福建省艾滋病感染的流行病学和病毒亚型 之间相互关系的研究

目的通过分子流行病学调查,明确福建省人类免疫缺陷病毒-1(HIV-1)流行毒株亚型与艾滋病(AIDS)流行的关系.方法通过艾滋病监测网络发现全省HIV/AIDS病例,应用核苷酸序列分析技术确定HIV-1亚型,结合流行病学资料分析福建省AIDS的流行状况.结果截至2000年底,全省累计发现188例HIV感染者,其中AIDS59例(已死亡53例).经异性性接触感染占65.4%,经血途径感染占9.0%,境外感染占44.1%,其中在东南亚等国家感染约占83.1%,境内感染占39.9%.41例HIV/AIDS病例的HIV-1亚型分析表明福建省存在A、B、C和E4种亚型,E亚型占75.6%(31/41),均为经异性性接触途径感染;B亚型17.1%(7/41),主要经血途径感染.A和C亚型分别为1和2例.E亚型基因离散率为(12.245±3.894)%,B亚型基因离散率为(10.762±2.707)%.表明福建省E亚型流行株的来源复杂,与感染地点、时间有关.结论福建省AIDS流行速度正在加快,病毒感染者主要经异性性接触途径感染,HIV-1流行毒株主要为E亚型.     

690例HIV+/AIDS首诊病例的临床特征及与免疫状态和病毒载量相关性研究

目的以艾滋病病毒（HIV）感染的首诊病例分析临床特征与免疫状态和病毒载量的关系。方法横断面分析了690例HIV感染病例,采用SPSS13．0统计软件分析。结果690例HIV感染病例中男性是女性的2倍,平均年龄35.3岁;感染途径以性途径传播为主,其中因男男性行为和异性性行为而感染的分别是17．5％和16．7％;男男性行为感染者以来自北京地区且学历在大学以上者为主;夫妻间性传播感染占7.8％,双性性行为感染占11．6％。来自河南、安徽、山西、河北等地区的非法采供血／血浆和接受HIV污染的受血者,在发现感染原因中以医院的各种筛查为主,尤其是因皮肤病性病的筛查而发现占多数,发现时多数病例已有严重的免疫缺陷,其中37．3％的病例CD4^＋ T淋巴细胞〈50个／μl;此外,婚前和孕期检查、出入境检疫等都是重要的发现环节;首诊时临床的系统疾病发病率前五位依次是：皮肤病、肺炎、上呼吸道感染、肝炎、消化道念珠菌病;此时患者同时合并的病种增加;但当CD4^＋ T淋巴细胞〉251个/μl时,各种疾病的发病减少;病毒载量越高,CD4^＋ T淋巴细胞数越低,机会感染和并发症越多。结论首诊时HIV感染患者的免疫水平已经很低,病情已经接近艾滋病期。     

Opportunistic infections in HIV-positive patients hospitalized in the Clinic of Infectious Diseases AMG

Opportunistic infections are one of the major problem among HIV infected patients still connected with high mortality. The aim of the investigation is to evaluate the incidence and mortality from opportunistic infections in HIV infected population in Pomeranian region of Poland. The paper presents analysis of incidence of opportunistic infections among 141 AIDS patients hospitalised in Clinic for Infectious Diseases in Gdańsk from 1988 to 2001/June/. In examined group 179 opportunistic infections were diagnosed. Most frequent was oesophageal candidiasis 58%, tuberculosis 29%, pneumocystis carinii pneumonia 21% and central nervous system toxoplasmosis 13%. The occurrence of opportunistic infections depends on CD4 count and rises with CD4 decline. Opportunistic infections were the reason of death in 33 from 74 cases/45%/. CONCLUSIONS: In examined group 28% of patients did not know about HIV infection when first opportunistic infection was diagnosed. Most frequent opportunistic infections in AIDS patients were oesophageal candidiasis, tuberculosis, pneumocystis carinii pneumonia and toxoplasmosis. In 98% of cases opportunistic infection developed when no HAART nor infection prophylaxis was administered. Opportunistic infection was the reason of death in 45% of cases, the most frequent were PCP and CNS toxoplasmosis.     

