Triazole-based novel bis Schiff base colorimetric and fluorescent turn-on dual chemosensor for Cu2+ and Pb2+: application to living cell imaging and molecular logic gates

A triazole-based novel bis Schiff base colorimetric and fluorescent chemosensor (L) has been designed, synthesized and characterized by elemental analysis, ¹H-NMR, ESI-MS, FTIR spectra and DFT studies. The receptor L showed selective and sensitive colorimetric sensing ability for Cu²⁺ and Pb²⁺ ions by changing color from colorless to yellow and light yellow respectively in CH₃OH–tris-buffer (1 : 1, v/v). However, it displayed strong fluorescence enhancement upon the addition of both Cu²⁺ and Pb²⁺ ions, attributed to the blocking of PET. The fluorometric detection limits for Cu²⁺ and Pb²⁺ were found to be 12 × 10⁻⁷ M and 9 × 10⁻⁷ M and the colorimetric detection limits were 3.7 × 10⁻⁶ M and 1.2 × 10⁻⁶ M respectively; which are far below the permissible concentration in drinking water determined by WHO. Moreover, it was found that chemosensor L worked as a reversible fluorescence probe towards Cu²⁺ and Pb²⁺ ions by the accumulation of S²⁻ and EDTA respectively. Based on the physicochemical and analytical methods like ESI-mass spectrometry, Job plot, FT-IR, ¹H-NMR spectra and DFT studies the detection mechanism may be explained as metal coordination, photoinduced electron transfer (PET) as well as an internal charge transfer (ICT) process. The sensor could work in a pH span of 4.0–12.0. The chemosensor L shows its application potential in the detection of Cu²⁺ and Pb²⁺ in real samples, living cells and building of molecular logic gate.

A novel triazole-based bis Schiff base colorimetric and fluorescent chemosensor (L) has been designed, synthesized and characterized. The chemo-sensor L shows its application potential in the detection of Cu²⁺ and Pb²⁺ in living cells and building molecular logic gate.     

A colorimetric and ratiometric fluorescent sensor for sequentially detecting Cu2+ and arginine based on a coumarin–rhodamine B derivative and its application for bioimaging

In this work, a colorimetric and ratiometric fluorescent sensor based on a coumarin–rhodamine B hybrid for the sequential recognition of Cu²⁺ and arginine (Arg) via the FRET mechanism was designed and synthesized. With the addition of Cu²⁺, the solution displayed a colorimetric change from pale yellow to pink which is discernible by the naked eye. Additionally, the fluorescence intensities of the sensor exhibited ratiometric changes for the detection of Cu²⁺ at 490 and 615 nm under a single excitation wavelength of 350 nm, which corresponded to the emissions of coumarin and rhodamine B moieties, respectively. The fluorescence color change could be visualized from blue to pink. The limits of detection were determined to be as low as 0.50 and 0.47 μM for UV-vis and fluorescence measurements, respectively. More importantly, the sensor not only can recognize Cu²⁺ and form a sensor-Cu²⁺ complex but can also sequentially detect Arg with the resulting complex. The detection limits for Arg were as low as 0.60 μM (UV-vis measurement) and 0.33 μM (fluorescence measurement), respectively. A fluorescence imaging experiment in living cells demonstrated that the fabricated sensor could be utilized in ratiometric fluorescence imaging towards intracellular Cu²⁺, which is promising for the detection of low-level Cu²⁺ and Arg with potentially practical significance.

A FRET-based colorimetric and ratiometric coumarin–rhodamine B fluorescent sensor was designed, and its sensing behaviors for sequentially detecting Cu²⁺ and arginine were studied systematically.     

A novel dihydro phenylquinazolinone-based two-in-one colourimetric chemosensor for nickel(ii), copper(ii) and its copper complex for the fluorescent colourimetric nanomolar detection of the cyanide anion

