氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的效果分析

目的探讨氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果。方法选取2014年4月至2015年8月长葛市人民医院收治的高血压合并冠心病患者80例,随机分成对照组和观察组,每组40例。对照组口服硝苯地平控释片,观察组口服氨氯地平阿托伐他汀钙片,观察两组治疗效果。结果观察组舒张压、收缩压、TG以及LDL-C明显低于对照组,HDL-C明显高于对照组,差异有统计学意义(P<0.05);观察组总有效率(92.50%)明显高于对照组(70.00%),差异有统计学意义(P<0.05)。结论氨氯地平阿托伐他汀钙片可以有效控制高血压合并冠心病患者的血脂、血压水平,缓解病情,提高生活质量。     

观察氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床疗效

目的:观察复方氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床疗效。方法:对100例诊断为高血压合并冠心病患者进行临床分组治疗,观察组给予口服氨氯地平阿托伐他汀钙片,对照组给予口服氨氯地平片,观察治疗半年后两组患者血压及血脂变化情况。结果:观察组服药后收缩压(SBP)及舒张压(DBP)下降程度均优于对照组(P<0.05)。血脂方面,观察组患者三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)以及高密度脂蛋白(HDL)改善亦优于对照组(P<0.05)。两组患者用药期间均未见明显不良反应。结论:氨氯地平阿托伐他汀钙片能够有效减低患者血压,控制血脂水平,且不良反应低,值得临床应用。     

探讨氨氯地平片联合阿托伐他汀钙片在高血压合并高血脂治疗中的临床应用价值

目的:探讨氨氯地平片联合阿托伐他汀钙片在高血压合并高血脂治疗中的临床应用。方法:选取2010年1月至2013年6月间于我院诊治的高血压合并高血脂患者84例,按其就诊顺序进行编号并随机分为对照组(42例)和观察组(42例),给予对照组患者常规降压、降脂治疗,给予观察组患者氨氯地平片联合阿托伐他汀钙片治疗,观察两组患者临床疗效并进行对比分析。结果:观察组患者治疗有效率90.48%明显高于对照组患者71.43%,且其SBP、DBP、TG、TC、LDL、HDL指标改善程度明显优于对照组患者相应指标,以上组间差异均在统计学上有意义(P0.05)。结论:氨氯地平片联合阿托伐他汀钙片治疗高血压合并高血脂安全、有效,降压降脂效果明显,值得推广。     

氨氯地平阿托伐他汀钙片治疗高血压并高血脂的临床疗效

目的:研究高血压并高血脂采用氨氯地平阿托伐他汀钙片治疗的临床效果。方法:选取49例高血压并高血脂患者,将其分为治疗组和对照组,治疗组25例采用氨氯地平阿托伐他汀钙片治疗,对照组24例采用阿托伐他汀钙片治疗。结果:治疗组的总有效率高于对照组,两组比较差异有统计学意义(P<0.05);治疗组高密度脂蛋白胆固醇优于治疗组,治疗组的三酰甘油、总胆固醇、低密度脂蛋白胆固醇均低于对照组,两组比较差异具有统计学意义(P<0.05);两组患者的舒张压和收缩压均下降,两组比较差异有统计学意义(P<0.05)。结论:高血压并高血脂采用氨氯地平阿托伐他汀钙片治疗,对血压和血脂有明显控制作用,其治疗效果更加令人满意。     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的疗效

目的探讨氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果。方法选取于本院诊治的高血压合并冠心病患者120例并随机分为观察组和对照组,每组各60例。对照组给予氨氯地平治疗,观察组氨氯地平阿托伐他汀钙片口服治疗。观察并记录两组患者的血压控制情况、血脂控制情况以及临床治疗效果。结果两组患者经治疗后血压均有所降低(P0.05),观察组显著低于对照组(P0.05);观察组血脂整体控制情况优于对照组(P0.05);临床治疗总有效率高于对照组(P0.05)。结论氨氯地平阿托伐他汀钙片治疗高血压合并冠心病可有效控制血压以及血脂,值得临床推广。     

