安神中药远志的研究进展

远志具有悠久用药历史,且应用较为广泛。寡糖酯类、三萜皂苷类等化合物是远志的主要化学成分。现代药理学证明,远志具有镇静催眠、抗抑郁及脑保护等多种中枢药理作用。近年来,临床对于远志对安神作用的重视度逐渐增加。本文为活性成分、药理作用及临床应用对关于安神类中药远志的文献进行整理,如下。     

灵芝的药理作用和临床应用研究进展

灵芝作为最新纳入“药食同源”目录的名贵中药材之一,其药用历史悠久,药用价值高,化学成分多样,富含多种有益于人体健康的成分,具有广泛的药理作用,其主要药用部位有灵芝孢子粉、子实体、菌丝等。灵芝多糖、灵芝三萜、灵芝酸等成分被认为是灵芝发挥其不同药理作用的主要活性成分。现代药理学研究发现,其具有防治心血管疾病、保肝护肝、抗肿瘤、免疫调节、抗衰老、抗菌等作用,在辅助治疗肿瘤等方面疗效确切,应用广泛。目前对于灵芝的基础研究及临床前试验较为普遍,而临床应用研究亟待加强。本文对近年来灵芝药理作用的研究进展进行总结,梳理了其临床应用的现状,并对存在的问题进行了分析,对后续的开发和利用进行了展望,以期为灵芝相关健康产品的开发提供参考和借鉴。     

白芍总甙的药理作用与临床应用

文章通过分析白芍总甙抗炎、免疫调节、护肝和改善睡眠、抗缺氧的药理作用及其机制，指出白芍总甙具有治疗类风湿性关节炎、病毒性肝炎和防治老年病的临床作用。     

中药羌活的研究进展

该文介绍了羌活的种类和化学成分，并其对微生物的作用、药理作用和临床应用等方面的研究进展进行综述。     

黄芪化学成分及药理作用研究进展

黄芪为传统中药,具有广泛的药用价值,国内外学者对黄芪做了大量的研究工作。通过查阅大量文献资料,发现黄芪含有多糖、黄酮类及皂苷类等化学成分,在增强免疫功能、抗肿瘤、保肝、增强心肌收缩力及广泛的抗菌等方面发挥着重要的作用。本文综述了关于黄芪的化学成分、药理作用等方面的研究进展。     

当归对血管性痴呆作用机制的研究进展

当归具有补血活血的功效,可用于血瘀血虚类的症候。本文从当归的化学成分和其对脑血管系统的药理作用等方面,就其对血管性痴呆的作用机制进行综述。     

芍药不同部位芍药甙和苯甲酸的含量分析

赤芍为毛莨科植物芍药或川赤芍的干燥根。白芍为毛茛科植物芍药的根经水煮后晒干而得。现代研究表明，白芍含芍药苷、芍药内酯苷、氧化芍药苷、苯甲酰芍药苷、苯甲酸、鞣质、挥发油、B-谷甾醇、脂肪油等成分。其中，有效成分芍药甙，具有镇静、解痉、抗炎、抗应激性溃疡病等方面的药效，且毒性较小；而苯甲酸为其有害成分。为考察赤、白芍及芍药不同部位中芍药甙和苯甲酸的含量差异，作采用HPLC法对其进行定量分析，为芍药的产地加工与质量评价提供了科学依据。     

白芍总苷联合柳氮磺胺吡啶治疗强直性脊柱炎的疗效观察

目的观察白芍总苷联合柳氮磺胺吡啶治疗强直性脊柱炎的疗效和安全性。方法 42例符合强直性脊柱炎的标准的患者随机分为治疗组22例和对照组20例,治疗组口服白芍总苷和柳氮磺胺吡啶,对照组口服柳氮磺胺吡啶,两组均给予消炎止痛药物,疗程为6个月。结果经过6个月的治疗,两组间的晨僵持续时间、血沉、C反应蛋白、胸廓扩张度、Schober实验等指标方面较治疗前均明显降低,两组之间的晨僵持续时间、血沉、C反应蛋白的差别具有显著意义。治疗组不良反应的发生率明显小于对照组。结论白芍总苷联合柳氮磺胺吡啶治疗AS具有疗效确切不良反应小等优点,在临床有推广意义。     

祁连山棘豆化学成分的研究

本论文运用试管法对祁连山棘豆地上部分的化学成分进行了预试，初步确定其含有酚类物质，鞣质，糖、多糖及苷类，皂苷，生物碱，黄酮及其苷类，氨基酸，蛋白质，挥发油，油脂类等成分。     

