线香灸联合中药内服治疗复发性口腔溃疡临床疗效探讨

复发性口腔溃疡是临床多发口腔黏膜疾病,各年龄段均可出现,临床治疗除口服药物及外敷药物治疗以外,近年来探索出很多治疗方法,如激光、液氮、火针疗法等,现临床治疗中发现线香灸联合中药内服治疗复发性口腔溃疡时可大大缩短溃疡面的愈合时间,减轻患者疼痛,减少内服药物摄入。线香灸联合中药内服标本兼治,线香灸外治标,高温杀菌,促进溃疡面愈合,辨证选用中药内服治本,现通过临床典型案例,以临床试验为依据,从复发性口腔溃疡的病因病机出发,阐述线香灸联合中药治疗复发性口腔溃疡的作用机理,为临床治疗复发性口腔溃疡提供新的思路。     

知柏养营汤治疗复发性口腔溃疡疗效观察

目的观察知柏养营汤治疗复发性口腔溃疡的临床疗效。方法将112例复发性口腔溃疡患者随机分为两组,各56例;对照组给予常规治疗,治疗组给予知柏养营汤治疗,疗程3周。结果对照组总有效率为83.93%,治疗组为94.64%,治疗组临床疗效优于对照组(P0.05)。治疗后两组口腔溃疡疼痛积分均显著降低(P0.05,P0.01),且治疗组疼痛积分低于对照组(P0.05)。结论知柏养营汤可改善复发性口腔溃疡的临床症状,减轻疼痛。     

半夏泻心汤治疗复发性口腔溃疡63例体会

目的：探讨半夏泻心汤对复发性口腔溃疡患者的临床疗效.方法：选取63例复发性口腔溃疡患者作为研究对象,观察应用半夏泻心汤治疗效果.结果：痊愈35例,有效23例,无效5例,总有效率为92.06%.结论：半夏泻心汤治疗复发性口腔溃疡有较好疗效,值得临床推广.     

毫火针治疗复发性口腔溃疡20例

目的:观察毫火针治疗对复发性口腔溃疡的疗效。方法:对20例复发性口腔溃疡患者采用毫火针局部点刺的方法治疗,1次治疗后症状不缓解者可隔日再行治疗,疗程为3次。结果:痊愈2例,显效10例,有效6例,总有效率90%。结论:毫火针治疗复发性口腔溃疡疗效显著,值得临床推广。     

中西医结合治疗复发性口腔溃疡60例临床观察

目的:观察中西医结合治疗复发性口腔溃疡患者的临床疗效。方法:选取复发性口腔溃疡患者120例作为研究对象,按治疗方法不同分为观察组和对照组各60例。观察组采取中西医结合治疗;对照组采取西医治疗,观察两组患者临床疗效。结果:观察组患者临床治疗总有效率为98.33%,明显优于对照组的75.00%,差异具有统计学意义(P<0.05)。结论:中西医结合治疗复发性口腔溃疡患者临床疗效较好,值得临床推广。     

中西医结合治疗复发性口腔溃疡临床研究

目的:探讨中西医结合治疗复发性口腔溃疡的临床疗效。方法:将120例复发性口腔溃疡患者随机分为研究组和对照组各60例,研究组患者采用中西医结合治疗,对照组患者仅采用西药治疗,比较两组患者的临床疗效。结果:经过治疗,研究组患者治愈率、总有效率分别为63.3%、85.0%,对照组患者治愈率、总有效率分别为35.0%、53.3%,研究组临床疗效显著优于对照组,差异具有统计学意义(P0.05)。结论:中西医结合治疗复发性口腔溃疡临床疗效显著,可有效改善口腔黏膜充血状态,减少复发,值得临床推广应用。     

黄汤治疗复发性口腔溃疡56例疗效观察

目的:观察黄汤治疗复发性口腔溃疡的有效性,为其临床治疗提供用药参考。方法:2013年8月~2014年2月,选择复发性口腔溃疡患者56例,采用黄汤随证加减治疗。结果:本组56例患者中,临床治愈54例,显效2例,无效0例,治愈率达到96.43%。结论:黄汤治疗复发性口腔溃疡疗效确切,值得临床推广。     

清胃散加味治疗复发性口腔溃疡53例

目的:观察清胃散加味治疗复发性口腔溃疡的临床疗效.方法:选取复发性口腔溃疡患者53例,均给予清胃散加味治疗.结果:53例患者中,治愈49例,好转3例,未愈1例,有效率为98.11％.结论:清胃散加味治疗复发性口腔溃疡疗效显著.     

