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1.
目的探讨冠心病患者外周血循环内皮祖细胞(EPC)变化及其纤溶、黏附和炎症因子表达。方法选择冠心病患者57例(冠心病组)和对照组30例,提取EPC进行数量和细胞集落的比较。用酶联免疫吸附法和底物发光法检测EPC分泌组织型纤溶酶原激活物(tPA)和纤溶酶原激活物抑制剂(PAI)的浓度和活性。用反转录-聚合酶链反应(RT-PCR)检测EPC的tPA、PAI、血管细胞黏附分子1(VCAM-1)、细胞间黏附分子1(ICAM-1)、过氧化物酶体增殖因子活化受体γ(PPARγ)的mRNA表达水平。结果冠心病组EPC数量较对照组明显减少(P0.05),形成细胞集落数、细胞增殖能力也明显降低(P0.05)。与对照组比较,冠心病组EPC分泌的tPA含量和活性明显下降(P0.05),PAI含量和活性明显升高(P0.01)。RT-PCR检测结果显示,与对照组比较,冠心病组EPC的tPA、PPARγmRNA表达减弱,PAI、VCAM-1、ICAM-1 mRNA表达增强(P0.05)。结论冠心病患者外周血循环EPC数量减少,纤溶功能减低,黏附和炎症因子表达增强,其在冠心病发生发展中起到重要作用。 相似文献
2.
辛伐他汀对冠心病患者血管内皮功能作用的量效关系 总被引:1,自引:0,他引:1
目的探讨不同剂量(5mg,10mg,20mg)的辛伐他汀对冠心病患者血管内皮功能的作用及其量效关系。方法共入选80例冠心病患者,随机分为4组:对照组(不服用辛伐他汀),辛伐他汀5 mg组、辛伐他汀10 mg组、辛伐他汀20 mg组、每组20例,治疗8周。采用超声法检测血流介导的肱动脉内皮依赖性舒张功能(FMD),同时观察血脂水平的变化。结果辛伐他汀治疗8周后,5 mg、10 mg、20 mg呈剂量依赖性显著降低血总胆固醇(分别降低9%,18%,29%)和低密度脂蛋白胆固醇水平(分别降低12%、24%、35%),不同剂量组间P<0.05。对照组治疗8周后血脂水平无明显变化(P>0.05)。5 mg、10 mg、20 mg的辛伐他汀均可显著改善FMD[5mg:(3.41±2.99)%VS(7.46±5.11)%;10mg:(3.76±3.01)%比(7.98±4.92)%;20mg:(3.59±3.47)%比(8.09±6.10)%;P均<0.01]。但三组之间FMD的变化值比较无显著差异(P>0.05),且FMD的改善与血TC、LDL-C水平的降低不相关。对照组FMD虽有轻度增加,但无统计学意义。辛伐他汀治疗后肱动脉内径、肱动脉对硝酸甘油的反应均无显著改变。结论辛伐他汀5 mg、10 mg、20 mg治疗8周后,可显著改善冠心病患者血管内皮功能,但该作用无明显的量效关系,可能独立于调脂作用之外。 相似文献
3.
目的:探讨血浆内皮微粒(EMP)与冠心病的相关性。方法:冠心病组367例,其中稳定型心绞痛(SA)119例,急性冠状动脉综合征(ACS)248例,后者含不稳定型心绞痛(UA)158例,急性心肌梗死(AMI)90例。非冠心病组166例。ELISA法测定血浆ET-1,流式微球技术检测血浆EMP。结果:冠心病组ET-1、EMP水平升高,呈正相关(r=0.233,P=0.001)。ACS组EMP(547.405)显著高于非冠心病组(148.185)及SA组(429.890),亚组分析中UA组EMP(551.660)升高最为显著;冠心病冠状动脉病变支数与EMP无明显相关;AMI患者EMP与BNP、TnT、TnI间无明显相关;EMP与ACS患者短期预后相关(r=0.280,P<0.01)。结论:血浆EMP水平可反映冠心病内皮功能障碍,与冠心病的发生、冠状动脉斑块的不稳定性有关。 相似文献
4.