Currently, considerable efforts have been devoted to the detection and quantification of hazardous multi-analytes using a single probe. Herein, we have developed a simple, environment-friendly colourimetric sensor for the sensitive, selective and rapid detection of Ni²⁺ and Cu²⁺ ions using a simple organic Schiff base ligand L in methanol–Tris–HCl buffer (1 : 1 v/v, 10 mM, pH = 7.2). The probe L exhibited a binding-induced colour change from colourless to yellow and fluorescence quenching in the presence of both Ni²⁺ and Cu²⁺ ions. The interactions between L and the respective metal ions were studied by Job''s plot, electrospray ionisation-mass spectrometry (ESI-MS), Fourier-transform infrared spectroscopy (FT-IR), density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations. The limit of detection (LOD) of L towards Ni²⁺ and Cu²⁺ was calculated to be 7.4 × 10⁻⁷ M and 4.9 × 10⁻⁷ M, respectively. Furthermore, the L–Cu²⁺ complex could be used as a new cascade fluorescent-colourimetric sensor to detect CN⁻ ions with a very low level of detection (40 nM). Additionally, L could operate in a wide pH range, and thus was successfully applied for the detection and quantification of Ni²⁺ and Cu²⁺ in environmental samples, and for building OR- and IMPLICATION-type logic gates.

A novel colorimetric chemosensor L has been developed for the detection of Ni²⁺ and Cu²⁺ ions. The obtained L–Cu²⁺ complex can be used as a new cascade fluorescent-colorimetric sensor for the nanomolar detection of CN⁻ ions. This chemosensor has practical application.     

A simple hydrazone as a multianalyte (Cu2+, Al3+, Zn2+) sensor at different pH values and the resultant Al3+ complex as a sensor for F−

A new colorimetric and fluorescence molecular chemosensor based on triazole hydrazone can be used as a multi-probe for selective detection of Al³⁺, Zn²⁺, and Cu²⁺ by monitoring changes in the absorption and fluorescence spectral patterns. Results show that Al³⁺ and Zn²⁺ ions can induce remarkable fluorescence enhancement at pH 6.0 and pH 10.0, respectively, while the addition of Cu²⁺ ions leads to a significant UV-visible absorption enhancement in the visible range at pH 6.0. In addition, the resultant Al³⁺ complex could act as an ‘on–off’ fluorescence sensor for F⁻. The fluorescence sensor was also used to monitor intracellular Al³⁺, Zn²⁺, and F⁻ in Hela cells.

A fluorescent probe for Al³⁺ and Zn²⁺ was synthesised, and the resultant Al³⁺-complex was used for the detection of F⁻.     

An ‘‘off–on–off’’ sensor for sequential detection of Cu2+ and hydrogen sulfide based on a naphthalimide–rhodamine B derivative and its application in dual-channel cell imaging

A novel colorimetric and fluorometric sensor with unique dual-channel emission to sequentially detect Cu²⁺ and hydrogen sulfide (H₂S) was synthesized from naphthalimide–rhodamine B through the PET and FRET mechanism. The sensor showed a selective “off–on” fluorescence response with a 120-fold increase toward Cu²⁺, and its limits of detection were 0.26 μM and 0.17 μM for UV-vis and fluorescence measurements, respectively. In addition, 1–Cu²⁺ was an efficient “on–off” sensor to detect H₂S with detection limits of 0.40 μM (UV-vis measurement) and 0.23 μM (fluorescence measurement), respectively. Furthermore, the sensor can also be used for biological imaging of intracellular staining in living cells. Therefore, the sensor should be highly promising for the detection of low level Cu²⁺ and H₂S with great potential in many practical applications.

A novel colorimetric and fluorometric sensor with unique dual-channel emission to sequentially detect Cu²⁺ and hydrogen sulfide (H₂S) was synthesized from naphthalimide–rhodamine B through the PET and FRET mechanism.     

A simple fluorescent probe for detection of Ag+ and Cd2+ and its Cd2+ complex for sequential recognition of S2−

In this study, we designed and synthesized a simple probe 2-(8-((8-methoxyquinolin-2-yl)methoxy)quinolin-2-yl)benzo[d]thiazole (DQT) for detection of Ag⁺ and Cd²⁺ in a CH₃OH/HEPES (9 : 1 v/v, pH = 7.30) buffer system. Its structure was characterized by NMR, ESI-HR-MS and DFT calculations, and its fluorescence performance was also investigated. Probe DQT showed fluorescence quenching in response to Ag⁺ and Cd²⁺ with low detection limits of 0.42 μM and 0.26 μM, respectively. Importantly, the complexation of the probe with Cd²⁺ resulted in a red shift from blue to green, making it possible to detect Ag⁺ and Cd²⁺ by the naked eye under an ultraviolet lamp. The DQT-Cd²⁺ complex could be used for sequential recognition of S²⁻. The recovery response could be repeated 3 times by alternate addition of Cd²⁺ and S²⁻. A filter paper strip test further demonstrated the potential of probe DQT as a convenient and rapid assay.

