全数字化乳腺摄影对乳腺癌的诊断价值

目的探讨全数字化乳腺摄影对乳腺癌,尤其未扪及肿块的乳癌的诊断价值。方法搜集2005年3月至9月门诊、住院及体检作全数字化乳腺摄影检查1290例,从中发现并经手术、病理证实乳腺癌50例,其中,临床扪及肿块42例,未扪及肿块8例。所有病例常规摄双侧乳腺CC位(头尾位)、MLO位(内外斜位),必要时局部点压摄片。对未扪及肿块者,行术前定位。使用医生工作站高分辨竖屏显示器观察图像。结果42例临床扪及肿块的乳癌中,主要X线表现有单纯肿块22例,肿块伴钙化18例,结构紊乱2例;病理类型为浸润性导管癌30例,髓样癌6例,黏液腺癌4例,浸润性小叶癌2例。8例未扪及肿块的乳癌中,分别表现为单纯钙化5例,小结节影伴钙化2例,局部结构紊乱1例;病理类型为导管原位癌3例,导管浸润癌3例,小叶原位癌2例。结论全数字化乳腺摄影能较清晰显示乳腺癌的直接及间接X线征象,对乳腺癌尤其是未扪及肿块的乳癌具有重要的诊断价值。     

全数字化乳腺摄影在乳腺病变中的临床应用价值

目的探讨全数字化乳腺摄影(FFDM)在乳腺病变中的临床应用价值。资料与方法搜集经手术病理证实有完整临床资料的乳腺病变共102例,所有患者均行FFDM,结合病理进行影像学分析。结果 102例乳腺病变中乳腺癌31例,乳腺良性病变71例。临床触及肿块者63例,未触及肿块者39例。影像表现为肿块80例,单纯成簇微小钙化4例,结构紊乱并粗长毛刺2例,结构紊乱并微小钙化1例,局部片状致密影14例,无明显影像表现1例。FFDM对乳腺癌诊断敏感性为90.3%,特异性为94.4%,准确性为93.1%。结论 FFDM能清晰显示乳腺病变的X线征象,尤其能够显示乳腺癌的主要X线征象,为临床早期诊断乳腺病变创造了条件,尤其对临床未触及肿块的早期乳腺癌具有重要的临床价值。     

全数字化乳腺摄影技术在乳腺癌诊断中的应用价值

目的 探讨全数字化乳腺摄影技术(FFDM)在乳腺癌诊断中的应用价值.方法 搜集本院2006-04-2007-11门诊病例及健康体检者行FFDM检查者2900例,其中经手术病理证实的乳腺癌53例,分析其年龄分布特征,病理类型及X线表现特征.结果 53例乳腺癌的发病年龄为36～8l岁,其中40～59年龄段者占到总病例的66%.X线表现为单纯肿块者24例(45.3%).肿块合并钙化者17例(32.1%),单纯钙化者4例(7.6%).结构紊乱者5例(9.4%),结构紊乱并钙化者3例(5.6%).病理结果:浸润性导管癌43例,黏液腺癌4例,乳腺小叶癌2例,Paget病4例.结论 FFDM可以更清晰的显示乳腺病变的特征,对乳腺癌的早期诊断具有重要价值.     

全数字化乳腺摄影与MRI对乳腺恶性病变诊断的对比分析

目的 探讨乳腺癌全数字化乳腺摄影(full-field digital mammography,FFDM)与乳腺MRI的影像学表现,评价其对乳腺癌的诊断价值.方法 收集68例经穿刺或手术病理证实的乳腺癌病例,对比分析其X线摄影及MRI表现.全数字化乳腺摄影采用常规方法摄片,MRI采用自旋回波T1WI,T2WI序列及动态增强扫描等.结果 68例乳腺恶性肿瘤中,浸润性导管癌57例,浸润性小叶癌3例,叶状囊肉瘤1例,血管肉瘤1例,导管内癌2例,炎性乳癌2例,印戒细胞癌1例,Paget's病1例.乳腺X线摄影诊断正确61例,诊断准确率89.7％.MRI诊断正确66例,诊断准确率97.1％.结论 乳腺X线摄影是乳腺恶性病变的首选检查方法,MRI能更多的显示乳腺病灶的内部特征,二者联合应用对乳腺癌的临床诊断具有重要意义.     

