臀部化脓性汗腺炎继发巨大鳞状细胞癌1例

报告臀部化脓性汗腺炎继发巨大皮肤鳞状细胞癌1例。患者男,62岁,左臀部结节破溃伴痛40余年,外生性肿物20余年。皮肤科检查：左臀部覆盖黑色斑疹,质地较硬,边界尚清,表面凹凸不平,中央可见数个脓肿、窦道、瘘管及瘢痕,挤压后见淡黄色脓性分泌物流出,伴明显触痛、恶臭;左臀部下方近肛门侧见一约20 cm×20 cm大小的外生性肿块,呈菜花状生长,质地坚硬,活动性差,表面溃烂,可见较多脓性分泌物覆盖,触之易出血。直肠指诊：肛门松紧度可,肛内未触及肿块,指套不带血,腹股沟淋巴结无肿大。左侧臀部外生性肿块组织病理：肿瘤位于真皮内,部分与表皮相连,由鳞状上皮细胞团块组成,部分细胞胞浆透明,部分区域棘刺松解,异型性明显。免疫组织化学染色检查：P63(+),P40(+),CK5/6(+),CK7(-)。诊断：(左臀部)皮肤鳞状细胞癌、化脓性汗腺炎。治疗：手术切除。随访1年未见复发。     

手部冻疮继发鳞状细胞癌1例

1临床资料 患者女,17岁,因左手背部肿块伴恶臭半年就诊.患者8岁时左手背部冬天长冻疮,治疗后愈合.此后每年冬天均在同样部位生冻疮.半年前,冻疮部位皮肤出现破损、溃疡,有渗出,溃疡部位逐渐增生,高出皮肤,形成肿块,表面破溃,当地医院给予外用药物治疗,无效,肿物逐渐增大,渗出增多,出现恶臭味.遂来我科就诊,患者既往体健,系统回顾无特殊.皮肤科检查:左手背部桡侧皮肤肿物,直径约4cm,表面破溃、结痂,伴有明显恶臭味,肿物周边皮肤可见红斑.     

银屑病继发多发性皮肤鳞状细胞癌3例分析

例 1　患者 ,男 ,6 5岁。因全身皮肤红斑、鳞屑反复发作 40年 ,多处溃疡 8年于 1998年 9月 2 3日收住我科。患者于 195 8年无明显诱因左小腿外侧出现红斑、鳞屑等损害 ,诊为“银屑病”。曾先后用“白血宁”、“氨甲喋呤”、“乙双吗林 (连续用药 380 0粒 )”口服 ;“芥子气 +松节油”、“石蜡油”外擦 ;行臀部“蛋清皮下注射” ;“氨甲喋呤”静滴。上述每药开始使用时皮损可消退 ,停药半年至一年即再发 ,治疗过程中曾出现白细胞减少。自 1986年以后皮损持续存在。1990年起全身皮肤发红 ,脱屑加重 ,并相继在全身多处出现大面积皮肤溃疡及菜花…     

皮肤结核继发鳞状细胞癌

报告1例额部皮肤结核后并发带状疱疹及鳞状细胞癌(简称鳞癌).患者男,56岁.额部患皮肤结核20余年,2年前在皮肤结核的皮损处出现带状疱疹.通过正规的抗结核和病毒治疗后,皮损逐渐好转.大约1年前红斑处外伤后渐有两枚肿物长出,较大的肿物经手术切除而治愈,经组织病理证实为鳞癌,2个多月后,另一个肿物迅速生长,再次住院彻底切除肿物,术后组织病理也显示为鳞癌,随访至今未见复发.提示须注意长期皮肤结核的并发症,组织病理学检查非常重要.     

