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1.
Szprynger K Kwieciński J Szczepańska M Pierzchała K 《Pediatric nephrology (Berlin, Germany)》2000,14(10-11):993-996
Developmental disturbances and encephalopathy have been observed in children with chronic renal failure (CRF). The aim of this study was to investigate the efficiency of the cerebral circulation in uremic children. The study group consisted of 10 children with CRF on conservative treatment, 8 children on continuous ambulatory peritoneal dialysis (CAPD), and 8 children on maintenance hemodialysis (HD). Examination was performed using a TC2-64B, EME Doppler flowmeter machine and capnograph Datex, Normocap. Blood flow velocity in both middle cerebral arteries (MCA), at rest and after spontaneous hyperventilation for 30 s, was analyzed. The vascular reactivity coefficient was calculated as the percentage ratio of decline of blood flow velocity in MCA to PCO2 decrease. Baseline mean blood flow velocities of MCA in euvolemic children under conservative treatment and on CAPD were significantly higher than those in children on HD and healthy control children. The highest value of the vascular reactivity coefficient was significantly higher in the group of children with CRF on conservative and CAPD treatment, than in children on HD and healthy controls. We suggest that hyperreactivity of the cerebral circulation could be the result of impaired autoregulation of blood flow. Evaluation of cerebrovascular reactivity in uremic children requires further examination. 相似文献
2.
W. Sorteberg K. -F. Lindegaard K. Rootwelt A. Dahl R. Nyberg-Hansen D. Russell H. Nornes 《Acta neurochirurgica》1989,97(3-4):139-145
Summary The effect of intravenous acetazolamide L g on cerebral artery blood velocity and regional blood flow (rCBF) was investigated in eight normal subjects. Blood velocity was measured with 2 MHz pulsed Doppler in the proximal segments of the middle, anterior and posterior cerebral artery (MCA, ACA, and PCA) and in the distal extracranial internal carotid artery (ICA). The rCBF in the regions of interest tentatively corresponding to the perfusion territories of these vessels was estimated using133Xe inhalation and a rapidly rotating single photon emission computer tomograph.Both blood velocity and rCBF increased after acetazolamide. There was no significant difference between the percentage ICA blood velocity increase (22 ± 12%) and the percentage rCBF increase in the ICA region of interest (25 ± 9%). In the MCA, ACA, and PCA, however, blood velocity increased more (mean increase 36–42%) than the rCBF in the corresponding regions of interest (mean increase 24–26%). These differences were highly significant suggesting a direct and site specific effect of acetazolamide in narrowing the lumen of the proximal MCA, ACA, and PCA, but not of the extracranial ICA. We also propose that the effect of acetazolamide induces reciprocal changes in the extent of adjacent perfusion territories in individual brain hemispheres.Data compiled from all subjects investigated at two very different perfusion levels (before and after acetazolamide) revealed a significant positive correlation between blood velocity and rCBF. 相似文献
3.
Cerebral vasospasm diagnosis by means of angiography and blood velocity measurements 总被引:25,自引:0,他引:25
K. -F. Lindegaard H. Nornes S. J. Bakke W. Sorteberg P. Nakstad 《Acta neurochirurgica》1989,100(1-2):12-24
Summary We investigated 76 patients with known subarachnoid haemorrhage (SAH) in order to compare the results of angiography and non-invasive Doppler recordings of cerebral artery blood velocity in the diagnosis of cerebral vasospasm. One radiologist and one neurovascular surgeon assessed angiographic spasm visually on a four-level scale. The radiologist's ratings were the term of reference for the study.When there was angiographic spasm of the middle cerebral artery (MCA), the MCA blood velocity was higher and the blood velocity in the distal extracranical internal carotid artery (ICA) was lower than when MCA spasm was scored as absent. Analysis by Kappa statistics, a measure for the agreement between two independent judges with correction for random coincidence, revealed moderate agreement between angiographic spasm and the absolute MCA blood velocity (Kappa=0.47). However, there was substantial agreement (Kappa=0.64) between angiographic spasm and the index calculated from dividing the blood velocity in the MCA (VMCA) by the blood velocity in the ipsilaterial ICA (VICA). The results indicate that this VMCA/VICA index gives more appropriate information on MCA spasm.Congenitally asymmetric circles of Willis with one wide dominant ACA showed normal blood velocities. In asymmetry induced by vasospasm, the diameter of the major ACA was normal or even reduced, and the blood velocity was significantly elevated. Hence, the agreement between blood velocity recordings and angiographic findings was substantial (Kappa=0.64) when considering together the findings from both sides of the anterior circle of Willis. The agreement between angiographic spasm of the posterior cerebral artery (PCA) and the PCA blood velocity was substantial (Kappa=0.68).The two observers' rating of angiographic spasm agreed substantially on the MCA (Kappa=0.67) and the ACA (Kappa=0.71). Moderate agreement (Kappa=0.59) was obtained for the PCA. These findings show that assessing cerebral vasospasm angiographically is difficult. The present study therefore indicates that with regard to diagnosing cerebral vasospasm, the reliability of blood velocity measurements match the reliability of judging angiograms visually.This work was supported by The Norwegian Council on Cardiovascular Diseases. 相似文献
4.
