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Assessment of the corpus callosum at 20-24 weeks' gestation by three-dimensional ultrasound examination. 总被引:1,自引:0,他引:1
W Plasencia T Dagklis M Borenstein B Csapo K H Nicolaides 《Ultrasound in obstetrics & gynecology》2007,30(2):169-172
OBJECTIVES: To determine the range of positions of the fetal head in which a three-dimensional (3D) volume is acquired for subsequent successful imaging of the corpus callosum. METHODS: We used 3D volumes of the fetal head obtained from singleton pregnancies at 20 to 23 + 6 weeks' gestation. The volumes, which had been acquired with the head in different positions, were then reconstructed with the objective of obtaining a mid-sagittal section of the brain to demonstrate the presence of the corpus callosum. RESULTS: In the reconstructed mid-sagittal sections it was possible to demonstrate the corpus callosum in at least 90% of cases when the 3D volume acquisition plane was (1) mid-sagittal with the angle between the transducer and the direction of the fetal nose ranging from 0 degrees to 179 degrees and from 330 degrees to 359 degrees , (2) oblique around the crown-rump axis with an angle from the mid-sagittal plane of less than 30 degrees , (3) oblique around the anteroposterior axis from the axial plane at the level of the biparietal diameter to the mid-sagittal plane or (4) axial at the level of the biparietal diameter with an angle between the transducer and the midline echo of the brain of 60-119 degrees . In the mid-sagittal sections either the translucent corpus callosum or a comma-shaped echogenic structure was seen depending on whether the plane of volume acquisition was sagittal or axial. CONCLUSIONS: In 3D ultrasound examination the extent to which the corpus callosum can be demonstrated to be present is entirely dependent on the plane of volume acquisition. 相似文献
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C F A Peralta P Cavoretto B Csapo H Vandecruys K H Nicolaides 《Ultrasound in obstetrics & gynecology》2005,26(7):718-724
OBJECTIVE: To establish reference intervals with gestation for the right and left lung areas and lung area to head circumference ratio (LHR). METHODS: This was a cross-sectional study of 650 normal singleton pregnancies at 12-32 weeks of gestation. We measured the left and right lung areas on the cross-sectional plane of the thorax, used for examination of the four-chamber view of the heart, by three different techniques: firstly, manual tracing of the limits of the lungs; secondly, multiplication of the longest diameter of the lung by its longest perpendicular diameter; thirdly, multiplication of the anteroposterior diameter of the lung at the mid-clavicular line by the perpendicular diameter at the midpoint of the anteroposterior diameter. RESULTS: The respective mean left and right lung areas (manual tracing) increased with gestational age, from 36 and 58 mm(2) at 12 weeks to 220 and 325 mm(2) at 20 weeks and 594 and 885 mm(2) at 32 weeks. This 16-fold increase in lung area was accompanied by a four-fold increase in head circumference. Consequently, the left and right LHR increased with gestational age. The most reproducible way of measuring the lung area was by manual tracing of the limits of the lungs and the least reproducible was by multiplying the longest diameter of the lungs by their longest perpendicular diameter. Furthermore, the method employing the longest diameter, compared with the tracing method, overestimated both the left and the right lung areas by about 45% and the method employing the anteroposterior diameter overestimated the area of the right lung by about 35%, but not that of the left lung. CONCLUSIONS: In the antenatal prediction of pulmonary hypoplasia by the assessment of lung area it is important to take gestational age into account. Dividing the lung area by the head circumference does not correct for the gestation-related increase in lung area. Reproducible measurement of the lung area is provided by manual tracing of the limits of the lungs, rather than by multiplication of lung diameters. 相似文献
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Doppler assessment of cardiac function at 11-14 weeks' gestation in fetuses with normal and increased nuchal translucency. 总被引:1,自引:0,他引:1