A fluorescent probe for detection of Ag⁺ and Cd²⁺ and its Cd²⁺ complex for sequential recognition of S²⁻.     

A highly selective multi-responsive fluorescence sensor for Zn2+ based on a diarylethene with a 4,6-dimethylpyrimidine unit

A novel turn-on mode fluorescent diarylethene containing a 4,6-dimethylpyrimidine unit was developed to fluorescently sense Zn²⁺. Its multiple-responsive properties induced by Zn²⁺/EDTA and ultraviolet/visible light have been systematically studied. The fluorescence sensor could efficiently detect Zn²⁺ with a 10 times enhancement of emission intensity and fluorescence color change (dark-green). In addition, the sensor showed clear discrimination from Cd²⁺. The limit of detection of the sensor was measured to be 8.48 × 10⁻⁸ mol L⁻¹ for Zn²⁺. Finally, a molecular logic circuit was fabricated with the emission at 528 nm as the output signal and light and chemical stimuli as input signals.

A novel multi-responsive fluorescence sensor based on a diarylethene derivative with a 4,6-dimethylpyrimidine unit was developed for Zn²⁺ detection.     

Dual-response detection of Ni2+ and Cu2+ ions by a pyrazolopyrimidine-based fluorescent sensor and the application of this sensor in bioimaging

Herein, a dual-response fluorescent sensor, L, based on pyrazolopyrimidine was designed and developed for the simultaneous detection of Ni²⁺ and Cu²⁺ ions in the presence of other metal ions; the structural characterization of L was carried out by FTIR spectroscopy, NMR spectroscopy, HRMS and X-ray diffraction analysis. The sensor L effectively displayed fluorescence quenching towards the Ni²⁺ and Cu²⁺ ions with high sensitivity without interference from other metal ions. The results reveal that L binds to Ni²⁺ and Cu²⁺ in a 2 : 1 pattern, which matches well with the result of the Job''s plot. The association constants of L with Ni²⁺ and Cu²⁺ were 3.2 × 10⁴ M⁻¹ and 7.57 × 10⁴ M⁻¹, respectively. The detection limits (DLs) are down to 8.9 nM for Ni²⁺ and 8.7 nM for Cu²⁺. The fluorescence imaging of L in T-24 cells was investigated because of the low cytotoxicity of L, indicating that L could be used to detect Ni²⁺ and Cu²⁺ in living cells.

A pyrazolopyrimidine-based fluorescent sensor L was developed and applied for detection of Cu²⁺ and Ni²⁺ in ethanol solution by photoluminescence quenching. It shows low cytotoxicity and good imaging characteristics for Cu²⁺ and Ni²⁺ in living cells.     

A chemosensor with a paddle structure based on a BODIPY chromophore for sequential recognition of Cu2+ and HSO3−

In this study, a highly selective chemosensor ML based on a BODIPY fluorescent chromophore was synthesized for sequential recognition of Cu²⁺ and HSO₃⁻ in a CH₃OH/H₂O (99 : 1 v/v) system, which contained three recognition sites and its structure characterized by ¹H NMR, ¹³C NMR and ESI-HR-MS. The sensor ML showed an obvious “on–off” fluorescence quenching response toward Cu²⁺ and the ML-Cu²⁺ complex showed an “off–on” fluorescence enhancement response toward HSO₃⁻. The detection limit of the sensor ML was 0.36 μM to Cu²⁺ and 1.4 μM to HSO₃⁻. In addition, the sensor ML showed a 1 : 3 binding stoichiometry to Cu²⁺ and the recovery rate of ML-Cu²⁺ complex identifying HSO₃⁻ could be over 70%. Sensor ML showed remarkable detection ability in a pH range of 4–8.

A highly selective chemosensor based on a BODIPY chromophore for sequential recognition of Cu²⁺ and HSO₃⁻.     