白芍总苷结合他克莫司软膏治疗口腔扁平苔藓的疗效分析

目的研究白芍总苷胶囊结合0.03%的他克莫司软膏治疗口腔扁平苔藓的临床疗效。方法选取2012年9月~2013年9月收入我院的口腔扁平苔藓患者144例,随机分为治疗组和对照组各72例。对照组口服白芍总苷胶囊治疗,治疗组使用白芍总苷胶囊结合他克莫司软膏进行治疗,并对两组患者的临床疗效进行评价。结果治疗组治疗2个月后的总有效率为97.22%,明显高于对照组的75.00%,具有统计学差异(χ2=6.97,P0.05)。结论治疗口腔扁平苔藓使用白芍总苷胶囊结合他克莫司软膏短期疗效好,值得临床推广应用。     

基于数据挖掘的叶天士治疗月经病用药规律研究

目的探索叶天士治疗月经病的用药规律及特点。方法整理《临证指南医案》《未刻本叶氏医案》中关于月经病的医案。采用EXCEL 2010、SPSS Clementine 11.1、SPSS 22.0、Liquorice软件进行药物频数分析、关联规则分析、聚类分析和复杂网络分析。结果 (1)药物频数、性味分析:出现频率在0.20以上的高频药物有:白芍(0.37)、当归(0.36)、茯苓(0.35)、人参(0.25)、阿胶(0.20)、大枣(0.20)、甘草(0.20)、桂枝(0.20),在所有药物和高频药物中,甘味药和温性药均出现最多。(2)关联规则分析得出最常见的4个药组为:桂枝、白芍、大枣;桂枝、大枣、甘草;白芍、大枣、甘草;白芍、阿胶、生地。(3)聚类分析得出3组药物,分别为:桂枝、大枣、甘草、生姜、白芍、炙甘草;小茴香、香附、当归、茯苓;生地、阿胶、煅牡蛎、人参、茯神,主要为通阳药和养阴药的配伍。(4)复杂网络分析得出核心处方药物为:当归、白芍、茯苓、人参、香附、甘草、生地、阿胶、桂枝、大枣。结论叶天士治疗月经病多用甘味药与温性药,通过灵活化裁经方,组合成调和营卫、益阴、通阳、化瘀止血的常用药对,且注重兼顾充养胞宫气血和活血通经两方面的治疗。     

基于数据挖掘探讨腹泻型肠易激综合征(肝郁脾虚型)用药规律研究

摘要：目的 以数据挖掘为基础探讨腹泻型肠易激综合征（IBS-D）中的核心药对和潜在配伍规律,以期为今后的临床治疗及理论研究提供更多的选择和参考。方法 收集文献数据库中从建库至2020年12月的所有关于肝郁脾虚型IBS-D的相关文献,提取相关方药信息后运用相关软件进行频数分析、关联规则分析、聚类分析。结果 共纳入704篇文献,228味药物,中药归经以脾经为主,药性以温为主,药味以甘为主,补虚药用之最多;前8位高频药物为白术、白芍、陈皮、防风、茯苓、柴胡、党参、甘草;关联规则分析示白术、陈皮、防风、白芍有强关联性;聚类分析分为6类,分别为方剂痛泻要方、参苓白术散、柴胡疏肝散、半夏泻心汤加减及活血行气类与温中涩肠类。结论 数据挖掘研究为IBS-D今后的理论、临床研究提供了依据;临床上多用痛泻要方加减治疗,且多秉持柔肝健脾,温中涩肠原则,并结合临床实际情况进行辨证论治。     

The phytochemistry,pharmacology and traditional medicinal use of Glechomae Herba – a systematic review

Glechomae Herba is a Chinese herb, which has been used in China for thousands of years, mainly for the treatment of nephrolithiasis. This paper summarizes the modern research progress on Glechomae Herba from the aspects of botany, traditional medicinal use, phytochemistry, pharmacology, pharmacokinetics, analytical methods and quality control. In addition, it also points out the deficiencies of current research on this herb and provides possible directions for its development. So far, more than 190 chemical components have been isolated and identified from Glechomae Herba, including organic acids and their esters, volatile oils, flavonoids and their glycosides, terpenes and other chemical components. Its extracts and compounds have a wide range of pharmacological effects, including anti-stone, anti-inflammatory, bacteriostatic, cholagogic and diuretic, effect on ileum smooth muscle, anti-tumor effect on tumor and hypoglycemic effects. However, future studies should focus on drug metabolism, clarify its pharmacodynamic mechanism, and establish a reasonable quality control standards for Glechomae Herba.

Glechomae Herba is a Chinese herb, which has been used in China for thousands of years, mainly for the treatment of nephrolithiasis.     

