A New Secoiridoid Glycoside from Swertia cincta

Objective To study the chemical constituents of Swertia cincta.Methods Preparative liquid chromatography was employed.The structures of the compounds were elucidated by spectroscopic analysis.Results Three secoiridoid glycosides were isolated from S.cincta and identified as 8-methoxyl-eustomorusside(1),secoiridoids eustomorusside(2),and eustomoside(3).Conclusion Compound 1 is a new secoiridoid glycoside.Compounds 2 and 3 are isolated from this plant for the first time.     

毛冬青根中的新三萜皂苷

目的研究毛冬青Ilex pubescens根的化学成分。方法采用硅胶、Sephadex LH-20等柱色谱法对毛冬青根中的化学成分进行分离纯化,应用谱学技术和化学方法鉴定化合物的结构。结果分离鉴定了1个三萜苷皂类化合物3-O-β-D-吡喃木糖基-3β,19α,24-三羟基齐墩果酸(1)。结论化合物1为新的化合物,命名为毛冬青皂苷D。     

A New Phenylpropanol Glycoside from Twigs and Leaves of Rhododendron primulaeflorum

Objective To study the constituents in the twigs and leaves of Rhododendron primulaeflorum. Methods The constituents were separated and purified with chromatographic methods. Their structures were elucidated by spectroscopic methods (1D, 2D NMR, IR, and HR-ESI-MS) and chemical analyses. Results One new phenylpropanol glycoside, 4-hydroxyl-5-methoxyl-phenylpropanol-3-O-β-D-glucopyranoside (1), and its aglycone (2) were successfully isolated from the twigs and leaves of R. primulaeflorum. Conclusion Compound 1 is a new phenylpropanol glycoside. Compounds 1 and 2 are isolated from this plant for the first time.     

Secoiridoid glycoside and alkaloid constituents of Hydrangea chinensis

A new secoiridoid glycoside, hydrachoside A (1), along with 14 known compounds, was isolated from the leaves of Hydrangea chinensis. The absolute stereochemistry of the side chain attached to C-15 on the secoiridoid glycoside hydrangenoside E (2) was determined by NMR spectral analysis. The structures of compounds 1 and 2 were elucidated on the basis of spectral data. The previously reported structure, hydrachine A (3), was revised as its epimer, (-)-neodichroine (4), a new compound.     

女贞子中一个新的裂环环烯醚萜苷类成分

目的研究女贞子的化学成分。方法采用硅胶、ODS、Sephadex LH-20和RP-HPLC等色谱分离手段对女贞子70%乙醇提取物的醋酸乙酯萃取部位进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果分离得到1个裂环环烯醚萜苷类化合物,鉴定为6′-O-肉桂酰基-8-表-金吉苷酸(6′-O-cinnamoyl-8-epi-kingisidic acid,1)。结论化合物1为新化合物。     

新鲜苦瓜中的一个新C30甾醇苷(英文)

目的:研究新鲜苦瓜中的化学成分。方法:采用硅胶柱色谱和ODS柱色谱进行化学成分分离纯化,并利用波谱数据分析和理化性质进行结构鉴定。结果:从新鲜苦瓜中分离得到1个新C30甾醇苷,结构鉴定为25ξ-异丙烯-胆甾-5,(6)-烯-3-O-β-D-吡喃葡萄糖苷(1)。结论:化合物1为新的C30甾醇苷。     

Secoiridoid glycosides from Gentiana scabra.

Two new secoiridoid glycosides, 4'-O-beta-D-glucopyranosylgentiopicroside (1) and 6'-O-beta-D-glucopyranosylgentiopicroside (2), have been isolated from the rhizomes and roots of Gentiana scabra together with three known compounds, olivieroside, 1-O-beta-D-glucopyranosylamplexine, and benzyl alcohol O-alpha-L-arabinopyranosyl (1 --> 6)-beta-D-glucopyranoside. The structures of 1 and 2 were elucidated using chemical and physicochemical (MS and NMR) studies.     