Maltezos CK Papanas N Papas TT Georgiadis GS Dragoumanis CK Marakis J Maltezos E Lazarides MK 《Vascular and endovascular surgery》2007,41(5):389-396
AIM: The aim of the present study was to evaluate the changes in blood flow of anterior and middle cerebral arteries following carotid endarterectomy, using transcranial Doppler (TCD) flow studies. PATIENTS AND METHODS: This study included 100 patients (72 men, mean age 65 years) who underwent carotid endarterectomy because of high-grade carotid stenosis or symptoms of ischemic stroke. Endarterectomy was performed by a distal shunt between the common carotid and internal carotid arteries. Blood flow in the anterior and middle cerebral arteries was assessed by TCD preoperatively and also in the postoperative period (1st and 4th day; 1st, 6th, and 12th month). Collateral circulation in the Willis circle was evaluated by common carotid compression. RESULTS: Patients with bilateral carotid stenosis > or =70% exhibited a significantly increased flow velocity in the ipsilateral anterior cerebral artery (ACA), middle cerebral artery (MCA), and in the contralateral ACA. Patients with entirely occluded contralateral internal carotid artery showed the most pronounced changes in cerebral hemodynamics. Blood flow velocities returned to the preoperative values at 1 to 12 months following endarterectomy. Hyperperfusion syndrome was manifested in 14 patients, who exhibited significantly higher flow velocities in the ipsilateral MCA compared with asymptomatic patients. CONCLUSIONS: A transient bilateral increase of blood flow velocity in the anterior part of the Willis circle may often occur in the immediate postoperative period following carotid endarterectomy. Although its clinical significance is not entirely understood, this increase may be associated with cerebral hyperperfusion syndrome. 相似文献
5.
M-Y Nielsen H H Sillesen L G J?rgensen T V Schroeder 《European journal of vascular and endovascular surgery》2002,24(1):53-58
OBJECTIVES: to assess the haemodynamic effect of carotid artery surgery, and to relate postoperative changes to the state of cerebral circulation before revascularisation. MATERIALS AND METHODS: using transcranial Doppler we studied bilateral middle cerebral artery (MCA) flow velocities before and on 1st day, 2nd or 3rd day and 4th or 5th day and 3 months after carotid surgery in 61 patients. In addition, ipsilateral MCA flow velocity was monitored continuously during surgery. Data were related to the internal carotid artery (ICA) perfusion pressure (cerebral perfusion pressure index, CPPI), measured directly before ICA clamping. RESULTS: postoperatively, MCA flow velocities increased significantly overall (p<0.01), mainly due to pronounced and longer lasting flow velocities in the group of 18 patients with CPPI<0.7 (p<0.05). Flow velocities peaked - absolute as well as relative - on the first postoperative day and then gradually levelled off to reach preoperative values after 4-5 days in patients with high CPPI, whereas MCA flow velocities remained increased in the group of patients with low CPPI. At 3 months flow velocities in both groups were normalised. New neurological symptoms occurred in four patients, who all had low CPPI preoperatively (22% (4/18) vs 0%; Fisher's exact test: p=0.006). CONCLUSION: some degree of hyperperfusion was seen in most patients, but the changes were significantly more pronounced in patients with preoperative hypoperfusion, who also suffered significantly more neurological complications. 相似文献
6.
