棘层松解性棘细胞瘤

组织病理特征 本文2张组织病理图片的主要特征是：表皮增厚,呈乳头瘤样增生,皮突延长;表皮棘层松解,主要位于表皮的下部：棘层松解不伴有角化不良：未见明显的角化过度和角化不全。[第一段]     

棘层松解性棘细胞瘤

组织病理特征本文2张组织病理图片的主要特征是:表皮增厚,呈乳头瘤样增生,皮突延长;表皮棘层松解,主要位于表皮的下部;棘层松解不伴有角化不良;未见明显的角化过度和角化不全.     

面部鳞癌伴皮角1例

患者女,73岁。左面部角状增生物半年。皮肤科检查:左耳前见1个疣状增生物,呈角状,高约1.2 cm,基底直径宽约0.5 cm。表面尖端似角化状,硬,中下部约显皮色。整个病灶硬度如鼻尖,无触痛。基底周边可见约0.1 cm的淡红皮损。边界清,与皮下组织无黏连,可摇动。治疗采用病灶组织梭形切除术,皮损组织病理:上皮细胞和基底细胞异形增生,病理性核分裂象多见,并可见角珠。套状角状物为角化物伴坏死。临床结合病理检查,诊断:面部鳞癌伴皮角。     

阴茎疣状癌1例

1临床资料患者男,60岁,农民。阴茎肿物渐增大1年余。患者1年前无明显原因出现阴茎肿物,无自觉症状,无疼痛、瘙痒和泌尿系感染,未予任何治疗。近来皮损逐渐增大。否认不洁性生活史,配偶无异常。体检:系统检查未见明显异常,未触及浅表淋巴结肿大。皮肤科情况:阴茎根部、阴茎近端及龟头可见巨大疣(菜花)状增生物,呈灰白或淡红色,质硬,上覆黄色或黑色痂皮、污秽,无分泌物,最大处直径约8 cm,伴有恶臭(图1),血、尿、粪常规、肝、肾功能、骨盆X线平片等检查均正常。皮损组织病理示:表皮乳头瘤样增生,可见角化不全、角化不良细胞及空泡细胞,真皮部…     

角化性皮肤病

960144 局限性足底角化伴多发性皮角1例/王晓…//临床皮肤科杂志。-1995,24(4).-252 男,34岁。病期6年,双足外侧趾跖关节部各有一灰白角状硬物,长2.5cm。弯曲呈钩状。角质坚硬,基底部皮肤角化。左脚拇、次趾结节坚硬高出皮面0.6～1.0cm,表面有鳞屑。结合病理检查诊断为皮角。分次切除后痊愈。     

阴茎疣状癌并发皮角

报告1例阴茎疣状癌并发皮角。患者男,33岁。阴茎龟头部赘生物伴恶臭2年余。皮肤科检查见龟头部有一4cm×4cm×5cm大的肿块,表面湿润,呈颗粒状,伴感染、化脓和坏死,龟头1点钟处包皮内可见3cm长的角化性赘生物。经皮损组织病理检查诊断为鳞状细胞癌,癌细胞侵及阴茎海绵体;赘生物高度角化过度,基底部可见表皮增生和炎性细胞浸润。人乳头瘤病毒(HPV)6/11、16/18DNA实时PCR扩增结果均为阳性。腹股沟淋巴结穿刺未见癌细胞。治疗上采取阴茎大部切除术。     

阴茎疣状黄瘤1例

患者男,50岁。1年前,阴茎包皮外伤后出现一小溃疡,愈合后局部出现淡红色米粒大丘疹,逐渐增至1.0cm x0.5cm大的淡红色疣状孤立性肿物,呈透明颗粒状,界清,无分泌物。皮损组织病理示:表皮乳头瘤样增生,角化不全,角化过度,棘层肥厚,真皮乳头内见大量泡沫细胞。诊断:疣状黄瘤。     

鼻部巨大型角化棘皮瘤

报告1例鼻部巨大型角化棘皮瘤。患者男,45岁。因鼻部包块3个月。无痛痒,曾在当地医院行手术切除,组织病理诊断为角化棘皮瘤。术后10余天于手术部位再次出现新生肿物,并逐渐增大至鸡蛋大,我院皮损组织病理检查:表皮增生,角化过度,伴有角栓形成及角囊肿形成,表皮突不规则延伸,呈假上皮瘤样增生,真皮见以淋巴细胞、浆细胞为主的炎性细胞浸润,伴局灶性异物肉芽肿形成。诊断:鼻部巨大型角化棘皮瘤。转上级医院手术切除。     

Cowden综合征1例

患者女,19岁,口腔、面、四肢丘疹15年,腹痛2周。皮肤科情况:口腔黏膜、舌部、面部及四肢可见散在皮色角化性丘疹,部分呈疣状或乳头瘤样,面部为甚。胃肠镜检查:消化道多发性息肉。组织病理学检查:(胃窦黏膜)增生性息肉伴中度慢性炎症,HP(+);(舌部)鳞状上皮乳头状瘤;(右前臂)表皮角化过度,局部棘层及颗粒层增生。诊断:Cowden综合征。     

表现为角状增生的化脓性肉芽肿

报告1例呈角状增生表现的化脓性肉芽肿。患者女，32岁。下唇正中有一黑褐色柱状增生物，凸出皮面约1．5cm。皮损组织病理检查示毛细血管扩张性肉芽肿。     

Palisading granuloma of the penis: a variant of subcutaneous granuloma annulare

INTRODUCTION: Subcutaneous granuloma annulare on the penis has only been reported exceptionally. OBSERVATION: A 41 year-old man presented with four small, asymptomatic nodules on the glans penis. Histological examination of a biopsy revealed a deep palisading granuloma progressing not only around the alcian-blue necrobiosis areas but also around the smooth muscle fibers. The lesion regressed spontaneously after two years of progression. DISCUSSION: Palisading granuloma of the penis appears to be a most particular clinical form of subcutaneous granuloma annulare. It is characterized by small single or multiple nodules localized on the penis. On histological examination, the granuloma is deep and concentrates around the network of smooth muscle fibers of dartoic origin.     

