碘油、PYM、GF混合乳剂肝动脉栓塞治疗肝海绵状血管瘤48例临床分析

1998年4月～2005年6月,我们采用碘油、平阳霉素（PYM）、明胶海绵（GF）混合乳剂栓塞治疗肝海绵状血管瘤（CHL）48例,疗效满意。现报告如下。     

经导管动脉栓塞治疗肝海绵状血管瘤

目的评价经导管肝动脉栓塞术治疗肝海绵状血管瘤的疗效。方法经导管注入碘油和平阳霉素混合乳剂,再用适量明胶海绵颗粒加强栓塞治疗肝海绵状血管瘤28例(34次),术后随访12～24月,观察栓塞前、后瘤体的变化及临床症状缓解情况。结果所有患者经1～3次栓塞治疗后临床症状完全消失,瘤体均有不同程度的缩小,部分缓解者(瘤体缩小大于50%)19例(67.9%,19/28),好转者(瘤体缩小25%～50%)7例(25%,7/28),均无严重并发症发生。结论碘油和平阳霉素混合乳剂加适量明胶海绵颗粒联合栓塞是治疗肝海绵状血管瘤较为理想的方法,临床观察安全有效。     

介入栓塞治疗不同体积肝血管瘤的临床疗效及血流动力学特征

目的探讨平阳霉素碘油乳剂肝动脉栓塞治疗不同体积肝血管瘤的临床疗效。方法将30例肝血管瘤患者分为3组,分别为A组病灶5 cm者6例、B组病灶为5~8 cm者15例、C组病灶8 cm者9例。采用世界卫生组织(WHO)实体瘤疗效评价标准对经肝动脉平阳霉素碘油栓塞治疗12~24个月后的疗效进行分析。结果介入栓塞治疗后A组血管瘤平均缩小率82.7%,栓塞有效率为100%(6/6)。B组血管瘤平均缩小率70.5%,栓塞有效率为86.7%(13/15)。C组平均缩小率63.5%,栓塞有效率为77.8%(7/9)。A组血管瘤平均缩小率及总有效率显著优于B、C组,差异有统计学意义(P0.05)。B组血管瘤平均缩小率及总有效率高于C组,差异有统计学意义(P0.05)。结论介入栓塞的疗效与肝血管瘤体积呈负相关。     

微波刀消融肝海绵状血管瘤的临床报告

目的探讨在B超引导下使用微波刀消融肝海绵状血管瘤的临床价值。方法63例肝海绵状血管瘤患者随机分成观察组39例，应用B超引导下冷循环微波刀局部消融治疗，对照组24例选用肝动脉介入注射平阳霉素碘油乳剂栓塞硬化，观察两种方法术后1年临床治愈率。结果术后6月，观察组有7例（17．9％，7／39）血管瘤有血供，进行第2次微波消融术。对照组16例（66．7％，16／24）血管瘤有血供，进行2次介入治疗（P〈0．01）。术后12个月，观察组28例患者瘤体缩小超过50％，治愈率为71．8％（28／39）；对照组15例瘤体缩小超过50％，治愈率为62．5％（P〉0．05）。结论采用B超引导下冷循环微波刀局部消融治疗肝海绵状血管瘤效果确切。     

介入栓塞术治疗肝海绵状血管瘤8例报告

1999年4月～2002年2月，我们分别用无水酒精，碘油 明胶海绵，碘油乳化剂(PLE)栓塞治疗肝海绵状血管瘤(CHL)患者8例，现将其疗效、术后肝功变化及并发症分析报告如下。     

肝血管瘤动脉造影诊断与栓塞治疗

为了探讨肝血管瘤(CHL)的肝动脉造影诊断及特异性鉴别诊断征象,总结栓塞治疗效果,寻求理想栓塞方法,回顾分析了25例CHL选择性肝动脉造影的表现与鉴别诊断征象,观察平阳霉素(PYM)超液态碘化油乳剂栓塞治疗的效果,随访6-48个月。CHL典型的瘤体显影形态,造影剂染色时间的特点,可与肝癌鉴别,动-静脉瘘的出现作为鉴别依据缺乏特异性;25例栓塞治疗,其中1次栓塞18例,2次栓塞7例,瘤体均缩小达50％以上,临床有效率达100％,无严重并发症发生。选择性肝动脉造影是诊断肝血管瘤较理想的方法,介入栓塞治疗应作为首选方法推广应用。     

