血清脂蛋白(a)水平与冠状动脉病变的关系

目的 探讨血清脂蛋白水平与冠心病患者冠状动脉病变的关系.方法 冠状动脉造影患者323例,分为冠心病组和正常对照组,其中根据冠状动脉病变狭窄程度分为轻度、中度、重度狭窄组,根据冠状动脉病变范围分为单支病变组、双支病变组和多支病变组.分别测定其血清脂蛋白、总胆固醇、低密度脂蛋白、甘油三酯水平.结果 冠心病组血清脂蛋白、总胆固醇、低密度脂蛋白、甘油三酯水平明显高于正常对照组.其中血清脂蛋白、总胆固醇和低密度脂蛋白水平与冠状动脉病变呈正相关;双支及多支病变组明显高于对照组和单支病变组(P<0.01),中度狭窄和重度狭窄组明显高于对照组和轻度病变组(P<0.01).结论 血清脂蛋白、总胆固醇和低密度脂蛋白能够反映冠状动脉的病变情况,其水平随冠状动脉病变范围及病变程度的加重而升高,可作为预测冠状动脉病变的一个因素. Abstract： Objective To investigate the possible relationship between the serum LP(a) and coronary artery changes in patients with coronary heart disease (CHD). Methods Coronary angiography (CAG) was performed in 323 patients. The patients were divided into CHD group and control group. The serum levels of lipids were measured. According to the coronary number of stenosis, CHD group was further divided into 1-vessel group, 2-vessel group and 3-vessel group according to the degree of coronary lesion, CHD group was further divided into light stenosis group, moderate stenosis group and severe stenosis group. Results The levels of total cholesterol (TC),LP(a),LDL-C and triglyceride (TG) in CHD patients were significant higher than those in the control group. The serum levels of TC,LP(a) and LDL-C were significantly related to CHD (P<0.01).The serum levels of TC,LP(a) and LDL-C were higher in the 2-vessel group and 3-vessel group than that in the control group and 1-vessel group (P<0.01).The serum levels of TC,LP(a) and LDL-C were higher in the moderate stenosis group, severe stenosis group than that in the control group and light stenosis group(P<0.01). Conclusions The increasing of TC, LP(a) and LDL-C are associated with the stenosis degrees and lesion degrees of coronary artery in patients with CHD which indicated that TC,LP(a) and LDL-C have clinical significance for evaluating the change of degree of coronary artery lesion.     

血清胆红素和血脂对冠心病发生的作用

目的 探讨血清胆红素和血脂在冠心病发生中的作用.方法 75例冠心病患者被分为高脂血症组(46例)和非高脂血症组(29例),35例正常健康成人作为对照组,分别测定血清总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)以及总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)水平等指标作对比分析.结果 高脂血症组TBIL、DBIL、IBIL均低于非高脂血症组和正常对照组,差异有统计学意义(P＜0.05);非高脂血症组血清胆红素水平低于正常对照组,差异有统计学意义(P＜0.05).高脂血症组同非高脂血症组、正常对照组比较,TC、TG和LDL增高,HDL降低,差异有统计学意义(P＜0.05);非高脂血症组同正常对照组比较,TC、TG和LDL增高,HDL降低,但差异无统计学意义(P＞0.05).结论 低胆红素水平在高脂血症和非高脂血症的冠心病发生中起着重要的作用,是冠心病的独立危险因素. Abstract： Objective To investigate the effection of serum bilirubin and serum lipid on coronary heart disease (CHD). Methods Seventy -five patients with CHD group were divided into hyperlipidemia group(46 cases) and non- hyperlipidemia group (29 cases),35 healthy controls (healthy control group)were enrolled in the study. Serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL)serum triglycride ( TG), total cholestrol ( TC ), low density lipoprotein (LDL), high density lipoprotein (HDLand serum lipid were examined for all subiects,and then the results were compared and analyzed. Results The contents of serum TBIL, direct bilirubin (DBIL), indirect bilirubin (IBIL)were lower in hyperlipidemia group than those of non - hyperlipidemia and healthy control group, the difference was significant (P ＜0. 05 ). The contents of serum bilirubin were lower in non - hyperlipidemia group than those of healthy control group, the difference was significant( P ＜ 0.05 ). TC,TG and LDL were higher and HDL was lower in hyperlipidemia group than those of healthy control group and non - hyperlipidemia group, the difference was significant( P ＜0.05). TC,TG and LDL were higher and HDL was lower in non -hyperlipidemia group than those of healthy control group,There was no difference in the two groups( P ＞0.05). Conclusions The lower serum bilirubin level is an independent risk factor of coronary heart disease in hyperlipidemia and non- hyperlipidemia groups.     