下咽癌皮肤转移1例

<正>患者男,65岁,农民。因颈部皮肤多发丘疹及结节2周,于2021年6月18日来我院皮肤科就诊。患者2周前无意间发现颈部皮肤出现一丘疹,呈暗红色,无明显症状,一直未诊治,病程中丘疹逐渐增大、增多。既往史：8个月前下咽鳞癌伴颈部淋巴结转移,在我院耳鼻喉科行下咽癌根治+下咽修复重建+左颈淋巴结清扫+颈血管神经探查+人工真皮皮瓣修复+气管切开术,术后规律在我院肿瘤科行化疗及放射治疗,约半年前已完成化学药物治疗疗程。家族中无类似疾病患者。     

溃疡性皮肤转移性鳞状细胞癌1例

患者男，51岁，因躯干起皮疹，破溃，伴疼痛20个月，加重3个月，于2003年4月17日收住我院，2001年8月患者无明显诱因上胸部出现散在黄豆大红色斑丘疹，触之质地硬，有疼痛感，未予特殊治疗。数月后部分皮损中央破溃，覆有黄色脓液，伴有臭味，溃疡面逐渐扩大，并不断有新皮疹出现，曾外用鱼肝油软膏，中华汤伤油膏涂于溃疡处，无改善。     

皮肤鳞状细胞癌

皮肤鳞状细胞癌的发病率仅次于基底细胞癌,为最常见的皮肤癌之一。近年来其发病率在许多国家不断增加。该文较详细介绍了关于鳞状细胞癌的流行病学、病因学、临床特征、诊断和治疗的研究近况。     

原发性皮肤鳞状细胞癌淋巴结转移的评估与治疗

原发性皮肤鳞状细胞癌是一种常见的皮肤恶性肿瘤，一般不发生转移。一旦发生转移，通常首先扩散至区域淋巴结群，进而扩散至全身,严重致死。本文对原发性皮肤鳞癌淋巴结转移的评估以及治疗进行了综述。     

皮肤梭形细胞鳞状细胞癌1例

患者男,70岁,阴茎增生物半年余。患者半年多前无明显诱因出现阴茎新生物,无明显疼痛、瘙痒等不适,自行外用抗生素药膏后无明显好转;曾因尿道梗阻行包皮环切术,否认冶游史。皮肤科情况：冠状沟左侧可见一增生物,表面凹凸不平,有湿润感,但无明显分泌物,触痛(-),双侧腹股沟淋巴结未触及。病理诊断为冠状沟皮肤梭形细胞鳞状细胞癌(HPV不相关型)。     

疣状皮肤结核继发鳞状细胞癌

患者女,51岁。因右臀部结节,疣状增生伴瘙痒20多年,形成肿块1年,于2004年6月7日来我院就诊。患者20多年前右臀中段无明显诱因出现一蚕豆大红色结节,微痒,搔抓后破溃,流少许淡黄色黏稠分泌物,自用“中药”外敷无效,皮损周围出现散在丘疹或结节,并逐渐增大、增多。     

日光角化病继发鳞癌1例

报告1例日光角化病继发鳞癌。患者男,82岁。四肢灰褐色角化性丘疹2年,右小腿皮损明显增生为痛性结节伴溃疡20天。左小腿组织病理同时具有日光角化病和鳞癌特点表皮角化过度柱和角化不全柱交替出现,颗粒层灶性增厚,棘层肥厚,棘细胞排列紊乱,胞核有间变,表皮突的芽蕾突向真皮浅层,真皮浅层见大小不等的鳞状细胞团和角珠,细胞呈异型性,可见核分裂相,真皮浅层炎细胞浸润。提示日光角化病和鳞癌关系密切。     

播散性浅表性光化性汗孔角化症并发鳞状细胞癌1例

患者男,55岁.全身泛发环状丘疹,中央呈轻度萎缩,边缘呈堤状隆起的棕色皮损40年,3年前左踝部出现一菜花样增生,反复多次发生溃疡.左踝增生处皮损组织病理:表皮可见两个充满角蛋的凹陷及角化不全柱,下方颗粒层消失,棘层肥厚:真皮内大量鳞状细胞团块,小血管周围大量以淋巴细胞为主的单核细胞浸润.诊断:播散性浅表性光化性汗孔角化症;鳞状细胞癌.本病属常染色体显性遗传,有恶变倾向.     

Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

Disseminated superficial actinic porokeratosis (DSAP) consists of multiple annular, hyperkeratotic lesions that have a bilateral distribution on sun-exposed areas, particularly the extremities. DSAPs have a wider distribution than porokeratosis of Mibelli and usually develop during the 3rd or 4th decade of life. Squamous cell carcinoma that arises in the classical type of porokeratosis of Mibelli is well-documented, but there are only a few reports of squamous cell carcinoma in DSAP. Here, we describe a 62-year-old man with DSAP who developed squamous cell carcinoma on his right forearm.     

