原发性高血压心律失常与血脂、血糖、纤维蛋白原、血尿酸关系的研究

目的探讨首次诊断的原发性高血压患者心律失常的发现率、类型及其与高血压水平和心血管危险因素的关系.方法 1995.6～2001.3首次诊断的原发性高血压1216例,用24小时动态心电图监测心律失常,测定血压、血脂、血糖、纤维蛋白原、血尿酸等指标,用方差分析和相关回归分析统计结果.结果 514例患者出现心律失常,发生率为42.3%,268例出现室性心律失常,发生率为22.04%,370例出现室上性心律失常,发生率为30.4%, 68例出现传导阻滞及其他心律失常,发生率为5.6%.各种心律失常的发生率随血压级别的增高而增高,室性心律失常的发生与总胆固醇脂、甘油三脂、血糖、纤维蛋白原、血尿酸呈正相关(r=0.43, 0.24,0.36, 0.51, 0.37),室上性心律失常的发生与总胆固醇脂、甘油三脂、血糖、纤维蛋白原呈正相关(r=0.28,0.32,0.34,0.44).传导阻滞及其他心律失常与血尿酸呈正相关(r=0.41).结论首次诊断的原发性高血压患者,心律失常的发生率高,心律失常的发生与高血压水平及心血管危险因素有关,控制高血压,消除心血管危险因素是防治心律失常发生的手段.     

原发性高血压心律失常与血脂、血糖、纤维蛋白原、血尿酸关系的研究

目的 探讨首次诊断的原发性高血压患者心律失常的发现率、类型及其与高血压水平和心血管危险因素的关系。方法 1995.6-2001.3首次诊断的原发性高血压1216例，用24小时动态心电图监测心律失常，测定血压、血脂、血糖、纤维蛋白原、血尿酸等指标，用方差分析和相关回归分析统计结果。结果 514患者出现心律失常，发生率为42.3%，268例出现室性心律失常，发生率为22.04%，370例出现室上性心律失常，发生率为30.4%，68例出现传导阻滞及其他心律失常，发生率约为5.6%。各种心律失常的发生率随血压级别的增高而增高，室性心律失常的发生与总胆固醇脂、甘油三旨、血糖、纤维蛋白原、血尿酸呈正相关（r=0.43,0,24,0.36,0.51,0.37），室上性心律失常的发生与总胆固醇脂、甘油三旨、血糖、纤维蛋白原呈正相关(r=0.28,0.32,0.34,0.44）。传导阻滞及其他心律失常与血尿酸呈正相关（r=0.41）。结论 首次诊断的原发性高血压患者，心律失常的发生率高，心律失常的发生与高血压水平及心血管危险因素有关，控制高血压、消除心血管危险因素是防治心律失常发生的手段。     

老年男性动态血压与人体测量指标的关系

我们于1993～1994年对91例年龄≥60岁的老年男性的动态血压及人体测量指标进行了测定和分析,以探讨其动态血压与体质指数(BMI)和脂肪分布的相关性。     

北京市老年人群体重、血脂、血压及血糖水平的调查与分析

为了解老年人心血管疾病发病的相关因素，抽样检测北京市６２３例６０岁以上老年人的健康状况，其中宣武区市民２８９例，大兴县郊区农民１９４例，怀柔县贫困山区农民１４０例。发现城市市民及郊区农民总胆固醇及甘油三酯水平明显高于山区农民（Ｐ＜０．０１及０．０５）。城市市民超重及肥胖的发生率、高脂血症及高血糖的发生率明显高于郊区及山区农民（Ｐ＜０．００１及０．０５）。女性超重及肥胖者的比例高于男性（Ｐ＜０．０５）。随年龄老化超重及肥胖者的比例减小（Ｐ＜０．００１）。超重及肥胖者中高脂血症、高血压病及糖尿病的发生率较正常体重者及消瘦者明显增加（Ｐ均＜０．００１），冠心病及钙化性瓣膜病的发生率差异无显著性。     