选择性肝动脉栓塞治疗肝海绵状血管瘤

肝海绵状血管瘤是最常见的肝脏良性肿瘤，占肝脏良性病变的41.6％，直径〉5cm者为巨大肝血管瘤。随着介入放射治疗学的发展，超选择性肝动脉栓塞为肝海绵状血管瘤的治疗提供了一种安全有效的途径。     

平阳霉素乙碘油瘤体灌注联合明胶海绵动脉栓塞治疗颌面部多发性海绵状血管瘤(附1例报告)

对于多发性海绵状血管瘤，尚无有效治疗方法。近来，我们采用平阳霉素乙碘油瘤体灌注联合明胶海绵动脉栓塞治疗颌面部多发性海绵状血管瘤1例，疗效较好。现报告如下。     

碘油乳剂肝动脉栓塞治疗肝癌临床分析

肝脏肿瘤缺乏特异症状,目前临床诊断的病例手术切除率低于50％。1976年Gold-stein应用肝动脉栓塞治疗肝癌获得成功以来,肝动脉栓塞术在临床上已越来越受到重视。本组手术中采用碘油乳剂经肝动脉栓塞治疗肝癌27例,现结合文献报告如下。     

集束射频治疗肝海绵状血管瘤

集束射频治疗是近年引进的一项治疗肝癌的新技术,自2001年3月以来,我们尝试应用射频治疗肝海绵状血管瘤,取得较好疗效。     

动脉栓塞术与微波消融术治疗肝海绵状血管瘤患者临床疗效对比研究*

目的 对比研究动脉栓塞术(TAE)与微波消融治疗肝海绵状血管瘤(CHL)患者的临床疗效。方法 2014年1月～2018年4月我院综合介入科就诊的74例CHL患者,其中37例接受微波消融治疗,另37例接受TAE治疗,随访6个月。结果 两组疗效比较,无统计学差异(86.5%对75.7%,P>0.05);治疗后,微波消融组血清丙氨酸氨基转移酶和天门冬氨酸氨基转移酶水平分别为(47.9±5.7)U/L和(35.5±4.3)U/L,显著低于TAE组【分别为(93.5±11.2)U/L和(61.3±5.8)U/L,P<0.05】;术后12 h、24 h和48 h时,微波消融组视觉模拟评分分别为(2.8±0.5)分、(1.7±0.2)分和(1.1±0.1)分,显著低于TAE组【分别为(4.7±0.9)分、(2.6±0.8)分和(1.8±0.3)分,P<0.05】;治疗后,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 TAE和微波消融治疗CHL患者疗效类似,术后不良反应发生率低,临床可根据技术条件选择应用。     

Cardiac cavernous hemangioma.

Among primary cardiac tumors, hemangiomas are relatively rare with a reported incidence of 2.8%. To date, less than 100 cases are reported in literature. We present a 40-year-old woman with atypical chest discomfort of 1 month duration, previous history of glomus tumor of hand and a large cavernous hemangioma of right atrium.     

Evaluation of indications for the surgical treatment of cavernous hemangioma of the liver

The indications for liver resection performed in 18 patients with cavernous hemangioma of the liver at the Second Department of Surgery, Kyushu University Hospital, from 1985 to 1993, were reevaluated. The mean age of the patients was 49.7 years. Two patients had abdominal pain and 3 had gastric symptoms. Hepatocellular carcinoma could not be ruled out in 4 patients. None of the other patients had any clinical manifestations other than detection of the tumor. The average size of the tumors was 7.8cm (range 1–21 cm). In all, five partial resections, three subsegmentectomies, seven segmentectomies, and three bisegmentectomies of the liver were performed. No severe complications were encountered postoperatively, and no recurrences were found after the operation. A review of the literature revealed that spontaneous rupture of such tumors is infrequent. It therefore seems that there was no indications for surgery in our patients, except for the 4 in whom hepatocellular carcinoma could not be ruled out. Although elective liver resection for cavernous hemangioma is safe, the indications for surgery should be more narrowly defined in the future.     

