肥大性瘢痕与瘢痕疙瘩

本文通过对肥大性瘢痕和瘢痕疙瘩的病因学、临床表现、病理学、治疗方法及预防进行介绍，以达到对肥大性瘢痕和瘢痕疙瘩的全面了解，熟悉瘢痕与瘢痕疙瘩的治疗方法，达到理想的治疗效果，从而减少复发，达到治疗疾病的目的。     

二联疗法治疗增生性瘢痕临床观察

目的观察联合应用弹性加压包扎疗法与瘢痕内曲安缩松注射疗法治疗增生性瘢痕的疗效及安全性.方法选择64例具有典型烧伤或创伤病史和外观特征而确诊的增生性瘢痕病人,平均年龄46±7.28岁.随机分为两组:治疗组32例用弹力绷带加压包扎和瘢痕内注射曲安缩松治疗1.5个月,对照组单用弹力绷带加压包扎治疗.根据两组治疗前后瘢痕体积、外观、患者自觉症状的变化判定疗效.结果治疗组与对照组总有效率分别为83.21%和60.98%(P<0.01),两组均未发生明显不良反应,患者均能耐受.结论弹性加压包扎与瘢痕内曲安缩松注射二联疗法治疗增生性瘢痕安全有效.     

增生性瘢痕诊治的研究进展

增生性瘢痕(Hypertrophic Scar,HS)属于病理性瘢痕的一种。本文主要介绍增生性瘢痕在诊断和治疗上的研究进展。     

强脉冲光治疗烧伤后增生性瘢痕的临床疗效观察

目的:观察强脉冲光(IPL)对烧伤后增生性瘢痕的治疗效果。方法:采用波长为560 nm的IPL Queen光子嫩肤仪治疗50例不同部位烧伤后的增生性瘢痕,治疗4～6次为一个疗程,相邻2次间隔时间2周,总治疗周期1～3个月。根据患者治疗前后的照片对比和瘢痕增生减退程度来评定疗效。结果:通过患者不同治疗阶段的照片对比,结果显示不同患者对强脉冲光治疗的反应不尽相同,影响因素较多。虽治疗有效率达72%,但普遍需进行不短于2个月的治疗时间。结论:强脉冲光(IPL)对烧伤后增生性瘢痕有一定的治疗效果,可以作为一种治疗方法应用于临床。     

56例增生性瘢痕综合治疗方法的探讨

化学物或火、电等多种原因烧灼伤引起深11度或皿度皮肤损伤后，均会形成不同程度的捷痕增生。作为非手术治疗方法之一，常使用确炎舒松注入增生搬痕组织局部，可使搬痕软化，但注射时局部疼痛较甚，患者较难于接受，若治疗面积大其用量多可引起不同程度的副作用。为此我所自199     

增生性瘢痕形成机制及治疗的现况与展望

从增生性瘢痕的分子生物学特点、影响增生性瘢痕形成的各种因素及治疗手段三个方面进行综述。     

超脉冲二氧化碳点阵激光治疗增生性瘢痕患者的临床效果

目的探讨超脉冲二氧化碳点阵激光治疗增生性瘢痕患者的临床效果。方法选择2019年10月至2020年10月威海市妇幼保健院收治的55例增生性瘢痕患者作为研究对象,根据治疗方法的不同将其分为对照组(27例)和试验组(28例)。对照组实施常规治疗,试验组实施超脉冲二氧化碳点阵激光仪治疗,比较两组的治疗效果。结果治疗后,两组温哥华瘢痕评估量表(VSS)、视觉模拟评分法(VAS)、四项目瘙痒评估量表(FIIQ)评分均低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05);试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论应用超脉冲二氧化碳点阵激光治疗增生性瘢痕患者的临床效果确切,能显著减轻患者瘢痕疼痛、瘙痒程度。     