OBJECTIVE: To investigate cardiac dysfunction as a potential underlying mechanism for increased nuchal translucency (NT) in fetuses with chromosomal abnormality or heart defects. METHODS: Myocardial performance index (MPI) and atrioventricular valve E/A ratios for both sides of the heart were measured by Doppler echocardiography in fetuses at 11-14 weeks' gestation. The study groups consisted of 159 normal control fetuses, 199 otherwise normal fetuses but with increased NT > or = 4 mm, 142 fetuses with trisomy 21, 58 with trisomy 18, 19 with trisomy 13, 37 with Turner's syndrome and 24 with isolated heart defects. Groups were compared using Student's t-test and confidence intervals for differences between groups were calculated. RESULTS: Otherwise normal fetuses with increased NT showed no difference in any of the cardiac Doppler parameters from normal controls. Mean E/A ratio was slightly but significantly increased in trisomy 21 fetuses compared with normal controls (0.604 vs. 0.578 on the right, P = 0.011; 0.581 vs. 0.542 on the left, P = 0.0001). E/A ratio was not significantly different between any of the other groups and the normals but there was a small increase in absolute E-wave velocity in trisomy 18 fetuses. MPI was significantly decreased in trisomy 21 fetuses, (0.330 vs. 0.378, P = 0.002 on the left) and also in Turner's syndrome fetuses (0.301 vs. 0.352 on the right, P = 0.04; 0.320 vs. 0.378 on the left, P = 0.034) implying better performance, but not in the other groups. CONCLUSIONS: The magnitude and/or direction of the differences shown do not support a major role for cardiac functional abnormality in the development of NT. Important cardiac dysfunction could not be demonstrated in association with increased NT in normal or abnormal fetuses. 相似文献
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OBJECTIVE: To determine if the lateral ventricular atrial diameter differs between male and female fetuses at 20-24 weeks' gestation. DESIGN: Prospective study. METHODS: The transverse diameter of the ventricular atrium was measured from inner wall to inner wall for a total of 202 pregnant women with 105 male fetuses and 97 female fetuses. RESULTS: The mean diameter of the ventricular atrium for the 202 fetuses was 4.96 +/- 0.96 mm (range, 2.1-8.4 mm). The 105 males had a mean diameter of 4.95 +/- 0.98 mm and the 97 females a mean diameter of 4.97 +/- 0.94 mm. There was no statistical difference between the sexes. CONCLUSIONS: In our population, there was no difference between ventricular atrial diameter in male and female fetuses at 20-24 weeks' gestation. 相似文献
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L Rovas P Sladkevicius E Strobel L Valentin 《Ultrasound in obstetrics & gynecology》2006,27(4):392-402
OBJECTIVES: To create reference values representative of normal findings on two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVS) examination of the cervix from 17 to 41 weeks' gestation and to determine the agreement between cervical measurements taken by 2D and 3D TVS. METHODS: Cross-sectional study covering 17 to 41 weeks in 419 nulliparous and 360 parous women who delivered at term and who underwent 2D and 3D TVS examination of the uterine cervix. We examined approximately 25 women in each gestational week. The length, anteroposterior (AP) diameter and width of the cervix (and of any cervical funnel) and AP diameter of the cervical canal were measured. Results were plotted against gestational age. The agreement between 2D and 3D ultrasound results was expressed as the mean (+/- 2 SDs) difference between the results of the two methods and as the interclass correlation coefficient (inter-CC). RESULTS: There was excellent agreement between measurements taken by 2D and 3D ultrasound (inter-CC values, 0.80-0.98) but measurements of cervical length taken using 3D ultrasound were greater than measurements taken by 2D ultrasound (mean difference, -0.04 +/- 0.36 cm). Cervical length did not change substantially between 17 and 32 gestational weeks but decreased progressively thereafter. Cervical length was similar in nulliparous and parous women at 17-32 weeks, but from 33 weeks the cervix tended to be longer in parous women. In nulliparae, cervical length decreased from a median of 3.8 (range, 0.7-6.1) cm at 17-32 weeks to 2.3 (range, 0.4-6.0) cm at 33-40 weeks and to 0.7 (range, 0.2-1.5) cm at 41 weeks. In parous women, the corresponding figures were 3.9 (range, 1.0-6.1) cm, 3.0 (range, 0.4-5.7) cm and 0.8 (range, 0.4-3.4) cm (results obtained by 3D ultrasound). Cervical AP diameter and width did not differ between nulliparous and parous women. Median AP diameter increased from 3.0 (range, 2.0-4.6) cm at 17-30 weeks to 3.5 (range, 1.8-5.5) cm at 31-40 weeks and to 4.0 (range, 2.8-5.9) cm at 41 weeks. Cervical width was 3.7 (range, 2.3-6.0) cm at 17-30 weeks and 4.5 (range, 2.3-6.1) cm at 31-41 weeks. The percentage of women with funneling increased from 4% (3/84) at 17-18 weeks to 63% (12/19) at 41 weeks and the percentage of women with an open cervical canal increased from 19% (15/84) to 72% (13/19). Funneling and opening of the cervical canal were equally common in nulliparous and parous women. CONCLUSIONS: Reference data provide the basis for studies of pathological conditions. Common reference values for nulliparous and parous women can be used for cervical AP diameter and width from 17 to 41 weeks and for cervical length from 17 to 32 weeks. Separate reference values for cervical length for nulliparous and parous women should be used from 33 to 41 weeks. 相似文献
