消旋卡多曲联合蒙脱石散治疗小儿轮状病毒性肠炎的疗效观察

目的：探讨消旋卡多曲联合蒙脱石散治疗小儿轮状病毒性肠炎的疗效。方法：选择轮状病毒性肠炎患儿68例,分为观察组和对照组。两组患儿均予以调整饮食、补液、纠正脱水及酸碱平衡紊乱等基础治疗。观察组予以消旋卡多曲联合蒙脱石散治疗,对照组予以单纯蒙脱石散治疗。观察两组患儿治疗后主要临床症状和体征改善时间,并进行临床疗效观察。结果：观察组患儿大便外观、呕吐、腹痛及大便常规等恢复正常时间明显短于对照组（均P〈0．05）;治疗72h后,观察组的临床总有效率（94．12％）明显高于对照组（73．53％）（Х^2=5．31,P〈O．05）。结论：消旋卡多曲联合蒙脱石散治疗轮状病毒性肠炎的疗效明显优于单纯的蒙脱石散治疗,能明显改善患儿的临床症状,缩短患儿病程。     

消旋卡多曲治疗小儿轮状病毒性肠炎疗效观察

目的：观察消旋卡多曲治疗小儿急性轮状病毒性肠炎的疗效及安全性。方法：筛选100例急性轮状病毒性肠炎患儿,随机分为两组。①组给予口服消旋卡多曲片治疗;②组给予口服蒙脱石散＋妈咪爱;结果：两个治疗组的疗效、不良反应的差异无统计学意义（P〉0．05）。结论：消旋卡多曲治疗小儿急性轮状病毒肠炎的安全性、有效性值得肯定。     

消旋卡多曲治疗小儿轮状病毒肠炎疗效观察

目的:观察消旋卡多曲治疗小儿轮状病毒肠炎的疗效.方法:将小儿轮状病毒肠炎病例随机分治疗组30例和对照组30例.在常规治疗的基础上,治疗组予消旋卡多曲口服,对照组予蒙脱石散口服,观察疗效和不良反应.结果:治疗组有效率93%,明显高于对照组73%,两组均未发生严重不良反应.结论:消旋卡多曲治疗小儿轮状病毒肠炎能较快减少腹泻,明显缩短急性腹泻病程.     

消旋卡多曲和蒙脱石散联合治疗轮状病毒肠炎疗效观察

目的 探讨消旋卡多曲和蒙脱石散联合治疗轮状病毒肠炎的治疗效果.方法 选取笔者所在科室2008年9月～2008年12月收治的用酶联免疫吸附试验检到粪便RV-Ag(IgM)阳性的110例患儿,随机分为治疗组(消旋卡多曲和蒙脱石散联合治疗)和对照组(常规治疗),对两组患儿疗效进行临床观察.结果 治疗组疗效明显高于对照组,经χ2检验P<0.01,两组结果比较有显著性差异.结论 消旋卡多曲和蒙脱石散联合治疗轮状病毒肠炎临床效果好.     

消旋卡多曲联合蒙脱石散治疗小儿轮状病毒性肠炎效果观察

目的：探讨消旋卡多曲联合蒙脱石散治疗小儿轮状病毒性肠炎的临床效果。方法选择2012年1月—2014年6月我院收治的小儿轮状病毒性肠炎患儿90例,随机分为观察组和对照组,每组45例。对照组给予消旋卡多曲颗粒治疗,观察组在对照组的基础上加用蒙脱石散治疗。比较2组治疗效果、退热时间、大便次数正常时间、脱水纠正时间以及住院时间。结果观察组治疗总有效率为97.78%,明显高于对照组的82.22%,差异有统计学意义（P<0.05）;观察组退热时间、大便次数正常时间、脱水纠正时间以及住院时间均明显短于对照组,差异具有统计学意义（P<0.05）。结论采用消旋卡多曲联合蒙脱石散治疗小儿轮状病毒性肠炎,能够明显改善患儿的临床症状,取得比较理想的治疗效果,值得推广应用。     