Large cavernous hemangioma in the cecum treated by laparoscopic ileocecal resection

A cavernous hemangioma of the cecum is a rare vascular malformation but is clinically important because of the possibility of massive bleeding. We report a case of a large cavernous hemangioma with pericolic infiltration in the cecum which was removed successfully using minimally invasive surgery.     

Source of blood supply of liver cavernous hemangioma and sclerosis and embolization treatment

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A case of polypoid cavernous hemangioma of the sigmoid colon excised by colonoscopic polypectomy

A 28-year-old Japanese man was admitted to our institute because of sharp anal pain and a mass that prolapsed from the anus after defecation. After spinal anesthesia for emergency operation, the mass spontaneously withdrew into the anus and the pain disappeared. Surgery was postponed. Barium enema and colonoscopy revealed a pedunculated polyp in the sigmoid colon, which was removed by snare polypectomy with electrocautery. The resected polyp was granular and reddish, and measured 33 × 22 × 14 mm. Histological examination of the polyp revealed a cavernous hemangioma. Hemangioma of the colon is rare; only 52 cases have been reported in Japan. Of these patients, eight underwent endoscopie polypectomy. The present lesion is the largest thus treated that has been documented. Endoscopie polypectomy seems to be a safe and preferable procedure for the diagnosis and treatment of small, solitary polypoid hemangiomas of the colon.     

肝多发血管瘤肝动脉介入栓塞治疗及疗效分析

目的 评价肝动脉介入栓塞术在治疗肝多发血管瘤的疗效,探讨术前、术中、术后正确的处理对提高患者治愈率及预防和减少并发症方面的作用。方法以我院2010年1月～2013年3月收治的25例肝多发血管瘤进行肝动脉介入栓塞治疗的患者为研究对象,观察其并发症及疗效。结果25例患者,其中1例2个血管瘤融合为直径共12cm的病灶分2次栓塞,第1次栓塞,1个月后瘤体体积缩小50％以上,给予第2次栓塞,6个月后复查,瘤体完全消失;其余24例病灶均1次栓塞成功,3个月后复查,病灶完全消失。全组病例均随访3个月到48个月,现全部治愈,无一例复发。结论肝动脉介入栓塞治疗肝多发血管瘤安全、有效,建议首选;介入栓塞治疗前注意适应证的选择,术中技术人员娴熟的操作,术后注意并发症的处理,才能取得满意的治疗效果。     

Retroperitoneal cavernous hemangioma resected by a pylorus preserving pancreaticoduodenectomy

A retroperitoneal hemangioma is a rare disease. We report on the diagnosis and treatment of a retroperitoneal hemangioma which had uncommonly invaded into both the pancreas and duodenum, thus requiring a pylorus preserving pancreaticoduodenectomy (PpPD). A 36-year-old man presented to our hospital with abdominal pain. An enhanced computed tomography scan without contrast enhancement revealed a 12 cm × 9 cm mass between the pancreas head and right kidney. Given the high rate of malignancy associated with retroperitoneal tumors, surgical resection was performed. Intraoperatively, the tumor was inseparable from both the duodenum and pancreas and PpPD was performed due to the invasive behavior. Although malignancy was suspected, pathological diagnosis identified the tumor as a retroperitoneal cavernous hemangioma for which surgical resection was the proper diagnostic and therapeutic procedure. Reteoperitoneal cavernous hemangioma is unique in that it is typically separated from the surrounding organs. However, clinicians need to be aware of the possibility of a case, such as this, which has invaded into the surrounding organs despite its benign etiology. From this case, we recommend that combined resection of inseparable organs should be performed if the mass has invaded into other tissues due to the hazardous nature of local recurrence. In summary, this report is the first to describe a case of retroperitoneal hemangioma that had uniquely invaded into surrounding organs and was treated with PpPD.     

巨大肝海绵状血管瘤切除1例报告

1病例资料 患者,女,58岁,因＂上腹部膨隆伴进食后胀满不适1个月＂于2011年8月15日入院。查体：肝肋下5cm处可触及,质硬,边缘钝,表面稍有结节感,无压痛。实验室检查无明显异常,吲哚菁绿（ICG）15 min滞留率为5.8%。腹部增强CT示：