恶性纤维组织细胞瘤的诊断与治疗进展

恶性纤维组织细胞瘤具有恶性度高、转移快、易复发、预后差等特点,其发生率在软组织肿瘤中居首位。通过病理组织学特征、免疫组化标记物的表达、X线、CT、MRI的影像学特点可以准确的诊断出恶性纤维组织细胞瘤。单纯手术的复发率和转移率均较高。行广泛性、根治性切除术联合放疗与化疗取得了满意的治疗效果。分子水平技术的不断发展为恶性纤维组织细胞瘤的诊断、治疗、预后提出了新的诊疗思想。     

肿瘤干细胞与恶性纤维组织细胞瘤的治疗进展

肿瘤干细胞是肿瘤组织中存在的一部分具有干细胞性质的亚群,他们具有自我更新、无限增殖和多向分化的潜能。肿瘤干细胞理论认为肿瘤难以根除是因为肿瘤干细胞的存在。恶性纤维组织细胞瘤是一种常见的恶性肿瘤,术后复发率极高,目前其根除仍是一个难题。现已有文章报道分离出了恶性纤维组织细胞瘤中的肿瘤干细胞,这无疑给根除恶性纤维组织细胞瘤带来了新的希望。     

12例肺恶性纤维组织细胞瘤的诊断与治疗

对肺恶性纤维组织细胞瘤１２例进行了回顾性分析，旨在提高对其临床表现、诊断和外科处理的认识。结果本组病人病程长短差异较大，胸部Ｘ线、ＣＴ检查缺乏特征性表现，气管镜及痰脱落细胞学检查阳性率不高，术后局部复发率为３３．３％，远处转移率为４１．７％，３年生存率为２５％。结论：肺恶性纤维组织细胞瘤应以手术治疗为主，如能早期诊断，彻底切除并配合放、化疗综合治疗，可望改善其不良预后，提高治疗效果     

软组织恶性纤维组织细胞瘤的治疗

发生于软组织的恶性纤维组织细胞瘤１２例，平均年龄６１．９岁，平均随访２９个月。本病与发生在骨组织的恶性纤维组织与细胞瘤不同，病理学还可分为席纹样－多形性型。粘样型。巨细胞型，黄色肉芽肿型，本病局部广泛切除可以得到较好的治疗。综合治疗特别放疗及化疗药物的应用，对减少复发，治疗转移有一定的疗效。     

软组织恶性纤维组织细胞瘤的治疗(附12例报告)

发生于软组织的恶性纤维组织细胞瘤１２例，平均年龄６１．９岁，平均随访２９个月。本病与发生在骨组织的恶性纤维组织细胞瘤不同，病理学还可分为席纹样－多形性型、粘液样型、巨细胞型、黄色肉芽肿型。本病局部广泛切除可以得到较好的治疗，综合治疗特别放疗及化疗药物的应用，对减少复发，治疗转移有一定的疗效。     

骨原发性恶性纤维组织细胞瘤

骨原发性恶性纤维组织细胞瘤赵春和,向国元,叶学正,田明,韦正超骨原发性恶性纤维组织细胞瘤（ｍａｌｉｇｎａｎｔｆｉｂｒｏｕｓｈｉｓｔｉｏｃｙｔｏｍａ,ＭＦＨ）比较少见。自１９的年０’Ｂｒｅｎ及Ｓｔｏｕｔ首次提出恶性纤维黄色瘤（即恶性纤维组织细胞瘤）以来...     

小肠恶性纤维组织细胞瘤一例

患者女 ,69岁 ,因阵发性腹痛 2 0余日就诊。体格检查 :全身浅表淋巴结无肿大 ,左下腹部触及一实性包块 ,约8ｃｍ× 7ｃｍ× 6ｃｍ ,活动度小 ,有触疼。妇科检查无异常发现。Ｂ超报告为右下腹实性占位性病变。临床考虑为腹腔恶性肿瘤。行剖腹探查手术 ,术中见肿瘤位于回肠 ,约7ｃｍ× 6ｃｍ× 5ｃｍ ,与周围组织无粘连 ,腹腔其他脏器无异常 ,亦无肿大淋巴结 ,将肿瘤段肠管切除。病理检查 :切除肠管长 1 4ｃｍ ,肿瘤距两切缘分别为 3ｃｍ及 4ｃｍ ,大小为 7ｃｍ×6ｃｍ× 5ｃｍ ,切开肿瘤见中央有一腔隙 ,内面为肠粘膜 ,表面尚光滑 ,腔隙外周…     

肢体软组织恶性纤维组织细胞瘤

作者总结１１例发生于软组织的恶性纤维组织细胞瘤，男３例，女８例，平均年龄３１岁，平均病期７个月，随访６年。本病与发生在骨组织的肿瘤在临床方面表现为发病部位的不同，局部软组织肿物生长较快，形成结节，发生溃疡时呈菜花样外观。病理学表现出典型的成纤维细胞及组织细胞特征，胶原纤维排列成漩涡状，细胞核有异型性，有分裂相。本病预后较一般肉瘤要好，局部扩大切除范围可以得到根治性治疗。在随访过程中未发现有远处转移的病例。     

