vulgaris. Diffuse deposition of IgG and C3 in the intercellular substance of the conjunctival epithelium was demonstrated by direct immunofluorescence. Indirect immunofluorescence testing disclosed binding of autoantibodies to rodent bladder and intestinal epithelium. Immunoprecipitation disclosed antibodies reactive to Desmoplakin I (250 kd), bullous pemphigoid (230 kd), Desmoplakin II (210 kd) and 190-kd proteins. Ophthalmologists and pathologists should be aware of the conjunctival changes in paraneoplastic pemphigus.     

眼睑皮肤缺损利用阴茎皮肤修复的效果

目的 评价男性眼睑皮肤缺损,采用阴茎皮肤游离皮片移植术修复整形,恢复眼睑功能和容貌的效果.方法 自2003年1月至2011年8月,男性眼睑皮肤缺损32例,切取自体阴茎皮肤,制成相应植床大小的游离皮片,如不足植床面积再辅以睑周围皮瓣修复整形.结果 32例术后观察6 ～ 24个月,眼睑功能和容貌基本恢复.结论 采用阴茎皮肤游离皮片移植术,可有效治疗眼睑皮肤缺损,效果良好.     

Eyelid skin disinfecting and conjunctival bacteria in cataract surgery

Purpose: To evaluate the effect on conjunctival micro‐organisms of chlorhexidine alcohol 0.5% eyelid wash in cataract patients. Methods: In this single‐centre experimental study, 120 patients scheduled to undergo cataract operation were cultured in the conjunctiva before the operation and after the insertion of the intraocular lens. Bacterial samples for aerobic and anaerobic cultures were taken with a polyvinyl alcohol pad and transported in peptone water to the microbiological laboratory where they were analysed in a blinded fashion. Half of the patients received a standardized eyelid scrub with chlorhexidine alcohol 0.5%, while the rest did not. The conjunctiva of all patients was rinsed preoperatively with chlorhexidine solution 0.05%. Results: In all the between‐group comparisons, the treated eyelid group had slightly lower bacterial counts than the control group on the postoperative samples, but differences were far from statistically significant. Within‐group comparisons revealed statistically significant reduction in colonies and species between the preoperative and postoperative sampling. Conclusion: In this experimental culture study, no evidence was found to suggest that preoperative eyelid chlorhexidine alcohol wash is effective in further reducing bacterial counts in the conjunctiva when the conjunctiva itself is rinsed preoperatively with chlorhexidine solution. The present results, however, do not contradict that the wash may be of some marginal help in reducing bacterial contamination of the operation field. Consequently, this part of the prophylactic protocol is still in practice in our institution.     

Eyelid involvement in acanthosis nigricans: the importance of systemic screening

A 53-year-old man presented with thickening and hyperpigmentation of the eyelids. After the diagnosis of acanthosis nigricans was made, further investigation of a possible underlying disorder, including biochemical and instrumental examinations, indicated the presence of glucose intolerance, which had been diagnosed 3 years after the clinical appearance of acanthosis nigricans. Eyelid involvement in acanthosis nigricans is rare. Ophthalmologists should be aware of the possibility that acanthosis nigricans can exist in the periocular area and perform a systemic assessment of the patient for the presence of an underlying condition.     

Ocular surface involvement in pemphigus vulgaris: An interdisciplinary review

PurposeA review of the published literature on the history, pathogenesis, and treatment of pemphigus vulgaris (PV) and its ocular involvement.MethodsLiterature searches were conducted in MEDLINE (Ovid), and google scholar for pemphigus vulgaris and ocular PV. Inclusion criteria were given to meta-analysis, case-controlled studies, and documented case reports. The data were examined and independently analyzed by more than two of the authors.ResultsPV is a humoral autoimmune disease with a preponderance of IgG4 anti-desmoglein 3 antibodies. Upon antibody binding, there is an intracellular signaling mechanism that leads to blister formation. Ocular findings are seen in up to 16% of PV patients with conjunctivitis being the most common clinical presentation. New steroid-sparing agents have helped with the control of this deadly disease, and with better understanding of the pathogenesis of PV, other cytokine blockers currently available are promising steroid-sparing agents.ConclusionsOcular pemphigus can occasionally present prior to mucocutaneous findings. Recalcitrant conjunctivitis with conjunctival blisters should warrant a workup for systemic PV.     

眶外侧水平皮下蒂皮瓣法眼睑缺损修复术

目的：应用局部皮瓣法行上下眼睑皮肤缺损修复，方法：于眶外侧形成皮下蒂皮瓣转移修复上下眼睑皮肤缺损，结果：手术20例，皮瓣全部成活，效果满意。结论：本术式对较大面积眼睑皮脸缺损的修复，简单实用，易于掌握，值得推广。     

Diseases of the skin,lids and lashes 2: Eyelid infections

In the previous section I described the anatomy and structure of the skin. In this section I will discuss the common infections that can afflict the eyelids and surrounding tissues.     

