胺碘酮在老年人慢性心力衰竭合并心律失常中的应用研究

目的 探讨胺碘酮治疗老年人慢性心力衰竭合并心律失常的临床效果.方法 将2009年3月-2011年4月我院收治的老年人慢性心力衰竭合并心律失常49例,在常规抗心力衰竭治疗基础上,给予胺碘酮治疗.结果 治疗后心率、射血分数、QT间期离散度、心律失常均有明显改善,差异有统计学意义(P＜0.05).治疗前后对比差异有统计学意义(P＜0.05).结论 胺碘酮治疗老年人慢性心力衰竭合并心律失常的临床效果好,不良反应小,值得临床推广.     

口服胺碘酮治疗慢性心力衰竭合并室性心律失常的临床效果分析

目的探讨口服胺碘酮治疗慢性心力衰竭合并室性心律失常临床效果。方法选择我院2009年8月至2011年8月慢性心力衰竭合并室性心律失常患者84例,随机分为观察组和对照组。对照组采用常规治疗,观察组同时给予胺碘酮口服。结果观察组总有效率显著高于对照组,差异有统计学意义(P<0.05);观察组病死率和再次入院率显著低于对照组,差异有统计学意义(P<0.05)。结论口服胺碘酮治疗能够显著改善慢性心力衰竭合并室性心律失常临床症状,降低患者病死率,提高临床治疗效果,疗效显著。     

厄贝沙坦联用胺碘酮治疗慢性心力衰竭合并室性心律失常的疗效分析

目的探讨厄贝沙坦联用胺碘酮治疗慢性心力衰竭(CHF)合并室性心律失常(VA)临床疗效。方法选择常宁市中医院CHF合并VA患者91例,随机分为观察组和对照组。两组患者均给予常规治疗,对照组同时给予胺碘酮。观察组给予胺碘酮和厄贝沙坦。结果观察组心功能疗效总有效率与对照组比较,差异有统计学意义(P<0.05);观察组VA疗效总有效率与对照组比较,差异有统计学意义(P<0.05)。结论厄贝沙坦联用胺碘酮能显著CHF合并VA患者临床症状,改善心功能,控制心律失常,临床效果显著。     

86例心力衰竭合并室性心律失常患者胺碘酮治疗的护理

目的探讨胺碘酮对心力衰竭合并室性心律失常患者的治疗效果及护理体会。方法对2008年2月至2010年2月在我院心内科治疗的86例心力衰竭合并室性心律失常患者进行胺碘酮治疗后密切观察,并针对性的对患者进行护理。结果治疗组心力衰竭合并室性心律失常患者38例治疗有效,对照组则30例治疗有效,两组患者治疗率差异有统计学意义(P<0.05)。结论胺碘酮能有效控制心力衰竭患者的室性心律失常,再加上严密细致的临床护理,可提高临床治疗效果。     

临床应用胺碘酮对患有心力衰竭合并心律失常患者的治疗中护理

目的研究分析临床应用胺碘酮对患有心力衰竭合并心律失常的患者治疗的过程中护理方法和效果,以便临床对心力衰竭合并心律失常患者进行更加有效的治疗和更好的护理。方法选取我院自2009年8月至2011年1月患有心力衰竭合并心律失常的患者100例,随机分成两组,每组50例,分别称为观察组和对照组,观察组采用胺碘酮进行综合性针对性护理,对照组采用胺碘酮进行常规护理。结果观察组治疗效果明显好于对照组,差异具有显著性,有统计学意义(P<0.05)。结论临床应用胺碘酮对患有心力衰竭合并心律失常患者的治疗效果很好,采用针对性护理干预可以让患者的治疗效果更好,对患者的治疗有很大的好处。     

