Lipid peroxidation during experimental cholera intoxication

Cholera intoxication in albino mice was induced by intraperitoneal injection of endotoxin in doses of LD₁₆, LD₂₄, and LD₅₀ and combination of endo- and enterotoxin in doses equivalent to LD₂₅. Dose-dependent activation of superoxide dismutase, phasic changes in the contents of MDA and conjugated trienes and dienes, and modulatory influence of enterotoxin on catalase activity in the blood were observed during intoxication. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 399–401, April, 2000     

Inhibition of lipid peroxidation in synaptosomes from rat brain by peptide and protein fraction isolated from fetal human brain

Peptide and protein fractions isolated from fetal human brain inhibit with different efficiency nonenzymatic lipid peroxidation in synaptosomes from rat brain. These fractions reciprocally capture the superoxide anion radicals generated in the reaction of 6-hydroxydopamine autooxidation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 8, pp. 233–235, August, 1996     

Lipid peroxidation in plasma of patients with osteogenic sarcoma

The intensity of free-radical oxidation reactions assessed by the thiobarbituric acid test and by recording the “fast flash” of Fe²⁺-induced chemiluminescence is higher in patients with osteogenic sarcoma than in normal subjects. This effect is not sex-dependent and does not depend on previous therapy with drugs triggering free-radical reactions. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 199–201, August, 1997     

Lipid peroxidation level in the focus of compression ischemia in the cerebral cortex of rats

Pathomorphological changes in a focus of ischemia, the level of lipid peroxidation (as indicated by the content of products reacting with thiobarbituric acid), and the postischemic levels of adenyl nucleotides and tissue lipids were studied in rats with focal compression ischemia of the cerebral cortex. An increased level of the TBA-reactive products paralleled by a reduction of the concentrations of adenyl nucleotides and tissue lipids was found to be in clear-cut correlation with the processes of neuronal injury and death and with subsequent repair phenomena in the focus of cortical ischemia. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 12, pp. 589–590, December, 1994 Presented by O. S. Adrianov, Member of the Russian Academy of Medical Sciences     

Lipid peroxidation in the brain of rats differing in resistance to emotional stress

It is found for each of the rat brain regions studied (cerebral cortex, subjacent white substance, and brainstem) that both the initial levels of 2-thiobarbituric acid-reactive products and the rates of their increment are highest in rats resistant to emotional stress and lowest in stress-prone rats, and that the rates at which lipid peroxidation products accumulate are highest in the brainstem and lowest in the white substance. A correlation is presumed to exist between individual resistance to cerebral ischemia and the rate of lipid peroxidation in particular brain regions of healthy rats. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, № 10, pp. 384–387, October, 1994     

Lipid peroxidation and antioxidant system in children living in the Northern Transbaikal region

Exposure to extreme environmental factors of the North creates prerequisites for hyperactivation of free-radical oxidation reactions which may limit the adaptive potential of cells and organism. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 581–583, November, 1998     

Lipid peroxidation parameters in the internal organs of rats with different degrees of resistance to hypoxia

Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming that oxidation plays a major role in the damaging and lethal effects of acute hypoxia. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 1, pp 26–29, January, 1996 Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences     

Lipid peroxidation after acute intoxication of cats with anthio and the effect of ionol on their survival

Acute intoxication with the organophosphorus pesticide Anthio considerably increases the intensity of lipid peroxidation in Nembutal-anesthetized cats. Pretreatment with the synthetic antioxidant ionol prolongs the survival of the cats. Ionol has no appreciable effect on respiratory and hemodynamic parameters. Lipid peroxidation may contribute to the disturbances caused by Anthio. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 12, pp. 625–628, December, 1996     

Parameters of lipid peroxidation in erythrocytes of children being treated for acquired severe aplastic anemia

It is shown that a peroxidase-catalase mechanism of antioxidant defense predominates in the erythrocytes of children with acquired aplastic anemia, and that the high level of lipid peroxidation (LPO) processes in such children dictates the need for continued antioxidant therapy during all phases of the disease. The antioxidant effect of glucocorticoids appears to be quite sufficient for eliminating the more severe effects of LPO. Translated fromByulleten' Eksperimental'noii Biologii i Meditsiny, Vol. 117, N ^o 1, pp. 36–38, January, 1994 Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences     

Effect of the tranquilizer mebicar on lipid metabolism and lipid peroxidation on the model of hypokinesia in rats