脂蛋白相关磷脂酶A2与冠状动脉粥样硬化病变程度及斑块稳定性的关系

目的 探讨脂蛋白相关磷脂酶A2(Lp-PLA2)与冠状动脉粥样硬化病变程度及斑块稳定性的关系.方法 对160例可疑冠心病患者行冠状动脉造影,根据冠状动脉造影结果分为冠状动脉造影正常的对照组(34例)和冠心病组(126例),冠心病组根据临床类型分为急性冠状动脉综合征组(86例)和稳定型心绞痛组(40例).以病变支数和Gensini积分评价动脉粥样硬化病变程度,以临床类型评价斑块稳定性.检查所有患者血清Lp-PLA2水平、高敏C-反应蛋白(hs-CRP)等指标,分析Lp-PLA2、hs-CRP等与病变支数、Gensini积分、斑块稳定性的关系.结果 冠心病组Lp-PLA2水平显著高于对照组(P＜0.05),而且随着冠状动脉病变支数的增加和Gensini积分的增加而逐渐升高,在急性冠状动脉综合征组较稳定型心绞痛组升高.Lp-PLA2水平与hs-CRP无明显相关性.结论 冠心病患者血清Lp-PLA2水平与冠状动脉粥样硬化病变程度及斑块稳定性有关. Abstract： Objective To investigate the correlations between serum levels of lipoprotein -associated pospholipase A2 ( Lp - PLA2 ) and the severity and stability of coronary atherosclerosis. Methods Coronary angiography (CAG) was performed in 160 patients who were suspected as having coronary artery disease(CAD). According to the coronary artery chanrges and plaque characters in CAG, all patients were divided into control group( n =34) and CAD group( n = 126). According to the clinical types,the CAD patients were divided into acute coronary syndrome (ACS) group ( n = 86) and stable angina pectoris (SAP) group ( n = 40). The number of diseased coronary branches and Gensini' s score was used for evaluate the severity of atherosclerosis. The clinical types was used for evaluate the stability of plaque. Lp - PLA2 and hs - CRP were measured in all the patients. The correlation between serum LpPLA2 with hs - CRP and the number of diseased coronary branches, Gensini's score, clinical types were analyzed. Results Lp - PLA2 in CAD patients was significantly higher than that in control group ( P＜0.05) and increased with the increasing number of diseased coronary branches and Gensini's score.Lp -PLA2 in ACS group was higher than SAP group. Lp -PLA2 level had no correlated with hs -CRP.Conclusions CAD patients serum Lp - PLA2 level is correlated with the severity of atherosclerosis and the stability of plaque.     

早发冠心病闭塞病变临床分析

目的 分析早发冠心病(PCAD)闭塞病变患者的传统危险因素及冠状动脉病变的特点.方法 收集患者的临床资料和血管造影结果,对52例PCAD闭塞病变患者、61例晚发冠心病(LCAD)闭塞病变患者和58例非冠心病患者的传统危险因素、冠状动脉病变特点和介入治疗的结果进行统计学分析.结果 危险因素分析显示,PCAD组与LCAD组比较血脂异常、阳性家族史、吸烟比率偏高(P＜0.05).冠状动脉造影结果显示,PCAD组的单支病变较LCAD组偏高(P＜0. 05);单支闭塞和双支闭塞率均较LCAD组偏低,但差异无统计学意义(P＞0.05).PCAD组经皮冠状动脉介入术(PCI)闭塞血管的开通率为62.07%,与LCAD组比较差异无统计学意义(P＞0.05).结论 PCAD组的发病与传统危险因素密切相关,冠状动脉病变的严重程度与LCAD组相当,闭塞血管多半可经PCI术开通. Abstract： Objective Analysis of traditional risk factors of patients with premature coronary artery disease (PCAD) occlusion and coronary lesion characteristics. Methods Collection of clinical data and angiographic results, fifty-two cases of PCAD occlusion patients, sixty-one cases of late-onset coronary artery disease (LCAD) patients with occlusive disease and 58 cases of non-coronary artery disease, coronary lesion characteristics and the results of interventional treatment were statistical analyzed. Results Risk factor analysis showed that, PCAD group and LCAD group dyslipidemia, positive family history, high rates of smoking (P＜0.05). Coronary angiography showed that, PCAD group of single-vessel disease group compared with LCAD higher (P＜0.05), single vessel occlusion and two-branch occlusion rate lower than those in LCAD group, but there was no statistical significance (P＞0.05). PCAD group of percutaneous coronary intervention (PCI) occlusion of blood vessels opening rate was 62.07%, compared with LCAD was no statistical significance (P＞0.05). Conclusions PCAD groups with the traditional risk factors for disease are closely related, the severity of coronary artery disease and LCAD group's, occluded vessels usually can be opened by the PCI technique.     