河南省2012－2014年新报告HIV感染者中HCV抗体流行状况分析

目的 了解河南省2012－2014年新报告HIV感染者中HCV抗体的流行情况。方法 通过艾滋病综合防治数据信息管理系统对河南省2012年7月1日至2014年6月30日新报告的HIV感染者进行信息整理、HIV-1 BED新发感染检测和HCV抗体检测。结果 4 267例新报告HIV感染者中HCV抗体阳性率为13.19%(563/4 267),感染途径为注射吸毒者的HCV抗体阳性率最高(77.27%),采血浆/输血、异性性传播、同性性传播和母婴传播人群的HCV抗体阳性率分别为15.06%、15.81%、3.74%和8.96%。开封(32.04%)、驻马店(25.00%)、商丘(25.00%)、周口(18.86%)和南阳(14.67%)为HCV抗体阳性率最高的前五个省辖市。BED阳性者(HIV新近感染者)中HCV抗体阳性率为7.50%(86/1 146)。多因素logistic回归分析发现:BED阴性、年龄>40岁、农民、HIV感染途径为注射吸毒以及报告地区为开封市、南阳市、商丘市、驻马店市和周口市为HCV感染的危险因素。结论 2012－2014年河南省新报告HIV感染者中HCV抗体流行率有降低的趋势,但是部分地区和重点人群仍存在较高的HCV抗体流行率。     

重庆市涪陵区艾滋病病毒感染者流行病学分析

目的通过对艾滋病感染者调查分析,了解重庆市涪陵区艾滋病疫情现状、特点及流行趋势。方法应用回顾性流行病学方法调查全区304例艾滋病感染者及患者,综合分析涪陵区艾滋病流行病学特征及流行趋势。结果涪陵区艾滋病人群感染率为0.13%(95%可信限:0.12%~0.14%,P=0.05),男性高于女性(χ2=12.1,P<0.005);性途径感染是主要传播途径,男男同性性行为感染占性感染的37.41%;注射式吸毒感染有下降趋势;各人群感染率差异明显,91.26%的感染者为20~50岁,且文化程度较低;全区感染者均为HIV-1型病毒感染。结论艾滋病已经在普通人群中流行,但仍处于低水平流行中,性途径是主要传播方式,男男同性性行为传播方式成为重要传播方式,感染者及发病死亡人数增长迅速,流行趋势有进入高速增长期的可能。     

Methods for estimating HIV prevalence: A comparison of extrapolation from surveys on infection rate and risk behaviour with back-calculation for the Netherlands

Objectives: To compare HIV prevalence estimates (total number infected) by using extrapolation from surveys on infection rate and risk behaviour (EIR) in specific segments of the population and back-calculation (BC) on reported AIDS cases. To discuss potential sources of bias and error, and to identify areas for improvement of the methodology. Design: Systematic comparison and epidemiological assessment of data input, underlying assumptions, and output. Methods: Low, possibly unbiased and high estimates of HIV prevalence as of January 1996 for homo/bisexual men, injecting drug users, heterosexual men and women with multiple partners, and blood transfusion recipients and haemophiliacs were derived from surveys and continuous data collections on HIV infection rate and risk behaviour in the Netherlands between 1992 and 1996. These were compared with estimates (point and 95% CI) by empirical Bayesian BC on AIDS cases 1982–1995. Results and conclusions: The estimate of HIV prevalence by EIR was 13,806 with low and high estimates of 9619 and 17,700, respectively. The HIV prevalence estimate by BC was 8812 (95% CI: 7759–9867). The available data from EIR are too limited for accurate estimates of HIV prevalence. EIR estimates could be improved considerably with more precise data on prevalence of risk behaviours and HIV prevalence rate for homosexual men. More confidence can be put in the BC estimates, but these could be underestimates because of the age effect on incubation time, pre-AIDS treatment and relapse of risk behaviour. BC estimates could be improved by a better representation of the incubation time distribution (including the effect of age thereupon), better data on the effectiveness and uptake of pre-AIDS antiretroviral treatment and prophylaxis of opportunistic infections, and on the level of underreporting.     