Functionalization of silver nanoparticles with mPEGylated luteolin for selective visual detection of Hg2+ in water sample

A novel colorimetric sensor based on mPEGylated luteolin-functionalized silver nanoparticles (mPEGylated luteolin-AgNPs) in an aqueous solution was prepared. The mPEGylated luteolin-AgNP solution was utilized to detect Hg²⁺ with high sensitivity and selectivity in the presence of other metal cations including Na⁺, K⁺, Mg²⁺, Zn²⁺, Ni²⁺, Mn²⁺, Ba²⁺, Pb²⁺, Sr²⁺, Ca²⁺, Cd²⁺, Al³⁺ and Cu²⁺. The solution could be induced to aggregate, and a color change from yellow-brown to colorless was observed in the presence of Hg²⁺. Meanwhile, the sensor was successfully used to detect Hg²⁺ in tap water with satisfactory recovery ranges using the standard addition method.

A novel colorimetric sensor for selective detection of Hg²⁺ based on mPEGylated luteolin functionalized silver nanoparticles was prepared.     

Selective determination of Ag+ in the presence of Cd2+, Hg2+ and Cu2+ based on their different interactions with gold nanoclusters

In this work, a fluorescence method was developed for selective detection of Ag⁺ in the presence of Cd²⁺, Hg²⁺, and Cu²⁺ based on gold nanoclusters (AuNCs). That is, bovine serum albumin (BSA) templated AuNCs with double emission peaks were synthesized using BSA as a protective agent. AuNCs with uniform distribution and average size between 2.0 and 2.2 nm were synthesized using a green and simple method, and showed bright orange-red fluorescence under ultraviolet light. AuNCs have two emission peaks at 450 nm and 630 nm with an excitation wavelength of 365 nm. Under alkaline conditions, Cd²⁺ can combine with the surface sulfhydryl groups of BSA–AuNCs to form Cd–S bonds, which cause AuNCs to aggregate, resulting in an increase in fluorescence intensity at 630 nm. Conversely, due to the d¹⁰–d¹⁰ metal affinity interaction, the addition of Hg²⁺ can reduce the fluorescence peak at 630 nm. Ag⁺ was reduced to Ag⁰ by gold nuclei in AuNCs, forming a stable hybrid Au@ AgNCs species with blue-shifted and enhanced fluorescence. Finally, the paramagnetic behavior of Cu²⁺ combined with BSA causes the excited electrons of the gold cluster to lose their energy via ISC, eventually leading to simultaneous quenching of the two emission peaks. The results show that the limit of detection (LOD) of Ag⁺, Hg²⁺, Cd²⁺ and Cu²⁺ is 1.19 μM, 3.39 μM, 1.83 μM and 5.95 μM, respectively.

A fluorescence method was developed for selective detection of Ag⁺ in the presence of Cd²⁺, Hg²⁺, and Cu²⁺ based on gold nanoclusters. The limit of detection for Ag⁺, Hg²⁺, Cd²⁺ and Cu²⁺ is 1.19 μM, 3.39 μM, 1.83 μM and 5.95 μM, respectively.     

An ink-jet printed dual-CD ratiometric fluorescent paper-based sensor for the visual detection of Cu2+

Copper ion (Cu²⁺) plays an important role in the human body because it is beneficial for metabolism. However, an excessive or slight amount of Cu²⁺ can cause various symptoms. Therefore, it is necessary for human health to realize the trace and visual detection of Cu²⁺. Referring to traditional fluorescence test papers, the qualitative and semi-quantitative detection of Cu²⁺ could be realized by a dual-carbon dots (CDs) ratiometric fluorescent paper-based sensor with the advantages of environmental protection, portability and low cost. In this paper, the inkjet-printed test paper with the best mixing ratio of the two CDs has been researched to maximize the spectral energy transfer of ion detection (maximum color gamut expansion). Among them, the preparation method of b-CDs has been improved, increasing the photoluminescence quantum yield (PLQY) to 88.9%. The sensitivity detection limit of the double emission ratio sensor was 0.15 nM in solution, and the human eye can distinguish at least 3 μmol L⁻¹ Cu²⁺ in the paper-based sensor. Compared with the traditional single-emission sensor, the human eye was more sensitive to the color change of the emission ratio sensor. The results indicate that we not only realized the micro detection of Cu²⁺ with convenient methods, but also provided a promising strategy for the visual detection of Cu²⁺.

A fluorescent test paper sensor for qualitative and semi-quantitative detection of Cu²⁺ is designed based on high photoluminescence quantum yield (PLQY) carbon dots (CDs).     