The relationship between plasma apolipoprotein A-Ⅳ levels and coronary heart disease

Objective To evaluate the relationship between plasma apoA-Ⅳ levels and coronary atheros clerosis and to explore its relation to other risk factors.Methods Using ELISA techniques, plasma apoA-Ⅳ levels were quantified in 181 patients w ho underwent coronary angiography (CAG).Patients were divided according to the ir coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n=118) and a control group (normal CAG, n=63).The severity of athero sclerosis was assessed by stenosis scoring of the different lesions.Other para meters, including apoA-Ⅰ,apoB, Lp(a), HDL-C, LDL-C, TG, and T C, were measured as well.Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA-Ⅳ levels.Results When compared with the control group, plasma apoA-Ⅳ levels were found to be lo wer in the CHD group.There was a weak negative correlation between plasma apoA -Ⅳ levels and the severity of coronary atherosclerosis.ApoA-Ⅳ was found to be a relatively independent risk factor for CHD.We also found a positive corr elation between apoA-Ⅳ and triglyceride levels.Conclusions ApoA-Ⅳ may be important in the prediction of CHD and coronary atherosclerosis severity.It may also play an important role in the metabolism of triglycerides .     

冠心病合并2型糖尿病患者冠状动脉造影临床分析

目的 探讨冠心病合并2型糖尿病患者冠状动脉造影的特点.方法 选择120例冠心病患者进行冠状动脉造影,其中合并糖尿病60例,无糖尿病60例,根据临床特点及造影结果进行对比.结果 冠心病合并糖尿病患者冠状动脉血管病变明显重于单纯冠心病组.多表现为多支血管病变及弥漫性病变(P＜0.05).结论 冠心病合并糖尿病患者冠状动脉造影主要表现为广泛和严重的冠状动脉血管病变. Abstract： Objective To study the coronary artery disease characteristics by coronary angiography in coronary heart diseases patients with type 2 diabetes mellitus. Methods 120 cases of coronary heart disease were treated with coronary angiography, including 60 cases with type 2 diabetes,60 cases of non -diabetic, clinical characteristics and imaging results were compared. Results Coronary artery disease in patients with coronary artery disease with diabetes mellitus was more serious than the other group ( P ＜ 0.05). Conclusions Coronary angiography in patients with coronary heart disease with diabetes mellitus for coronary artery disease mainly manifested more extensive and severe.     

D-二聚体与纤维蛋白原在冠心病中的临床意义

目的 研究D-二聚体(D-Dimer,DD)与纤维蛋白原(Fg)的含量在冠心病患者中的差异.方法 将入选的130例经冠状动脉造影(CAG)的患者分为确诊的冠心病组94例与正常对照组36例,其中冠心病组又分为急性心肌梗死(AMI)组25例、不稳定型心绞痛(UAP)组36例和稳定型心绞痛(SAP)组33例;再将冠心病组按CAG结果分为轻度病变组24例、中度病变组27例和重度病变组43例.用免疫透射比浊法分别测定DD、Fg含量进行比较.结果 AMI、UAP两组DD、Fg含量及阳性检出率明显高于SAP和对照组(P＜0.05),AMI组的DD、Fg含量明显高于UAP组(P＜0.05),重度病变组DD、Fg含量高于轻、中度病变组(P＜0.05).结论 联合检测DD与Fg在冠心病的诊断中具有重要的临床意义. Abstract： Objective To examine the diversity of D -dimer(DD) and fibrinogen (Fg)in the patients with coronary heart disease(CHD). Methods The 130 subjects were divided into CHD group(94 cases) which were confirmed by coronary artery angiography(CAG) and control group (36 cases). CHD group was divided into acute myocardial infarction (AMI) group (25 cases), unstable angina pectoris (UAP) group (36 cases) and stable angina pectoris (SAP) group ( 33 cases). In addition, CHD group was divided into slight (24 cases), moderate (27 cases)and severe (43 cases)lesion groups according to the outcome of CAG. The levels of DD and Fg were measured respectively and compared among all groups. Results The levels of DD, Fg in AMI and UAP groups were significantly elevated as compared with that of SAP and control groups ( P＜0.05), and DD, Fg in AMI group were higher than that of UAP group. The levels of DD and Fg in severe lesion group were higher than that of moderate and slight groups ( P＜0.05 ). Conclusions To measure the levels of DD and Fg simultaneously has important clinical significance in CHD.     