Efavirenz versus indinavir among HIV-1 naive patients in Abidjan (Ivory Coast)

OBJECTIVE: The authors had for aim to compare the therapeutic efficiency and tolerance of 2 NRTI+efavirenz (EFV) versus 2 NRTI+indinavir (IDV) in HIV infected adults in Abidjan. METHODS: A retrospective and multicentric study was made on 327 HIV-1 naive patients, 142 in the EFV group and 185 in the IDV group followed in Abidjan from November 1998 to December 2003. The analysis concerned clinical advents (opportunistic infections) and immunovirological parameters (CD4, viral load). Patients received 2 NRTI such as AZT+3TC or D4T+3TC combined either with EFV or IDV. The principal judgement criterion was therapeutic failure. We assessed the percentage of patients with undetectable viral load and the frequency of grade 3-4 adverse effects after 24 months of follow-up. RESULTS: Clinical improvement of patients' state and regression of opportunistic infections were identical in the two groups. The average gain of CD4 was superior to 177 in EFV versus +219 in IDV (p=0.004). The percentage of patients with undetectable viral load was 66% for EFV versus 59% for IDV (p=0.04). The frequency of adverse effects was more elevated with EFV than IDV, 39% versus 23% (p=0.002) initially, but seemed to decrease later. CONCLUSION: HAART with EFV is at least as efficient as with IDV in terms of reduction of viral load and increased CD4 count and is an excellent low-cost first line treatment.     

广西某县HIV现场监测与定点监测的流行病学特征研究

目的 探讨现场监测与定点监测发现人类免疫缺陷病毒（human immunodeficiency virus, HIV）阳性人群的流行病学特征,为有效发现HIV阳性病例提供防治依据。方法 在广西艾滋病高发区选择某县,获取2013年1月1日～2014年3月31日发现报告的HIV阳性数据（定点监测）,同期对当地常住人口进行现场HIV抗体检测同时收集相关信息（现场监测）。运用对应分析法分析两种疾病监测方式下发现的HIV阳性人群流行病学特征间的关联性。结果 现场监测214 586人,发现阳性1 195例,发现率0.56%（1 195/214 586）;定点监测151 365人,发现阳性584例,发现率0.39%（584/151 365）,现场监测发现率高于定点监测（χ2=53.69,P<0.001）;对应分析显示,现场监测更容易发现“年龄在55～岁、文盲/小学文化、农村、异性传播、HIV感染者和CD4细胞计数≥200（个/mm3）”的特征人群;定点监测更容易发现“30～岁、初中高中及以上文化、城镇、艾滋病、其他传播途径和CD4细胞计数<200（个/mm3）”的特征人群。结论 实施现场监测有利于发现非病症感染者,老年人群、低文化程度和农村人群是HIV感染的重点高危人群。     

Current aspects of Salmonella bacteremia cases in the Ibrahima Diop Mar Infectious Diseases clinic, Fann National Hospital Center (Senegal)