耳针巧治口腔溃疡

正笔者从医17年,临床治疗复发性口腔溃疡的患者147例,患者从五六岁幼儿至七八十岁老翁都有。根据复发性口腔溃疡的症状,将复发性口腔溃疡分为四种类型,即外感时毒、肝火上炎、肝郁脾虚、心肾阴虚。采用耳针分型治疗复发性口腔溃疡,多数首次治疗即可止痛,3~5次痊愈。现将临床经验略述如下。中医认为,复发性口腔溃疡与情志劳倦、热     

甘草泻心汤治疗化疗后口腔溃疡的应用

口腔溃疡是临床常见的口腔黏膜病,不同性别、年龄阶段、种族、地域的人都有可能患病,肿瘤患者化疗后,由于化疗药物的伤害,更容易产生口腔溃疡,并且具有反复性,相当于西医的复发性口腔溃疡。但目前复发性口腔溃疡的发病机制尚不明确,西医也没有根治复发性口腔溃疡的特效治疗方法及药物,而临床上中医药之甘草泻心汤对于治疗化疗后病人的复发性口腔溃疡尚有一定疗效,为了更好地指导临床合理用药,现将甘草泻心汤治疗化疗后口腔溃疡的临床应用进行介绍。     

Immunomodulating effects of "tien-hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations

Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. In our institution, an immunomodulating agent, levamisole, is used to treat RAU with satisfactory therapeutic effect. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. To test whether THL has immunomodulating effects on antigen-stimulated proliferation response (PR) of peripheral blood mononuclear cells (PBMC) and T-cells isolated from RAU patients and to test whether THL is a potential drug for treating RAU, PBMC or T-cells isolated from RAU patients were incubated with lipopolysaccharides (LPS) from Escherica coli, phytohemagglutinin (PHA), staphylococcal enterotoxin B (SEB), glutaraldehyde-inactivated tetanus toxoid (TT), glucosyltransferase D (GtfD), or antigens of Streptococcus mutans in the presence or absence of THL. We found that THL significantly increased the LPS-stimulated PR of PBMC from active RAU patients, the GtfD-stimulated PR of PBMC and of T-cells from inactive RAU patients, and the S. mutans-stimulated PR of PBMC from inactive RAU patients. However, THL could also significantly reduce the SEB-stimulated PR of PBMC and of T-cells from active RAU patients and S. mutans-stimulated PR of T-cells from active RAU patients. These results suggest that THL can modulate the antigen-stimulated PR of PBMC and T-cells from RAU patients. Therefore, it may be a potential immunoceutical agent for treatment of RAU.     

甘草泻心汤治疗复发性阿弗他溃疡60例疗效观察

[目的]观察甘草泻心汤治疗复发性阿弗他溃疡的临床疗效。[方法]120例患者随机分为治疗组和对照组两组,治疗组采用甘草泻心汤治疗,对照组采用桂林西瓜霜,比较两组的疗效。[结果]治疗组总有效率为95.0%,对照组为56.37%,治疗组治疗效果优于对照组。[结论]甘草泻心汤治疗复发性口腔溃疡具有较好的疗效。     

Relation between treatment with traditional Chinese medicine for recurrent aphthous ulcer and human zinc and copper]

The purpose of the study is to explore the relation between general condition of patients with recurrent aphthous ulcer (RAU) and human zinc and copper with TCM conception of the organism as a whole, and adjustment effect of human body zinc and copper by TCM treatment. Results showed that the average value of serum zinc of 75 cases of RAU was on lower level within normal range, serum copper was normal, the rate of copper to zinc was higher than normal value. Analysis using the TCM theory showed serum zinc of patients of deficiency symptom-complex was lower than excessiveness symptom-complex, the rate of copper to zinc of patients of deficiency symptom-complex was higher than normal range. The zinc content of serum and the rate of copper to zinc were different in patients of various symptom-complexes of RAU. The zinc and copper contents of serum were adjusted, the rate of copper to zinc was normalized and the immune function of T-cell increased distinctly by TCM treatment according to an overall differentiation of symptoms and signs. Thus the therapeutic effect of TCM was better than zinc preparation.     

贞芪扶正颗粒与胸腺肽联合治疗复发性口腔溃疡的疗效观察

目的：探讨贞芪扶正颗粒与胸腺肽联合治疗复发性口腔渍疡的疗效。方法：治疗组48例，口服贞芪扶正颗粒和胸腺肽片；对照组48例，仅口服胸腺肽片。观察两组疗效。结果：治疗组有效率为97．9％，治愈率为35．4％；对照组有效率为89．6％，治愈率为16．7％。两组治愈率比较差异有显著性（Х^2=4．3808，P〈0．05）。结论：贞芪扶正颗粒与胸腺肽联合治疗复发性口腔溃疡疗效好，治愈率高。     