目的研究冠状动脉粥样硬化性心脏病(冠心病)合并左心功能不全的患者在传统治疗基础上合用心肌代谢调节药物曲美他嗪对心功能的影响。方法84例冠心病心功能不全患者采用预制随机信封法分成两组,对照组按指南予传统的冠心病、心功能不全二级预防:治疗组在传统治疗基础上合用曲美他嗪持续口服。比较两组治疗前后纽约心脏协会心功能分级、二维超声测量的左心室射血分数。结果治疗组与对照组3个月时和6个月时纽约心脏协会心功能分级改善/不变/恶化百分构成比比较,差异无统计学意义(P〉0.05)。左心室射血分数的改善在治疗组显著优于对照组:3个月时两组比较,差异有统计学意义(4.2%±2.2%/)vs.1.9%±0.9%,P〈O.01):6个月时两组比较,差异有统计学意义(7.1%±3.6%vs.3.3%±1.1%,P〈0.01)。两组在3个月时和6个月时血压、心率的下降比例比较,差异无统计学意义(P〉0.05)。结论在传统二级预防基础上合用曲美他嗪可进一步改善冠心病合并左心功能不全的患者心功能。 相似文献
5.
OBJECTIVE: To determine the effect of postprandial lipid changes on endothelial function in patients with coronary artery disease (CAD) after a high-fat meal. METHODS: We studied 50 CAD patients and 25 control participants, who were all normocholesterolemic. Flow-mediated vasodilatation of the brachial artery was evaluated by the high-resolution ultrasound technique before and after a single high-fat meal (800 calories; 50 g fat). RESULTS: Postprandial serum triglyceride level increased significantly at 2-7 h and mean flow-mediated vasodilatation was impaired significantly (from 4.22 +/- 0.44 to 2.75 +/- 0.33%, P < 0.01) for 75 subjects. The increment in 2 h serum triglyceride level correlated positively with the decrement in postprandial flow-mediated vasodilatation (r = 0.459, P < 0.01). Postprandial triglyceride level was significantly higher in CAD patients than in control participants. Flow-mediated vasodilatation was significantly impaired in CAD patients (from 3.04 +/- 0.39 to 1.69 +/- 0.23%, P < 0.01) and control participants (from 6.58 +/- 0.52 to 4.87 +/- 0.19%, P < 0.05) after a high-fat meal. The impairment of flow-mediated dilatation was more severe in CAD patients (44.41%) than in control participants (25.99%, P < 0.01). CONCLUSION: Postprandial endothelium-dependent vasodilatation after a single high-fat meal was severely impaired in normocholesterolemic CAD patients and control participants. The disordered postprandial metabolism of triglyceride-rich lipoproteins may play an atherogenic role by inducing endothelial dysfunction. 相似文献
6.
Abnormalities of vascular endothelial function may contribute to increased coronary heart disease risk in UK Indian Asians 总被引:8,自引:0,他引:8 下载免费PDF全文
OBJECTIVE: To test the hypothesis that abnormalities of endothelial function are present in Indian Asians and may contribute to their increased coronary heart disease risk. SETTING: Single centre in west London. PATIENTS: 26 Indian Asian and 18 European white healthy male subjects, aged 35 to 61 years recruited from general practice lists. DESIGN: Brachial artery diameter responses to reactive hyperaemia and sublingual glyceryl trinitrate were compared using high resolution ultrasound. RESULTS: Mean (SEM) flow mediated, endothelium dependent dilatation was reduced in Indian Asians compared with European whites, at 3.2 (0.8)% v 5.9 (1.0)%, p = 0.03. In contrast, there were no significant differences in baseline brachial arterial diameter (4.6 (0.1) v 4.6 (0.1) mm, p = 0.65) or glyceryl trinitrate induced dilatation (18.8 (1.5)% v 18.5 (1.7)%, p = 0.90) between Indian Asians and European whites, respectively. Univariate analysis showed that Indian Asian race was significantly associated with impaired flow mediated dilatation (regression coefficient = -2.8 (1.3)%, p = 0.03), and in multivariate analysis, this relation was independent of both conventional coronary heart disease risk factors and markers of insulin resistance. CONCLUSIONS: Endothelial function is impaired in healthy UK Indian Asians compared with European whites, and the defect is not accounted for by major coronary heart disease risk factors. Endothelial function may be modulated by novel risk factors in Indian Asians. 相似文献
7.
