格林-巴利综合征

随着预防接种工作的广泛开展 ,脊髓灰质炎基本被消灭 ,格林 巴利综合征 (Guillian Barre′syndrome,GBS)已成为目前我国和多数国家小儿最常见的急性周围神经病。临床上GBS以肢体进行性对称性弛缓性瘫痪为主要特征 ,伴有腱反射减低或消失 ,病程进展大多不超过 4周。大部分患儿可完全恢复 ,10 %～ 15 %患儿遗留不同程度的肌无力 ,1.7%～ 5 .0 %死于急性期呼吸肌麻痹。　　一、病因与病理变化目前认为GBS是一种多种因素诱导的急性免疫性周围神经病 ,T淋巴细胞、抗体、巨噬细胞和细胞因子都参与本病的致病过程。GBS的病变可累及运动神经…     

静脉注射免疫球蛋白治疗儿童格林—巴利综合征的临床研究

目的：探讨大剂量静脉注射免疫球蛋白（IVIG）治疗儿童格林－巴利综合征（GBS）的有效性和安全性。方法：对符合GBS诊断的54例随机分为3组,分别给予IVIG、新鲜血浆和皮质激素治疗,并对疗效进行对比观察。结果：IVIG治疗组在控制病情进展方面明显优于新鲜血浆和皮质激素组（P＜0．05和P＜0．01）;在呼吸肌麻痹、球麻痹的恢复和肌力提高的时间上亦明显提前于别两组（P＜0．05和P＜0．01）。IVIG可提高重症GBS患儿机体的免疫力,减少继发感染,并缩短疗程。结论：IVIG治疗儿童GBS是一种安全有效的方法。     

简易血浆置换治疗格林-巴利综合征疗效观察

目的　探讨简易血浆置换治疗儿童格林 -巴利综合征的疗效。方法　将 6 8例格林 -巴利综合征分为 3组 :简易血浆置换 30例、注射人丙种球蛋白组 16例、常规治疗组 (对照组 ) 2 2例 ,观察各组疗效 ,并进行统计学分析。结果　简易血浆置换组平均起效时间 5 .5 2d ,有效率 93.33% ;注射人丙种球蛋白组平均起效时间 5d ,有效率 93.75 % ;常规治疗组平均起效时间 9.35d ,有效率 6 8.18%。丙球组血浆置换组与对照组疗效均有显著差异 (χ =6 .4 92　 6 .6 9,P <0 .0 1) ;丙球组与血浆置换组无显著差异 (χ =0 .0 5 3　P <0 .0 5 )。 结论　简易血浆置换治疗儿童格林 -巴利综合征经济、简单、有效。     

23例格林-巴利综合征临床分析

格林 巴利综合征 (GBS)又称急性炎症性脱髓鞘性多发性神经病 ,其病理改变为周围神经和神经根的脱髓鞘及小血管周围淋巴细胞和巨噬细胞的炎性反应。现对 2 3例GBS的临床 ,肌电图及病理改变进行分析 ,报告如下。资料与方法一、临床资料　我院 1990年 6月～ 2 0 0 2年 6月诊断GBS患儿 2 3例 ,男 15例 ,女 8例 ;11个月 1例 ,1～ 3岁 7例 ,～ 6岁 9例 ,～ 14岁 6例。急性起病者 18例 ,亚急性起病 5例。发病前 1个月内有感染史 8例 ,其中 6例有肠道感染史 ,2例有上呼吸道感染史。首发症状为四肢麻木、疼痛等感觉障碍 13例 ,双下肢无力 7例 ,四…     

格林-巴利综合征患儿的免疫学指标及疗效观察

目的 观察格林-巴利综合征患儿免疫生化及激素治疗效果。方法 总结近年来23例小儿格林-巴利综合征，对部分患儿进行脑脊液和(或)血液免疫学、病原特异性抗体检测，并对激素治疗效果进行评价。结果 痛原学检查ll例，10例血柯萨奇病毒IgM、IgG均阳性，7例血EB病毒IgM阳性，2例血肺炎支原体IgM、I如阳性。50％血IgM增高，3例血IgG增高，1例血IgE增高。血T细胞亚群检查3例，2例降低，l例正常。14例(60．87％)脑脊液呈蛋白-细胞分离现象。10例(66．67％)脑脊液中可见寡克隆抗体电泳带(OB)。激素治疗22例，肌力开始恢复时间4～43d。结论 本征与感染密切相关，并同时存在异常体液、细胞免疫，激素治疗可能有效。     

