阿霉素热碘油栓塞对兔肝VX2肿瘤的血流动力学影响

目的利用多普勒超声研究阿霉素热碘油栓塞治疗后兔肝VX2肿瘤及肝脏的血流动力学变化.方法 30只荷瘤兔,随机分为3组,分别采用37℃生理盐水、37℃阿霉素碘油及60℃阿霉素热碘油经兔肝动脉灌注治疗,1周后多普勒超声观察肿瘤血供及肝动脉、门静脉血流动力学变化,检测结果与治疗前相应血管的多普勒参数进行比较.肝动脉及肿瘤血管造影结果作为金标准.结果阿霉素热碘油灌注栓塞后肝动脉血流速度明显降低(P<0.05),阻力指数增大(P<0.05),门静脉血流速度及内径均无明显变化(P>0.05);治疗前,所有病灶能量及彩色多普勒均可检测出瘤内及瘤周较丰富血流信号,治疗后显示阿霉素热碘油组瘤内及瘤周血流信号均明显减弱,部分消失.结论阿霉素热碘油栓塞可更有效地阻断兔肝VX2肿瘤供血,多普勒超声可显示该血流的变化,便于对阿霉素热碘油栓塞治疗肝肿瘤的疗效进行及时评价.     

常温肝内胆管缺血时间的安全时限:极限值在哪?

背景:胆道缺血再灌注损伤是肝移植、肝切除和肝动脉栓塞化疗后胆管损伤的主要原因之一.但是,常温下肝脏究竟能够耐受多长时间的肝内胆管缺血目前尚无定论.目的:利用兔胆道缺血再灌注损伤模型,分析兔肝内胆管缺血的安全时限.方法:将家兔以抽签法随机分为假手术组、肝动脉和胆总管联合阻断1.5,2,2.5,3 h组.假手术组只游离胆总管、肝总动脉及门静脉,肝动脉和胆总管联合阻断1.5,2,2.5,3 h组用无损伤动脉夹平左、右肝管开口上缘夹闭肝动脉和胆总管及疏松结缔组织,阻断1.5,2,2.5,3 h后去除动脉夹即恢复肝动脉或胆道血流.术后1周统计动物存活情况,并进行肝功能检测.结果与结论:假手术组及肝动脉和胆总管联合阻断1.5 h组动物术后1周无死亡,阻断2 h存活率为87.5%,随着阻断胆道血流时间的延长,动物生存率逐渐下降,提示动物耐受胆道血流阻断的最大安全时限为2 h.胆道缺血2 h以内肝脏病理组织学变化相对较轻,以细胞水肿和炎细胞浸润为主,坏死灶呈点状或小片状,以可逆性损伤为主:而缺血2 h以上胆管上皮坏死脱落明显,肝坏死呈多灶性、大片状,损伤不可逆.组织学变化同样证实2 h可能是常温下兔耐受肝内胆管血流阻断的最大安全时限.     

肝段动脉化疗栓塞治疗肝癌

经导管肝动脉栓塞术(TAE)巳广泛地用于肝癌的非手术治疗,常规TAE不能造成肿瘤组织的完全坏死,反复TAE治疗也会给肝功能带来损害。肝段动脉化疗栓塞是在TAE基础上发展起来的新技术.众所周知,肝癌除主要地接受肝动脉分支供血外,部分地接受门静脉分支和胆管周围血管丛的供养,肝段动脉化疗栓塞的目的就是同时封闭肿瘤组织周围各种供养血管。我们报告了12例肝癌患者接受肝段动脉化疗栓塞的初步经验,重点地对插管技术、适应症和应用理论进行了讨论。     

5例经改良式门静脉化疗泵局部灌注化疗病人的护理

<正>肝癌的血液供应主要来自肝动脉,肝动脉化疗栓塞(TACE)疗效确切,肝动脉被栓塞后门静脉与肝动脉的吻合支成为肿瘤的主要血液供应,因此经皮穿刺门静脉置管局部灌注化疗可提高肿瘤周边区域药物浓度,从而获得更好的癌细胞杀伤效应,同时减少静脉化疗时病人的全身毒副反应[1]。临床上经门静脉置管灌注化疗多是将留置导管置入门静脉,然后连接埋置于皮下的化疗泵。但这种方式易出现切口感染、化疗泵周围皮下血肿或积液、化疗药外渗引起局部组织坏死等并发症,不仅增加病人     