不同方法治疗小儿轮状病毒肠炎的疗效对比

目的探讨两种不同方法治疗小儿轮状病毒肠炎的疗效。方法选取50例小儿轮状病毒肠炎患儿,随机分为2组。对照组25例,给予利巴韦林治疗;治疗组25例,给予喜炎平联合消旋卡多曲及蒙脱石散治疗,2组同时给予常规基础治疗。观察比较2组患儿症状改善时间、临床疗效及不良反应。结果治疗组和对照组的退热时间、呕吐停止时间、大便次数及性状正常时间差异均有统计学意义（P〈0.05）,治疗组各症状改善显著优于对照组;2组治疗总有效率分别为96.0%和72.0%,差异具有统计学意义（P〈0.05）,治疗组的疗效显著优于对照组;2组均无明显不良反应。结论喜炎平联合消旋卡多曲及蒙脱石散治疗小儿轮状病毒肠炎疗效更为显著,同时能够有效缩短症状改善时间,且安全性好,值得在临床推广应用。     

消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎的临床分析

目的:探讨消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎的临床效果。方法:将小儿轮状病毒肠炎患者90例,随机分成治疗组和对照组,每组45例(n=45),对照组患者给予蒙脱石散治疗,治疗组患者给予消旋卡多曲联合蒙脱石散治疗。对两组患者的临床有效率、退热时间、止泻时间、疗程及不良反应情况进行对比分析。结果:治疗组总有效率为86.7%,显著高于对照组的68.9%,差异有统计学意义(P<0.05);治疗组退热时间、止泻时间及疗程分别为1.74±0.30d、2.28±0.41d、4.16±0.82d,均显著低于对照组的2.44±0.41d、3.59±0.52d、5.30±0.94d,差异有统计学意义(P<0.05);两组均未发生严重不良反应。结论:消旋卡多曲联合蒙脱石散可以有效的治疗小儿轮状病毒肠炎,且退热止泻时间及疗程较短。     

补锌联合消旋卡多曲及布拉酵母菌散治疗小儿轮状病毒性肠炎的疗效观察

目的 补锌联合消旋卡多曲及布拉酵母菌散治疗小儿轮状病毒性肠炎的疗效.方法 选取本院2018年10月至2019年10月收治的94例轮状病毒肠炎患儿作为研究对象,采用抽签法分为观察组和对照组,每组47例.两组均给予常规治疗,在此基础上,对照组给予甘草锌颗粒联合消旋卡多曲颗粒治疗,观察组在对照组基础上给予布拉酵母菌散治疗.比较两组临床疗效、临床症状消失时间、不良反应发生率.结果 观察组治疗总有效率高于对照组(P<0.05).观察组退热时间、呕吐及腹泻停止时间均短于对照组(P<0.05).治疗期间,两组尿常规及肝肾检查结果正常,未发生不良反应.结论 补锌联合消旋卡多曲及布拉酵母菌散治疗小儿轮状病毒性肠炎疗效显著,可缩短患儿临床症状消失时间,且具有较高的安全性.     

补锌联合消旋卡多曲及布拉酵母菌散治疗小儿轮状病毒性肠炎的疗效观察

目的 补锌联合消旋卡多曲及布拉酵母菌散治疗小儿轮状病毒性肠炎的疗效.方法 选取本院2018年10月至2019年10月收治的94例轮状病毒肠炎患儿作为研究对象,采用抽签法分为观察组和对照组,每组47例.两组均给予常规治疗,在此基础上,对照组给予甘草锌颗粒联合消旋卡多曲颗粒治疗,观察组在对照组基础上给予布拉酵母菌散治疗.比较两组临床疗效、临床症状消失时间、不良反应发生率.结果 观察组治疗总有效率高于对照组(P<0.05).观察组退热时间、呕吐及腹泻停止时间均短于对照组(P<0.05).治疗期间,两组尿常规及肝肾检查结果正常,未发生不良反应.结论 补锌联合消旋卡多曲及布拉酵母菌散治疗小儿轮状病毒性肠炎疗效显著,可缩短患儿临床症状消失时间,且具有较高的安全性.     

热毒宁注射液联合消旋卡多曲治疗轮状病毒肠炎疗效观察

目的:观察热毒宁注射液联合消旋卡多曲颗粒治疗小儿轮状病毒肠炎的临床疗效.方法:96例小儿轮状病毒肠炎患儿随机分成治疗组和对照组.治疗组用热毒宁注射液静滴,口服消旋卡多曲颗粒治疗;对照组用热毒宁注射液静滴.结果治疗组总有效率91.7%,对照组总有效率81.3%,在临床疗效方面两者对比有统计学学意义(P＜0.01).结论:热毒宁注射液联合消旋卡多曲颗粒治疗小儿轮状病毒肠炎疗效显著.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.