肠易激综合征临床评估与住院期间直接经济负担指标的典型相关分析

目的:探讨肠易激综合征患者临床评估指标与住院期间直接经济负担指标之间的相关性。方法:回顾广东省中医院2010年1月—2022年12月收治的271例肠易激综合征患者的病历资料,观察临床评估指标(年龄、病程、合并病情况、血清白蛋白计量、血红蛋白计量、入院肠道症状、入院上消化道症状、全身症状等)与住院期间直接经济负担指标(住院时间和住院费用),对两组资料进行典型相关分析。结果:肠易激综合征患者入院中医证型以脾虚湿盛证为主,老年人证型中虚证较其他年龄层明显增加。典型相关分析结果提示,纳入肠道症状评分后的第1典型相关系数为0.615(P<0.001)。年龄、病程、合并病种数、肠道症状评分与住院时间、费用均呈正相关(P<0.05);血清白蛋白、血红蛋白与住院时间、住院费用呈负相关(P<0.05)。结论:肠易激综合征患者的临床评估指标与经济负担指标具有一定的相关性。初诊评估肠易激综合征患者需关注患者的基础病及临床症状,还要评估患者的营养状态,从而合理用药并加强营养支持,减少患者住院经济负担。     

冠心病患者血压和血脂及血糖达标率分析

目的分析经冠状动脉造影诊断为冠心病患者的血压、血脂和血糖达标率情况,评价其3个危险因素达标率对冠心病的影响。方法选择冠心病患者2916例,根据指南规定的达标标准,分析入院时的血压、血脂和血糖水平及出院时的血压水平。结果 291 6例冠心病患者血压以<130/80 mm Hg(1 mm Hg=0.13 kPa)为达标,入院时达标率28.4%,出院时87.5%;以<140/90 mm Hg为达标,入院时达标率65.8%,出院时90.0%。HDL-C和TG入院时达标率分别为23.0%和58.0%;978例高危患者LDL-C和TC入院时达标率分别为54.3%和49.5%,1 938例极高危患者LDL-C和TC入院时达标率分别为17.4%和5.8%。糖尿病患者538例,占冠心病的18.5%,入院时达标率仅为1.9%;糖尿病和空腹血糖受损者共1138例,占冠心病的39.0%。结论冠心病患者入院时血压、血脂和血糖的达标率相对较低,尤其以空腹血糖理想达标率及极高危患者LDL-C和TC达标率低为特点,提高冠心病患者的血糖、血脂和血压达标率,对于冠心病的二级预防极为重要。     

广州市中老年人群血压水平与血尿酸和尿素氮的关系

目的探讨广州市中老年人群收缩压(systolic blood pressure,SBP)、舒张压(diastolic bloodpressure,DBP)与血尿酸(uric acid,UA)、血尿素氮(blood urea nitrogen,BUN)浓度的相关性及两组指标间典型相关特征。方法采集广州市中老年人群242例的血标本检测血UA、BUN浓度等,应用柱式水银血压计测量上臂血压3次,取平均血压值。各研究指标间相关性采用Pearson相关分析,应用多元相关分析进一步分析SBP、DBP与血UA、BUN浓度两组指标间的典型相关性,应用逐步回归分析估计因变量为SBP、DBP,解释变量为UA、BUN的回归系数和标准回归系数。结果Pearson相关分析显示广州市中老年人群242例的SBP与血UA浓度呈正相关(r=0.16023,P=0.0126);SBP与血BUN浓度呈正相关(r=0.16424,P=0.0105);DBP与血UA浓度呈正相关(r=0.16562,P=0.0099);DBP与血BUN浓度呈正相关(r=0.13506,P=0.0358)。本组SBP、DBP与血清UA、BUN浓度两组指标间的典型相关系数R...     