Novel single excitation dual-emission carbon dots for colorimetric and ratiometric fluorescent dual mode detection of Cu2+ and Al3+ ions

In this study, dual-emission carbon dots (D-CDs) are synthesized via a simple one-step solvothermal treatment of red tea. The obtained D-CDs are characterized by XPS, IR, TEM, XRD, fluorescence and UV-vis spectroscopy techniques. It is found that D-CDs present a strong red fluorescence emission peak at 671 nm and weak blue fluorescence emission peak at 478 nm under the excitation wavelength of 410 nm. The unique dual-emission properties of D-CDs provide great opportunities in ratiometric fluorescence sensing applications. The results show that Cu²⁺ ions can quench the fluorescence of the red emission band of D-CDs effectively, resulting in the disappearance of red fluorescence ultimately. Upon the addition of Al³⁺ ions, the fluorescence of blue emission band at 478 nm grows apparently, and the fluorescence color transforms gradually from red to orange, then to yellow-green. Based on these findings, a novel ratiometric fluorescence and colorimetric dual mode nanosensor is developed for simultaneous detection of Cu²⁺ and Al³⁺ ions. Regarding Cu²⁺ ions, the fluorescent detection linear range is 0.1–50 μM with detection limit of 0.1 μM, and the colorimetric detection limit is estimated as 25 μM. With regard to Al³⁺ ions, the fluorescent detection linear range is 0–20 μM and 25–100 μM with detection limit of 0.5 μM, and the colorimetric detection limit is 20 μM. Furthermore, the fluorescence response mechanisms of Cu²⁺ and Al³⁺ ions were discussed detailed. To the best of our current knowledge, this will be the first research work on the simultaneous determination of Cu²⁺ and Al³⁺ using D-CDs as fluorescent probes.

D-CDs with strong red emission and weak blue emission as an effective colorimetric and ratiometric fluorescence sensing probe are employed to realize the simultaneous detection of Cu²⁺ and Al³⁺ ions without any interference effect.     

A rapid on-site analysis method for the simultaneous extraction and determination of Pb2+ and Cd2+ in cereals

In order to achieve rapid on-site screening and solve the problem of rapid pretreatment for the determination of lead (Pb²⁺) and cadmium (Cd²⁺) in cereals by a portable electrochemical analyzer with disposable screen-printed electrodes (SPEs), a new reliable and simple extraction method for Pb²⁺ and Cd²⁺ in cereals was developed. The Pb²⁺ and Cd²⁺ in cereals were purified by a mixed solution of 1 mol L⁻¹ potassium iodide (KI)/5% vitamin C (VC)/ethyl acetate after being extracted by 10% HNO₃, which transfers the Pb²⁺ and Cd²⁺ into ethyl acetate after a reaction with KI–VC. Then, the Pb²⁺ and Cd²⁺ were eluted from ethyl acetate with 5% HNO₃ and were determined by an electrochemical analyzer with screen printed electrodes. Under the optimized conditions, the matrix calibration curves of Pb²⁺ and Cd²⁺ in rice and wheat showed good linear relationships with R² > 0.996. The method shows a detection limit (LOD) for Cd²⁺ in rice and wheat of 6.7 μg kg⁻¹ and 11.5 μg kg⁻¹, and the corresponding values for Pb²⁺ were 34.9 and 31.1 μg kg⁻¹, respectively. The relative standard deviation (RSD) was less than 8.7% for Cd²⁺ and Pb²⁺. In addition, the recoveries of the tested reference materials using this method were between 80% and 120%. From sample pretreatment to testing results, the whole process took no more than 25 min, and the operation was simple for operators, green to the environment, cheap in terms of instruments, and above all suitable for on-site detection. The results implied that this portable electrochemical method with new pretreatment may be a good choice for screening Pb²⁺ and Cd²⁺ in cereal samples on-site.

To achieve rapid on-site screening rapid pretreatment for the determination of Pb²⁺ and Cd²⁺ in cereals by a portable electrochemical analyzer with disposable screen-printed electrodes, a new reliable and simple extraction method for Pb²⁺ and Cd²⁺ was developed.     

