注意缺陷多动障碍成年人视觉搜索中的注意特点

目的:探讨注意缺陷多动障碍(ADHD)成年人在视觉搜索任务中不同工作记忆负荷下的注意特点。方法:选取45例符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的成年人ADHD患者,以及44例年龄、性别、智商相匹配的健康成年人,通过工作记忆引导的视觉搜索任务来比较两组被试在低工作记忆负荷与高工作记忆负荷条件下的反应时与正确率。结果:在低工作记忆负荷[(823±144)ms vs.(754±123)ms,P0.01]与高工作记忆负荷[(912±163)ms vs.(851±162)ms,P0.01]条件下,成年人ADHD组的反应时均大于正常对照组。在两种任务中,低工作记忆负荷的反应时低于高工作记忆负荷下的反应时[ADHD患者,(823±144)ms vs.(912±163)ms,P0.01;对照,(754±123)ms vs.(851±162)ms,P0.01],低工作记忆负荷的正确率高于高工作记忆负荷下的正确率[ADHD患者,(95.9±4.3)% vs.(91.2±14.3)%;对照,(95.8±4.2)% vs.(94.4±4.9)%,P0.01]。结论:成年人ADHD患者在视觉搜索中存在自上而下注意缺陷。此外,视觉工作记忆负荷影响了ADHD患者的注意功能,当视觉工作记忆负荷增加时,注意资源相应减少,搜索效率降低。     

成人注意缺陷多动障碍患者的工作记忆特点

目的:探讨成人注意缺陷多动障碍(ADHD)患者的工作记忆特点。方法:选取49例符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的ADHD成人,以及44名性别、年龄、总智商相匹配的正常对照,进行不同任务负荷n-back任务,比较两组人群反应时(RT)、正确率和个体内反应时标准差(ISD)。结果:成人ADHD患者及正常对照被试在完成3种n-back任务时,其反应时和个体内反应时标准差均随工作记忆负荷增加而增大(P<0.01),而正确率随工作记忆负荷增加而减小,呈现等级变化规律;两组比较,在完成中等工作记忆负荷的1-back任务时,ADHD成人患者的反应时明显长于正常成人[(501.5±97.1)ms vs.(461.7±74.7)ms,P<0.05],且其变异性也大于对照组[(164.5±43.9)ms vs.(145.4±45.2)ms,P<0.05]。但两组在完成3个任务的正确率上未见统计学差异。结论:ADHD成人患者可能存在语言工作记忆能力损害,在中等记忆负荷任务上受损最严重,反应慢且其注意力波动大,这可能与其工作记忆容量下降整体输出不足及注意力维持能力差有关。     

海洛因依赖者对吸毒相关图片线索的注意偏向

目的: 利用情绪Stroop任务测量海洛因依赖者是否存在对吸毒相关图片线索的注意偏向.方法: 利用NeuroSCAN工作站STIM2编程,记录并比较研究组和对照组(各15例)对3类图片(包括中性、高唤起性、海洛因相关性)边框颜色的反应时及正确率.结果: 海洛因相关图片反应时研究组长于对照组[(819.8±110.2)ms vs.(634.6±87.8)ms,P＜0.01],高唤起性图片的反应时对照组长于研究组[(734.7±100.1)ms vs.(642.3±78.1)ms,P=0.01].重复测量的方差分析发现存在刺激类别的主效应(F=31.63,P＜0.01)以及组别和刺激类别的交互效应(F=11.31,P＜0.01).海洛因相关图片的反应时与吸毒时间呈正相关(r=0.41,P＜0.05).结论: 海洛因依赖者存在对吸毒相关图片线索的注意偏向.     