伴有糖代谢紊乱冠心病患者的临床特征 总被引:15,自引:0,他引:15
为了解冠心病患者伴有或不伴有糖代谢紊乱时临床特点,为此,回顾分析810例冠心病患者,其中合并糖尿病占17.2%,合并应激性高血糖状态占15.8%。冠心病合并糖尿病患者中伴高血压、脑卒中、高脂血症及阳性家族史率较非糖尿病冠心病患者明显升高,该组患者无胸痛型较多(占49.2%),病情较重,病死率是非糖尿病冠心病者的2.36倍,该组病人中近四分之一的糖尿病诊断于冠心病之后,近四分之一是两者同时诊断,无论二者诊断先后,其冠心病的其它危险因素的伴发率、临床特征及病死率无显著差异。这提示糖尿病与冠心病可能为伴发或并发关系,前者是后者的危险因素之一,糖尿病的早期诊治对冠心病的预后非常重要。合并应激性高血糖状态的患者年龄较大,病情较重,病死率高,需予重视。 相似文献
8.
目的 本实验旨在探讨螺内酯对冠心病患者内皮细胞功能的影响。方法 选择 5 0例冠心病患者作为实验组 ,5 0例健康者作为对照组 ,给药前先测定实验组和对照组的内皮素 (ET)、血栓素 A2 (TXA2 )、一氧化氮 (NO)、前列环素 (PGI2 ) ,再予以实验组螺内酯 2 0 m g/ d,3个月后再测定实验组的 ET、TXA2 、NO、PGI2 并进行比较。结果 给药前实验组的 ET、TXA2 水平较对照组高 ,NO、PGI2 水平较对照组低 ;给药后 NO、PGI2 水平较给药前高 ,ET、TXA2 较给药前低。结论 螺内酯可以有效地改善血管内皮细胞功能 ,对逆转冠心病患者内皮细胞功能紊乱起着重要的作用。 相似文献
9.
目的研究经皮冠状动脉介入治疗(PCI)对冠心病合并左心收缩功能不全患者心功能的影响。方法选取118例冠心病合并不同程度左心收缩功能不全患者为研究对象,行PCI治疗,采用超声心动图检测每搏输出量(SV)、每分钟排血量(CO)、左室射血分数(LVEF)、左室短轴缩短率(FS),对比PCI术前后左心功能的改变。并以该类患者单纯药物治疗48例作为对照组,对比治疗后6个月两组患者心功能改善情况。结果两组患者治疗6月后,SV、CO、LVEF、FS均明显改善。PCI组患者心功能改善优于药物治疗组。结论PCI治疗可明显改善冠心病合并左心收缩功能不全患者的心功能。 相似文献
10.
目的:探讨冠心病合并糖尿病患者血清高敏C反应蛋白(hs-CRP)水平与冠脉病变程度的相关性。方法:选取130例住院的冠心病患者分为两组:冠心病合并糖尿病组患者61例,单纯冠心病组患者69例。所有患者应用免疫比浊法测定hs-CRP、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)浓度,行冠状动脉造影检查,以Gensini冠状动脉积分评价冠状动脉病变程度。结果:冠心病合并糖尿病组患者的血清hs-CRP、FPG水平和Gensini冠状动脉积分均高于单纯冠心病组患者(P<0.05),采用多元线性回归分析表明,冠心病合并糖尿病组患者血清hs-CRP水平升高与Gensini冠状动脉积分呈正相关(t=2.22,P<0.05)。结论:血清hs-CRP水平升高与冠心病合并糖尿病患者冠脉病变严重程度相关。 相似文献
11.
血尿酸水平与冠心病心功能不全关系的研究 总被引:1,自引:0,他引:1
目的 检测冠心病心功能不全患者的血尿酸水平,研究二者在疾病发生发展过程中的关系.方法 将冠心病患者分为两组:心功能正常组215例,心功能不全组131例,心功能不全组按纽约心脏病学会NYHA分Ⅱ~Ⅳ级.应用尿酸氧化酶法测定空腹血尿酸浓度,并通过统计学方法分析患者心功能程度与血尿酸浓度的关系.结果 ①心功能不全组血尿酸浓度为(410.87±108.30)μmol/L,高尿酸血症发生率为46.15%;心功能正常组血尿酸浓度为(331.82±90.06)μmol/L,高尿酸血症发生率为15.20%,两组比较P<0.01.②心功能不全Ⅱ级组血尿酸浓度为(376.47±105.07)μmol/L,高尿酸血症发生率为25.00%;心功能不全Ⅲ级组血尿酸浓度为(396.52±104.89)μmol/L,高尿酸血症发生率为34.21%;心功能不全Ⅳ级组血尿酸浓度为(436.13±107.22)μmol/l,高尿酸血症发生率为63.64%.结论 冠心病心功能不全者血尿酸水平升高,随着心功能的下降血尿酸水平升高,高尿酸血症发生率增加,血尿酸浓度高低与心功能不全严重程度呈正相关. 相似文献
12.