Thiolated poly(aspartic acid)-functionalized two-dimensional MoS2, chitosan and bismuth film as a sensor platform for cadmium ion detection

In this work, a sensitive electrochemical platform for determination of cadmium ions (Cd²⁺) is obtained using thiolated poly(aspartic acid) (TPA)-functionalized MoS₂ as a sensor platform by differential pulse anodic stripping voltammetry (DPASV). The performance of the TPA–MoS₂-modified sensor is systemically studied. It demonstrates that the TPA–MoS₂ nanocomposite modified sensor exhibits superior analytical performance for Cd²⁺ over a linear range from 0.5 μg L⁻¹ to 50 μg L⁻¹, with a detection limit of 0.17 μg L⁻¹. Chitosan is able to form a continuous coating film on the surface of the GC electrode. The good sensing performance of the TPA–MoS₂-modified sensor may be attributed to the following factors: the large surface area of MoS₂ (603 m² g⁻¹), and the abundant thiol groups of TPA. Thus, the TPA–MoS₂-modified sensor proves to be a reliable and environmentally friendly tool for the effective monitoring of Cd²⁺ existing in aquacultural environments.

In this work, a sensitive electrochemical platform for determination of cadmium ions (Cd²⁺) is obtained using thiolated poly(aspartic acid) (TPA)-functionalized MoS₂ as a sensor platform by differential pulse anodic stripping voltammetry (DPASV).     

Sensitive electrochemical sensor based on poly(l-glutamic acid)/graphene oxide composite material for simultaneous detection of heavy metal ions

Heavy metal pollution can be toxic to humans and wildlife, thus it is of great significance to develop rapid and sensitive methods to detect heavy metal ions. Here, a novel type of electrochemical sensor for the simultaneous detection of heavy metal ions has been prepared by using poly(l-glutamic acid) (PGA) and graphene oxide (GO) composite materials to modify the glassy carbon electrode (GCE). Due to the good binding properties of poly(l-glutamic acid) (PGA) for the heavy metal ions (such as Cu²⁺, Cd²⁺, and Hg²⁺) as well as good electron conductivity of graphene oxide (GO), the heavy metal ions, Cu²⁺, Cd²⁺, and Hg²⁺ in aqueous solution can be accurately detected by using differential pulse anodic stripping voltammetry method (DPASV). Under the optimized experiment conditions, the modified GCE shows excellent electrochemical performance toward Cu²⁺, Cd²⁺, and Hg²⁺, and the linear range of PG/GCE for Cu²⁺, Cd²⁺, and Hg²⁺ is 0.25–5.5 μM, and the limits of detection (LODs, S/N ≥ 3) Cu²⁺, Cd²⁺, and Hg²⁺ are estimated to be 0.024 μM, 0.015 μM and 0.032 μM, respectively. Moreover, the modified GCE is successfully applied to the determination of Cu²⁺, Cd²⁺, and Hg²⁺ in real samples. All obtained results show that the modified electrode not only has the advantages of simple preparation, high sensitivity, and good stability, but also can be applied in the field of heavy metal ion detection.

A novel electrochemical sensor with high stability and good reproducibility for the simultaneous detection of heavy metal ions was prepared by using PGA/GO to modify the GCE, showing high sensitivity of superior to most of the reported values.     

Enhanced chemical sensing for Cu2+ based on composites of ZIF-8 with small molecules

Two organic molecules, pyridoxal hydrazide (PAH) and salicylaldehyde based Rhodamine B hydrazone (RBS) were integrated into zeolitic imidazolate framework-8 (ZIF-8) to give composites, namely PAH/ZIF-8 and RBS/ZIF-8. The organic molecules and ZIF-8 are proposed to be assembled via hydrogen bonds and π–π stacking in the composites. The mass fraction of PAH and RBS in the composites was calculated to be 21.86% and 29.3%. The fluorescence of PAH/ZIF-8 is quenched regularly by Cu²⁺. The detection limit for Cu²⁺ was calculated to be 1.42 nM for PAH/ZIF-8, which is one order of magnitude lower than that of PAH. The detection limit for Cu²⁺ was determined to be 0.8 μM for RBS/ZIF-8, which is three times lower than that of RBS. The two composites both display high selectivity to Cu²⁺ over competing metal ions. The PAH/ZIF-8 fluorescent sensor was successfully applied to Cu²⁺ determination in environmental water. PAH/ZIF-8 exhibits excellent cell membrane permeability and low cytotoxicity in cellular imaging. The enhanced chemical sensor was designed by introducing small molecules into ZIF-8 for the specific recognition of Cu²⁺.