复发性口腔溃疡辨证论治与机体微量元素锌、铜关系的初步探讨

为了探讨复发性口腔溃疡患者全身状态与锌、铜的关系和辨证论治对机体锌、铜的影响及其与疗效的关系,观察复发性口腔溃疡患者75例,并对其中37例在辩证论治的基础上选用锌剂治疗。结果表明:75例复发性口腔溃疡患者血锌均值在正常范围的下限,血铜均值正常,铜锌比值高于正常。用中医辨证分析复发性口腔溃疡与锌、铜的关系,虚证型血锌低于实证型、铜/锌比值高于正常,不同证型的口腔溃疡患者血锌含量和铜/锌比值可有差异。中医辨证论治能调整血清锌、铜的含量,使铜/锌比值正常化,并能显著提高细胞免疫功能,从而获得比口服锌剂更佳的疗效。     

口腔解毒汤治疗复发性阿弗他溃疡临床疗效观察

目的:观察具有滋阴清热作用的口腔解毒汤内服与外用治疗复发性阿弗他溃疡的疗效。方法:采用口腔解毒汤治疗复发性阿弗他溃疡128例,并与西药治疗对照。结果:近期疗效:治疗7d时中药组溃疡面积、充血面积缩小及疼痛缓解程度缓解明显优于西药组(P0.05,P0.01)。远期疗效:中药组128例,痊愈15例(11.7%),显效68例(53.1%),有效40例(31.3%),总有效率96.1%;西药组100例,痊愈5例(5%),显效28例(28%),有效40例(40%),总有效率73%;两组比较,差异有统计学意义(P0.01)。结论:口腔解毒汤内服与外用具有减轻溃疡周围口腔黏膜充血、立即止痛、加速溃疡面愈合的疗效,并能显著延长溃疡复发间歇期。     

口怡方治疗复发性口腔溃疡40例临床观察

目的 观察口怡方治疗复发性口腔溃疡的临床疗效.方法 将80例复发性口腔溃疡患者随机分为2组,治疗组40例采用口怡方治疗,对照组40例采用口服维生素B2及西地碘治疗,疗程均为2周.在就诊当天及治疗第5、14 d评价平均溃疡期和疼痛指数.结果 治疗组第5、14 d平均溃疡期缩短,与对照组比较差异均有统计学意义(P<0.05...     

"Tien-Hsien liquid" can modulate antigen-stimulated cytokine production by T-cells isolated from patients with recurrent aphthous ulcerations

Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. Our previous study found that THL can modulate the antigen-stimulated proliferative response of peripheral blood mononuclear cells and T-cells isolated from RAU patients. In this study, we further tested whether THL can modulate the antigen-stimulated cytokine production by T-cells isolated from RAU patients. To achieve this goal, T-cells isolated from 19 RAU patients were incubated with phytohemagglutinin (PHA), glutaraldehyde-inactivated tetanus toxoid (TT), glucosyltransferase D (GtfD), or antigens of Streptococcus mutans in the presence or absence of THL. The levels of interleukin (IL)-2, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), IL-6, or IL-10 in the supernatants of T-cell cultures were measured by cytokine enzyme-linked immunosorbent assay (ELISA) kits. We found that THL significantly increased the PHA- or TT-stimulated TNF-alpha, IL-6, and IL-10 production by T-cells isolated from RAU patients. However, THL could also significantly decrease the TT-stimulated IL-2 production, the GtfD-stimulated IL-2, TNF-alpha, IL-6 and IL-10 production, and the S. mutans-stimulated IFN-gamma, TNF-alpha, and IL-10 production by T-cells isolated from RAU patients. These results indicate that THL can modulate the antigen-stimulated cytokine production by T-cells isolated from RAU patients. Because RAU is probably a Thl-mediated disease with elevated levels of IL-2, IFN-gamma, TNF-alpha and IL-6 in either the patient's sera or oral lesions and these increased levels of cytokines can be reduced by THL, we suggest that THL may be a potential immunoceutical agent for treatment of RAU.     

补阳还五汤加味治疗阿弗它溃疡的临床观察

用补阳还五汤加味治疗复发性阿弗它溃疡 (RAU) 96例 ,疗程 2～ 3周 ,总有效率为88 5 %。观察发现RAU患者微循环血液流速、流量与正常人比较差异具有显著性意义 (P <0 0 5 ) ;治疗后微循环流速、流量以及血液流变性均得到了明显改善 ,与治疗前比较P <0 0 5。     

口疮平液配合激光治疗口腔溃疡80例

目的:探讨口疮平液口服配合MDC-500I型半导体激光治疗机(MDC)局部治疗复发性口腔溃疡(RAU)的治疗效果。方法:将RAU患者130例随机分为治疗组80例和对照组50例,治疗组予口疮平液口服全身治疗及MDC口内局部照射;对照组予西瓜霜喷入溃疡面局部治疗,连续7天为1个疗程后作疗效评价。结果:治疗组总有效率91.3%,明显高于对照组72.0%(P<0.01);免疫检查中,治疗组治疗后IgG、补体C3明显高于对照组(P<0.01)。结论:口疮平液口服配合MDC局部照射治疗RAU的临床疗效明显优于西瓜霜局部喷入。