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Fetal biometry at 14-40 weeks' gestation. 总被引:2,自引:0,他引:2
Normal ranges for a wide variety of biometrical parameters were established from cross-sectional data on 1040 normal singleton pregnancies resulting in livebirth at term of normal, and appropriately grown infants. Patients were selected so that the birth weight distribution was similar to that reported by Yudkin and colleagues' and the ranges can, therefore, be used for any population that has a similar birth weight distribution. 相似文献
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Intraabdominal extrapulmonary sequestration is seen very rarely. When a left suprarenal mass is detected in prenatal sonography, vascularization of the lesion should be evaluated with color Doppler sonography. We present a case of intraabdominal extrapulmonary sequestration that was diagnosed by color Doppler ultrasound at 22 weeks' gestation. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2013 相似文献
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J M Martínez M Echevarría O Gómez M Del Río A Borrell B Puerto A Fortuny 《Ultrasound in obstetrics & gynecology》2003,22(5):464-469
OBJECTIVE: The aim of our study was to obtain measurements of the jugular vein and carotid artery pulsatility index (PI) at 10-14 weeks' gestation in chromosomally normal and abnormal fetuses with or without increased nuchal translucency (NT), in order to explore whether a relationship exists between increased NT and overperfusion of the head. METHODS: This was a prospective study involving 179 pregnant women at high risk for chromosomal anomalies or structural malformations who were referred for chorionic villus sampling or first-trimester ultrasound examination at 10-14 weeks' gestation, respectively. Color and pulsed Doppler ultrasound were used to obtain jugular vein and carotid artery blood flow velocity waveforms at the level of the mid-neck. All Doppler measurements were obtained by a single investigator. The PIs of the jugular vein and carotid artery were correlated with NT measurement and fetal karyotype. RESULTS: Doppler measurements of the jugular vein and carotid artery were successfully obtained in 90.5% of the fetuses. The fetal karyotype was abnormal in 13 cases, including three trisomies 21 and two trisomies 18, and normal in 149 cases. In the group with normal karyotype the NT was above the 95th percentile in 22 cases (15%). No correlation between the jugular vein or the carotid artery PI and the thickness of the NT was found. There were no significant differences when comparing the values of the jugular vein and carotid artery PI between the group with normal NT and the group with increased NT, or between the group with a normal karyotype and an abnormal karyotype. CONCLUSION: Our results suggest that NT is not related to blood flow impedance in either the carotid artery or the jugular vein. Overperfusion and venous congestion of the head do not appear to be a causative pathophysiological mechanism involved in increased NT. 相似文献
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L Pasquini R C Wimalasundera A Fichera O Barigye L Chappell N M Fisk 《Ultrasound in obstetrics & gynecology》2006,28(5):681-687