目的:探讨冠心病患者血浆脂肪细胞因子Chemerin的变化及其影响因素。方法:选择对照组21例,冠心病组57例。空腹抽血,测定血浆脂肪细胞因子Chemerin水平及空腹血糖、血脂、肌酐、高敏C反应蛋白等生化指标。结果:冠心病组血浆Chemerin明显高于对照组[(225.25±23.74)pg/L∶(205.13±11.02)pg/L,P<0.05]。Chemerin与冠状动脉病变支数呈正相关,r=0.368,P<0.05;与入院时心率、白细胞总数、中性粒细胞、高敏C反应蛋白、纤维蛋白原、空腹血糖、肌酐呈显著正相关,r值分别为0.595、0.596、0.609、0.442、0.485、0.546、0.669,P<0.05;与入院时收缩压水平呈负相关,r=-0.419,P<0.05。结论:冠心病患者血浆脂肪细胞因子Chemerin显著升高,且与冠状动脉病变支数、心率、血压、白细胞、中性粒细胞、高敏C反应蛋白、纤维蛋白原、空腹血糖和肌酐水平等密切相关。 相似文献
13.
目的观察冠心病患者外周血内皮祖细胞(EPCs)数量及生物学功能的变化,进一步探讨肝细胞生长因子(HGF)对其影响,为临床应用HGF提供理论依据。方法收集50例非冠心病患者(对照组)、50例冠心病患者(冠心病组;每例分为HGF干预组和非HGF干预组)外周血,应用流式细胞仪和ELISA法分别检测各组CD133+/CD34+细胞的数量和HGF水平;采用密度梯度离心法分离培养各组外周血中EPCs,通过MTT法、Transwell迁移试验、黏附能力测定试验及PI—AnnexinV双重染色法来分别检测EPCs的增殖、迁移、黏附能力和凋亡水平。结果与对照组比较,冠心病组外周血中CD133+/CD34+细胞数量减少[(2.15±0.69)%1)S(5.26±1.16)%,P〈0.011,血浆中HGF浓度升高[(6.80±1.22)w(2.62±0.83)gg/L,P〈0.01],EPCs增殖、迁移、黏附等生物学功能减弱(P〈0.05);HGF干预组EPCs增殖、迁移、黏附等生物学功能显著改善(P〈0.05)。各组细胞凋亡水平差异无统计学意义(P〉0.05)。结论外周血中CD133+/CD34+细胞数量和血浆中HGF水平的变化可能成为冠心病患者新的危险评估因素。 相似文献
14.
BACKGROUND: Endothelial dysfunction is present in patients with coronary artery disease (CAD) or with congestive heart failure. HYPOTHESIS: This study was performed to evaluate the impact of systolic heart function on endothelial function in patients with CAD. METHODS: The study population consisted of 283 consecutive patients (mean age 59 years, 176 men) undergoing coronary angiography. Endothelial function was assessed by measuring flow-mediated vasodilation (FMD) of the brachial artery. RESULTS: Patients (n = 236) with an ejection fraction (EF) > or = 55% on routine echocardiogram were younger (mean age 58 vs. 62 years), showed a lower prevalence of diabetes (15 vs. 38%) and myocardial infarction (13 vs. 66%), and showed a higher FMD (4.8 +/- 2.4 vs. 4.0 +/- 2.0%, p < 0.05) than patients (n = 47) with an EF < 55%. The correlation coefficient between FMD/endothelial function and EF/systolic heart function was 0.149 (p < 0.02) in the overall study population. Multivariate analysis showed that of age, gender, frequency of diabetes mellitus, myocardial infarction, and CAD extent, EF was the only significant independent parameter correlating with FMD in patients with CAD. CONCLUSIONS: Compared with the other tested risk factors, EF surprisingly was the only significant independent parameter correlating with endothelial function in patients with CAD. Our results support the view that endothelial function is an independent prognostic factor in patients with CAD. 相似文献
15.