海藻酸钙凝胶栓塞治疗兔VX2肝种植瘤

背景:液体海藻酸钙凝胶是最近出现的一种新型栓塞材料,具有良好的生物相容性,可经微导管输送,不易形成异位栓塞等特点,在动静脉畸形和动脉瘤动物实验中效果良好.目的:为了寻找更安全有效的肝癌栓塞材料,创新性使用液体海藻酸钙凝胶肝动脉栓塞兔VX2肝种植瘤.方法:采用改良开腹接种法建立VX2肝种植瘤模型.以数字表法随机分为对照组、实验组.直视下细针穿刺肝动脉造影,对照组仅行肝动脉造影,实验组造影后使用液体海藻酸钙凝胶栓塞治疗.于栓塞治疗前、治疗后7d行肝脏CT扫描,多平面重建测量肿瘤大小.栓塞治疗7d后取肿瘤行病理组织学检查,评估海藻酸钙凝胶栓塞对肿瘤和正常肝组织的影响.结果与结论:使用液体海藻酸钙凝胶栓塞后造影显示肿瘤的供血动脉中断,闭塞.实验组兔肝肿瘤生长率明显低于对照组 (P < 0.05).对照组肿瘤坏死以轻度坏死为主;实验组肿瘤坏死以重度坏死为主,肝可见多发灶状坏死.两组间坏死程度差异有显著性意义(P < 0.05).实验组甲苯胺蓝染色可见肝动脉分支、叶间小动脉,入肝微动脉完全闭塞,肝窦内有少量海藻酸钙凝胶.结果说明海藻酸钙凝胶可在肝肿瘤血管门部至入肝微动脉间形成广泛栓塞,阻断肿瘤的血供,抑制肿瘤的生长.     

肝癌的非手术治疗

在我国肝癌多伴肝硬化,肝功能代偿能力差,可切除率仅10%～3 7%[1,2],术后总体复发率达65%[3],故非手术疗法在肝癌的治疗中起着重要的作用.当前非手术疗法包括:①区域治疗;②局部治疗;③全身治疗.分述如下. 1 区域治疗 又称经肝动脉治疗,是根据肝癌的血供主要来源于肝动脉而设计的.原发性肝癌的血供约90 %由肝动脉供血,少部分由门静脉供血,而正常肝脏75%的血供来自门静脉.经肝动脉治疗分两种途径:①经皮股动脉穿刺插管抵达肝动脉;②开腹术中肝动脉插管. 分两种措施:①施放化学或放射性抗癌物质杀灭肿瘤细胞,向肿瘤注入化学抗癌物质称为经肝动脉灌注化疗(TAI),常用的化学药物为顺铂、阿霉素、丝裂霉素和5-FU等.向肿瘤植入放射性抗癌物质称经肝动脉放疗(TAR),常用的放射源是131I和-90Y.②堵塞血管以阻断肿瘤血供造成组织缺血坏死称为经肝动脉栓塞(TAE),常用的栓塞物质为明胶海绵.临床上经肝动脉治疗采用双重措施:化疗联合栓塞(TACE).     

5例经改良式门静脉化疗泵局部灌注化疗病人的护理

肝癌的血液供应主要来自肝动脉,肝动脉化疗栓塞（TACE ）疗效确切,肝动脉被栓塞后门静脉与肝动脉的吻合支成为肿瘤的主要血液供应,因此经皮穿刺门静脉置管局部灌注化疗可提高肿瘤周边区域药物浓度,从而获得更好的癌细胞杀伤效应,同时减少静脉化疗时病人的全身毒副反应[1]。临床上经门静脉置管灌注化疗多是将留置导管置入门静脉,然后连接埋置于皮下的化疗泵。但这种方式易出现切口感染、化疗泵周围皮下血肿或积液、化疗药外渗引起局部组织坏死等并发症,不仅增加病人痛苦、延长住院时间,而且增加护士的工作量。针对这些并发症,我中心2013年1月-8月为5例原发性肝癌病人采取了改良式门静脉化疗泵植入法,取得了较好效果。现报告如下。     