不典型急性心肌梗死相关因素的分析及干预

目的：探讨不典型急性心肌梗死(AMI)发病的危险因素及干预方法，指导临床治疗。方法：采用回顾性分析方法对53例AMI患的非典型临床特征，危险因素，合并症，诱发因素进行分析．结果：非典型AMI多见于老年病人，A型性格、有家族史、高脂血症、高血压为其发病的危险因素，劳累、情绪激动、酗酒为其常见诱因，且常并发心力衰竭，心源性休克，心律失常。结论：对可疑AMI思，应动态观察其心电图及酶学变化，一旦确诊，应及时治疗，并根据存在的危险因素，采取相应的干预措施。     

757例老年人血压、血糖与血脂测定及相关性分析

脂质紊乱、高血压、高血糖是动脉硬化发生的危险因素，三者同时并存即为代谢综合征。近年来，代谢综合征的发生率日益增加，其与心脑血管疾病的相关性日益受到关注。2006年7—12月，我们共为757例老年人进行血压、血糖、血脂检测，并对其高血压病、糖尿病、脂质紊乱的相关性进行了分析。现报告如下。     

血压、血脂及血糖水平与老年性痴呆的相关性

目的探讨血压、血脂及血糖与老年性痴呆的相关性。方法选择2013年和2015年均进行年度体检的同一组65岁以上老年人群进行常规血压、血脂及血糖检测,采用临床痴呆评定量表(CDR)对入选者进行认知能力评分,对评分结果进行单一病种及综合性比较。结果入选患者1 418例,其中2013年确定为痴呆者112例,均为轻度痴呆,占总人数比7.89%;2015年度痴呆者上升为149例,轻度129例,中度17例,重度3例,占总人数比10.51%,与2013年度比较有统计学意义(P0.05)。入选患者中高血压534例,2013年度确诊痴呆18例,2015年度29例,两者占总人数比例有统计学差异(P0.05)。入选患者中高脂血症506例,2013年度确诊痴呆26例,2015年度38例,两者占总人数比例有统计学差异(P0.05)。入选患者中糖尿病884例,2013年度确诊痴呆73例,2015年度120例,两者占总人数比例有统计学差异(P0.05)。结论高血压、高血脂和高血糖均为发生老年性痴呆的基础性疾病,应当给予有效的早期干预。     

Excess Weight,Anthropometric Variables and Blood Pressure in Schoolchildren aged 10 to 18 years

Background

The prevalence of hypertension among children and adolescents is estimated to range between 1% and 13%. Excess weight and central obesity are related to blood pressure levels in adults, and may be important in the early pathogenesis of SH when present in childhood.

Objectives

To study the association between anthropometric variables and blood pressure levels in schoolchildren from the 5^th and 8^th grades, and to identify which parameter was more strongly correlated with blood pressure levels.

Methods

Contemporary cross-sectional study with probabilistic population-based cluster sampling of schoolchildren enrolled from the 5^th to the 8^th grades in public elementary schools of Porto Alegre. Data on familial risk factors and anthropometry were collected. Statistical analysis included correlations and cluster-adjusted confidence intervals.

Results

The mean age of participants was 12.57 (± 1.64) years, and 55.2% of them were females. Abnormal blood pressure levels were found in 11.3% of the sample and borderline values, in 16.2%. Among the anthropometric variables analyzed, hip circumference was the one with the strongest correlation with increased blood pressure (r = 0.462, p < 0.001), followed by waist circumference (r = 0.404, p < 0.001) and abdominal skinfold (r = 0.291, p < 0.001).

Conclusion

We observed an association of waist circumference and skinfolds with increased blood pressure levels in the schoolchildren of the sample. Therefore, it is of the utmost importance that early measurements of blood pressure, and waist and hip circumferences become a routine in health services in order to prevent this condition.     