全数字化乳腺摄影和彩超对乳腺疾病的诊断效果分析

目的 探讨全数字化乳腺摄影和彩超对乳腺疾病的临床诊断效果.方法 对来笔者医院诊治的40例乳腺疾病患者资料进行分析,患者均行彩色多普勒超声和全数字化乳腺摄影检查,将两种检查结果与病理结果对比,分析两种诊断方法的准确性.结果 本组40例中,29例病理阳性,11例病理阴性;全数字化乳腺摄影检查27例阳性,13例阴性,阳性诊断符合率为93.1％;彩超检查17例阳性,23例阴性,阳性符合率为58.6％,全数字化乳腺摄影阳性诊断符合率高于彩超(P＜0.01).29例年龄＞40岁患者中,病理诊断阳性22例,阴性7例;全数字化乳腺摄影检查阳性符合率为90.9％(20/22),高于彩超检查的阳性符合率(54.5％,12/22) (P＜ 0.01);11例年龄≤40岁患者中,病理诊断8例阳性,3例阴性;全数字化乳腺摄影检查阳性符合率87.5％(7/8),高于彩超检查的阳性符合率(62.5％,5/8),但差异无统计学意义(P＞0.05).结论 全数字化乳腺摄影对乳腺疾病的诊断准确率比彩超高,应作为乳腺疾病的常规诊断方法.但其对于≤40岁患者的诊断准确率不高,需要结合其他方法诊断.     

全数字化乳腺X线摄影对乳腺导管原位癌的诊断价值

目的探讨全数字化乳腺X线摄影(full-field digital mammography,FFDM)对乳腺导管原位癌的诊断价值。方法回顾性分析52例经穿刺或手术病理证实的乳腺导管原位癌的X线摄影表现。结果以恶性钙化为主要征象32例,钙化表现为微细、多形性,呈簇状、群集或段性分布,其中单纯钙化24例,钙化合并局灶性致密8例;表现为肿块8例,其中3例肿块边缘见毛刺;单纯局灶性致密3例;结构扭曲2例;导管造影显示导管内占位性病变3例;X线无异常发现4例。结论 FFDM可以清晰显示微小钙化、小结节、局灶致密及结构扭曲等征象,尤其对微小钙化敏感,对乳腺导管原位癌的诊断具有重要价值。     

全数字化乳腺X线摄影对乳腺炎性疾病的诊断价值

目的:分析乳腺炎性疾病的全数字化乳腺X线摄影(FFDM)表现,提高该病与乳腺癌的鉴别诊断水平。方法:回顾性分析39例经穿刺或手术病理证实的乳腺炎性疾病的FFDM表现。结果:39例患者中,26例为慢性乳腺炎,5例为浆细胞性乳腺炎,8例为肉芽肿性乳腺炎。X线表现为肿块影17例,局部腺体非对称性致密影20例,结构扭曲2例。伴同侧腋下淋巴结致密影7例,局部或乳晕区皮肤增厚12例,乳头凹陷7例。结论:结合临床资料并细致分析乳腺炎性疾病的FFDM表现,有助于提高该病诊断与鉴别诊断水平。     