胺碘酮治疗心力衰竭合并室性心律失常疗效分析

目的探讨胺碘酮治疗量心力衰竭合并室性心律失常临床疗效。方法运用随机数字表法将2004年12月至2010年5月在吉林省舒兰矿业(集团)公司总医院心内科治疗的108例心力衰竭合并室性心律失常患者分为胺碘酮治疗组和常规治疗组,每组各54例患者,2周后再次对患者治疗效果进行评估。结果通过对2组心力衰竭合并室性心律失常患者进行治疗后发现,胺碘酮治疗组43例治疗有效,有效率为79.63%;而常规对照组30例治疗有效,有效率为59.26%,2组患者治疗有效率差异有统计学意义(c2=5.280,P<0.05);2组患者不良反应出现较少,差异在2组患者间差异无统计学意义(P>0.05)。结论胺碘酮是一种安全有效的控制心力衰竭患者的室性心律失常的药物,不良反应少,值得在临床内科治疗中推广应用。     

胺碘酮联合美托洛尔治疗慢性心力衰竭合并室性心律失常的疗效观察

目的观察胺碘酮联合美托洛尔治疗慢性心力衰竭并室性心律失常的疗效。方法选取2008年5月—2011年6月来我院就诊治疗的慢性心力衰竭并室性心律失常患者60例。随机分为对照组(30例)和治疗组(30例)。对照组采用单纯美托洛尔治疗,治疗组采用胺碘酮联合美托洛尔治疗,比较两组的疗效。结果治疗组患者在心功能改善及心律失常纠正效果都明显优于对照组,差异有统计学意义(P<0.05)。结论胺碘酮联合美托洛尔治疗慢性心力衰竭并室性心律失常疗效显著且安全可靠。     

胺碘酮在心力衰竭合并室性心律失常中的应用效果分析

目的观察胺碘酮治疗心力衰竭合并室性心律失常中的临床效果。方法将2012年2月—2013年2月期间来我院就诊的68例心力衰竭合并心律失常患者,随机进行分为两组,对照组(34例)和观察组(34例),对照组34例患者采用常规的抗心力衰竭和改善心律失常治疗;观察组在对照组治疗的基础上加用胺碘酮,治疗3个月对比两组患者治疗指标。结果对照组总有效率79.4%,观察组总有效率97.1%,两组患者治疗效果对比差异具有统计学意义(P<0.05)。结论在常规治疗的基础上加用胺碘酮治疗心力衰竭合并室性心律失常疗效确切,用药方便安全,值得临床推广应用。     

步长稳心颗粒治疗老年人慢性心力衰竭合并心律失常的疗效观察

目的 观察步长稳心颗粒对老年人慢性心力衰竭合并心律失常的治疗效果.方法 将慢性心力衰竭合并心律失常的老年患者共68例随机分成两组,对照组给予常规抗心衰药物+胺碘酮治疗,治疗组在常规抗心衰药物、胺碘酮基础上加用步长稳心颗粒治疗,观察4周,比较治疗前后患者的临床症状、实验室检查、静息心电图及动态心电图的变化.结果 治疗4周后,治疗组总有效率97.1％,对照组总有效率82.7％,两组总有效率差异有统计学意义(x2=9.322,P＜0.05).结论 稳心颗粒对于老年人慢性心力衰竭合并心律失常患者能够发挥良好作用,安全可靠.     

胺碘酮治疗老年慢性心力衰竭合并心律失常的效果观察

目的探讨胺碘酮治疗老年慢性心力衰竭合并心律失常效果。方法选择我院100例2016年4月至2018年2月老年慢性心力衰竭合并心律失常患者。随机分组,对照组采取常规药物治疗,胺碘酮治疗组则采取常规药物+胺碘酮治疗。比较两组疾病疗效;慢性心力衰竭合并心律失常病情控制时间、住院日数;治疗前后患者心功能QTc以及平均心率水平;不安全事件。结果胺碘酮治疗组疾病疗效、慢性心力衰竭合并心律失常病情控制时间、住院日数、心功能QTc以及平均心率水平相比较对照组更好,P <0.05。胺碘酮治疗组和对照组不安全事件相似,P> 0.05。结论常规药物+胺碘酮治疗老年慢性心力衰竭合并心律失常效果好。     