多发伤后肝脏血流异常彩色多普勒表现1例

患者男,55岁.因车祸致肝、胃等多脏器破裂,行肝、胃、小肠修补术后患者反复消化道出血、大量腹水,肾功能恶化.超声检查:肝脏形态饱满,右叶最大斜径17.00 cm,实质回声均匀,门静脉内径约0.90 cm,管腔内未见异常回声,彩色多普勒为暗淡的蓝色离肝血流(图1).肝动脉增粗,内径约0.52 cm,血流速度加快,舒张期流速38.50 cm/s,收缩期血流129.00 cm/s,阻力指数0.70.下腔静脉肝后段内径约1.10～2.30 cm,管腔内未见异常回声,局部管腔内彩色血流流速略增快.肝静脉未见狭窄,为离肝血流.腹腔可见较多液性暗区,下腹部最大深度8.30 cm.双肾、脾脏未见异常.半小时后行DSA间接法门静脉造影,分别采用肠系膜上动脉、脾动脉选择性插管注入造影剂,门静脉及其分支可显影,显影过程缓慢且显影浅淡.     

肝癌介入治疗后致高血压急症1例的抢救及护理

肝癌介入治疗是通过采用Seldinger技术将导管置于腹腔动脉、肝动脉或肝内动脉内灌注化疗药物和／或栓塞剂,使肿瘤细胞坏死、肿瘤缩小或消失。目前常用的方法为经导管肝动脉灌注化疗、经导管肝动脉灌注栓塞术。     

螺旋CT三维重建对各肝段门静脉解剖结构的观察

目的利用经动脉性门静脉造影CT重建门静脉、肝静脉三维结构，观察生理状态下的各肝段门静脉的分支形式。方法73例病人，导管置入于肠系膜上动脉内，注入造影剂后门静脉期和肝静脉期连续扫描肝脏。三维重建门静脉及肝静脉，分析各肝段内的门静脉的分支形式。结果肝右叶4个段的门静脉分支形式分为4个类型，肝左叶外侧段的门静脉分为3个类型，内侧段分为2个类型。结论门静脉的三维图像重建及类型分析对术前手术方式的确定有一定的临床意义。     

兔肝VX2移植瘤门静脉阻断模型的建立及其多层螺旋CT评价

背景:临床研究发现肝癌门静脉阻断有利于抑制肝癌的生长,促进未阻断肝组织的代偿性增生,并降低经门静脉途径的转移,目前尚需动物实验进一步验证。目的:探讨兔肝VX2移植瘤门静脉阻断模型的建立方法,及其多层螺旋CT评价价值。)设计:随机分组设计、动物实验。单位:解放军第三军医大学新桥医院放射科。材料:实验于2002-07/2005-01在第三军医大学新桥医院影像学实验室完成。选择新西兰大白兔40只,随机数字表法分为4组,每组10只,门静脉阻断即刻移植瘤体组、瘤体移植3周后门静脉阻断组、阴性对照组、阳性对照组。方法:采用开腹包埋接种法移植兔肝VX2肿瘤,分别进行门静脉阻断后即刻移植瘤体和移植瘤体生长3周后行门静脉阻断,同时设立阴性对照组(门静脉左外支行假手术阻断,兔肝左外叶假性包埋接种)、阳性对照组(移植瘤体未行门静脉阻断)。所有实验兔均行兔多层螺旋CT检查。主要观察指标:门静脉阻断后肝大体变化、瘤体变化、肿瘤转移情况,肝动脉、门静脉各级分支的多层螺旋CT血管成像显示率,肝血流量、血容量、平均通过时间、血管表面通透性和肝动脉灌注分数。结果:纳入动物40只,均进入结果分析。①门静脉阻断即刻移植瘤体组于门静脉分支结扎术3周后均未见瘤体生长。瘤体移植3周后门静脉阻断组动物左内叶明显萎缩,肿瘤的生长明显受抑制,其瘤体最大径明显小于阳性对照组[分别为(2.55±0.46),(3.59±0.37)cm,t=5.57,P<0.001]。瘤体移植3周后门静脉阻断组肝内转移及肺转移发生率也明显少于阳性对照组(分别为10%,40%和100%,90%);但两者的邻近转移率差异却无显著性意义。②多层螺旋CT血管成像检查对Ⅲ级以上肝动脉分支的显示率明显低于Ⅰ、Ⅱ级肝动脉分支的显示率(分别为40%,100%,70%,P<0.05)。门静脉各级分支的显示率差异无显著性意义(P>0.05)。③门静脉阻断即刻移植瘤体组、瘤体移植3周后门静脉阻断组肝血流量、血容量、平均通过时间和血管表面通透性值均较相应对照组降低,但肝动脉灌注分数值均明显增高。结论:门静脉左外支结扎是兔肝VX2移植瘤门静脉阻断的理想模型。多层螺旋CT在兔肝门静脉阻断效果的评价中起着重要作用。     