Extramammary Paget's disease involving the penis, scrotum and the axilla

A 57-year-old man with a 2-year history of extramammary Paget's disease of the penis, scrotum and the axilla attended our urology clinic. The lesion in the axilla had been noticed 14 months later than the lesion involving the penis and scrotum. We performed a resection of both local extramammary Paget's disease lesions with a 3-cm margin. Intraoperative frozen sections were also used to ascertain clear surgical margins. Neither signs of recurrence nor underlying internal malignancy has developed after 2-year follow up. From our experience, extramammary Paget's disease may occur in multiple sites. In the absence of metastatic disease and underlying internal malignancy, a wide excision is recommended in the management of multiple lesions of extramammary Paget's disease.     

Multiple keratoacanthomata. A unique case and review of the current classification.

A case of multiple keratoacanthomata is described, with involvement of the palms and soles, and erosive lesions of the eyelids and penis. Several lesions healed spontaneously, leaving circular scars. Some were atypical clinically, taking the form of keratotic tumors. Methotrexate produced marked improvement of all lesions but had to be abandoned because of thrombocytopenia. The current classification of keratoacanthomata is reviewed.     

Nonvenereal sclerosing lymphangitis of the penis.

Sclerosing lymphangitis of the penis with a purplish, cord-like structure, singular or multiple around the coronal sulcus, appears 24 to 48 hours after sexual relations. There is edema of the glans penis and coronal area, which is doughy and plastic. The condition is self-limited.     

In-transit metastases from squamous cell carcinoma penis

An in-transit metastasis is one that is located between the primary tumor and the closest lymph node region and results from tumor emboli getting trapped in the lymphatic channels. A 65-year-old male patient who had undergone partial amputation of the penis and bilateral inguinal lymph node resection for squamous cell carcinoma of the penis 4 months earlier developed multiple cutaneous metastatic lesions in the pubic region and scrotum. The case is reported for the uncommon presentation of in-transit metastases.     

Agminated cellular blue naevi of the penis: dermoscopic,confocal and histopathological correlation of two cases

Blue naevi may present rarely as multiple lesions grouped in a circumscribed area, described as agminated blue naevi. This clinical presentation may mimic metastatic malignant melanoma. We present two cases of agminated cellular blue naevi of the penis, with dermoscopy, reflectance confocal microscopy and histopathological correlation. Dermoscopy of the area showed multiple grouped lesions of homogeneous dark‐brown to blue colour. Using reflectance confocal microscopy, focusing on the bluish areas, predominantly bright dendritic cells were visible at the dermoepidermal junction and papillary dermis, while in the brownish areas the presence of dendritic and bright cells predominated in the basal layer. Our patients are of special interest as they are the first cases, to our knowledge, reported of agminated blue naevi on the penis, studied by both dermoscopy and confocal microscopy, confirming the diagnosis with histopathological correlation. Moreover, one case represented a divided or ‘kissing’ blue naevus of the penis.     

Primary tuberculosis of the glans penis

A 60-year-old man presented with multiple superficial ulcers on the glans penis. Histopathology, a positive tuberculin test result, and therapeutic response to antituberculous therapy confirmed the diagnosis of penile tuberculosis. Examination was otherwise normal except for a solitary enlarged reactive lymph node on the right side. There was no evidence of coexistent tuberculous infection elsewhere.     

Necrobiotic granulomas localised to the penis: a possible variant of subcutaneous granuloma annulare

Three young men developed multiple firm asymptomatic nodules confined to the shaft of the penis. Skin biopsies from all 3 cases showed prominent necrobiotic granulomas indistinguishable from granuloma annulare. One of the patients had repeated recurrent nodules confined to the penis which were removed surgically over a period of 20 months. This unusual, but benign, presentation of granuloma annulare has to be distinguished from other granulomatous and malignant processes which may present as penile nodules.     

阴茎大汗腺汗囊瘤1例

报告阴茎大汗腺汗囊瘤1例.患者男,23岁.阴茎部出现一米粒大小肤色丘疹渐增大1月余.皮损组织病理学检查示表皮大致正常,真皮内可见一扩大的囊腔,囊壁由1～2层细胞构成,细胞核呈圆形或椭圆形,位于细胞底部,可见明显的顶浆分泌现象,未见囊内容物.诊断:阴茎大汗腺汗囊瘤.予手术完整切除皮损,切缘干净规整,对皮缝合后表面无渗液....     

AIDS-associated Kaposi's sarcoma in a heterosexual male--a case report

A 39 year old married heterosexual male presented with extensive purpuric macules, papules, and lichenoid plaques scattered over his skin and mucocutaneous surfaces for one year. The lesions were larger in both his groins, and were associated with lymphedema of his penis and scrotum. His serology for the HIV-1 virus was positive. Biopsies from multiple lesions confirmed the diagnosis of Kaposi's sarcoma. Histochemistry was positive for the HHV-8 virus. He subsequently developed pulmonary and peritoneal effusions and died 3 months later of cardiopulmonary arrest.