Daily 18-hour hypokinesia induces atherogenic shifts in the blood lipid spectrum and activates lipid peroxidation in rats. Mebicar is shown to have a correcting effect on lipid metabolism and on the intensity of lipid peroxidation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 535–537, May, 1996     

Time course of lipid peroxidation during adaptation of men to novel ecological conditions

Changes in the intensity of lipid peroxidation and serum activities of superoxide dismutase and catalase were similar after 18-month adaptation to new ecological conditions of soldiers serving in two different regions. All values increased and reached the maximum by the 6th month, after which they stabilized; catalase activity decreased after 6 months. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 678–682, December, 1997     

Phospholipid spectrum and lipid peroxidation in cell membranes of brain tissue in thymectomized rats

Lipid peroxidation (LPO) processes and the phospholipid (PL) content and composition in the homogenate and in the mitochondrial and supramitochondrial compartments of brain cells of adult male rats were studied 3 and 6 months after thymectomy. Thymectomy was found to markedly increase the rate of LPO and to reduce antiradical activity in all cellular compartments. A reliable increase of the level of total phospholipids in the homogenate and mitochondria was observed by the third month after thymectomy and a reduction of its control levels during the sixth month postoperation. On the other hand, a reduction of the content of total phospholipids was observed in the supramitochondrial fraction by the sixth month of the experiment. An increase of the phosphatidylethanolamine (PE) and phosphatidylserine (PS) contents was found to be mainly responsible for the changes in the level of total phospholipids. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 7, pp. 22–24, July, 1994 Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences     

Multiresistance and lipid peroxidation system of thermoresistantShigella sonnei strains

The content of lipid peroxidation products increases in lipids isolated fromShigella sonnei after heating. Thermoresistant strains are characterized by higher activity of superoxide dismutase and catalase and by stable activity of glutathione reductase and glutathione transferase compared with thermolabile strains. Thermoresistant strains are also resistant to some antibiotics and hydrogen peroxide. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 69–71, July, 1996     

Intensity of lipid peroxidation: Indicator of inflammation severity in chronic bronchitis

The content of products of lipid peroxidation and antioxidative activity were measured in exhaled air condensate and blood sera of patients with chronic bronchitis. Exacerbation of purulent bronchitis was found to be associated with an increase of heptane-soluble products of lipid peroxidation in serum and condensate, which was not observed in patients with catarrhal bronchitis. In catarrhal bronchitis, the content of heptane-soluble products is increased only in the serum; antioxidative activity increased in exhaled air condensate in catarrhal bronchitis and decreased in serum and condensate in purulent bronchitis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 202–204, August, 1997     

Antioxidant defense and lipid peroxidation in rat tissue after hypobaric hypoxia

Posthypoxic period is characterized by increased formation of lipid peroxidation products. Changes in the antioxidant enzyme systems include decreased catalase and glutathione reductase activities and elevated content of reduced glutathione. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 519–521, November, 1998     

Effect of epithalone on the age-specific changes in the time course of lipid peroxidation inDrosophila melanogaster

The effect of epithalone on the age-specific time course of lipid peroxidation was studied in inadaptiveDrosophila melanogaster strains. A single dose of epithalone at the larval stage decreased the level of conjugated hydroperoxides and Schiff bases throughout the life span of imago. Strain- and sex-specific differences in the time course of the studied sign are characterized. Translated fromByulleten’s Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 585–588, November, 2000     

Effect of naftidrofuryl on lipid peroxidation in serum and erythrocyte plasma membrane of patients with diabetes mellitus

Effect of naftidrofuryl, a blocker of serotonin 5S₂-receptors (Dusodril-retard), on the malonic dialdehyde content in the serum and erythrocyte membranes is studied in diabetics with and without angiopathies. A 40-day treatment with Dusodril-retard normalizes the serum content of malonic dialdehyde, an intermediate product of lipid peroxidation, and has no effect on the malonic dialdehyde content of the erythrocyte plasma membrane. A negative correlation is established between blood levels of total cholesterol, β lipoproteins, and malonic dialdehyde levels in patients with diabetes mellitus. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 338–341, September, 1996     

Effect of chorionic gonadotropin on normalization of lipid peroxidation

A study is performed of the effect of chorionic gonadotropin on lipid peroxidation in the liver and myocardium of white rats injected subcutaneously with tetrachloromethane for a long time. Chorionic gonadotropin is shown to reduce the content of diene conjugates and Schiff bases, which suggests an antioxidant effect of the hormone. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 6, pp. 572–573, June, 1994 Presented by Yu. A. Romanov. Member of the Russian Academy of Medical Sciences.