职业紧张对血糖、血脂影响的研究

目的 探讨职业紧张与血糖、血脂之间的关系。方法 应用职业紧张测量表(OSI)于2002年对福州铁路系统及福州某工厂共289名男性职工进行职业紧张与血脂、血糖关系的人群调查，并进行LSD检验及又生分析；结果 在控制了非职业紧张因素的条件下，职业紧张与血糖升高(RR＝2．46)、血脂升高(RR＝1．23)都有独立的相关关系，并且与常见的主要危险因素有协同作用。结论 职业紧张是引起男性职工血糖、血脂升高的重要危险因素之一。     

The Systolic Blood Pressure Difference Between Arms and Cardiovascular Disease in the Framingham Heart Study

Background

An increased interarm systolic blood pressure difference is an easily determined physical examination finding. The relationship between interarm systolic blood pressure difference and risk of future cardiovascular disease is uncertain. We described the prevalence and risk factor correlates of interarm systolic blood pressure difference in the Framingham Heart Study (FHS) original and offspring cohorts and examined the association between interarm systolic blood pressure difference and incident cardiovascular disease and all-cause mortality.

Methods

An increased interarm systolic blood pressure difference was defined as ≥10 mm Hg using the average of initial and repeat blood pressure measurements obtained in both arms. Participants were followed through 2010 for incident cardiovascular disease events. Multivariable Cox proportional hazards regression analyses were performed to investigate the effect of interarm systolic blood pressure difference on incident cardiovascular disease.

Results

We examined 3390 (56.3% female) participants aged 40 years and older, free of cardiovascular disease at baseline, mean age of 61.1 years, who attended a FHS examination between 1991 and 1994 (original cohort) and from 1995 to 1998 (offspring cohort). The mean absolute interarm systolic blood pressure difference was 4.6 mm Hg (range 0-78). Increased interarm systolic blood pressure difference was present in 317 (9.4%) participants. The median follow-up time was 13.3 years, during which time 598 participants (17.6%) experienced a first cardiovascular event, including 83 (26.2%) participants with interarm systolic blood pressure difference ≥10 mm Hg. Compared with those with normal interarm systolic blood pressure difference, participants with an elevated interarm systolic blood pressure difference were older (63.0 years vs 60.9 years), had a greater prevalence of diabetes mellitus (13.3% vs 7.5%,), higher systolic blood pressure (136.3 mm Hg vs 129.3 mm Hg), and a higher total cholesterol level (212.1 mg/dL vs 206.5 mg/dL). Interarm systolic blood pressure difference was associated with a significantly increased hazard of incident cardiovascular events in the multivariable adjusted model (hazard ratio 1.38; 95% CI, 1.09-1.75). For each 1-SD-unit increase in absolute interarm systolic blood pressure difference, the hazard ratio for incident cardiovascular events was 1.07 (95% CI, 1.00-1.14) in the fully adjusted model. There was no such association with mortality (hazard ratio 1.02; 95% CI 0.76-1.38).

Conclusions

In this community-based cohort, an interarm systolic blood pressure difference is common and associated with a significant increased risk for future cardiovascular events, even when the absolute difference in arm systolic blood pressure is modest. These findings support research to expand clinical use of this simple measurement.     

长沙市不同体重指数社区人群血压、血脂和血糖干预前后的变化

目的 分析社区干预在不同重指数社区人群中的效果。方法 选定长沙市开福区10万城市居民,开展社区心脑血管病综合性干预研究,分别于1997年和2000年在所研究的人群中抽样进行危险因素调查。结果 肥胖人群（BMI＞25）所占比例在干预组和对照组中均增加;血压和血脂等危险因素在BMI＞25和BMI＜18．5的人群中变化较小,而BMI在18．5－25之间的人群干预前后变化较大。结论 进行社区人群心脑血管病综合防治是有效的,但需针对不同的人群采取与之相适宜的措施,以达到最佳干预效果。     

Canonical Correlation Analysis of Factors Involved in the Occurrence of Peptic Ulcers