探讨氨氯地平阿托伐他汀钙片治疗高血压并高血脂的临床疗效

目的:探讨氨氯地平阿托伐他汀钙片治疗高血压并高血脂的临床疗效。方法:选取2015年6月～2016年12月我门诊收治的100例高血压合并高血脂患者,将其随机分为对照组50例与观察组50例,对照组患者给予氨氯地平进行治疗,观察组患者采用氨氯地平阿托伐他汀钙片进行治疗,观察组两组患者疗效并比较分析。结果:观察组患者治疗后血压、血脂治疗总有效率显然高于对照组(P0.05)。结论:临床中对高血压合并高血脂患者实施氨氯地平阿托伐他汀进行治疗,其具有显著临床疗效,可有效控制患者血脂及血糖水平,值得推广。     

氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的疗效评价

目的了解氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的疗效;方法将100例高血压合并冠心病患者随机分为实验组和对照组,实验组患者给予氨氯地平阿托伐他汀钙片治疗,对照组患者给予阿托伐他汀钙片治疗,比较两组患者的治疗效果;结果实验组患者的血压控制率(96%、48例)要明显高于对照组患者(82%、41例),其差异有统计学意义(P0.05);实验组患者的心电图控制率(86%、43例)要明显高于对照组患者(64%、32例),其差异有统计学意义(P0.05);实验组患者的不良反应发生率(2%、1例)明显低于对照组患者(16%、8例),其差异有统计学意义(P0.05);结论在治疗高血压合并冠心病患者时选择氨氯地平阿托伐他汀钙片进行治疗,可以取得更好的疗效,并且降低不良反应的发生。     

氨氯地平阿托伐他汀钙片治疗高血压并高血脂临床分析

目的:分析氨氯地平阿托伐他汀钙片应用于高血压并高血脂治疗中的临床效果。方法:随机选取70例高血压并高血脂患者,将患者分为观察组与对照组,每组35例。观察组采用氨氯地平阿托伐他汀钙片治疗,对照组采用氨氯地平片治疗。结果:观察组降压治疗总有效率与高血脂治疗有效率均高于对照组,两组差异有统计学意义(P<0.05)。结论:氨氯地平阿托伐他汀钙片应用于高血压并高血脂治疗中,可获得良好的治疗效果,值得推广。     

氨氯地平阿托伐他汀钙片治疗高血压并高血脂患者的临床价值研究

目的评析氨氯地平阿托伐他汀钙片治疗高血压并高血脂的临床效果。方法抽选112例高血压并高血脂患者随机分为各56例的对照组与实验组,分别予以阿托伐他汀钙片、氨氯地平阿托伐他汀钙片治疗,完成8w治疗后以血压、血脂的改善来评估治疗效果,并观察用药安全性。结果对比两组治疗前血压、血脂水平均无明显差异(P0.05),对比各组治疗前后各项指标均得以改善(P0.05),而实验组的改善更为显著(P0.05);两组均未见明显严重不良反应。结论针对高血压并高血脂给予氨氯地平阿托伐他汀钙片治疗有助于患者血压、血脂的有效控制,效果显著,可供临床重视应用。     

两种方法治疗高血压合并冠心病的疗效观察

目的:观察氨氯地平阿托伐他汀钙片与硝苯地平缓释片治疗高血压合并冠心病的临床疗效。方法:选择进行高血压合并冠心病治疗的100例患者为研究对象,随机平均分为研究组和对照组,研究组50例给予氨氯地平阿托伐他汀钙片治疗,对照组50例给予硝苯地平缓释片治疗,比较两组患者的临床疗效。结果:两组患者经过6周治疗后,研究组临床疗效总有效率为88.00%,对照组临床疗效总有效率为70.00%,研究组明显优于对照组,两组总有效率比较,差异具有统计学意义(P<0.05)。结论:氨氯地平阿托伐他汀钙片比硝苯地平缓释片治疗高血压合并冠心病的疗效更好,值得临床推广使用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.