门静脉瘤栓注射胶体_(32)磷酸铬的可行性研究

目的 :通过动物实验探讨超声导向门静脉瘤栓穿刺注射胶体32磷酸铬治疗门静脉瘤栓的可行性。方法 :分别将胶体32磷酸铬或生理盐水注入新西兰白兔门静脉左支及其邻近肝实质内 ,观察实验前后肝功能、外周血象及肝脏病理改变、32磷在体内的分布 ,了解门静脉有无狭窄。结果 :胶体32磷酸铬注入门静脉或肝实质后主要分布于肝内 ,未见门静脉狭窄 ,实验前后外周血象无显著变化 ,肝功能呈一过性升高 ,肝脏病理检查肝组织无明显坏死。结论 :超声导向门静脉瘤栓穿刺注射胶体32磷酸铬行内放疗具有可行性     

Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs.

Metabolic acidosis due to organic acids infusion fails to elicit hyperkalemia. Although plasma potassium levels may rise, the increase is smaller than in mineral acid acidosis. The mechanisms responsible for the different effects of organic acid acidosis and mineral acid acidosis remain undefined, although dissimilar hormonal responses by the pancreas may explain dissimilar hormonal responses by the pancreas may explain the phenomena. To test this hypothesis, beta-hydroxybutyric acid (7 meq/kg) or hydrochloric acid (3 meq/kg) was infused over 30 min into conscious dogs (n = 12) with chronically implanted catheters in the portal, hepatic, and systemic circulation, and flow probes were placed around the portal vein and hepatic artery. Acid infusion studies in two groups of anesthetized dogs were also done to assess the urinary excretion of potassium (n = 14), and to evaluate the effects of acute suppression of renal electrolyte excretion on plasma potassium and on the release/uptake of potassium in peripheral tissues of the hindleg (n = 17). Ketoacid infusion caused hypokalemia and a significant increase in portal vein plasma insulin, from the basal level of 27 +/- 4 microU/ml to a maximum of 84 +/- 22 microU/ml at 10 min, without changes in glucagon levels. By contrast, mineral acid acidosis of similar severity resulted in hyperkalemia and did not increase portal insulin levels but enhanced portal glucagon concentration from control values of 132 +/- 25 pg/ml to 251 +/- 39 pg/ml at 40 min. A significant decrease in plasma glucose levels due to suppression of hepatic release was observed during ketoacid infusion, while no changes were observed with mineral acid infusion. Plasma flows in the portal vein and hepatic artery remained unchanged from control values in both acid infusion studies. Differences in renal potassium excretion were ruled out as determinants of the disparate kalemic responses to organic acid infusion compared with HCl acidosis. Evaluation of the arteriovenous potassium difference across the hindleg during ketoacid infusion demonstrates that peripheral uptake of potassium is unlikely to be responsible for the observed hypokalemia. Although the tissue responsible for the different kalemic responses could not be defined with certainty, the data are compatible with an hepatic role in response to alterations in the portal vein insulin and/or glucagon levels in both acid infusion studies. We propose that cellular uptake of potassium is enhanced by hyperinsulinemia in ketoacid infusion, and release of potassium results from increased glucagon levels in HCl acidosis. Whether the changes in plasma potassium that other types od organic acid acidosis produce are accounted for by a similar hormonal mechanism remains to be determined.     