学龄前注意缺陷多动障碍儿童的视觉-运动整合能力

目的:探讨学龄前注意缺陷多动障碍(ADHD)儿童的视觉-运动整合能力特点,为实施有针对性的早期干预方案提供依据.方法:采用1∶1病例对照的设计,选取符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ) ADHD诊断标准的4～6岁儿童(混合型37例、注意缺陷为主型28例、多动/冲动为主型14例)及正常对照各79例.采用视觉-运动整合发育测验(VMI)来评定视觉-运动整合情况.结果:ADHD儿童VMI测验异常检出率高于对照组(32.9％ vs.7.6％,P＜0.01);ADHD各亚型VMI测验异常检出率从高到低依次为混合型、注意缺陷为主型、多动/冲动为主型,各亚型组间差异均有统计学意义(45.9％ vs.25.0％ vs.14.3％,均P＜0.05);ADHD儿童的VMI测验得分低于正常对照组[(90.2±19.4) vs.(100.5±10.7),P＜0.05],混合型ADHD儿童的VMI测验得分低于注意缺陷为主型和多动/冲动为主型[(84.5±23.1) vs.(93.7±15.2),(97.9±11.5);均P＜0.05].结论:学龄前ADHD儿童可能存在视觉-运动整合能力方面的缺陷,对学龄前ADHD儿童视觉-运动整合能力的评估有助于早期识别和早期预防学习和行为问题.     

注意缺陷多动障碍儿童的时间知觉特征

目的:探讨注意缺陷多动障碍(ADHD)儿童的时间知觉特征及其可能相关的原因。方法:选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)中ADHD的诊断标准,Conners父母症状问卷和Conners教师评定量表中的多动指数Z≥1.5的儿童55例及正常对照儿童55例,以中国修订韦氏儿童智力量表手册(C-WISC)评定总体智商,以时间辨别任务测试(TDTT)、Coirs积木测验(CBT)、儿童持续注意反应测试(C-SART)分别评定100 ms和1000 ms的时间知觉差别阈限值、视觉工作记忆广度、持续性注意的遗漏性错误次数和执行错误次数。结果:ADHD儿童总体智商得分低于正常组儿童[(97.4±11.2)vs.(110.3±12.1),P<0.01)],C-SART中的遗漏性错误次数高于正常儿童[(25.5±2.4)vs.(14.6±2.1),P<0.01]。100 ms条件下,ADHD儿童与正常儿童的时间知觉差别阈限值差异无统计学意义(P>0.05)。1000 ms条件下,注意缺陷多动障碍儿童时间知觉差别阈限值高于正常儿童(P<0.01)。在控制总体智商之后,注意缺陷多动障碍儿童加工1000 ms时的差别阈限值与其CBT得分呈负相关(r=-0.54 P<0.01),与其C-SART中的遗漏错误和执行错误次数呈正相关(r=0.47、0.44,均P<0.01)。结论:注意缺陷多动障碍儿童相比正常儿童存在时间知觉缺陷,这一缺陷可能与其持续性注意和工作记忆的受损有关。     

孤独症儿童对静态和动态视向提示信息的加工

目的:探索在静态和动态呈现条件下孤独症儿童对视向提示信息加工的特征.方法:选取符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)孤独症诊断标准的儿童和年龄性别匹配的正常对照儿童各10名.通过l张图片形成的静态视向提示和5张图片形成的动态视向提示,采用2(组别:孤独症儿童,正常儿童)×2(呈现方式:静态,动态)×2(提示性:有效提示,无效提示)的重复测量方差分析,比较两组儿童在不同呈现方式下的视向提示反应的正确率和反应时.结果:在静态条件下,孤独症儿童识别视向的正确率低于正常对照组儿童[(94.8±1.3)％vs.(99.5±1.3)％,P＜0.05],且反应时较长[(470.2±23.8) ms vs.(389.2±23.8) ms,P＜0.05];在动态条件下,有效提示的识别正确率高于无效提示[(98.8±0.5)％vs.(93.8±0.3)％,P＜0.05],且有效提示的反应时短于无效提示[(463.1±19.7) ms vs.(504.8 ±21.4) ms,P＜0.01],孤独症儿童的反应时长于正常对照组儿童[(544.6±28.4) ms vs.(423.3±28.4) ms,P＜0.05].结论:本研究发现提示孤独症儿童存在与正常儿童一样的视向注意转移,并无特异性视向注意损伤,孤独症儿童对动态视向信息加工可能较静态视向信息加工更敏感.     