采用180°旋转皮瓣修复眼睑肿物切除术后眼睑皮肤缺损的临床研究

目的　探讨采用180°旋转皮瓣修复眼睑肿物切除术后眼睑皮肤缺损的安全性和有效性。方法　回顾性分析29例38眼采用180°旋转皮瓣修复眼睑肿物切除术后造成的眼睑皮肤缺损患者。术中按照标记线切除肿物后,在肿物一侧或两侧标记松弛的上睑或下睑皮肤量,按照重睑或眼袋延长线切开皮肤,在靠近皮肤缺损区的上方或下方留5 mm左右宽的蒂,分离皮瓣,并带有少量的眼轮匝肌,然后将皮瓣旋转180°,修剪皮瓣后间断缝合,再连续缝合供皮区皮肤切口。术后加压包扎48 h。对术后外观和皮瓣的存活情况进行连续性观察。结果　所有180°旋转皮瓣均在眼睑缺损区良好存活,不需要打包加压,而且皮瓣收缩量低,术后手术瘢痕相对隐蔽。2眼皮瓣在术后早期出现皮瓣尖端发黑;多数皮瓣蒂部早期存在轻度猫耳现象,术后3个月猫耳逐渐平复,除1眼术后6个月因上睑皮肤松弛和猫耳现象而行上睑成形术外,其余患者均无需二次手术。结论　180°旋转皮瓣手术操作相对简单,可避免发生眼睑外翻、变形等并发症,是眼睑前层缺损修复的备选方法。     

Lower Eyelid Epiblepharon Associated with Lower Eyelid Retraction

Purpose

To describe a series of patients with lower eyelid epiblepharon associated with lower eyelid retraction.

Methods

We retrospectively reviewed the medical records of patients who underwent surgery for lower eyelid retraction, epiblepharon, or thyroid-associated ophthalmopathy (TAO) between October 1999 and March 2007. Patients with both lower eyelid retraction and epiblepharon on preoperative examination were included in this study.

Results

Twenty-seven eyelids of 20 patients with both lower eyelid retraction and epiblepharon were enrolled. The underlying causes of lower eyelid retraction included congenital retraction (seven eyelids), congenital fibrosis of the extraocular muscles (CFEOM; seven eyelids), TAO (seven eyelids), post-operative cicatricial retraction (five eyelids), and facial nerve palsy (one eyelid). Eight of 27 eyelids were successfully corrected after the repair of retraction without the repair of epiblepharon, regardless of the cause of lower eyelid retraction. Another four eyelids with epiblepharon associated with TAO resolved after only orbital decompression. Cilia-everting sutures were additionally applied for epiblepharon in another 14 eyelids, 12 of which did not require the excision of a skin fold or the orbicularis muscles. Only one eyelid with mild retraction and epiblepharon underwent simple epiblepharon repair. Recurrence of retraction or epiblepharon developed in three eyelids during follow-up.

Conclusions

In cases with both lower eyelid retraction and epiblepharon, the retraction should be repaired first, and then the epiblepharon can be corrected selectively according to the severity of the case.     

Eyelid Entropion

Entropion is a common eyelid malposition in which the margin turns inward against the globe. If untreated, this condition can cause irritative symptoms like ocular discomfort, corneal abrasion, microbial keratitis, corneal vascularization, and visual loss. It may be classified as cicatricial, congenital, acute spastic and involutional. Involutional entropion is the most common type seen in general ophthalmic practice and its prevalence is increasing as the population ages. There are several treatment strategies including nonsurgical and surgical procedures. This paper describes the surgical techniques most commonly used to treat entropion: everting sutures (Quickert), transverse blepharotomy and marginal rotation (Weis procedure), orbicularis transfer technique, tarsal strip, and advancement of the lower lid retractors.     

Eyelid sparganosis

PURPOSE: To report a case of sparganosis in the muscle layer of the eyelid. DESIGN: Observational case report. METHODS: A 67-year-old man with migratory painful swelling on the eyelid that was unresponsive to medications was evaluated and treated surgically. RESULTS: Computed tomography showed a 1.5 x 1.5-cm sized, thick-walled lesion and ultrasound biomicroscopy showed hypoechoic tubular and cystic lesions. During surgery, a white, thread-like plerocercoid, 7 cm in length was detected in the orbicularis muscle of the lower eyelid. Histopathologic examination demonstrated the characteristic feature of the sparganum larva and foreign body granulomatous reaction. Serodiagnosis by enzyme-linked immunosorbent assay was positive. Three months postoperatively, the lesion resolved completely. CONCLUSION: Although rare, sparganosis should be suspected in a moving eyelid mass unresponsive to the medical treatment.