Quantitative in vivo and in vitro sex differences in artemisinin metabolism in rat

1. The pharmacokinetics of the antimalarial compound artemisinin were compared in the male and female Sprague-Dawley rat after single dose i.v. (20 mg.kg) or i.p. (50 mg.kg) administration of an emulsion formulation. 2. Plasma clearance of artemisinin was 12.0 (95% confidence interval: 10.4, 13.0) l.h. kg in the male rat and 10.6 (95% CI: 7.5, 15.0) l.h. kg in the female rat suggesting high hepatic extraction in combination with erythrocyte uptake or clearance. Artemisinin half-life was 0.5 h after both routes of administration in both sexes. Values for plasma clearance and half-lives did not statistically differ between the sexes. 3. After i.p. administration artemisinin AUCs were 2-fold higher in the female compared with male rat (p 0.001). Artemisinin disappearance was 3.9-fold greater in microsomes from male compared with female livers and it was inhibited in male microsomes by goat or rabbit serum containing antibodies against CYP2C11 and CYP3A2 but not CYP2B1 or CYP2E1. 4. The unbound fraction of artemisinin in plasma was lower (p 0.001) in plasma obtained from the male (8.8 2.0%) compared with the female rat (11.7 2.2%). 5. The possibility of a marked sex difference, dependent on the route of administration, has to be taken into account in the design and interpretation of toxicological studies of artemisinin in this species.     

Quantitative in vivo and in vitro sex differences in artemisinin metabolism in rat

1. The pharmacokinetics of the antimalarial compound artemisinin were compared in the male and female Sprague-Dawley rat after single dose i.v. (20 mg x kg(-1)) or i.p. (50 mg x kg(-1)) administration of an emulsion formulation. 2. Plasma clearance of artemisinin was 12.0 (95% confidence interval: 10.4, 13.0) 1 x h(-1) x kg(-1) in the male rat and 10.6 (95% CI: 7.5, 15.0) 1 x h(-1) x kg(-1) in the female rat suggesting high hepatic extraction in combination with erythrocyte uptake or clearance. Artemisinin half-life was approximately 0.5 h after both routes of administration in both sexes. Values for plasma clearance and half-lives did not statistically differ between the sexes. 3. After i.p. administration artemisinin AUCs were 2-fold higher in the female compared with male rat (p < 0.001). Artemisinin disappearance was 3.9-fold greater in microsomes from male compared with female livers and it was inhibited in male microsomes by goat or rabbit serum containing antibodies against CYP2C11 and CYP3A2 but not CYP2B1 or CYP2E1. 4. The unbound fraction of artemisinin in plasma was lower (p < 0.001) in plasma obtained from the male (8.8 +/- 2.0%) compared with the female rat (11.7 +/- 2.2%). 5. The possibility of a marked sex difference, dependent on the route of administration, has to be taken into account in the design and interpretation of toxicological studies of artemisinin in this species.     

Interindividual variability in metabolic activation in humans in vivo

In assessing interindividual variability in metabolic activation, the toxic metabolite is often too unstable for conventional analysis. Possible alternatives include a stable product of the reactive metabolite e.g. cysteinyl derivatives of N-acetyl-4-benzoquinoneimine, the toxic metabolite of paracetamol, adducts with DNA or protein, and indirect measurement of the activity of the enzyme(s) producing the active metabolite. An example of the last approach is the use of furafylline, a highly specific inhibitor of human CYP1A2, to determine the extent of the metabolic activation of the cooked food mutagens PhIP and MeIQx. The extent of inhibition, determined from levels of unchanged amine in urine, is an indirect measure of the activity of the activation pathway. Further refinement of this approach, allied to improved measures of the biological process of interest should prove of value in evaluating interindividual variability and its role in the risk assessment process.     