有人际关系困扰的大学生的内隐心理活动

目的:探索有人际关系困扰(ID)问题的大学生在人际交往过程中的内隐心理活动特点,为ID者的心理辅导与干预治疗提供理论指导.方法:选取329名大学生,使用人际关系综合诊断量表(IRIDQ)将其分成ID组(IRIDQ得分为15～28分,n=43)、普通组(IRIDQ得分为9～ 12.11分,n=50)和无困扰组(IRIDQ得分为0～3.76分,n=50).采用GNAT (the Go/No-go Association Task)内隐联想范式和情绪STROOP范式测试三组在人际关系上的内隐认知、内隐情绪、内隐社交意向的反应时、击中率与虚报率(用于计算信号辨别率指数d’).结果:方差分析显示,在内隐认知、内隐情绪、内隐行为意向的平均反应时上,组别主效应均显著(均P ＜0.001),进一步多重比较发现,ID组积极内隐认知反应时长于普通组和无困扰组[(594.2±17.0) ms vs.(533.4±15.5) ms vs.(503.3±13.9) ms;均P＜0.01],而消极内隐认知反应时则短于普通组和无困扰组[(554.5±18.5) ms vs.(600.6±28.8) ms vs.(610.4±19.8)ms;均P＜0.01];ID组内隐情绪反应时长于普通组和无困扰组[积极情绪词(442.1±18.5) ms vs.(415.6±17.5) msvs.(395.7±12.9) ms;消极情绪词(434.3±17.5) ms vs.(390.1±13.1) ms vs.(389.8±15.5) ms;均P＜0.01]; ID组内隐社交意向反应时长于普通组和无困扰组[(593.6±10.7) ms vs.(395.6±12.0) ms vs.(381.2±8.1) ms;均P＜0.01],而社交情境d'最短[(0.8±0.6)vs.(1.8±0.8)vs.(2.2±0.6);均P ＜0.05)].结论:人际关系有困扰者存在消极的自我内隐认知和情绪干扰,人际交往行为有退缩意向.     

注意缺陷多动障碍儿童的工作记忆存储特征

目的:探讨注意缺陷多动障碍(ADHD)儿童工作记忆存储能力特征。方法:对26名符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的ADHD儿童和39名年龄及性别与之匹配的正常儿童,进行中国修订-韦氏儿童智力量表(C-WISC)、背数测验变式、方块图敲击试验变式和Kaufman儿童能力评估成套测验的寻找位置和手动作分测验测试,测查言语工作记忆和视空间工作记忆存储能力。结果:ADHD组在10 s后背数测验[(5.5±1.3)vs.(6.8±1.5)]、倒背数字[(3.3±1.1)vs.(4.1±1.0)]、方块图敲击试验[(4.4±1.1)vs.(5.1±0.8)]、10 s后敲击试验[(3.4±1.3)vs.(4.1±1.1)]、手动作测试[(8.5±3.3)vs.(10.4±3.1)]得分均低于正常组(均P0.05),两组在顺序背数测试[(6.6±1.0)vs.(7.1±1.0)]和寻找位置测试[(10.3±2.8)vs.(11.5±2.8)]得分差异无统计学意义(均P0.05)。多重线性回归分析表明,10 s后背数测试(β=0.31)、方块图敲击测试(β=0.29)、10秒后敲击试验(β=0.24)的得分高低与是否患ADHD相关(P0.05)。结论:ADHD儿童可能存在语音环信息保持能力损害和空间序列性信息存储能力缺陷。     

注意缺陷多动障碍儿童在不同情绪面孔刺激下的持续注意任务事件相关电位

目的:了解不同情绪面孔刺激下注意缺陷多动障碍(ADHD)患儿执行持续注意任务时的事件相关电位特征。方法:选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的混合型ADHD患儿32例(年龄9~15岁)及年龄、性别匹配的正常对照组儿童32例,要求被试在高兴、中性、恐惧和愤怒等4种情绪面孔刺激随机呈现后执行注意与选择任务,同时记录事件相关电位。观察ADHD患者和正常对照组儿童面孔诱发的N170电位及靶刺激诱发的P300电位的特征。结果:ADHD组患儿在4种不同情绪面孔刺激下颞枕区面孔特异性N170波波幅均低于对照组[如恐惧面孔,(17.7±9.5)μv vs.(25.8±14.0)μv,P0.05],顶枕区P300潜伏期长于对照组[如恐惧面孔,[(454.2±51.3)ms vs.(433.0±29.8)ms,P0.05]。ADHD患儿组在四情绪面孔诱发的N170波幅和潜伏期差异无统计学意义(P0.05),诱发的P300在四种情绪刺激中以恐惧面孔刺激后执行注意任务的P300波幅最低,潜伏期最长。结论:ADHD儿童在4种不同情绪面孔刺激下,以恐惧面孔刺激引起的P300波幅最低,且P300潜伏期延长最明显。提示恐惧面孔可能影响ADHD患儿情绪调节,并影响其持续注意过程。     