OBJECTIVE: The aim of this study was to describe epidemiological, clinical and bacteriological aspects of Salmonella bacteremia in the Fann university hospital infectious diseases clinic. PATIENTS AND METHOD: This study was carried out on data recorded between January 1, 1996 and December 31, 2003. The strains were identified according to biochemical (API 20E, BioMérieux) and antigenic features. Their susceptibility to antibiotic drugs was tested by antibiogram. Research of strains secreting of an extended-spectrum betalactamase was performed. RESULTS: Fifty five cases of Salmonella bacteremia were recorded as follows: S.Typhi bacteremia (32 cases), S. Paratyphi C bacteremia (4 cases), S. typhimurium bacteremia (9 cases), S. enteritidis bacteremia (32 cases) and S. spp bacteremia (8 cases). All the strains were susceptible to ciprofloxacin, ceftriaxone, aztreonam, amoxicillin+clavulanic acid and 90 % of them were susceptible to cotrimoxazole. Bacteremia occurred in 50 HIV infected patients (49%). Salmonella other than Typhi bacteremia were more often present in patients with HIV (81% vs 36% in patients without HIV infection) (P = 0.00001). The lethality rate was 42%. This rate was higher in patients with HIV (56 vs 23% in patients without infection) (P = 0.002). CONCLUSION: The lethality rate of Salmonella bacteremia is high, especially in AIDS patients. Therefore, priority must be given to prevention and chemoprophylaxis with cotrimoxazole should be a good way to reduce the incidence of bacteremia in AIDS patients.     

Are US populations appropriate for trials of human immunodeficiency virus vaccine? The HIVNET Vaccine Preparedness Study

Questions exist about whether testing of preventive human immunodeficiency virus (HIV)-1 vaccines, which will require rapid recruitment and retention of cohorts with high HIV-1 seroincidence, is feasible in the United States. A prospective cohort study was conducted in 1995-1997 among 4,892 persons at high risk for HIV infection in nine US cities. At 18 months, with an 88% retention rate, 90 incident HIV-1 infections were observed (1.31/100 person-years (PY), 95% confidence interval (CI): 1.06, 1.61). HIV-1 seroincidence rates varied significantly by baseline eligibility criteria--1.55/100 PY among men who had sex with men, 0.38/100 PY among male intravenous drug users, 1.24/100 PY among female intravenous drug users, and 1.13/100 PY among women at heterosexual risk-and by enrollment site, from 0.48/100 PY to 2.18/100 PY. HIV-1 incidence was highest among those men who had sex with men who reported unprotected anal intercourse (2.01/100 PY, 95% CI: 1.54, 2.63), participants who were definitely willing to enroll in an HIV vaccine trial (1.96/100 PY, 95% CI: 1.41, 2.73), and women who used crack cocaine (1.62/100 PY, 95% CI: 0.92, 2.85). Therefore, cohorts with HIV-1 seroincidence rates appropriate for HIV-1 vaccine trials can be recruited, enrolled, and retained.     

重庆市涪陵片区老年人群艾滋病流行特征分析

目的 分析重庆市涪陵片区2010 - 2017年老年人群HIV/AIDS的流行病学特征,为制定针对该人群的艾滋病防控措施提供科学依据。方法 通过中国疾病预防控制信息系统收集2010 - 2017年涪陵区疾病预防控制中心艾滋病确证实验室确诊的涪陵片区≥50岁老年人群HIV/AIDS资料,对病例的流行病学特征进行分析。结果 2010 - 2017年确诊的涪陵片区老年HIV/AIDS病例共404例,占总确诊数的30.65%,呈逐年上升趋势（χ2 = 45.79,P＜0.01）。老年HIV/AIDS确诊时平均年龄为（60.76±8.52）岁,以男性（70.79%）、农民（70.30%）、已婚有配偶（68.81%）、小学及以下文化（66.58%）、其他就诊者检测发现（35.40%）、异性传播（90.35%）为主。异性传播中,男性更容易通过非婚异性性接触感染（χ2 = 106.80,P＜0.01）,女性更容易通过配偶/固定性伴阳性性接触感染（χ2 = 121.57,P＜0.01）。确诊的病例中,146例在1年内检测过CD4,呈逐年递增的趋势（χ2 = 60.63,P＜0.01）。结论 涪陵片区老年艾滋病病例疫情发展较快,老年人群已成为重点防控对象,应根据其流行病学特征采取针对性的综合干预措施,控制HIV的传播。     