探讨血清视黄醇结合蛋白4与冠心病的相关性

目的 观察冠心病患者血清视黄醇结合蛋白4(RBP4)水平,并探讨RBP4与冠心病的关系.方法 64例冠心病患者分为急性心肌梗死(AMI)组10例,不稳定型心绞痛(UAP)组42例,稳定型心绞痛(SAP)组12例,另选择21例冠状动脉造影结果正常者为对照组.采用酶联免疫吸附法(ELISA)测定血清RBP4水平.结果 血清RBP4在AMI和UAP组中高于SAP组和对照组,差异有统计学意义(P＜0.05),在SAP组与对照组之间差异无统计学意义(P＞0.05);血清RBP4在单支、双支、三支病变组中均高于对照组(P＜0.05),但在单支、双支与三支病变组之间差异均无统计学意义(P＞0.05).结论 RBP4可作为预测斑块稳定性的标志物,为冠心病危险分层及采取积极干预措施提供依据,但不能反映冠状动脉狭窄程度及范围. Abstract： Objective To investigate the serum retinol - binding protein 4 ( RBP 4 ) of coronary heart disease (CHD)patients and evaluate whether plasma macrophage migration inhibitory factor were associated with CHD. Methods Sixty -four patients with CHD were divided into the acute myocardial infarction (AMI) group ( n = 10), the unstable angina pectoris (UAP) group ( n = 42) and the stable angina pectoris(SAP) ( n = 12),21 normal subjests without CHD diagnosed by CAG served as the control group. The serum level of RBP4 measured by enzyme linked immune sorbent assay (ELISA). Results The serum level of RBP4 were higher in AMI and UAP group thai in SAP group and control group ( P ＜ 0. 05 ). The mean level of RBP4 in SAP group was not differently significantly, compared with that in control ( P ＞ 0. 05 ) ;The mean level of in single, double and three vessel lesion group were higher than that in control group (P ＜0. 05 ),but the serum levels of RBP4 among single, double and three were not significant different ( P ＞ 0. 05).Conclusions RBP4 may act as one of vulnerable plaques,we can take active to stabilize vulnerable plaques and decrease the occurrence of cardiac events,but may not reflect the severity of artery stenosis.     

Rosiglitazone Improving Clinical Outcomes in Type 2 Diabetes with Coronary Artery Disease after Percutaneous Coronary Intervention

Objective Rosiglitazone, an agonist of peroxisome proliferator-activated receptor-γ （PPARγ）, is an insulin- sensitizing antidiabetic agent and inhibits restenosis in animal blood vessels. This study was designed to investigate its effects on clinical outcomes of patients with type 2 diabetes and coronary artery disease （CAD） after percutaneous coronary intervention （PCI）. Methods Patients with diabetes and CAD who had undergone PCI were randomly assigned to a rosiglitazone group or a control group. Patients in the rosiglitazone treatment group were treated with rosiglitazone 1 day before PCI （4mg once daily） and treatment was continued until the 6 months follow-up; while in the control group, patients were treated with placebo 1 day before the procedure and until the 6 months follow-up. Adverse events were death, myocardial infarction and urgent target vessel revascularization within 6 months after PCI. Results Seventy patients in the rosiglitazone group and 66 patients in the control group survived during the follow-up. Baseline characteristics among patients in the two groups were well balanced. There was no significant difference in target vessels or the procedure of stent implantation. Compared with the control group, treatment with rosiglitazone was associated with a lower rate of death, myocardial infarction and urgent target vessel revascularization （5.7% vs 19.7%, P=0.013）. Conclusion Rosiglitazone could reduce the risk of the adverse cardiovascular event and improve clinical outcomes in type 2 diabetes with coronary artery disease after PCI.     

Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion

Background  The plasma cystatin C concentration (PcyC) has been demonstrated to have prognostic value in acute coronary syndrome, but the study of PcyC in patients with borderline coronary lesions is limited. Moreover, the effects of atorvastatin and probucol on PcyC and the severity of coronary lesions are unknown. This study was to evaluate the effects of the combination of atorvastatin and probucol on PcyC and severity of coronary lesion in patients with borderline coronary lesions.

Methods  One hundred and thirty consecutive patients with borderline coronary lesions (40% to 60% isolated single stenosis assessed by quantitative coronary angiography) were enrolled into the borderline coronary lesion (BCL) group, and one hundred and thirty-six subjects without coronary lesions comprised the controls (CTR). The subjects in the BCL group were randomized into routine treatment (RTT, n=60), and combined treatment with atorvastatin 20 mg plus probucol 1.0 g daily added to routine medication (CBT, n=70), both groups were treated for 6 months continuously. The levels of PcyC, high-sensitive C-reactive protein (hs-CRP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were determined. One hundred and four subjects in the BCL group were rechecked by coronary angiography.

Results  PcyC levels were significantly higher in the BCL group than in the CTR group; (2003.26±825.73) ng/ml vs. (1897.83±664.46) ng/ml (P <0.01). Compared with patients in the RTT group, the levels of PcyC, TC, LDL-C, TG and hs-CRP were significantly lower in the CBT group (P <0.05). Moreover, there was a trend towards a slight decrease in the RTT patients, (54.38±10.67)% vs. (50.29±9.89)% (P >0.05), and a significant decrease in the CBT patients, (53.65±9.48%) vs. (40.38±12.93)% (P <0.05), in the mean percent stenosis of borderline coronary lesions before and after six months of treatment.

Conclusions  Cystatin C played an important role in the development of coronary artery disease, and was associated with the severity of coronary lesions. The combination of atorvastatin and probucol decreased PcyC levels, and could be the treatment of choice.

     

阿托伐他汀对冠心病合并充血性心力衰竭患者血管内皮功能的影响

目的 研究阿托伐他汀对冠心病(CHD)合并充血性心力衰竭(CHF)患者血浆中一氧化氮(NO)、降钙素基因相关肽(CGRP)和内皮素(ET)的影响.方法 将68例CHD并CHF患者随机分为两组,常规治疗组(地高辛、氢氯噻嗪、硝酸异山梨酯)34例,联用组常规用药加阿托伐他汀34例,另选34例健康体健者为正常对照组.采用Greiss法测定NO水平,放射性免疫法测定治疗前后血中CGRP和ET的水平.结果 CHD并CHF患者中NO和CGRP水平明显低于正常组(P＜0.01),ET显著高于正常组(P＜0.01),治疗后均显著改善(P＜0.01),且以联用组改善更为显著,与常规组治疗后比较差异有统计学意义(P＜0.05).结论 常规用药加阿托伐他汀能显著改善CHD合并CHF患者的NO、CGRP和ET的代谢失衡. Abstract： Objective To study the effect on levels of plasma calcitonin gene-related peptide (CGRP) and endothelin(ET) of atorvastatin in patients with coronary artery heart disease(CHD) complicated with congestive heart failure(CHF). Methods Patients with CHD complicated with CHF were divided into two groups usual medicine group(usual medicine) and atorvastatin group. The plasma CGRP and ET levels were observed before and after treatment. Results The levels of CGRP in patients with CHF were lower than that in normal group before treatment (P＜0.05),and the level of ET was higher (P＜0.05),the improvement of CGRP and ET in atorvastatin group was better than that in the usual medicine group(P＜0.05). Conclusions Atorvastatin had the action of improving the imbalance of CGRP and ET in Patients with CHD complicated with CHF.     