烧伤植皮取皮区瘢痕增生的临床观察

<正>植皮在烧伤治疗中是一常用而重要的方法,在深度烧伤,不管是早期切、削痂或蚕食脱痂,大都需要植皮来促进创面愈合和最终消灭创面,而后期整形、植皮更是必不可少     

浅析增生性瘢痕治疗中硅酮凝胶治疗的效果

目的：分析增生性瘢痕给予硅酮凝胶治疗的临床效果。方法：以我院2014年1月至2015年12月收治的54例增生性瘢痕患者作为研究对象,随机分为两个组别,对照组（医用弹力套治疗）、试验组（硅酮凝胶治疗）各27例,观察临床疗效,比较瘢痕组织的改善时间。结果：试验组治疗有效率为96.3%,高于对照组的77.8%;瘢痕组织瘙痒、刺痛、充血、厚度改善时间均短于对照组,差异有统计学意义（P＜0.05）。结论：硅酮凝胶治疗增生性瘢痕疗效确切,有利于缩短恢复时间,值得临床推广。     

矽肺动物模型的病理观察

目的 探讨二氧化硅致大鼠及贵州小香猪肺组织纤维化的变化.方法 采用非暴露法建立SD大鼠、贵州小香猪矽肺动物模型,光学显微镜及透视电镜下观察其肺内病理变化,免疫组化法观察肺组织中细胞因子的表达.结果 (1)大鼠及猪矽肺模型主要形态学变化:染尘7～15d,在肺泡腔内可见矽尘、大量的巨噬细胞、尘细胞、肺上皮细胞及少量的中性粒白细胞,形成巨噬细胞肺泡炎及Ⅰ级结节;染尘30～90 d,肺组织的呼吸性细支气管及肺泡内、小叶间隔、血管及支气管周围、胸膜下形成Ⅰ～Ⅲ级结节,少数动物模型可见Ⅳ级结节,伴淋巴细胞浸润.(2)大鼠及贵州小香猪肺组织中细胞角蛋白(CK)、肺表面活性物质相关蛋白A( SP-A)、吞噬细胞(CD68)、碱性成纤维细胞因子(b-FGF)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、转化生长因子(TGF-1)、NF-κB/P50、NF-κB/P65、血管内皮生长因子(VEGF),随着染尘时间的延长,表达逐渐减弱,但仍高于对照组.60～90 d CD68仍呈阳性表达.(3)电镜观察肺泡上皮和巨噬细胞的变化:在SiO2刺激下,肺泡Ⅰ型上皮脱落,Ⅱ型上皮细胞及巨噬细胞增生,且细胞功能活跃.结论 建立的大鼠及猪肺纤维化模型符合巨噬细胞肺泡炎至纤维化的演变过程.     

A virtual issue highlighting animal studies of eating disorders as valuable tools for examining neurobiological underpinnings and treatment of eating disorders

While studies in humans suggest a role for psychosocial factors as well as biological and genetic processes in the development of eating disorders, the specific etiologic mechanisms remain largely unknown. In this virtual issue, we present a collection of 14 archived articles from the International Journal of Eating Disorders to highlight the utility of animal studies of eating disorders to advance our understanding of eating disorder etiology. Selected articles establish animal studies as valid tools to study disordered eating behavior, offer insight into potential neurobiological mechanisms, and highlight novel targets for future pharmacological treatments. Clinical implications of each article's findings are included to demonstrate the translational value of animal studies for the eating disorders field. We hope that the exciting concepts and findings in this issue inspire future animal studies of eating disorders.     

围刺治疗对实验性增生样皮损模型鼠皮损组织学观察

目的观察围刺治疗对实验性增生样皮损模型鼠皮损组织学的影响。方法外用二硝基氟苯在鼠背部建立增生样皮损动物模型，应用围刺治疗与外用药（艾洛松）比较真皮内单核细胞计数和表皮厚度指数的变化。结果（1）单核细胞计数（P=0．001，P〈0．05）说明三组间有统计学差异，治疗组间相比较（P=0．012，P〉0．05）说明两组间无统计学差异。（2）表皮厚度指数（P=0．001，P〈0．05）说明三组间有统计学差异，治疗组间相比较（P=0．719，P〉0．05）说明两组间无统计学差异，可认为不同的治疗方法对增生样皮损动物模型的治疗没有差别。结论围刺治疗增生样皮损动物模型有效。     