The impact of risk factors on the development of peptic ulcers has been shown to vary among different populations. We sought to establish a correlation between these factors and their involvement in the occurrence of peptic ulcers for which a canonical correlation analysis was applied. We included 7,014 patient records (48.6% women, 18.4% duodenal ulcer [DU], 4.6% gastric ulcer [GU]) of those underwent upper gastroendoscopy for the last 5 years. The variables measured are endoscopic findings (DU, GU, antral gastritis, erosive gastritis, pangastritis, pyloric deformity, bulbar deformity, bleeding, atrophy, Barret esophagus and gastric polyp) and risk factors (age, gender, Helicobacter pylori infection, smoking, alcohol, and nonsteroidal anti-inflammatory drugs [NSAIDs] and aspirin intake). We found that DU had significant positive correlation with bulbar deformity (P=2.6×10^–23), pyloric deformity (P=2.6×10^–23), gender (P=2.6×10^–23), H. pylori (P=1.4×10^–15), bleeding (P=6.9×10^–15), smoking (P=1.4×10^–7), aspirin use (P=1.1×10^–4), alcohol intake (P=7.7×10^–4), and NSAIDs (P=.01). GU had a significantly positive correlation with pyloric deformity (P=1,6×10^–15), age (P=2.6×10^–14), bleeding (P=3.7×10^–8), gender (P=1.3×10^–7), aspirin use (P=1.1×10^–6), bulbar deformity (P=7.4×10^–4), alcohol intake (P=.03), smoking (P=.04), and Barret esophagus (P=.03). The level of significance was much higher in some variables with DU than with GU and the correlations with GU in spite of being highly significant the majority, were small in magnitude. In conclusion, Turkish patients with the following endoscopic findings bulbar deformity and pyloric deformity are high-risk patients for peptic ulcers with the risk of the occurrence of DU being higher than that of GU. Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU; aspirin has a significant impact on both DU and GU.     

Relationship of Five Anthropometric Indices and Blood Pressure in an Adult Chinese Population

The study examined the relationship of blood pressure (BP) with anthropometric indices, including body mass index (BMI), waist-to-hip ratio (WHR), conicity index (CI), waist circumference (WC), and hip circumference (HC). The sample consisted of 731 females and 911 males aged 20–60 years randomly recruited from Shanxi Province of PR China. There was an increasing trend of systolic blood pressure (SBP), diastolic blood pressure (DBP), and the five anthropometric indices in successively older age groups. Except for female HC, all the other anthropometric indices were significantly correlated with BPS. Among them, WC and HC exhibited the highest correlations in female (0.38–0.42) and in male (0.36–0.37), respectively. The result indicates that HC is not protective for metabolic risk factors in males. Principal component analysis (PCA) was performed on all the five anthropometric indices and four major principal components (PCs) were obtained to explain greater variances (R² == 0.173–0.212) in BPS than did anyone of five anthropometric indices (R² == 0.0001–0.176). The same analyses were conducted on any two, three, and four indices of the five anthropometric ones, in order to get the smaller and optimal sets of indices to estimate BPs. Our results suggest that BMI, WC, and HC are the smallest set of anthropometric indices to optimally estimate BP for the males, and WC and BMI for the females.     

老年性痴呆患者脑神经递质与基本认知能力的典型相关分析

目的利用典型相关分析方法,探讨老年性痴呆患者的脑神经递质与基本认知能力的相互关系。方法运用分层随机抽样方法抽取潍坊市区老年性痴呆患者60名,运用脑电超慢涨落图仪测量脑电载波涨落信息,反映脑神经递质含量;基本认知能力测验软件测量7项基本认知能力。结果两组指标之间密切相关。结论老年痴呆患者两组指标中的主要指标为S5(乙酰胆碱),X3(汉字旋转效率)、X4(数字工作记忆广度)、X7(无意义图形再认),为进一步研究简化了指标体系。