31例格林—巴利综合征病因学研究

目的 检测急性感染性多发性神经根炎（GBS）病儿急性期、恢复期血清及脑脊液抗空肠弯曲菌（CJ）IgG抗体,探讨GBS的病因。方法 采用酶联免疫吸附试验方法研究31例GBS病儿急性期、恢复期血清及脑脊液中抗CJ IgG抗体,设立两组对照组,即非GBS神经系统疾病组和正常组。结果 GBS病儿急性期、恢复期血清抗CJ IgG抗体水平均高于两组对照组,脑脊液抗CJ IgG抗体水平高于对照组（P＜0．01）。结论 东北地区空肠弯曲菌感染与GBS的发病有关,尤其是与GBS亚型急性运动轴索神经病（AMAN）发病密切相关。     

空肠弯曲菌感染与格林—巴利综合征致病机制研究进展

格林－巴利综合征（GBS),病因尚未完全阐明，发病与细菌或病毒前驱感染有关，空肠弯曲菌是一种最常见的前驱感染细菌，目前大多数学者认为该菌通过分子模拟机制导致GBS。     

空肠弯曲菌感染与格林-巴利综合征致病机制研究进展

格林-巴利综合征(GBS)，病因尚未完全阐明。发病与细菌或病毒前驱感染有关，空肠弯曲菌是一种最常见的前驱感染细菌，目前大多数学者认为该菌通过分子模拟机制导致GBS。     

Guillain-Barre syndrome following dengue fever

Guillain-Barre syndrome is a post infectious polyradiculoneuropathy. It is equally prevalent in both the adult and the pediatric populations. Guillain-Barre syndrome following dengue fever is not a classically described entity and has not been reported in children.     

Guillain-Barre syndrome: a review

Guillain-Barre syndrome (GBS) is a rare acute paralytic polyneuropathy, with an incidence of about 1 in 100,000. It occurs in adults and children. It is an autoimmune disorder of the peripheral nervous system often triggered by acute infections – the most common being gastrointestinal or respiratory – leading to an immune mediated response of producing antibodies to antigens which react with the myelin sheath of the peripheral nerves, resulting in demyelination and/or axonal injury. In severe cases, GBS may lead to respiratory failure, and even death. Current treatment options include treatment with intravenous immunoglobulin and/or plasmapharesis which are aimed at neutralising, and removal of circulating antibodies from the bloodstream respectively, alongside supportive measures to maintain motor function.     

Immunologic abnormalities in patients with hemophilia A

To assess the immunologic status of healthy persons with hemophilia A, we performed studies of T cell immunity in 21 patients, 10 given only cryoprecipitate and 11 given factor VIII concentrate. Patients in the factor VIII group had significantly decreased helper/suppressor T cell ratios. Both groups had diminished mononuclear cell response to phytohemagglutinin and normal mixed lymphocyte culture, compared with controls. Abnormalities in T cell number or function did not correlate with the presence of antibody to cytomegalovirus, Epstein-Barr virus, or hepatitis B. Physicians caring for patients with hemophilia A should realize that asymptomatic individuals may have early evidence of immunodeficiency.     

Encephalopathy complicated by Guillain-Barre syndrome and hydrocephalus and associated with acute Bartonella quintana infection

We describe a 16-month-old girl who suffered from encephalopathy leading to intensive care unit hospitalization, complicated by Guillain-Barre syndrome and hydrocephalus, and who had serologic and molecular evidence of central nervous system infection by B. quintana. The possible association of B. quintana with Guillain-Barre syndrome and hydrocephalus has not been previously described and demonstrates the growing spectrum of neurologic complications of Bartonella spp. infections.