全数字化乳腺摄影对临床未触及肿块乳癌的诊断价值

目的　探讨全数字化乳腺摄影对临床未触及乳癌的诊断价值。方法　收集 2 0 0 3 -0 4～ 0 7门诊及体检 412例中遇到的 3 4例乳癌 ,其中临床触及肿块的 2 2例 ,未触及肿块的 12例。全部病例采用全数字化乳腺摄影机检查 ,并经病理证实 ,检查体位常规采用CC位 (头尾位 )、MLO位 (内外斜位 ) ,必要时加照侧位及局部点片。对临床未触及包块的乳癌 ,均行术前定位。结果　 2 2例临床触及肿块的乳癌中 ,髓样癌 4例 ,硬癌 2例 ,浸润性导管癌 16例。 12例临床未触及包块的乳癌中 ,X线呈现微小钙化 6例 ,其中癌前病变 1例、导管原位癌 2例、导管浸润性癌 3例 ;呈现微小结节 2例 ,其中 1例导管原位癌、1例导管浸润癌 ;呈现微小结节半结节内微小钙化 2例 ,1例导管原位癌、1例导管浸润癌 ;呈现结构紊乱区 1例 ,为小叶原位癌 ,结构紊乱区伴微小钙化 1例 ,为浸润导管癌。结论　全数字化乳腺摄影能清晰显示乳腺癌的直接及间接征象 ,尤其对临床未触及包块的乳癌具有更重要的诊断价值     

乳腺疾病的全数字化乳腺摄影与磁共振检查对比研究

目的:全数字化乳腺摄影与磁共振检查对乳腺疾病的诊断价值。材料和方法:本研究收集了自2003年12月至2006年1月期间行全数字化乳腺摄影并同时行磁共振检查患者共67例,全部经病理证实,其中良性病变38例,恶性病变29例。采用美国GE Senographe2000D全数字化乳腺摄影机及美国GE1.5Tesla MRI扫描仪;采用专门乳腺线圈。全部病例行动态增强扫描和图像后处理。结果:本组显示FFDM对乳腺疾病诊断的敏感性、特异性及准确性分别为74.29%,92.1%,83.36%;MRI对乳腺疾病诊断的敏感性、特异性及准确性分别为94.29%,89.47%,91.78%。结论:对于乳腺癌诊断FFDM的特异性高于MRI,而敏感性较低。     

全数字化乳腺X线三维定位创新技术在不可触及性病变术前定位的应用

目的 探讨全数字化乳腺X线引导下的三维立体定位创新技术对不可触及性乳腺病变术前定位的临床价值.方法 回顾性分析乳腺不可触及性病变并行术前定位的106例患者,根据乳房X线片(0°及90°)人工计算进针深度,定位时利用全数字化乳腺X线三维立体定位系统(GE Senogrphe DS)自动计算进针深度,将此值与人工计算的进针深度值相结合,再结合患者,定位前皮肤弹性以及腺体结构情况,调整进针深度,置入定位针,临床根据定位导丝位置对病变进行切除,术后再行X线摄影与术前对比,判断病变是否被完整切除.结果 全数字化乳腺X线引导下的三维立体定位系统对不可触及性乳腺病变的定位准确率达到100%,手术均能完整切除,11例出现不良反应,主要表现为晕厥,经休息、心理安抚及输液处理后均能较快恢复.结论 术前行乳腺X线引导下的三维立体定位可以提高乳腺不可触及性病变切除的准确性,简单易行,具有推广价值.     

高频超声与全数字化乳腺摄影联合诊断乳腺导管癌的临床应用

目的:探讨乳腺导管癌的高频超声表现,并评价高频超声联合全数字化乳腺摄影检查对乳腺导管癌的诊断价值。方法:分析46例经病理证实的乳腺导管癌的超声表现,与相应病理结果进行对比分析。46例患者均行高频超声和全数字乳腺摄影检查。结果:高频超声探及到肿块46例,诊断乳腺癌45例,诊断率达98%。全数字化乳腺摄影诊断乳腺癌46例,诊断率达100%。高频超声和全数字化摄影对乳腺导管癌检出率无差别且无统计学意义(P>0.05)。结论:高频超声与全数字化乳腺摄影联合应用,可提高乳腺癌诊断的敏感性和准确性。     

Observer variability in screen-film mammography versus full-field digital mammography with soft-copy reading