Theophylline kinetics in peripheral tissues in vivo in humans

Several biochemical and cellular effects have been described for methylxanthines under in vitro conditions. However, it is unknown, whether threshold concentrations required to exert these effects are attained in target tissues in vivo. We therefore employed the microdialysis technique for measuring theophylline concentrations in peripheral tissues under in vivo conditions.Following in vitro and in vivo calibration, microdialysis probes were inserted into the medial vastus muscle and into the periumbilical subcutaneous adipose layer of healthy volunteers. Following single oral dose administration of 300 mg or i.v. infusion of 240 mg theophylline, in vivo time courses of theophylline concentrations were monitored in tissues and plasma. Major pharmacokinetic parameters (c_max, t_max, AUC) were calculated for plasma and tissue time courses. The mean AUC_tissue /AUC_plasma-ratio was 0.56 (p.o.) and 0.55 (i.v.) for muscle and 0.55 (p.o.) and 0.72 (i.v.) for subcutaneous adipose tissue.We conclude that microdialysis provides important information on the distribution and the tissue pharmacokinetics of theophylline.Abbreviations FPIA Fluorescence polarisation immuno assay - AUC Area under the curve - t_max Time to peak concentration - c_max Peak concentration     

休克时血中氧自由基的变化

本实验测定10名休克患者血浆和红细胞的丙二醛(MDA)、血浆总抗的氧化活性(AOA)的含量。结果表明:休克病人红细胞膜和血浆 MDA 含量(4.298±0.722;5.348±0.834)与对照组(3.235±0.682;4.356±1.081)比较明显增高(P<0.05);血浆 AOA(39.65±7.858)与对照组(48.21±10.81)比较明显降低(P<0.01)。提示:休克时,患者机体内自由基反应增强是引起组织细胞损伤的原因之一。     

Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis

AIM: To study the potential pathological role of endogenous angiopoietins in daunorubicin-induced progressive glomerulosclerosis in rats. METHODS: Seventy male Wistar rats were allocated randomly into a daunorubicin group (DRB; n=40) or a control group (n=30). The rats in the DRB group were injected with DRB (15 mg/kg), in their tails. Subsequently, at intervals of 1, 2, 4, 6, 8, and 12 weeks, 5 male Wistar rats in each group were chosen randomly for 24 h urinary protein quantitative measurements (24 h UPQM), and determination of plasma tumor necrosis factor alpha (TNF-alpha), angiopoietin-1 (Ang1), and angiopoietin-2 (Ang2) levels. Kidney sections were examined by electron microscopy, Periodic Acid Schiff (PAS) staining, immunohistochemical staining and in situ hybridization histochemistry. RESULTS: As glomerulosclerosis progressed in the DRB group, expression of Ang1 mRNA and protein in glomeruli decreased and expression of TNF-alpha protein, Ang2 mRNA and protein in glomeruli increased. Expression of Ang1 mRNA and protein in glomeruli were negatively correlated with 24 h UPQM, Fn protein expression, and mean area of extracellular matrix (MAECM). In comparison, expression of Ang2 mRNA and protein in glomeruli were positively correlated with 24 h UPQM, Fn protein expression and MAECM; furthermore, there was a positive correlation between plasma Ang2 and 24 h UPQM. Plasma TNF-alpha and expression of TNF-alpha in glomeruli were positively correlated with expression of Ang2 mRNA and protein in glomeruli. There was a negative correlation between Ang1 protein expression and Ang2 protein expression in glomeruli. CONCLUSION: During DRB-induced glomerulosclerosis, podocyte injury led to a shift in the balance of Ang1 and Ang2 in glomeruli. Increased TNF-alpha in plasma and glomeruli may upregulate Ang2 expression in glomeruli. Elevated Ang2 in both plasma and glomeruli may mediate protein permeability through the glomerular filtration barrier. Moreover, local expression of Ang2 may facilitate the progress of glomerulosclerosis by upregulating a component expression of extracellular matrix.     

Trichinellosis in immigrants in Switzerland

We describe a case of trichinellosis diagnosed at the Division of Infectious Diseases, Hospital of Lugano, in January 2009. This case was associated with a cluster of cases and was traced to the consumption of contaminated meat after a wild boar hunt in Bosnia.