OBJECTIVES: Increased perinatal mortality in monoamniotic twin pregnancies is attributed to cord accidents in utero and at delivery. We evaluated the following parameters in monoamniotic pregnancies: (1) the incidence of cord entanglement; (2) the effect of sulindac on amniotic fluid volume and stability of fetal lie; and (3) the perinatal outcome with our current management paradigm. METHODS: This is a retrospective review of monoamniotic pregnancies of >or=20 weeks' gestation managed with serial ultrasound surveillance, medical amnioreduction and elective Cesarean delivery at 32 weeks' gestation. Mean amniotic fluid index (AFI) and change in AFI in monoamniotic pregnancies managed with oral sulindac was compared with 40 gestation-matched monochorionic-diamniotic controls. RESULTS: Among 44 monoamniotic pregnancies, 20 with two live structurally normal twins at 20 weeks' gestation satisfied the inclusion criteria. All fetuses survived to 28 days postnatally despite early prenatal cord entanglement in all but one case. Whereas AFI remained stable throughout gestation in the controls, the AFI fell in those patients on sulindac from a mean value of 21.0 cm (95% CI, 18.5-23.6 cm) at 20 weeks to a mean of 12.4 cm (95% CI, 10.1-14.6 cm) at 32 weeks (ANOVA P across gestation = 0.001) but mainly remained within normal limits. Fetal lie was stabilized in 11/20 cases in the monoamniotic group compared with 13/40 in the control group (P < 0.0001). CONCLUSIONS: Cord entanglement appears unpreventable, as it typically occurs in early pregnancy. Sulindac therapy reduces AFI, leads to more stable fetal lie, and may prevent intrauterine death by diminishing the risk of constricting cords that are already entangled. Perinatal survival in monoamniotic pregnancies managed by a regime of sulindac from 20 weeks' gestation, close ultrasound surveillance and elective abdominal delivery at 32 weeks' gestation seems empirically higher than that in the literature. 相似文献
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OBJECTIVE: Fetuses affected by homozygous alpha-thalassemia-1 are anemic in the first trimester. We studied their nuchal translucency (NT) measurements at 12-13 weeks of gestation. METHODS: Nuchal translucency was measured prospectively in fetuses at risk of homozygous alpha-thalassemia-1. Measurements of those fetuses subsequently confirmed to be affected by homozygous alpha-thalassemia-1 but with a normal karyotype were compared to those of 440 controls. The controls were from the general obstetric population who had NT measurements at 12 or 13 weeks with known normal outcome. All the NT measurements were expressed as multiples of the median (MoM) for the gestational day. RESULTS: Between 1996 and 1998, 94 at-risk pregnancies were studied. Of these, 32 were subsequently confirmed to be affected by homozygous alpha-thalassemia-1. Chromosome study was not carried out in three cases and these were excluded from the analysis. Nuchal translucency MoMs for cases and controls were found to fit a log Gaussian distribution. The log means (standard deviation) for case and control NT MoM were 0.075 (0.156) and -0.0019 (0.091), respectively. The median NT MoM (95% CI) for cases was 1.19 (1.08-1.62) and was significantly higher than that of the controls (p < 0.001). However, there was extensive overlap of NT between cases and controls. CONCLUSION: Overall, there was a 19% increase in NT MoM in fetuses affected by homozygous alpha-thalassemia-1. This represents a difference of only 0.3-0.4 mm, which is clinically insignificant. This finding indirectly suggests that the increased NT in trisomic fetuses cannot be explained by fetal anemia. Conversely, the presence of increased NT in a fetus at risk of homozygous alpha-thalassemia-1 should alert one to the possibility of chromosomal abnormality rather than being attributed to fetal anemia. 相似文献
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M H B Carvalho R E Bittar M L Brizot P P S Maganha E S V Borges da Fonseca M Zugaib 《Ultrasound in obstetrics & gynecology》2003,21(2):135-139
OBJECTIVE: To compare cervical length measurements obtained at 11 to 14 weeks and 22 to 24 weeks of gestation in an unselected group of pregnant women and to correlate the measurements with time of delivery. METHODS: This was a prospective study involving 529 pregnant women attending for routine antenatal care who underwent transvaginal scans at 11-14 weeks and 22-24 weeks for evaluation of cervical length. The mean cervical length was calculated at both stages of gestation and lengths were compared between groups which delivered at term or prematurely, this being defined as delivery before 37 completed weeks of gestation. RESULTS: The mean cervical lengths at 11-14 and 22-24 weeks were, respectively, 42.4 mm and 38.6 mm. Cervical length at 11-14 weeks was not significantly different between the groups which delivered at term (42.7 mm) and preterm (40.6 mm). However, at the 22-24-week evaluation, cervical length was significantly shorter in the group which had a preterm delivery than in that which had a term delivery (26.7 mm and 39.3 mm, respectively; P = 0.0001). In the group of women with a previous history of one or more preterm deliveries, there was a greater shortening in cervical length from the first to the second evaluation than there was in the group of women with no previous history of preterm delivery. This shortening was also more pronounced in the group which delivered prematurely (from 40.6 mm to 26.7 mm) than in that which delivered at term (from 42.7 mm to 39.3 mm). CONCLUSION: There is a spontaneous shortening in the pregnant cervix from the first to the second trimester of pregnancy. The shortening is more rapid in pregnant women who deliver prematurely and who have a history of previous preterm delivery. 相似文献