An enhanced chemical sensor was designed by introducing small molecules into ZIF-8 for the specific recognition of Cu²⁺.     

A highly selective fluorescent probe for detection of Cd2+ and HSO3− based on photochromic diarylethene with a triazole-bridged coumarin-quinoline group

A novel photochromic diarylethene containing a quinoline-linked 3-aminocoumarin Schiff base unit (1O) was synthesized and used for the selective detection of Cd²⁺ and HSO₃⁻. The synthesized probe exhibited a straightforward response for the selective detection of Cd²⁺. Its fluorescence emission red-shifted ∼126 nm and was enhanced 24.9 fold in the presence of Cd²⁺. Meanwhile, the fluorescence color of 1O changed from dark cyan to golden yellow. The binding stoichiometry between 1O and Cd²⁺ was determined to be 1 : 1. A molecular logic circuit with three inputs and one output was successfully constructed with its light and metal-responsive behaviors. In addition, 1O was able to selectively recognize HSO₃⁻ with a 135-fold enhanced fluorescence emission and a notable fluorescence color change from dark cyan to bright cyan. The ¹H NMR and mass spectrometry analyses suggest that the HSO₃⁻ sensing of 1O is based on the hydrolysis of the Schiff base group of 1O.

A novel photochromic diarylethene containing a quinoline-linked 3-aminocoumarin Schiff base unit (1O) was synthesized and used for the selective detection of Cd²⁺ and HSO₃⁻.     

A facile fluorescent sensor based on nitrogen-doped carbon dots derived from Listeria monocytogenes for highly selective and visual detection of iodide and pH

Sensitive and visual analysis of iodide (I⁻) and pH is significant in environmental and food applications. Herein, we present a facile fluorescent sensor for highly selective and visual detection of I⁻ and pH based on nitrogen-doped carbon dots derived from Listeria monocytogenes (NCDs-LM). The NCDs-LM-based fluorescent sensor showed a good linear relationship to I⁻ concentrations, and the detection limit was calculated as 20 nmol L⁻¹. The developed sensor was successfully applied to the detection of I⁻ in drinking water and milk samples. Meanwhile, the as-synthesized NCDs-LM sensor can be used to detect pH, achieving a wide linear pH range. Furthermore, fluorescent test papers based on NCDs-LM were designed for semi-quantitative detection of I⁻ and pH via the naked-eye colorimetric assay. The present work indicates that the NCDs-LM-based fluorescent sensor has high potential for use in environmental monitoring and food analysis.

Listeria monocytogenes-derived nitrogen-doped carbon dots served as a facile fluorescent sensor with excellent sensing performances for iodide with low detection limit of 20 nmol L⁻¹ and wide pH range from 1.81 to 11.82.     

Robust colorimetric detection based on the anti-aggregation of gold nanoparticles for bromide in rice samples

Inorganic bromide (Br⁻) is an important contaminant ion as it can originate from the overuse of illegal methyl bromide as a fumigant in stored rice samples. Herein, we developed a simple and highly sensitive colorimetric sensor for bromide ion detection in rice samples. The sensor is based on the anti-aggregation of gold nanoparticles (AuNPs) by Br⁻ in the presence of Cr³⁺, which made the method more selective than other typical aggregations of nanoparticles. The AuNPs underwent an aggregation process as a result of the coordination of Cr³⁺ and the carboxylate group of a citrate ion stabilized the AuNPs, resulting in a red-to-blue color change. When Br⁻ was pre-mixed with the AuNPs and Cr³⁺ was added, the solution color changed from blue to red with an increase in the Br⁻ concentration. The anti-aggregation process can be detected with the naked eye and monitored using UV-vis spectrophotometry. The linear calibration curve ranged between 0.31 and 3.75 μM Br⁻ with a low LOD and LOQ of 0.04 and 0.13 μM. The recovery was excellent, ranging from 79.9–92.2% with an RSD of less than 4.0%. The good inter-day and intra-day precisions were 2.9–6.4% and 3.1–7.1%, respectively. The developed sensor has proved to provide a robust method for Br⁻ detection in rice samples.

In this work, we developed a AuNP colorimetric sensor for the facile, sensitive and selective detection of bromide ions in rice samples.