Full-field digital mammography (FFDM) with soft-copy reading is more complex than screen-film mammography (SFM) with hard-copy reading. The aim of this study was to compare inter- and intraobserver variability in SFM versus FFDM of paired mammograms from a breast cancer screening program. Six radiologists interpreted mammograms of 232 cases obtained with both techniques, including 46 cancers, 88 benign lesions, and 98 normals. Image interpretation included BI-RADS categories. A case consisted of standard two-view mammograms of one breast. Images were scored in two sessions separated by 5 weeks. Observer variability was substantial for SFM as well as for FFDM, but overall there was no significant difference between the observer variability at SFM and FFDM. Mean kappa values were lower, indicating less agreement, for microcalcifications compared with masses. The lower observer agreement for microcalcifications, and especially the low intraobserver concordance between the two imaging techniques for three readers, was noticeable. The level of observer agreement might be an indicator of radiologist performance and could confound studies designed to separate diagnostic differences between the two imaging techniques. The results of our study confirm the need for proper training for radiologists starting FFDM with soft-copy reading in breast cancer screening. Presented at ECR, Wien 2006.     

Screen film vs full-field digital mammography: image quality,detectability and characterization of lesions

The objective of this study was to compare screen-film mammography (SFM) to full-field digital mammography (FFDM) regarding image quality as well as detectability and characterization of lesions using equivalent images of the same patient acquired with both systems. Two mammography units were used, one with a screen-film system (Senographe DMR) and the other with a digital detector (Senographe 2000D, both GEMS). Screen-film and digital mammograms were performed on 55 patients with cytologically or histologically proven tumors on the same day. Together with these, 75 digital mammograms of patients without tumor and the corresponding previous screen-film mammograms not older than 1.5 years were reviewed by three observers in a random order. Contrast, exposure, and the presence of artifacts were evaluated. Different details, such as the skin, the retromamillary region, and the parenchymal structures, were judged according to a three-point ranking scale. Finally, the detectability of microcalcifications and lesions were compared and correlated to histology. Image contrast was judged to be good in 76%, satisfactory in 20%, and unsatisfactory in 4% of screen-film mammograms. Digital mammograms were judged to be good in 99% and unsatisfactory in 1% of cases. Improper exposure of screen-film system occurred in 18% (10% overexposed and 8% underexposed). Digital mammograms were improperly exposed in 4% of all cases but were of acceptable quality after post-processing. Artifacts, most of them of no significance, were found in 78% of screen-film and in none of the digital mammograms. Different anatomical regions, such as the skin, the retromamillary region, and dense parenchymal areas, were better visualized in digital than in screen-film mammography. All malignant tumors were seen by the three radiologists; however, digital mammograms allowed a better characterization of these lesions to the Breast Imaging Reporting and Data System (BI-RADS;) [corrected] categories (FFDM better than SFM in 23 of 165 vs 9 of 165 judged cases in SFM). In conclusion, digital mammography offers a consistent, high image quality in combination with a better contrast and without artifacts. Lesion detection in digital images was equal to that in screen-film images; however, categorization of the lesions to the BI-RADS classification was slightly better.     

数字乳腺断层摄影及其合成二维影像技术在乳腺癌筛查中的研究进展

目前乳腺X线检查仍是乳腺癌早期诊断的有效检查方法之一,主要包括全视野数字化乳腺摄影（FFDM）、数字乳腺断层摄影（DBT）、合成乳腺X线摄影（SM）以及3种技术的联合应用（FFDM联合DBT、SM联合DBT）。对DBT、SM和SM联合DBT在乳腺筛查中诊断效能、影像质量及辐射剂量等进行比较。SM联合DBT可有效平衡辐射剂量和诊断效能,但仍然在判读时间、信息的存储与传输和检查成本方面存在局限性。就以上3种检查技术在乳腺癌筛查中的研究进展予以综述。     

Comparison of full-field digital mammography workstation and conventional picture archiving and communication system in image quality and diagnostic performance

The object of this study was to compare of full-field digital mammography (FFDM) workstation and conventional picture archiving and communication systems (PACS) in image quality and diagnostic performance. We assembled 80 masses and 80 microcalcifications. Images were displayed on workstation, 5M, and 3M PACS monitors. The image quality for mammograms on workstation was significantly better than that for mammograms on PACS monitors. The sensitivity and NPV for microcalcifications on workstation were higher than those on PACS monitors. The conventional PACS cannot substitute for a FFDM workstation for mammographic evaluation.