Herpes simplex virus genital infection of the female guinea pig as a model for the evaluation of an experimental vaccine

Substantial protection against herpes simplex type 2 (HSV 2) infection of the female guinea pig genital tract was provided by immunization with an experimental HSV 2 vaccine prepared from the plasma membranes of infected MRC-5 cells. Protection was evaluated in terms of the modification of histopathological lesions and clinical signs and in changes in viral replication and serological responses in vaccinated and control animals.     

建立溶脲脲原体动物模型的实验研究

目的用溶脲脲原体(ureap lasm a urealyticum,UU)感染雄性大鼠泌尿系统,建立人工溶脲脲原体感染的动物模型。方法采用模拟性交的自然方式使雄性大鼠反复感染UU,16天后处死大鼠,解剖泌尿系统,分别取膀胱、前列腺及尿道中段进行UU培养。结果60%的大鼠尿道中段UU培养阳性,40%的大鼠前列腺UU培养阳性,膀胱UU培养阴性。结论成功建立了溶脲脲原体感染的实验动物模型,有助于研究抗支原体药物的作用及疗效。     

Ataxia-telangiectasia as a model system for studies of radiation protection mechanisms

Patients with ataxia-telangiectasia (AT), a human autosomal recessive genetic disease, are uniformly hypersensitive to ionizing radiation as measured by colony-forming ability and by chromosomal aberrations. Obligate heterozygotes, i.e., parents of AT patients, are slightly more radiosensitive than normal humans in terms of both colony-forming ability and chromosomal aberrations formed in G2. Thus, this system not only furnishes a model system to study factors that are responsible for radioresistance in normal human beings, but is also a unique tool for determining the role of gene dosage on radiation-induced cell killing. Because AT cells seem to be hypomutable to ionizing radiation, they also can be used to study the relationship between radiosensitivity and mutability and, therefore, carcinogenesis. Isolation of the defective gene that causes hypersensitivity in AT cells and its counterpart in normal cells should lead to a breakthrough in our understanding of radiation effects and how they can be prevented in human beings.     

日本血吸虫卵计量变异的模型建立与参数估计

目的建立虫卵计量变异的随机模型,并估计描述虫卵计量变异特征的参数。方法随机模型把人群中虫卵计量总变异分成两个来源：①虫卵计量在个体间的变异;②个体内虫卵计量的变异。用具有重复虫卵计数的实际资料对模型的参数进行估计。结果参数Ｍ、ｒ值在各年龄组中不同,ｋ值在各年龄组中近于相同;ｒ和Ｍ值的最佳年龄分割点分别为８和１２岁;模型Ｅ中假定ｋ值在各年龄组中相同,ｒ值在２～７岁和８岁以上年龄组间不同,Ｍ值在２～１１岁和１２岁以上年龄组间不同,ＡＩＣ值最小。结论年龄可能为影响Ｍ,ｒ值的重要因素,模型Ｅ为最佳模型     

Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates

The objective of this study was to determine the prevalence and genotypic range of Hepatitis E virus (HEV) in the pig population of northern Lao People's Democratic Republic (PDR). We collected 181 faecal samples from indigenous-breed pigs ≤6 months of age and the faeces was stored in RNA stabilisation buffer due to cold-chain and transport limitations. Twenty-one (11.6%) pigs had detectable HEV RNA and 43.5% of village pig herds were infected. Based on a 240 base pair-nucleotide sequence flanking the junction of open reading frames 1, 2 and 3 (ORF1, ORF2 and ORF3) the isolates were phylogenetically classified within genotype 4. Phylogenetic analyses revealed distinct genetic groupings of the Lao HEV isolates and two groups clustered with human and pig HEV isolates from China. This was the first study to demonstrate genotype 4 HEV in Lao PDR and indicates pigs are a potential reservoir for human HEV infection.