4排螺旋CT对冠状动脉粥样硬化性心脏病的临床价值

目的 探讨4排螺旋CT冠状造影在诊断冠状动脉粥样硬化性心脏病(简称冠心病)中的价值.方法 收集临床上初步拟诊为冠心病的35例患者的93支血管并进行螺旋CT冠状造影和常规冠状动脉造影检查,对比分析螺旋CT冠状造影的准确性.结果 螺旋CT冠状造影发现47支冠状动脉狭窄,常规冠状动脉造影检查发现51支冠状动脉狭窄.螺旋CT冠状造影发现的44支血管狭窄与冠状动脉造影结果一致,敏感性为86.3%,特异性为100%.螺旋CT冠状造影和常规冠状动脉造影检查结果大体一致.结论 4排螺旋CT冠状造影可作为诊断冠心病的一种无创筛选检查方法,提高了冠状动脉造影诊断冠心病的符合率. Abstract： Objective To explore the diagnosticclinical value of 4 -detector row spiral CT with coronary artery disease. Methods Spiral CT coronary angiography (CTCA) and conventionalcoronary angiography(CAG) were used in 93 arteries of 35 coronary artery disease patients. To analysis the precise level of CTCA through contrasting. Results CTCA showed the angiostegnosis with 47coronary arteries,CAG showed theangiostegnosis with 51coronary arteries. The angiostegnosis results of 44 coronary arteries were same with CTCA and CAG. The total sensitivity of CTCA was 86.3% , and specificity was 100%.The results of CTCA and CCA were coincidentalin general. Conclusions 4 - detector row spiral CT can be used as a noninvasive screening method for the patients with suspected coronary artery disease, and the coincidence ratewasincreased ofcoronary angiography with coronary artery disease.     

冠心病与血清高敏C反应蛋白、尿酸及血脂水平的检测与结果分析

目的 探讨冠心病患者血清高敏C反应蛋白(hs-CRP)、尿酸(UA)及血脂水平变化及临床意义.方法 抽取冠心病与健康对照组清晨空腹静脉血,应用全自动生化分析仪对血清hs-CRP、UA、血脂进行检测.结果 冠心病组高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AI(apoAI)含量低于健康对照组;hs-CRP、UA、甘油三酯(TG)、胆固醇、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(apoB)浓度高于健康对照组.结论 血清hs-CRP、UA及血脂水平的联合检测对冠心病的诊断具有重要意义. Abstract： Objective Discussion coronary disease blood serum high sensitivity C-reactive protein (hs-CRP),the blood lipids and the uric level change and clinical significance. Methods Extraction coronary disease group with the healthy control group early morning the empty stomach venous blood, applied the whole blood to move the biochemistry analyzer to the blood serum hs-CRP, the uric acid, the blood lipids carries on the examination. Results The coronary disease group blood serum the high density lipoprotein cholesterol and carry the lipoprotein AI content were lower than that in the healthy control group. The hs-CRP, the uric acid, the triglyceride, the low density lipoprotein cholesterol, carry lipoprotein B were higher than that in the control group. Conclusions Combined determination of the patient blood serum hs-CRP, uric acid, blood lipids level is important for the diagnosis of coronary artery disease.     

血管回声跟踪技术检测颈动脉弹性变化及主动脉瓣钙化与冠心病的相关性

目的 应用血管回声跟踪技术检测颈动脉弹性变化及二维超声观察主动脉瓣钙化,研究二者与冠状动脉粥样硬化关系及预测价值.方法 应用血管回声跟踪技术对196例行冠脉造影(CAG)受检者进行颈总动脉检查,记录血管弹性指标,包括弹性系数(Ep)、僵硬度(β)、顺应性(AC)、脉搏波传导速度(PWVβ).同时二维超声观察主动脉瓣有无钙化,并将上述结果与CAG结果进行t检验.结果 颈动脉弹性减退与冠脉病变的相关性:β、Ep与CHD呈正相关(r=0.281,r=0.253,P＜0.01,P＜0.05),AVC与CHD呈正相关(r=0.173,P＜0.05).结论 颈动脉弹性减退及主动脉瓣钙化是冠心病的高危因素,对冠心病有较大的预测价值. Abstract： Objective To study the relationship and predictive value of variation of carotid artery elasticity detected by echotracking (ET) technique and aortic valve calcification detected by two - dimensional ultrasonography with coronary heart disease (CHD). Methods The carotid artery elasticity of 196 cases who underwent coronary angiography(CAG) for suspected CHD were detected by echotracking (ET) technique and the indicators of artery elasticity were recorded, which includes elasticity modulus ( Ep), stiffness parameter ( β ), arterial compliance ( AC ) and pulse wave velocity ( PWVβ ).And aortic valve calcification was detected by two - dimensional ultrasonography, T test was carried out between the results of ultrasound examination and CAG. Results The indicators β, EP of carotid artery elasticity were positively correlated with the extent of CHD( r =0. 281,0.253; P ＜ 0.01, ＜ 0.05). In the mean time, positive correlation between aortic valve calcification and the extent of CHD was found (r = 0. 173, P ＜ 0.05). Conclusions Carotid artery elasticity reducing and AVC are high risk factors of CHD and have great values in predicting CHD.