中药金铁锁中一个新的环七肽

目的: 研究中药金铁锁中的化学成分。 方法: 利用葡聚糖凝胶Sephadex LH-20、硅胶、RP-18反相柱、中压等色谱方法进行化合物的分离纯化,根据化合物的理化性质、光谱数据进行结构鉴定。 结果: 从中药金铁锁中分离得到两个环七肽成分,tunicyclin C (1)和tunicyclin K (2)。 结论: Tunicyclin K 为一个新的天然产物。     

中药玉竹中新的次生代谢产物

目的 :研究中药玉竹Polygonatumodoratum的化学成分。方法 :用硅胶柱色谱法和光谱分析法分离和鉴定化学成分。结果 :从中药玉竹中分离到一个二肽类成分和一个呋甾烷醇苷 ,经化学和光谱分析鉴定其结构分别为N(N-苯甲酰基-S-苯丙胺酰基 )-S-苯丙胺醇醋酸酯 (1)和2 2-羟基-25(R ,S) 呋甾-5-烯-12-酮-3β ,22 ,26 三醇-26-O-β-D- 吡喃葡萄糖苷 (2 )。 结论 :化合物 (2 )为新化合物 ,同时也是首次报道的仅C-26位被糖基化的单糖链呋甾烷醇苷。     

Absolute stereostructures of new arborinane-type triterpenoids and inhibitors of nitric oxide production from Rubia yunnanensis

The aqueous acetone extract from the roots of a Chinese herbal medicine, Rubia yunnanensis, showed a potent inhibitory effect on nitric oxide production in lipopolysaccharide-activated macrophages. Five new arborinane-type triterpenes, rubianols-a (1), -b (2), -c (3), -d (4), and -e (5), and a new arborinane-type triterpene glycoside, rubianoside I (6), were isolated from the herbal crude extract together with 10 known compounds. The absolute stereostructures of 1-6 were determined on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method. The effects of the isolated constituents on nitric oxide production in lipopolysaccharide-activated macrophages were examined, and several triterpenes were found to show inhibitory activity.     

滇杠柳中的一个新强心苷

目的:研究滇杠柳中的化学成分。方法:利用硅胶,RP-18硅胶,MCI,Sephadex LH-20等柱色谱进行分离,波谱分析等方法鉴定化合物结构。结果:从滇杠柳氯仿萃取部分分离鉴定了10个单体化合物:滇杠柳苷元A-3-O-β-洋地黄毒吡喃糖苷(1),β-谷甾醇(2),滇杠柳苷Ⅰ(3),熊果酸(4),杠柳苷元(5),杠柳苷(6),北五加皮苷E(7),periplocoside M(8),胡萝卜苷(9),2α,3α,23-三羟基-乌苏-12-烯-28-羧酸(10)。结论:化合物1为一新的强心苷,化合物8为首次从滇杠柳中分离鉴定。     

A New ent-Kaurane Glycoside from the Stems of Acanthopanax gracilistylus

Objective To study the chemical constituents from the stems of Acanthopanax gracilistylus. Methods The chemical constituents of the plant were isolated and puried by column chromatography and their structures were elucidated on the basis of physicochemical properties and spectral data. Results A new ent-kaurane glycoside, named kaurane acid glycoside A { 16α,17-dihydroxy-ent-kauran-19-oic 19-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl] ester} (1), was isolated from the n-butanol part. Conclusion Compound 1...     

Secoiridoid glycosides from Gentiana scabra

Six new secoiridoid glycosides, gentiascabraside A (1), 6beta-hydroxyswertiajaposide A (2), 1-O-beta-d-glucopyranosyl-4-epiamplexine (3), and scabrans G3 (4), G4 (5), and G5 (6), have been isolated from the rhizomes and roots of Gentiana scabra together with a known compound, swertiajaposide A (7). The structures of the new compounds were determined by spectroscopic (NMR, MS) and chemical means.     