注意缺陷型和混合型注意缺陷多动障碍儿童的眼跳特征

目的:使用眼跳任务深入研究不同亚型注意缺陷多动障碍(Attention deficit hyperactivity disor-der,ADHD)儿童的抑制损伤。方法:选取金华市2所小学1500人,使用DSM-Ⅳ诊断标准、Conners儿童行为量表(父母问卷和教师问卷),筛查出10～13岁儿童48名,其中注意缺陷型(I型)11人,混合型(C型)19人,对照组18人,全体进行了正向眼跳和反向眼跳。结果:⑴反向眼跳中对照组的错误率低于I型和C型[(37.97±13.14)%vs.(70.90±15.78)%,(84.04±12.84)%;均P0.001],I型的错误率低于C型(P=0.015)。⑵对照组比C型更容易改正错误的眼跳[(95.39±7.49)%vs.(85.54±15.87)%,P0.05],对照组的矫正反应时要短于I型和C型(P0.05)。⑶反向眼跳中C型比对照组和I型精确性更差[(5.47±1.63)°vs.(4.41±1.00)°,(4.23±1.31)°;P0.05],正向眼跳中ADHD儿童有更多的先期性眼跳[(3.11±4.55)%vs.(1.11±1.98)%,P0.05]。结论:研究提示C型和I型的ADHD儿童存在抑制功能损伤,且I型的抑制功能好于C型。     

Schizophrenia in a North Swedish geographical isolate, 1900–1977. Epidemiology, genetics and biochemistry

Over 200 schizophrenic patients belonging to three major and interrelated pedigree complexes have been investigated over the past 30 years in a North Swedish geographically isolated population, presently numbering about 6,000. An intensive investigation of a number of biochemical correlates and genetic markers in a few selected families belonging to one of the major pedigrees has indicated new strategies for the current research program.
Schizophrenia, as defined operationally, is significantly associated with decreased activities of two enzymes (1) blood platelet monoamine oxidase, (2) plasma dopamine-β-hydroxylase, and (3) with the genetic marker Gc² (group specific antigen). Both enzymes are subject to genetic variation. A positive score for linkage between schizophrenia and low plasma DBH activity has been calculated, but, so far, available data are insufficient for discrimination between linkage and partial contribution of genetically controlled low plasma DBH to the pathogenesis of the disease. Alternatively, both mechanisms could be involved.
As a model for continued research, schizophrenia is explained as based on a double dominant-recessive genotype (Aabb), representing a vulnerability which in about 50 % of cases develops into clinical schizophrenia. It is suggested that the dominant mutation (A) operates on or affects MAO activity, and that the recessive genotype (bb) is instrumental in low variates of DBH activity and very likely such variates within the normal range of physiological variation. Moreover, it is suggested that the combined effects of MAO- and DBH-reduced efficiency on the metabolism of e.g. dopamine could be an essential pathogenic mechanism for the schizophrenic illness which is segregating in this population.     

Renal dysplasia and asplenia in two sibs

A family is reported in which two sibs, one male and the other female, both died within 24 hours of birth with enlarged polycystic kidneys. Postmortem histology in the second child showed gross renal dysplasia. In both children the pancreas was enlarged, nodular and cystic but the liver appeared macroscopically normal. In the second child, histological examination confirmed pancreatic fibrosis with cystic dilation of ducts, but showed portal fibrosis with bile duct proliferation in the liver.
This combination of findings is very reminiscent of those in a girl and her brother reported by Ivemark et al. (1959). The children reported here also showed absence or hypoplasia of the spleen, cardiac anomalies and other features of the Ivemark syndrome (Ivemark 1955), a quite different, usually sporadic, congenital disorder. It is suggested that the children described here have a distinct lethal congenital disorder, probably inherited in an autosomal recessive manner.     