云南省HIV - 1新近感染人群中病毒辅助受体流行情况分析

目的 研究云南省HIV - 1新近感染人群中病毒辅助受体的流行情况。方法 收集云南省2014年1 - 3月和2015年1 - 6月新报告HIV - 1感染者的血浆样品9 185份,对BED - 捕获酶免疫试验判断为新近感染的样品进行env基因扩增和基因分型,用Geno2Phemo和WebPSSM对病毒使用的辅助受体进行分析。结果 933份样品被判断为新近感染,扩增后获得546条env序列,分型包括C亚型（81.9%）,CRF01_AE（17.2%）,B亚型（0.7%）和CRF01_AE/C（0.2%）。异性性接触和注射吸毒感染中以C亚型为主,分别占86.7%和87.9%,而同性性接触感染中以CRF01_AE为主,占51.5%（34/66）。不同CD4+T淋巴细胞计数分组中,病毒基因型的构成无统计学差异。研究对象中,CCR5嗜性病毒占90.3%,CXCR4嗜性病毒占9.7%。CRF01_AE中CXCR4嗜性病毒的比例（45.7%）高于C亚型（2.0%）。同性性接触传播中CXCR4嗜性病毒的比例为27.3%,高于异性性接触和注射吸毒传播（7.5%和6.5%）。不同CD4+T淋巴细胞计数的分组中,CCR5和CXCR4嗜性病毒的构成无统计学差异。结论 新近感染人群中存在着一定比例的CXCR4嗜性的病毒,应加强对流行株的细胞嗜性的监测和评估。     

浙江省一起非婚非商业异性性传播HIV聚集性疫情调查

目的 明确浙江省一起非婚非商业异性性行为传播模式HIV感染者之间的传播关系。方法 对2020年1月至2022年1月浙江省浦江县新确证的疑似非婚非商业异性性传播HIV聚集性疫情相关HIV感染者及其性伴开展流行病学调查(流调),收集社会人口学特征、流动信息、HIV既往检测史、高危性行为史及性伴侣情况等信息。结合HIV分子传播网络监测进行传播关系分析,采集新确证HIV感染者在抗病毒治疗前的全血样本6~8 ml,分离出血浆。通过核酸提取、PCR扩增pol基因,通过Sequencher 5.0软件拼接整理测序结果,使用Cytoscape 3.6.0软件构建HIV分子传播网络进行分析。结果 2020年1月至2022年1月,浦江县共发现HIV感染者88例,其中异性性传播74例,有31例为非婚非商业性行为感染。初步个案调查发现,其中3例女性均与1例男性发生过无保护的非婚非商业异性性行为。4例感染者中,有2例的配偶HIV抗体检测阳性。对新确证感染者开展分子传播网络分析,共获得异性性传播序列65例,形成9个传播簇,最大传播簇中包含10例HIV感染者。HIV聚集性疫情共涉及HIV感染者11例,男性3例,女性8例;年龄均 ≥ 50岁,职业类型为农民或农村家庭妇女;追踪溯源到7例性伴,其中6例HIV阴性,1例未检测。18例调查对象的性社会网络关系中,夫妻关系6对,固定性伴关系8对,临时性伴关系3对。11例HIV感染者中,非婚非商业异性性传播9例,婚内传播2例。7例非婚非商业异性性伴与病例2(56岁男性农民)的流行病学关联,3例有流调和分子传播簇结果证实,3例有分子传播簇和流调结果证实,另有1例流调结果证实。结论 本起HIV聚集性疫情的传播模式是以病例2为核心,通过非婚非商业异性性行为传播HIV,继而引起婚内和固定性伴间的传播。流调与分子传播网络相结合的溯源调查支持本结论。     

成都地区45岁及以上艾滋病病毒感染者和艾滋病患者流行特征分析

目的 探究成都地区45岁以上艾滋病病毒感染者和艾滋病(HIV/AIDS)患者流行特征.方法 应用流行病学方式对2018—2020年期间成都地区45岁及以上HIV/AIDS患者发病资料予以分析.结果 2018—2020年新报告成都地区45岁及以上HIV/AIDS患者219例(35.67％),2018—2020年期间成都地...     