目的研究国人血清对氧磷酶1(PON1)基因192位Gln/Arg多态性对冠心病患者血管内皮功能的影响。方法应用聚合酶链式反应-限制性片断长度多态性(PCR-RFLP)方法,对石家庄地区汉族151例冠心病患者及91例正常对照者PON1基因192位Gln/Arg多态性进行分析,同时应用超声检测肱动脉内皮功能。结果冠心病组及正常对照组PON1基因均以QR基因型为主,其频率分别为48%和54%。冠心病组RR型基因频率高于对照组(P<0.05)。平衡法计算等位基因的频率,R等位基因在冠心病组明显增高(65%vs39%,P<0.05)。冠心病组PON1各基因型内皮依赖性舒张功能均低于对照组(P<0.05),以RR基因型最为明显,其次为QR基因性;而两组非内皮依赖性舒张功能差异无显著性。结论PON1基因192位Gln/Arg多态性可能与冠心病患者血管内皮功能异常有关。R等位基因可能为血管内皮功能受损的相对危险因素,且参与冠心病的发病。 相似文献
16.
CLINICAL PROBLEM: To examine the evidence supporting the recent National Cholesterol Education Program (NCEP) recommendation that low to moderate
levels of cholesterol should be aggressively managed in patients with coronary heart disease (CHD).
METHODS: Cohort studies and clinical trials with angiographic or clinical endpoints, that included CHD patients with low to moderate
levels of cholesterol, were systematically identified through a MEDLINE search and critically reviewed.
SYNOPSIS: None of the cohort studies show that a moderate level of cholesterol confers significantly increased risk of CHD death, although
a pooled relative risk of 1.14 (95% CI 1.08 to 1.4) suggests that there may be a slight excess risk. Of five angiographic
trials of CHD patients with moderate levels of cholesterol, two demonstrated no improvement in angiographic endpoints with
intensive lipid-lowering therapy and the other three are difficult to interpret since they included other interventions in
addition to the cholesterol-lowering regimen. No large clinical trial with clinical endpoints has been reported for CHD patients
with low to moderate levels of cholesterol.
RECOMMENDATIONS: The recommendation to treat CHD patients who have low to moderate levels of cholesterol with diet or drugs is not based on
convincing evidence of efficacy. This is in clear contrast to the recommendation for CHD patients with high levels of cholesterol,
for whom there is definitive clinical trial evidence of benefit from cholesterol-lowering therapy. While we await clinical
trial results for CHD patients with low to moderate levels of cholesterol, clinicians and patients must consider the possible
disadvantages of therapy in relation to the uncertain benefit.
Received from the Section of General Internal Medicine, Department of Medicine, Veterans Affairs Medical Center, and the University
of Minnesota School of Medicine, Minneapolis, Minnesota. 相似文献
17.
维生素C对高脂餐后内皮依赖性血管舒张功能的保护作用 总被引:7,自引:0,他引:7
目的探讨维生素C对高脂餐后内皮依赖性血管舒张功能变化的影响。方法74例冠心病患者被随机分为两组,分别在禁食12h后进食高脂餐与维生素C2g(A组,n=37)或单纯的高脂餐(B组,n=37)。分别采集餐前及餐后2、4、5、7h静脉血标本,用以测定血清甘油三酯(TG)、总胆固醇、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)浓度。采用高分辨血管外超声法检测餐前及餐后4h肱动脉血流介导的内皮依赖性血管舒张功能和硝酸甘油介导的内皮非依赖性血管舒张功能。结果冠心病患者空腹状态的内皮依赖性血管舒张功能显著受损。服用维生素C2g(A组)餐后4h内皮依赖性血管舒张功能较餐前无显著变化[(3.63±0.59)%∶(4.51±0.49)%,P=0.064];未服用维生素C2g(B组)餐后4h内皮依赖性血管舒张功能较餐前相比严重受损[(3.58±0.63)%∶(0.58±0.40)%,P<0.001]。高脂餐后硝酸甘油介导的内皮非依赖性血管舒张功能的变化无统计学意义[A组(19.48±1.38)%∶(20.25±1.21)%,P=0.498;B组(18.71±1.53)%∶(16.36±1.53)%,P=0.135]。两组受试者餐后2~7h血清TG浓度均显著升高。经相关分析结果显示B组受试者的餐后2h血清TG浓度增高值与餐后4h内皮依赖性血管舒张功能下降值显著正相关(r=0.395,P<0.02)。结论高脂餐后内皮依赖性血管舒张功能显著受损,大剂量维生素C对其有保护作用。 相似文献
18.