高效液相色谱-串联质谱法分析破骨风中裂环环烯醚萜苷类成分

目的：利用高效液相色谱-电喷雾串联质谱法（HPLC—DAD—ESI—MS^2）分析了破骨风中裂环环烯醚萜苷类成分。方法：采用该方法得到了破骨风中裂环环烯醚萜苷类成分的紫外（UV）色谱图、总离子流（TIC）色谱图和萃取离子（EIC）色谱图,以及相应色谱峰的紫外光谱图和EIC／MS^2的质谱图,结合文献对其进行解析。结果：鉴别出破骨风中6个裂环环烯醚萜苷类成分,分别为Jasminoside,Jaslanceoside A,Jaslanceoside B,Jaslanceoside C,Jaslanceoside D和Jaslanceoside E;同时发现还有4个未知结构裂环环烯醚萜苷类化合物存在,并对它们的结构进行了推测。结论：高效液相色谱-电喷雾串联质谱法可以用于分析破骨风中裂环环烯醚萜苷类成分。     

岗梅根中一个新的三萜皂苷(英文)

目的:研究岗梅根的化学成分。方法:采用硅胶、反相硅胶、Sephadex LH-20等柱色谱法对岗梅根的化学成分进行分离纯化,应用谱学技术和化学方法鉴定化合物的结构。结果:从岗梅根中分离并鉴定了4个三萜苷类化合物:(3β)-19-hydroxy-28-oxours-12-en-3-yl β-D-glucopyranosiduronic acid n-butyl ester(1),ilexasoside A(2),Monepaloside F(3)和ilexoside A(4)。结论:化合物1为新化合物,化合物3和4为首次从该植物中分离得到。     

当归芍药散活性部位DSS-A-N-30中1种新单萜苷

目的：对当归芍药散活性部位DSS-A-N-30的化学成分进行研究。方法：用大孔树脂柱色谱制备DSS-A-N-30,用硅胶和反相硅胶柱色谱分离各成分,用MS及NMR技术鉴定结构。结果：从DSS-A-N-30中分离得到了1个新单萜苷。结论：新化合物命名为4″-羟基白芍苷。     

何首乌中1个新的黄酮二苯乙烯苷

广东德庆为何首乌药材的道地产区之一,该研究综合运用大孔树脂(HP-20)、硅胶、凝胶(Sephadex LH-20)、制备型HPLC等色谱技术,从广东德庆产何首乌的块根中分离得到了1个化合物,并通过理化常数、波谱技术、计算圆二色谱及化学方法鉴定了其结构,为1个新的黄酮二苯乙烯苷,命名为何首乌黄酮茋B(polygonflavanol B,1)。     

大孔吸附树脂法富集龙胆中裂环烯醚萜苷类成分的实验研究

目的：进行龙胆中裂环烯醚萜苷类成分的富集。方法：采用70％乙醇冷浸，AB—8型大孔吸附树脂纯化的方法。结果：使提取物中龙胆苦苷的含量达到28．69％。结论：AB-8型大孔吸附树脂适合分离纯化龙胆中水溶性的裂环烯醚萜苷类成分。     

Sucrose esters and xanthone C-glycosides from the roots of Polygala sibirica.

Six new sucrose esters, sibiricoses A(1)-A(6) (1-6), two new xanthone C-glycosides, sibiricaxanthones A (7) and B (8), and a new acetophenone glycoside, sibiricaphenone (9), were isolated from the roots of Polygala sibirica together with six known glycosides. The structures of new compounds were elucidated on the basis of chemical and spectroscopic evidence. The structure of the known xanthone glycoside, polygalaxanthone III (10), was revised.     

9,19-cyclolanostane derivatives from the roots of Actaea pachypoda

Phytochemical investigation of the chemical constituents of the roots of Actaea pachypoda afforded 12 9,19-cyclolanostane type triterpenoids, including the new 7,8-dihydroactaeaepoxide 3-O-beta-d-xylopyranoside (1), 12-deacetoxyactaeaepoxide 3-O-beta-d-xylopyranoside (2), and 12beta-acetoxycimigenol (3). Their structures were determined by spectroscopic and chemical methods.