HIV-1 subtype in Scotland: the establishment of a national surveillance system

Historically, subtype B viruses in men who have sex with men (MSM) and injecting drug users (IDU) dominated the HIV epidemic in the United Kingdom, whereas non-B heterosexual infections dominate globally. Heterosexual contact is now the most common route of transmission in the United Kingdom. Here we monitor HIV subtype in Scotland, and link it to origin of infection. HIV-1 sequence was generated from new diagnoses and the subtype thus obtained linked with demographic data. Virus was subtyped from 80% (137/171) of all new diagnoses in Scotland. Of 58 individuals infected by heterosexual contact, 74% (43) harboured non-B viruses, contrasting with 7% (5/68) of those infected by IDU or MSM. Eighty-four per cent of non-Bs (46/55) were probably acquired outside the United Kingdom, but nine individuals probably acquired their non-B infection in the United Kingdom. Non-B subtypes of HIV-1 predominate in recently diagnosed, heterosexually acquired infections in Scotland and are present in all risk groups, even those with no exposure outside the United Kingdom.     

新疆地区40例艾滋病患者临床特点分析

目的分析某院收治的40例艾滋病患者的临床特征。方法回顾性研究2003年1月-2004年8月以发热或腹泻、消瘦为主诉收治诊断为人免疫缺陷病毒（HIV）感染患者的临床资料。结果40例患者的临床分期均已到艾滋病期，CD4+T淋巴细胞计数为（156.54±131.26）/μL（正常参考值为800～1 200/μL）。发热、咳嗽咳痰、消瘦、腹痛腹泻以及颈部淋巴结大为主要临床表现，部分患者有卡波西肉瘤；机会性感染及合并症以肝炎病毒感染（30例，75.00%）、肺结核（15例，37.50%）多见。HIV感染方式以静脉吸毒为主（32例，80.00%），其次为性途径感染（4例，10.00%）。距可能暴露（静脉吸毒、性接触、输血）HIV时间2～12年，平均（7.31±1.30）年。结论艾滋病期患者临床表现多样化，静脉吸毒是主要的感染传播方式。需采取多种措施预防控制HIV的传播，对患者加强抗病毒治疗与监测、随访，及时控制机会性感染以及病毒复制。     

Estimates of opportunistic infection incidence or death within specific CD4 strata in HIV-infected patients in Abidjan,Côte d’Ivoire: impact of alternative methods of CD4 count modelling

CD4 lymphocyte count is an important surrogate marker of HIV disease progression, but it is often unavailable at the time of clinical events. We analysed data from the Cotrame cohort (1999–2004) and the Trivacan Structured Treatment Interruption trial (2002–2005) to estimate the incidence of opportunistic infections and death within specific CD4 strata in HIV-infected patients receiving highly active antiretroviral therapy (HAART) in sub-Saharan Africa. We used three methods of CD4 modelling: the first assumed that CD4 cell count remained constant until the next measurement; the second assumed that it changed immediately to the level of the subsequent measurement; and the third assumed that it followed a linear function between two consecutive CD4 measurements. The cohort used in this analysis consisted of 981 patients. The incidence rates of opportunistic infections were highest in the lower CD4 strata and decreased in the higher CD4 count strata. The incidence rates of mild opportunistic infections and severe bacterial infections, however, remained high in the highest CD4 stratum. Although all confidence intervals overlapped among the three methods, the incidence rate estimates showed differences of up to 74% in the lowest CD4 stratum. Different methods of estimating CD4 counts at the time of clinical events led to minor differences in incidence rates, except in the CD4 stratum <50 cells/mm³, where the follow-up time was shorter. All of the models indicate that the overall incidence of opportunistic infections under HAART in sub-Saharan Africa is high. This suggests that prophylaxis against opportunistic infections may be needed even for patients receiving HAART.     