50例中晚期肝癌介入化疗的观察2.药物疗效分析

目的：通过对５０例中晚期肝癌行介入插管治疗后，总结了作者对不同类型肝癌选择灌注及栓堵治疗的实施体会和疗效分析，意在如何能提高肝癌的介入治疗效果。材料与方法：选择５０例原发性或继发性肝癌，采用Ｓｅｌｄｉｎｇｅｒ技术，行肝动脉灌注或栓堵，对单纯灌注及灌注加栓堵同时进行的方法作了对比。结果，单纯灌注者３２例显效率为４０．６％，灌注加栓堵者１８例，显效率为８８％，并对有门脉癌栓的１４例中的６例进行了栓堵，     

Effects of local thrombinaemia and endotoxinaemia on hepatic circulation in the anaesthetized dog

The acute response of the hepatic circulation to thrombinaemia and endotoxinaemia were investigated in the anaesthetized dog. Small amounts of thrombin were infused into the hepatic artery and portal vein. The effects of thrombin were compared to those of minor amounts of portally infused endotoxin. Portal pressure increased significantly following portal infusion of thrombin and endotoxin. Both substances decreased the blood flow markedly in the hepatic artery, while that in the superior mesenteric artery and portal vein decreased only slightly. Heparin and polyphlorethin phosphate (PPP) abolished all effects of thrombin. Bradykinin infused simultaneously inhibited only the effect on the hepatic artery. Vasoactive intestinal peptide, which has the same vasodilatory effect in the liver, did not. It is believed that thrombin and perhaps endotoxin exert a vasoconstrictive effect mediated by products released from platelets.     

原发性肝细胞癌患者动脉法与静脉法肝脏灌注CT成像对照研究

目的探讨静脉法肝脏灌注CT(PCT)成像及其去卷积算法的合理性。方法对同一组行肝动脉碘油抗癌药乳液化疗栓塞(Lp-THACE)治疗的原发性肝细胞癌病例同时行动脉法PCT(肝固有动脉和脾动脉插管)和静脉法PCT(右股静脉插管),在GE AW4.2工作站上采用perfusion3软件(GE Medical Systems)进行肝脏灌注CT分析,分别以二进一室模型去卷积算法(DOCMDM)和最大斜率算法(MS)得出肝脏灌注参数肝动脉灌注量(HAP)、门静脉灌注量(HPP)、肝动脉灌注分数(HAI)、肝血流量(HBF)。结果 11例原发性肝癌患者纳入此研究,其中10例静脉法PCT、10例肝动脉法PCT、7例脾动脉法PCT可用于灌注分析。动脉法与静脉法PCT-DOCMDM的肝癌组织、背景肝组织的4项灌注参数(HAP、HPP、HAI、HBF)差异无统计学意义(P>0.05);静脉法肝癌组织的3项灌注参数(HAP、HPP、HBF)其DOCMDM结果都显著大于MS法(P<0.05),背景肝组织3项灌注参数的两种算法间差异无统计学意义(P>0.05)。结论采用同一病例同时行动脉法和静脉法肝脏PCT,对照分析显示静脉法PCT-DOCMDM可以真实反映肝动脉与门静脉灌注;肝脏PCT-DOCMDM与PCT-MS对肿瘤组织灌注的评估存在较大差别,对背景肝组织灌注的评估比较相近。     

门静脉阻断兔肝VX2移植瘤的CT灌注评价

目的探讨CT灌注成像评价门静脉阻断兔肝VX2移植瘤后血流变化的价值。方法40只新西兰大白兔随机分为门静脉阻断后即刻移植瘤体组(A组)、移植瘤体生长3周后门静脉阻断组(B组)、阴性对照组(C组)、移植瘤体未行门静脉阻断的阳性对照组(D组)各10只。经CT灌注扫描后应用去卷积模式自动计算出肝血流量(BF)、血容量(BV)、平均通过时间(MTT)、血管表面通透性(PS)和肝动脉灌注分数(HAF)等CT灌注参数。结果实验A组BF、BV、MTT和PS值均较对照C组低,BF值:(1.40±0.70)ml/(100 g.min)比(133.21±14.42)ml/(100 g.min)(P<0.01);BV值:(0.33±0.17)ml/100 g比(28.77±3.32)ml/100 g(P<0.01);MTT值:(4.33±1.41)s比(11.67±0.58)s(P<0.01);PS值:(0.15±0.18)ml/(100 g.min)比(22.10±4.39)ml/(100 g.min)(P<0.01)。但实验A组的HAF值较对照C组明显增高:(0.99±0.03)比(0.25±0.06)(P<0.01)。实验B组的BF、BV、MTT和PS值较对照D组降低,而HAF值则明显增高(P<0.01)。结论CT灌注成像可无创直观形象地评价门静脉阻断后兔肝VX2移植瘤的灌注特点。     

