共查询到20条相似文献,搜索用时 78 毫秒
1.
应用免疫组化方法对5例皮肤B细胞性淋巴瘤进行研究。5例分为四种亚型:皮肤免疫细胞性淋巴瘤,中心细胞性和中心母细胞性各1例,中心细胞-中心母细胞性2例。CIL出现中心母细胞及瘤巨细胞,向高度恶性淋巴瘤转化,免疫组化显示:5例CD45,CD20阳性,CD45Ro均阴性。1例CCBL又示κ、λ、IgG,IgM均呈阳性,为双标记阳性,探讨其发性机理,并将各亚型与皮肤B细胞性假性淋巴瘤及组织细胞性淋巴瘤进行 相似文献
2.
皮肤透明细胞淋巴瘤三例 总被引:1,自引:0,他引:1
皮肤透明细胞淋巴瘤(clearcellymphoma)是皮肤T细胞淋巴瘤的一个亚型,比较少见。我们近见3例,报道如下。临床资料:男2例,女1例,年龄33~52岁,平均45.3岁,病程2~5个月,平均3.5个月。2例伴有发热,1例年前有皮肤淋巴瘤病史,3例皮肤损害均表现为红色浸润性斑块,质硬,边界清楚,浸润深浅不一,大小不等,蚕豆大至拳头大,1例压痛明显,1例浸润性斑块中心坏死结痂,1例局限于右乳房(见图1),2例广泛分布于胸背部及躯干四肢(见图2),1例伴有口腔粘膜糜烂和溃疡,1例颌下及颈部淋巴结肿大。实验室检… 相似文献
3.
5原发性皮肤滤泡性淋巴瘤(primarycutaneousfolicularlymphoma)此瘤约占所有皮肤B细胞淋巴瘤的40%~45%[1]。Burg认为它属于半恶性CML[2]。51临床表现:此种CML多见于男性老年人。皮肤结节、斑块或肿瘤好... 相似文献
4.
报告1例原发性皮肤中心母细胞淋巴瘤。患者,男,92岁。右小腿被蚊虫叮咬后出现肿块1年半,增多、扩大、破溃伴左小中块2个月。血常规、X光胸片、腹部B超、骨髓检查未划常。病检示肿瘤细胞形态似中心母细胞,免疫组化证实瘤细胞的B细胞性。EBER原位杂交末检测到EB病毒。患者未作放化疗,9个月后死亡。 相似文献
5.
皮肤B细胞淋巴瘤一例 总被引:2,自引:0,他引:2
原发于皮肤的T细胞淋巴瘤(CTCL)多见,如蕈样肉芽肿(MF)和Sezary综合征。而皮肤B细胞淋巴(cutaneousB-celllymphoma,CBCL)则少见[1~3],皮肤损害酷似MF的更少见。在此我们报告一例,并附以皮肤病理、免疫组化及超微结构观察。一、临床资料患者男,55岁。因全身皮肤的浸润性斑片、斑块性损害1年半于1993年2月4日入院。患者于1991年9月开始于右上肢出现约钱币大淡红色斑片,略痒,10余天后自行消退,但一周后,局部出现同样损害,且逐渐增多,发展到躯干及四肢、皮疹… 相似文献
6.
本文报告了应用盐裂皮损周围皮肤直接免疫荧光检查(DIF),诊断22例表皮下水疱病的结果,所有22例表皮下水泡病盐裂皮损周围皮肤DIF均显示IgG免疫复事物沉淀在表皮侧,真皮侧或表皮真皮两侧,阳性率为100%,其中表皮侧17例,表皮真皮两侧均有2例,此19例的均为大泡性类天疱疮(Bp),真皮侧3例,2例为获得性大疱性表皮性松解症(EBA),1例大疱性系统性红斑狼疮(BSLE),3例天疱疹和4例正常人 相似文献
7.
8.
目的:探讨表皮下自身免疫性大疱病疱液中抗基底膜带(BMZ)自身抗体的情况及在诊断中的意义。方法:应用非盐裂皮肤及盐裂皮肤间接免疫荧光技术(IF)检测38例表皮下自身免疫性大疱病患者疱液和血清中IgG、IgA、IgM、IgE及IgG亚型IgG1~IgG4抗BMZ抗体及滴度,并检测疱液和血清中结合补体C3的特异性抗BMZ抗体。结果:(1)疱液和血清中抗BMZ抗体及滴度和结合补体C3的特异性抗BMZ抗体均无显著性差异。(2)大疱性类天疱疮患者的疱液和血清中IgG抗BMZ抗体的亚型分布相同,主要为IgG1和IgG4。结论:疱液可作为IIF检测表皮下大疱病抗BMZ抗体的另一个有价值的标本来源。 相似文献
9.
目的:探讨白塞病(BD)的血管损害以及免疫学改变。方法:对45例BD患者的临床及病理学资料进行分析。结果:14例皮肤组织活检、1例扁桃体活检及1例食道粘膜活检病理改变均符合小血管炎症。2例(2/12)皮肤直接免疫荧光(DIF)阳性,为真皮小血管壁IgM和C3c沉积。4例并发心血管系统损害,其中2例为冠状动脉瘤伴血栓形成。1例为脑栓塞性舞蹈病,1例为食道下段溃疡并出血。有多项免疫学指标异常。10例检 相似文献
10.
11.
Smith KC 《Dermatologic therapy》2007,20(6):388-393
ABSTRACT: Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes. 相似文献
12.
It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin. 相似文献
13.
14.
Joan A. Puig‐Butillé Celia Badenas Zighereda Ogbah Cristina Carrera Paula Aguilera Josep Malvehy Susana Puig 《Experimental dermatology》2013,22(2):148-150
Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas. 相似文献
15.
16.
17.
18.
19.
Milissa U. Jones MD Michelle S. Flores MD Rasheda J. Vereen MD MBS Sabrina R. Szabo DO Nicholas F. Logemann DO Matthew D. Eberly MD 《Pediatric dermatology》2018,35(4):e248-e250
A 7‐week‐old girl, born at 30 weeks' gestational age, presented to clinic for evaluation of a crop of vesicular lesions that were noted after removal of a bandage that had been in place for 4 days. A punch biopsy of the lesion revealed fungal elements that were later identified as Rhizopus spp. The lesion began to self‐resolve, and no further treatment was needed, with full resolution of the lesion by 1 month after presentation. Clinicians should be aware of the variable presentations of mucormycosis and consider fungal infection in the differential diagnosis when evaluating vulnerable patients with skin eruptions. 相似文献
20.
Philip R. Cohen 《The Journal of dermatology》1996,23(4):290-292
A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions. 相似文献