Willett WC 《Journal of internal medicine》2012,272(1):13-24
The relation of dietary fat to risk of coronary heart disease (CHD) has been studied extensively using many approaches, including controlled feeding studies with surrogate end-points such as plasma lipids, limited randomized trials and large cohort studies. All lines of evidence indicate that specific dietary fatty acids play important roles in the cause and the prevention of CHD, but total fat as a percent of energy is unimportant. Trans fatty acids from partially hydrogenated vegetable oils have clear adverse effects and should be eliminated. Modest reductions in CHD rates by further decreases in saturated fat are possible if saturated fat is replaced by a combination of poly- and mono-unsaturated fat, and the benefits of polyunsaturated fat appear strongest. However, little or no benefit is likely if saturated fat is replaced by carbohydrate, but this will in part depend on the form of carbohydrate. Because both N-6 and N-3 polyunsaturated fatty acids are essential and reduce risk of heart disease, the ratio of N-6 to N-3 is not useful and can be misleading. In practice, reducing red meat and dairy products in a food supply and increasing intakes of nuts, fish, soy products and nonhydrogenated vegetable oils will improve the mix of fatty acids and have a markedly beneficial effect on rates of CHD. 相似文献
19.
目的通过研究冠状动脉粥样硬化性心脏病(冠心病)患者颈动脉内-中膜厚度(intima-media thickness,IMT)在经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗前后的变化,探讨其与冠心病的关系及在冠心病诊断与治疗中的临床应用价值。方法连续选择2005年10月至2007年08月在广西医科大学附属玉林市第一人民医院心内科住院,行冠状动脉造影和PCI治疗的冠心病患者57例为研究对象。检测入选患者治疗前和随访6个月后的IMT、血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇浓度等指标。结果 (1)IMT从术前(1.13±0.27)mm降至术后的(1.04±0.21)mm,差异有统计学意义(P〈0.01);其阳性率(≥1.00 mm)从术前73.68%(42/57)降至术后54.39%(31/57),差异有统计学意义(P〈0.05)。(2)术前血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇浓度分别为(5.43±1.29)mmol/L、(1.93±1.01)mmol/L、(3.75±1.20)mmol/L、(1.03±0.35)mmol/L,术后则分别为(5.08±0.67)mmol/L、(1.80±0.79)mmol/L、(3.36±0.58)mmol/L、(1.08±0.29)mmol/L;术前、术后比较均差异有统计学意义(P〈0.01)。结论经PCI治疗联合应用调脂药物能有效改善IMT和控制血脂,改善动脉硬化及冠心病病情,提示IMT对冠心病发生及其严重程度有一定预测的价值。 相似文献
20.
目的 应用四维应变成像 (4D-SI) 技术评价冠心病患者PCI术前后左室舒张功能。方法 根据疑似冠心病患者行冠脉造影术及左心导管检查结果,选取44例患者分为病例组:冠心病并左室舒张功能不全患者(需行PCI术)26例;对照组:冠心病并左室舒张功能正常18例。分别采集对照组及病例组PCI术前、术后3个月的常规超声心动图检测指标,测量左室舒张末期容积 (LVEDV) 、左室收缩末期容积 (LVESV) 、左室射血分数 (LVEF) ;运用 4D-SI 技术测得收缩末期纵向应变(GLS)、径向应变(GRS)、面积应变(GAS)、圆周应变(GCS)、纵向应变显像舒张指数(LSI-DI)、面积SI-DI (ASI-DI)、 径向SI-DI(RSI-DI)、圆周SI-DI(CSI-DI)。 结果 1.病例组GLS、GCS、GAS、GRS、LSI-DI、CSI-DI、ASI-DI、RSI-DI均小于对照组(P<0.05);病例组术后3月各参数均大于病例组术前(P<0.05);2. ROC 曲线分析结果显示LSI-DI的曲线下面积(AUC)0.921,截值为50.107%,灵敏度和特异性分别为89.2%、81.3%;ASI-DI的AUC 0.887,截值为49.233%,灵敏度和特异性分别为86.4%、79.1%。 结论 PCI术可有效改善冠心病患者左心室舒张功能,4D-SI的相关指标在一定程度上可评价冠心病患者左室舒张功能受损及PCI术后左室舒张功能的改善情况。 相似文献