The dominant diseases of modernized societies as omega-3 essential fatty acid deficiency syndrome: Substrate beriberi

About 1900, modern food selection and processing caused widespread $\text{epidemics}$ of the B vitamin deficiency diseases of beriberi and pellagra which, for genetic reasons, often expressed as different diseases ranging from bowel and heart disease to dermatoses and psychoses. But the B vitamins merely help convert essential fatty acids (EFA) into the prostaglandin (PG) tissue regulators and it now turns out that, through hydrogenation, milling and selection of w3-poor southern foods, we have also been systematically depleting, by as much as 90%, a newly discovered trace Nordic EFA (w3) of special importance to primates and sole precursor of the PG3(4) series, even as a concurrent fiber deficiency increases body demand for EFA. Since substrate EFA is processed by many B vitamin catalysts, an EFA deficiency will mimic a $\text{panh}$ypovitaminosis B, i.e., a mixture of $\text{substrate}$ beriberi and $\text{substrate}$ pellagra resembling vitamin beriberi and pellagra but exhibiting as even more diverse $\text{endemic}$ disease. This would consitute a second stage of the Modern Malnutrition and explain why some workers now hold the dominant diseases of modermized societies to be new, nutritionally based, pellagraform yet lipid-related and to range, once again, from heart disease to psychosis. It is an assumption that our dominant diseases are unrelated to each other or are merely revealed by our diagnostic acumen and therapeutic success; and that hydrogenating millions of tons of food oils annually, to destroy the rancidity producing w3-EFA, is safe for $\text{primates}$. Extensive beriberiform disease is reported here in 32 typical cases taken from medical practice which responds strikingly to linseed oil supplements (60% w3-EFA) in confirmation of identical results in Capuchins.     

'Very sore nights and days': the child's experience of illness in early modern England, c.1580-1720

Sick children were ubiquitous in early modern England, and yet they have received very little attention from historians. Taking the elusive perspective of the child, this article explores the physical, emotional, and spiritual experience of illness in England between approximately 1580 and 1720. What was it like being ill and suffering pain? How did the young respond emotionally to the anticipation of death? It is argued that children’s experiences were characterised by profound ambivalence: illness could be terrifying and distressing, but also a source of emotional and spiritual fulfilment and joy. This interpretation challenges the common assumption amongst medical historians that the experiences of early modern patients were utterly miserable. It also sheds light on children’s emotional feelings for their parents, a subject often overlooked in the historiography of childhood. The primary sources used in this article include diaries, autobiographies, letters, the biographies of pious children, printed possession cases, doctors’ casebooks, and theological treatises concerning the afterlife.     

Guidelines for the Validation and Use of Immunoassays for Determination of Introduced Proteins in Biotechnology Enhanced Crops and Derived Food Ingredients

Recent advancements in agricultural biotechnology have created a need for analytical techniques to determine introduced proteins in crops enhanced through modern biotechnology techniques. These proteins are expressed in plant tissues and may be present in food ingredients. Immunoassays are ideally suited for protein detection and may be used as both quantitative and threshold methods. Microplate ELISA and lateral flow devices are two of the most commonly used immunoassay formats for agricultural biotechnology applications. This paper provides general background information and a discussion of criteria for the validation and application of immunochemical methods to the analysis of proteins introduced into plants and food ingredients using biotechnology methods. It is the result of a collaborative effort of members of the Analytical Environmental Immunochemical Consortium. This collaborative effort represents the combined expertise of several organizations to reach consensus on establishing guidelines for the validation and use of immunoassays. Further, the paper offers developers and users a consistent approach to adopting the technology as well as aid in producing accurate and meaningful results.     

