Unrepaired Tetralogy of Fallot in an 85‐Year‐Old Man

Tetralogy of Fallot is the most common cyanotic congenital heart defect and accounts for about 5% of all congenital cardiopathies. The definitive treatment modality for tetralogy of Fallot is reparative surgery, which is recommended to be performed by the time of diagnosis. Without surgical repair, most patients would die during their childhood. In the past, survival data indicated that 66% of persons with tetralogy of Fallot not surgically treated lived until the age of 1, 49% lived until the age of 3, and 24% lived until the age of 10. We now present a rare case of a man with unrepaired tetralogy of Fallot who survived until the age of 85. He presented to our emergency room for dyspnea and palpitations due to a new‐onset high‐frequency atrial fibrillation and acute heart failure; transthoracic echocardiography showed the presence of tetralogy of Fallot. By consulting the scientific literature, we can say that this is the second patient who survived more than 80 years without surgical intervention.     

Oral condition and health status of people aged 80–85 years

Objectives:   To clarify the relationship between oral condition and health status, particularly bone mineral density (BMD), in the elderly aged 80 years or more.
Methods:   We examined the oral conditions and health status of two groups. One was elderly who lived at home and had at least 20 teeth at the age of 80 (8020 elderly). The other group consisted of elderly people residing in long-term care facilities (institutionalized elderly). The oral conditions we examined were the number of teeth, masticatory ability, occlusal force, stimulated salivary flow rate, saliva buffer ability, community periodontal index (CPI) and salivary occult blood test. The health status indicators we examined were BMD, grip strength, height, weight and body mass index (BMI).
Results:   The number of teeth, stimulated salivary flow rate, masticatory ability, and occlusal force in the 8020 elderly were significantly higher than in the institutionalized elderly. BMD, grip strength, height, weight and BMI in these 8020 elderly were also significantly higher than in the institutionalized elderly. Masticatory ability and occlusal force in the institutionalized elderly with high BMD (high BMD group) were significantly higher than in the institutionalized elderly with low BMD (low BMD group). Grip strength, height and weight in the high BMD group were higher than in the low BMD group.
Conclusions:   The 8020 elderly had good oral condition and health status compared to the institutionalized elderly. There may be a relationship between number of teeth and BMD in elderly aged 80–84.     

卡介苗－抗原85－B基因的信号肽序列的克隆和鉴定

目的克隆和鉴定卡介苗－抗原８５－Ｂ（ＢＣＧ－Ａｇ８５－Ｂ）基因的信号肽序列。方法采用聚合酶链反应（ＰＣＲ）技术，对ＢＣＧ的主要分泌抗原Ａｇ８５－Ｂ基因的５′端第９４～２１１的核苷酸的信号肽序列进行扩增，再将１１７ｂｐ的扩增片段克隆到质粒ｐＢｌｕｅｃｒｉｐｔＳＫ的ＳａｃＩ和ＥｃｏＲＩ酶切位点，并对此片段进行定序。结果序列分析表明，扩增的信号肽序列无碱基错配，同时在信号肽３′端下游可提供携带外源基因的１２个多克隆位点。结论构建一含信号肽序列的重组质粒（ＢＣＧ－ＳＯ１），为在ＢＣＧ中表达的外源抗原能分泌到ＢＣＧ之外提供了一有效的信号肽     

气单胞菌感染85例临床分析

气单胞菌是人类和许多动物疾病的病原,近年来感染人类的报道逐渐增多。1991～2001年我院共收治气单胞菌感染85例,分析如下。