Proximal bifurcation of hepatic artery: Novel findings on hepatic arteries demonstrated by ultrasound Doppler imaging, B-flow, and US angiography

Purpose It has generally been held that each portal branch is always accompanied by a single arterial branch in the liver. During Doppler ultrasound examination, however, we sometimes encounter a portal branch that appears to be associated with two arterial branches, a phenomenon referred to below asthis finding orthis phenomenon. Here we attempt to confirm that this finding is based on a correct interpretation of the image and to disclose its basic mechanism. Material and Methods Five cases of chronic liver disease in which this phenomenon appeared were analyzed with B-flow imaging. Videotapes obtained from 30 patients who had chronic liver disease and had undergone ultrasound angiography (USAG) with arterial infusion of CO₂ micro bubbles were reviewed in order to look for similar findings. Sixty-nine healthy controls were also examined with Doppler sonography for this purpose. Histopathologic specimens from 7 patients who had undergone hepatectomy (3 with hepatocellular carcinoma, 3 with metastatic tumor, and 1 with focal nodular hyperplasia) were examined to study the basic structure of the hepatic vessels. Results and Discussion Three parallel color signals (two pulsatile and one of a constant waveform) observed on Doppler examination were confirmed by the B-flow method to be three independent vessels in all five cases in which both Doppler sonography and B-flow imaging were used. In 13 (43%) of the 30 cases of USAG, two vessels along a portal branch were visualized by the inflow of micro bubbles, indicating that the two vessels were arteries. The trio of one portal and two arterial branches was also detected with Doppler sonography in 12 (17%) of the 69 healthy controls. In 10 (59%) of the 17 cases (5 of liver disease and 12 normal) that showed this finding on Doppler examination, bifurcations of the hepatic artery and portal vein were both visualized. Hepatic arterial branches were found to bifurcate slightly more proximal to the hepatic hilus than the accompanying portal branch. Histopathologic study revealed Glisson’s areas that contained one portal branch and two arterial vessels in nontumorous parts of specimens from all 7 patients with hepatectomy. Conclusion Two arterial branches can be demonstrated along a portal branch as a result of a more-proximal bifurcation of the hepatic artery than of the portal vein.     

不同途径移植骨髓间充质干细胞改善大鼠肝硬化

背景：骨髓间充质干细胞移植可减轻肝硬化程度,改善肝功能。目的：观察不同途径移植骨髓间充质干细胞对四氯化碳诱导大鼠肝硬化的作用。方法：将60只SD大鼠随机分为正常组、对照组、门静脉移植组、肝动脉移植组、尾静脉移植组,后4组采用四氯化碳联合乙醇制作肝硬化模型,对照组不进行移植,其余3组分别经门静脉、肝动脉、尾静脉移植大鼠骨髓间充质干细胞1×106。结果与结论：移植4周后,与对照组比较,移植3组大鼠肝功能均得到明显改善,血清白蛋白、胆碱酯酶显著升高（P〈0.05）,转氨酶、胆红素、凝血时间、Ⅳ型胶原显著降低（P〈0.05）,肝纤维化程度显著减轻（P〈0.05）。门静脉移植组及肝动脉移植组优于尾静脉移植组,前两者之间差异无显著性意义（P〉0.05）。说明经门静脉、肝动脉、尾静脉移植骨髓间充质干细胞均可减轻肝纤维化程度,改善肝功能,但肝动脉及门静脉移植途径优于外周血静脉途径。     

经皮肝穿门静脉联合经肝动脉热灌注治疗肝转移癌48例

目的:探讨经皮肝穿门静脉入路联合经肝动脉灌注加热的化疗药物和碘油治疗肝转移癌的疗效。方法:肝转移癌患者96例,随机分为联合组48例和对照组48例,分别采用经门静脉入路联合经肝动脉热灌注和常规经肝动脉化疗栓塞治疗。结果:术后复查CT、MRI,联合组有效率明显高于对照组,两组差异有统计学意义(P<0.05);术后随访6、12、18、24个月,联合组生存期明显优于对照组,两组差异有统计学意义(P<0.05)。结论:经皮肝穿门静脉入路联合经肝动脉热灌注治疗肝转移癌疗效比常规经肝动脉化疗栓塞方法更有效,且不良反应发生率与对照组无明显差异。