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多普勒超声观察正常11~14周胎儿心脏大血管的研究 总被引:2,自引:1,他引:1
目的 应用多普勒技术观察妊娠11+0~14+6周正常胎儿心脏大血管的血流动力学参数.方法 对230位正常妊娠孕妇在11+0~14+6周进行常规超声检查,同时观察胎儿心脏大血管.结果 主动脉血流速度高于主肺动脉和动脉导管,与孕周之间呈正相关,大动脉的射血时间与孕周之间呈正相关,而射血加速时间与孕周之间呈负相关;妊娠11~14周胎儿静脉导管显示率相对较低,而静脉导管的血流速度、搏动指数、阻力指数与孕周之间无相关性;至妊娠13周以后主动脉、主肺动脉、动脉导管的流速、射血时间和射血加速时间以及静脉导管的血流参数相对恒定.结论 妊娠13周以后可进行胎儿早期超声心动图检查,但胎儿心脏大血管的观察难度较大.胎儿心脏大血管的血流动力学表现可直接反映大血管本身状况,也可间接反应心脏的功能.当胎儿心脏结构或功能发生异常时,有可能引起大血管血流动力学的改变. 相似文献
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Rodrigo Ruano Mariane de Fátima Yukie Maeda Juliana Ikeda Niigaki Marcelo Zugaib 《Journal of ultrasound in medicine》2007,26(3):309-316
OBJECTIVE: The purpose of this study was to construct nomograms for diameters of the fetal main pulmonary artery (MPA), right pulmonary artery (RPA), and left pulmonary artery (LPA) according to gestational age (GA) and estimated fetal weight (EFW). METHODS: Between May 2005 and February 2006, MPA and branch artery diameters were prospectively estimated with ultrasonography in 220 healthy fetuses from 19 to 40 weeks' gestation and correlated with GA and EFW. RESULTS: Mean MPA, RPA, and LPA diameters ranged from 2.93, 1.71, and 1.66 mm, respectively, at 19 weeks to 9.23, 5.49, and 5.65 mm at 40 weeks. Linear regression yielded the following formulas for the expected diameters according to GA: MPA=-2.77 + 0.30 x GA; RPA=-1.71 + 0.18 x GA; and LPA=-1.95 + 0.19 x GA. The following formulas were obtained by logarithm distribution for the expected diameters according to EFW: MPA=-1.165 + 0.247 x log of estimated fetal weight (lnFW); RPA=-0.651 + 0.141 x lnFW; and LPA=-0.718 + 0.150 x lnFW. CONCLUSIONS: Nomograms of MPA and branch pulmonary artery diameters according to GA and EFW have been described, generating reference values. 相似文献
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Assessment of the fetal nasal bone at 11-14 weeks of gestation by three-dimensional ultrasound. 总被引:1,自引:0,他引:1
G Rembouskos S Cicero D Longo H Vandecruys K H Nicolaides 《Ultrasound in obstetrics & gynecology》2004,23(3):232-236
OBJECTIVE: To evaluate the benefit of three-dimensional (3D) ultrasound in the examination of the fetal nasal bone at 11-14 weeks of gestation. METHOD: We examined the fetal nasal bone in 120 stored volumes acquired transabdominally with a 3D scanner from singleton pregnancies at 11-14 weeks of gestation. The volume acquisition had been performed following conventional ultrasound examination that had demonstrated presence of the fetal nasal bone. The volumes were obtained with two-dimensional (2D) start images in transverse, coronal mid-sagittal, parasagittal and oblique longitudinal sections of the fetal head. RESULTS: In the transverse and coronal sections, a satisfactory image demonstrating presence of the nasal bone was achieved in only three and one, respectively, of the 20 volumes that we obtained. In mid-sagittal sections, the nasal bone was always visible when the angle was within a range of 30-60 degrees, without the need for sectional image analysis. None of the images with an angle >60 degrees or <30 degrees was satisfactory. In the parasagittal sections with the fetal profile at 45 degrees, a good-quality image of the nasal bone was possible in all cases that were examined, irrespective of the distance from the mid-sagittal plane. In the oblique longitudinal sections with the fetal profile at 45 degrees, there were 10 volumes where the 2D start section was at 0-25 degrees from the midline and in all these cases the nasal bone was successfully visualized. In contrast, only 5/20 cases where the 2D start section was at 25-90 degrees from the midline provided a satisfactory image demonstrating the nasal bone. In 5/10 volumes obtained with the fetus facing downwards the nasal bone was visible in both the 2D and 3D images. CONCLUSION: In a 3D volume the extent to which the nasal bone can be demonstrated to be present in a given reconstructed section is entirely dependent on obtaining a good initial 2D view. 相似文献