右下肢恶性纤维组织细胞瘤伴盆腔转移1例

<正>患者,男,45岁,右下肢肿物17年,皮肤破溃6月余,于2014年7月24日入院。患者17年前发现右大腿外侧肿物,轻度压痛,局部皮温正常,17年来肿物逐渐增大,6个月前肿物迅速增大,并逐渐撑破皮肤,肿物溃烂。查体:右膝关节上方可见大小约20 cm×18 cm的破溃创面,肿物呈菜花生长样,表面凹凸不平,伴有淡黄色脓液渗出,血运丰富。右大腿外侧及右腹股沟区分别可见约7     

骨的恶性纤维组织细胞瘤诊治分析

[目的]探讨骨的恶性纤维组织细胞瘤的临床特点、诊断及治疗方法。[方法]回顾性分析52例骨的恶性纤维组织细胞瘤患者的临床资料,包括发病部位、术前影像学检查、穿刺活检、肿瘤外科分期、治疗方法以及随访结果等。[结果]52例患者肿瘤位于膝关节周围32例、肩关节周围14例、股骨近端3例,跟骨、腰椎、髂骨各1例。术前常规行X线片、CT及MRI,并行穿刺活检。根据Enneking肿瘤外科分期,20例属于ⅡA期,32例属于ⅡB期。所有病例除1例保守治疗外,其余均行手术治疗,以保肢术为主,保肢率74.5%(38/51),同时进行术前、术后化疗及术后放疗。36例患者经过长期随访,随访率69.2%(36/52),其中局部复发9例,远处转移6例,5年生存率61.1%(22/36)。[结论]术前穿刺活检结合影像学检查对恶性纤维组织细胞瘤的诊断有很大帮助,治疗以保肢手术为主,术前、术后化疗以及术后放疗可以防止肿瘤复发,肿瘤的彻底切除是骨的恶性纤维组织细胞瘤治愈的关键。     

Retroperitoneal malignant fibrous histiocytoma

Five cases of malignant fibrous histiocytoma located in the retroperitoneum are reported. Paraneoplastic syndrome, abdominal mass, tendency to local recurrence, laborious therapy and poor prognosis are the clinical characteristics of this tumor. Accuracy of actual diagnosis is evaluated and pathological features are analyzed.     

Retroperitoneal malignant fibrous histiocytoma

We report a new case of retroperitoneal tumor: a malignant fibrous histiocytoma, in its less aggressive histologic type, the mixoid variety. This is a recently isolated histologic presentation from other sarcomas, with a low incidence, non-specific clinic findings and poor prognosis due to its tendency to reappear and to produce metastasis.     

Retroperitoneal malignant fibrous histiocytoma

Malignant fibrous histiocytoma is the commonest soft tissue sarcoma of adults. The soft tissue of the extremities is the commonest primary site of malignant fibrous histiocytoma. It is much less common in the female retroperitoneum, leading to diagnostic errors. The clinical, radiographic and CT signs are non-specific. This tumor can only be diagnosed by histology. An initial complete resection is essential for successful treatment of the primary tumor. Radiation therapy is limited and chemotherapy has only been successful in a limited number of cases. This tumor has a poor prognosis. These lesions are relatively rare and consequently difficult to study. The authors report three cases and review the literature.     

Primary renal malignant fibrous histiocytoma

The ninth case of a primary renal malignant fibrous histiocytoma to appear in the English literature is described. The patient underwent preoperative renal artery embolization followed by radical nephrectomy and adjuvant chemotherapy. While adjuvant chemotherapy has prolonged the disease free interval and improved the survival rates for patients with tumor arising at other sites, its use in our patient did not prevent the development of metastasis and the patient's early death.     

Retroperitoneal malignant fibrous histiocytoma.

Authors review the case history and follow-up a rare malignant fibrous histiocytoma patient, based on the relevant literary data. The tumor filled the retroperitoneum on the right side, in front of the right kidney. Intravenous urography and computer tomography revealed a 10 x 15 cm sized mass, suspect of being a kidney tumor. Upon surgery, the tumor was found to be a retroperitoneal malignant fibrous histiocytoma. In connection to the case, a brief review is given of the storiform type of malignant fibrous histiocytoma, regarding its etiological, clinical and pathological aspects, the difficulties in diagnosis, as well as the therapeutic possibilities. Authors regard their case worthy of publication because of the retroperitoneal location and significant size of the tumor, and because of the unproven diagnosis prior to surgery. Even after 4 years the patient is symptom- and complaint-free, and CT has revealed no metastases.     

Renal malignant fibrous histiocytoma.

The clinical, radiographic, and pathologic findings of 2 cases of malignant fibrous histiocytoma (MFH) of the renal capsule are reported and the 17 previous cases in the literature reviewed. Preoperative differentiation from renal adenocarcinoma was precluded by the overlap in clinical, laboratory, and radiologic findings, although MFH usually presented with a normal urine analysis and less parenchymal involvement on imaging studies. Pathologic differential diagnosis and therapeutic approaches are presented.