HLA in North Colombia Chimila Amerindians

HLA-A,-B,-C,-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing. A frequent extended haplotype was found:HLA-A*24:02-B*51:10-C*15:02-BRB1*04:07-DQB1*03:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico, California Gulf, Pacific Ocean). Other haplotypes had already been found in Amerindians from Mexico (Pacific and Atlantic Coast), Peru (highlands and Amazon Basin), Bolivia and North USA. A geographic pattern according to HLA allele or haplotype frequencies is lacking in Amerindians, as already known. Also, five new extended haplotypes were found in Chimila Amerindians. Their HLA-A*24:02 high frequencies characteristic is shared with aboriginal populations of Taiwan; also, HLA-C*01:02 high frequencies are found in New Zealand Maoris, New Caledonians and Kimberly Aborigines from Australia. Finally, this study may show a model of evolutionary factors acting and rising one HLA allele frequency (-A*24:02), but not in others that belong to the same or different HLA loci.     

Ultracryotomy: development and application (with examples from the yeast cytology) (author's transl)

The preparation steps usually necessary for obtaining ultrathin frozen sections of biological material (chemical prefixation, enclosing, cryoprotective treatment, freezing, sectioning, and post-staining the sections for transmission electron microscopy) are submitted to a critical analysis. The application of cryo-ultramicrotomy, in particularly for cytochemical purposes, is reviewed. Fundamental considerations of chemical prefixation and poststaining are supported by examples from yeast cytology. Furthermore, the efficiency of the cryo-ultramicrotomy (electron optical resolution of ultrastructural details) is demonstrated on yeast cells and protoplasts.     

The universal muscular chamber. A basic unit of the genitourinary, cardiovascular, gastro-intestinal, skeletal, cutaneous, respiratory and other systems, endocameral hypertension; and spasm, the key to their idiopathic diseases and arthropathies

Starting with the integument, we see many organs are contractile sacs or multiples thereof, which tubes or bags constitute the major part of the entire body. Recognition of this basic unit and its characteristics sheds new light, individually and collectively, on many disorders previously considered unrelated. Muscular tears and perforations develop in the walls of these chambers, being no way peculiar to those organs, wherein, hydrochloric acid occurs. So, it is not necessary to explain the absence of excessive acid from patients who exhibit holes in the gastric, uterine, aortic, duodenal, rectal, pulmonary, retina, and other walls. Muscle, not acid is the great common factor relating idiopathic disorders in the gastrointestinal tract to each other and to similar diseases in other systems. When the units are linked together, the lesions tend to appear as arthropathies, i.e. at the joints. Rephrasing common-place observations, frees us from conventional, conceptual cul-de-sacs. An observation is only as good as its interpretation, so all possibilities must be considered, otherwise, we will remain blinded by our misconceptions.     

Der Einfluß von Nahrungsmitteln und Rauchen auf die klinisch-chemische Diagnostik von Phäochromozytom,Neuroblastom und Karzinoid-Syndrom

Zusammenfassung Der Einfluß von verschiedenen Nahrungsmitteln auf Methoden zur Bestimmung von Adrenalin (AD), Noradrenalin (NA), Vanillinmandelsäure (VMS), Metanephrinen (MN), Homovanillinsäure (HVS) und 5-Hydroxyindolessigsäure (5-HIE) im 24 h-Harn zur Diagnose des Phäochromozytoms bzw. Karzinoid-Syndroms wurde untersucht. Die in die Untersuchung einbezogenen Nahrungsmittel waren: Tee, Kaffee, Mandeln, Ananas, Käse, Walnüsse, Vanillepudding, Bananen, Tomaten und Milchschokolade. Außerdem wurde der Einfluß des Zigarettenrauchens auf die Bestimmung von AD, NA, VMS und MN untersucht.Walnüsse führten zu einer starken Erhöhung der 5-HIE-Ausscheidung. Bananen erhöhten die Ausscheidung von AD, NA, VMS, MN und 5-HIE. Kaffee und Ananas bewirkten eine geringe Zunahme der MN-Werte. Rauchen von 20–30 Zigaretten/Tag beeinflußte keine der vier Variablen.Wenn die beschriebenen Methoden benutzt werden, sollte lediglich auf den Verzehr von Bananen und Walnüssen vor und während der Harnsammelperioden verzichtet werden, da die oberen Normgrenzen im Harn überschritten werden könnten. Ein Verzicht auf Kaffee und Ananas in normalen Mengen ist nicht erforderlich. Es besteht kein Anlaß, weiterhin die bisherigen umfangreichen Restriktionen der übrigen Nahrungsmittel beizubehalten.