小柴胡汤的药理作用及临床应用研究进展

小柴胡汤为"和解"第一方,其临床应用广泛,可用于多个系统疾病的治疗,且近年来小柴胡汤的药理作用研究已深入到分子生物学。通过查阅文献,对小柴胡汤的调节免疫、抗肝纤维化、抗肿瘤、调节内分泌等药理作用及对系统性红斑狼疮、咳嗽变异性哮喘、胆汁反流性胃炎、糖尿病、肿瘤等疾病的治疗进行综述。总结小柴胡汤的最新药理研究及临床新用,将对小柴胡汤的继续开发提供参考思路。     

Traditional uses,phytochemistry, pharmacology and toxicology of Lamiophlomis rotata (Benth.) Kudo: a review

Lamiophlomis rotata (Benth.) Kudo is a herbaceous plant of the family Lamiaceae, subfamily Lamioideae. Approximately, 127 chemical constituents have been isolated and identified from L. rotata, including iridoids, flavonoids, phenylethanoid glycosides, polysaccharides, and organic acids. These chemical constituents have extensive pharmacological properties, which include anti-nociceptive, haemostatic, anti-inflammatory, anti-tumour, immunomodulatory, antioxidant, and cardio-protective activities. Documentation of its historical use in traditional medicine and contemporary phytochemical and pharmacological research indicate that L. rotata has significant potential in therapeutic and health care applications. Both whole extracts and individual chemical components isolated from this plant exhibit a wide range of biological activities that warrant further investigation. These investigations can be assisted by careful review of existing traditional knowledge from diverse cultural backgrounds. A new search for chemical and biological markers and reinforced protection of the germplasm resources of L. rotata are also important to ensure targeted and sustainable use of this medicinal resource. The aim of this review was to provide comprehensive information on the botanical characteristics, traditional uses, ethnopharmacology, chemical and pharmacological properties, toxicity profile, and conservation status of L. rotata, to improve understanding of its mechanisms of action so that novel therapeutic agents may be developed from this plant.

The useful information of Lamiophlomis rotata (Benth.) Kudo was summarized, which provided a basis for the development of new therapeutic drugs for this plant.     

Pain Acceptance Decouples the Momentary Associations Between Pain,Pain Interference,and Physical Activity in the Daily Lives of People With Chronic Pain and Spinal Cord Injury

Pain acceptance is a robust predictor of adjustment to chronic pain; however, the dynamics of pain acceptance in daily life are largely unexamined. Furthermore, research on pain acceptance in those with pain and physical disability is needed. To examine pain acceptance in daily life, we collected 7 days of ecological momentary assessments of pain intensity and pain interference (5 times per day) with continuous accelerometry (physical activity) in 128 individuals with chronic pain and spinal cord injury. Multilevel modeling revealed that pain acceptance significantly moderated the momentary association between pain intensity and pain interference; those with higher pain acceptance experienced a blunted increase in interference when pain was high. Pain acceptance also moderated the association between pain intensity and physical activity; high pain acceptance was associated with an increase and low pain acceptance with a decrease in physical activity in the context of high pain. The activities engagement component of pain acceptance was a slightly more robust driver of these interaction effects; whereas activities engagement significantly moderated the association between momentary pain and pain interference as well as physical activity, pain willingness exerted a significant moderating effect on the momentary association between pain intensity and pain interference only. These findings suggest that both components contribute to the decoupling effects of pain acceptance. Task persistence did not show the same moderating effects, indicating that pain acceptance may be unique from other types of behavioral pain coping in its ability to decouple expected associations between pain intensity, pain interference, and physical activity.

中医护理技术在盆腔炎性疾病后遗症慢性盆腔疼痛病人中的应用进展

综述盆腔炎性疾病后遗症慢性盆腔疼痛的中西医研究现状,总结中药灌肠、穴位贴敷等多种中医护理技术在盆腔炎性疾病后遗症慢性盆腔疼痛病人中的应用进展,提出目前中医护理技术操作存在统一性较差等问题及对未来研究的展望,旨在为减轻病人盆腔疼痛、改善疾病症状、调节病人情绪、提高生活质量提供参考。     

肠道菌群与支气管哮喘发病相关机制研究进展

支气管哮喘是由多种细胞和细胞组分参与的气道慢性炎症性疾病.自"卫生假说"提出并随着哮喘发病机制研究的不断深入,肠道菌群与哮喘的相关性以及肠道菌群影响哮喘发病的相关机制成为研究热点.肠道菌群影响哮喘发病的机制复杂,尚未完全阐明,目前研究主要包括:肠道菌群通过影响机体免疫耐受、免疫细胞的分化成熟和组织特异性归巢,通过其代谢...