皮肤Merkel细胞癌伴鳞状细胞癌1例

患者女,76岁。左面颊部肿物1年,明显增大1个月。皮损特点为紫红色球形肿物。皮损组织病理示:表皮见团块状鳞状上皮中-重度异型增生,突破基底膜;真皮全层见形态一致的肿瘤细胞浸润,巢状或片状分布,圆形或卵圆形,胞质少、嗜碱性,核大、散点状分布染色质,核仁明显,可见多数核分裂相。免疫组化:CK20(部分+),P63及CKH(鳞状分化的细胞+),Syn(+),CgA(+),CD56(+),LCA(-),CK7(-),S100(-)。诊断:皮肤Merkel细胞癌伴鳞状细胞癌。     

A Case of Pseudovascular Adenoid Squamous Cell Carcinoma of the Skin with Spindle Cell Pattern

We report a case of pseudovascular adenoid squamous cell carcinoma which was in the form of a dome-shaped, cherry red tumor on the right cheek of an 86-year-old Japanese woman. Histologically, two types of atypical cells were identified; round cells in the upper part and spindle cells in the lower part. In the upper part, inter-anastomosing sinusoid-like pseudolumina were observed between the cords of the tumor cells. Immunohistochemically, the tumor cells did not express Factor VIII-related and CD34 antigens or bind Ulex europaes I agglutinin, except for only one anti-cytokeratin antibody. Ultrastructurally, the tumor cells contained tonofilaments and desmosomes and represented acantholysis. From the electron microscopy, possible role of capillary hyperpermeability on the acantholytic process of the neoplastic cells was suggested.     

A Case of Acantholytic Squamous Cell Carcinoma

Acantholytic squamous cell carcinoma is a well-defined variant of squamous cell cancer in which significant portions of the neoplastic proliferation show a pseudoglandular or tubular microscopic pattern. It usually presents as a nodule with various colors, and it is accompanied by scaling, crusting, and ulceration on the sun-exposed areas of older aged individuals. Histologically, the tumor consists of a nodular, epidermal-derived proliferation that forms island-like structures. At least focally or sometimes extensively, the tumor cells shows a loss of cohesion within the central gland-like or tubular spaces. This tumor resembles the structure of eccrine neoplasms, but it is negative for dPAS, CEA and mucicarmine and it is only positive for EMA and cytokeratins. Herein we report a case of acantholytic squamous cell carcinoma that occurred on the face of an 82-year-old woman.     

Incidental Gastric Signet-ring Cell Carcinoma Metastasis to the Skin in Basal Cell Carcinoma

Abstract is missing (letter).     

泛发性神经性皮炎继发鳞状细胞癌1例

患者男,75岁。2年前无明显诱因自觉四肢皮肤瘙痒,半年后双小腿及双肘皮肤粗糙,出现肥厚性斑块,瘙痒剧烈。3个月前左膝斑块处出现一增生性肿物。皮肤科情况四肢伸侧泛发大小不等的肥厚性斑块。左膝约3cm大小肿物。左膝肿物组织病理符合鳞状细胞癌。     

砷角化病并发鳞状细胞癌1例

患者男,57岁。全身皮肤色素异常30年。曾因"哮喘"服用砒霜1年。皮肤科情况:全身皮肤色素沉着并夹杂有色素脱失斑,躯干、四肢散在大小不等的黑褐色斑块,左季肋部可见一暗红色结节,上覆黑褐色痂。左右足踝部各见一红色结节,表面糜烂并覆分泌物。皮损组织病理示:鲍温病;砷角化病;鳞状细胞癌。     

Subungual Squamous Cell Carcinoma: A Case Series

Subungual tumors are rare in general. Of all tumors, subungual squamous cell carcinoma (SSCC) is the most frequent one. Protean clinical presentations and the lack of awareness of the disease are responsible for an incorrect or delayed diagnosis and subsequent delayed treatment. We have reported here four patients with SSCC who were previously wrongly diagnosed with a benign process and treated unsuccessfully for years. We would like to highlight the need of a biopsy in chronic or recurrent nail lesions that fail to respond to a previous conservative treatment in order to rule out SSCC.