重庆市部分地区新报告异性性传播HIV/AIDS感染方式分析

目的 了解重庆市部分地区新报告异性性传播HIV/AIDS的感染方式,为有效开展艾滋病经异性性传播的防控提供依据。方法 对重庆市部分地区2019年7月1日至10月1日新报告的异性性传播HIV/AIDS展开面对面问卷调查,收集社会人口学特征、异性性行为情况等相关数据。结果 共完成312例异性性传播HIV/AIDS的问卷调查,主要以男性（207,66.3%）、≥50岁（210,67.3%）、初中及以下文化程度（252,80.8%）、已婚或同居者（200,64.1%）为主。经商业性行为感染占48.7%（152/312）,经配偶/固定性伴感染占40.4%（126/312）,经非商业临时性行为感染占10.9%（34/312）。不同性别、年龄、职业的HIV/AIDS,感染方式差异有统计学意义（P<0.05）。多因素logistic回归分析结果显示,相比于经配偶/固定性伴感染,男性（OR=822.34,95% CI：103.99～6 503.10）、初中及以下文化程度者（OR=3.02,95% CI：1.05～8.66）的商业性行为感染HIV风险更大;而家务/待业者（OR=0.23,95% CI：0.07～0.76）的商业性行为感染HIV的风险更小;男性（OR=29.20,95% CI：9.40～90.75）、初中及以下文化程度者（OR=4.28,95% CI：1.24～14.81）的非商业临时性行为感染HIV的风险更大。除了在线下场所结识非婚异性性伴,有一定比例（6.2%）HIV/AIDS通过线上交友发展性伴关系,且性伴交往场所以低档为主。结论 重庆市部分地区新报告异性性传播HIV/AIDS的感染方式以线下低档场所结识性伴,并经商业性行为感染为主,应深入了解异性性传播HIV/AIDS的感染方式,制定有针对性的干预策略。     

Non Hodgkin's and Hodgkin's lymphomas and HIV: frequency, outcome and immune response under HAART; Clermont-Ferrand University Hospital, 1991-2003

OBJECTIVES: The authors had for aim to identify cases of non Hodgkin's (NHL) and Hodgkin's (HL) lymphomas in HIV1-infected patients to assess 1) their incidence, before and after 1996, 2) the clinical features and outcome under treatment together with the survival rate of the patients, 3) the immune reconstitution of lymphoma-free patients under HAART. PATIENTS AND METHODS: A retrospective study was made of HIV1-infected patients managed at the Clermont-Ferrand University Hospital from 1991 to 2003 for the diagnosis and treatment of HIV1-related lymphomas. RESULTS: Forty-one patients were included: 35 NHL and 6 HL giving a cumulative incidence rate estimate from 2.4% between 1991 and 1996 to 3.4% between 1997 and 2003 while other opportunistic diseases were decreasing. A high proportion of aggressive and disseminated disease was observed among NHL cases. Complete remission was achieved in 17 (49%) and 5 (83%) NHL and HL cases respectively. The mean survival was 109+/-54 months and was correlated with CD4 cell count at lymphoma diagnosis (univariate analysis). Among responding patients, 5 died: 3 from opportunistic infections, 1 commited suicide, and 1 from hepatic carcinoma. For responding patients, the mean increase of CD4 cell count under HAART was 58/mm3 over a 2 year-period and 192/mm3 over a 5 year-period of follow-up. CONCLUSIONS: The incidence of lymphomas in HIV-infected patients has not decreased since the introduction of HAART. The immune status assessed by CD4 cell count on diagnosis is correlated with survival. Immune restoration in lymphoma-free patients under HAART is poor.