Surgical approach to giant intracranial aneurysms. Operative experience with 80 cases. 总被引:3,自引:0,他引:3
The authors report experience with the surgical management of 80 giant intracranial aneurysms (greater than 2.5 cm in diameter) during a 10-year period in which they performed 594 operations for aneurysms. The overall incidence of giant aneurysms was 13% but varied according to location: 20% of aneurysms of the internal carotid artery (ICA); 13% of middle cerebral artery (MCA) aneurysms; 1% of anterior cerebral artery (ACA) aneurysms; 15% of aneurysms of the basilar artery caput (BAC); and 18% of vertebrobasilar trunk (VB) aneurysms. Twenty-five patients had a subarachnoid hemorrhage (SAH), 49 had mass effect from the aneurysm, and six had ischemic events. There was no apparent difference in results related to the presence or absence of an SAH. Poor results were attributable to the operation except in the two cases of ACA aneurysm in which preexisting dementia persisted. Mortality was 4% and morbidity was 14%, varying from a combined low morbidity-mortality of 8% for ICA lesions to a high to 50% for BAC aneurysms. During the period of the study, different techniques were developed in an attempt to lower the risks of surgery. Ultimately ICA aneurysms were monitored with cerebral blood flow measurements and electroencephalography before and after temporary ICA ligation, then approached following resection of the anterior clinoid or treated with bypass in combination with ICA ligation. Aneurysms of the MCA were either opened during temporary MCA occlusion or resected in combination with a bypass procedure. Bypass grafts and circulatory arrest with extracorporeal circulation may have a role in giant aneurysms of the posterior circulation. 相似文献
7.
Cerebral perfusion during nonpulsatile cardiopulmonary bypass 总被引:1,自引:0,他引:1
Tryggve Lundar Karl-Fredrik Lindegaard Tor Frøysaker Rune Aaslid Jan Wiberg Helge Nornes 《The Annals of thoracic surgery》1985,40(2):144-150
The recording of middle cerebral artery (MCA) flow velocity by the transcranial Doppler method offers a new, noninvasive, continuous technique for studies of cerebral circulation. Comparative studies of electromagnetic internal carotid artery (ICA) flowmetry and MCA flow velocity by the transcranial Doppler technique have demonstrated that observed changes in MCA flow velocities reflect concomitant changes in cerebral circulation. Eleven high-risk patients undergoing cardiopulmonary bypass (CPB) procedures were included in a pilot study. Arterial blood pressure (BP), central venous pressure, and epidural intracranial pressure (EDP) were recorded during CPB. Cerebral electrical activity was recorded by a cerebral function monitor. Flow velocity in the MCA was increased during nonpulsatile CPB in 10 of the 11 patients. This increase was related to the degree of hemodilution, and the flow velocity during steady-state CPB was 80 to 300% of the prebypass value. The MCA flow velocity changed, however, in a pressure-passive manner with the cerebral perfusion pressure (CPP = BP - EDP) in the individual patient, which indicates that cerebral autoregulation was not operative. During the first 15 minutes after termination of bypass, the MCA flow velocity was reduced, but remained higher than the prebypass level, 110 to 210% of the level during the last 5 minutes preceding CPB. 相似文献
8.
127 patients with aneurysmal subarachnoid haemorrhage (SAH) were analyzed for the relationship between the amount of blood clots as detected by initial computed tomography (CT) up to 48 hours after SAH and changes of blood flow velocities as measured using transcranial Doppler ultrasonography (TCD). All patients were operated on within 72 hours after SAH. Patients who presented with remarkable brain oedema or with pathological intracranial pressure (ICP) due to mass effects of a haematoma, and who were in a poor neurological condition classified according to Hunt-Hess as grade V were excluded from this study. Serial TCD examination of the middle cerebral arteries (MCA) and anterior cerebral arteries (ACA) started within 48 hours after SAH and were performed daily up to three weeks. A statistically significant correlation between blood load designated according to Fisher's grading as group CT I-CT IV and mean flow velocities (MFV) was found in groups CT I, II, and III. High values of MFV in MCA examinations were noted in patients with severe SAH (group CT III)--161 cm/s, and low values in patients without SAH (group CT I)--119 cm/s. Patients with haematocephalus and/or haematoma without a mass effect (group CT IV) had lower blood flow velocities than patients with severe SAH (group CT III) but values were higher than in patients without SAH (group CT I). The number of days for which MFV in the MCA was > 120 cm/s and was statistically (p < 0.05) correlated with the amount of blood clots as observed in the respective CT (in group CT I, II, and III). MFV values in the anterior cerebral artery (ACA) were lower than those obtained in the middle cerebral artery (MCA) in all groups. Statistically significant (p < 0.05) differences were noted between groups CT I and CT III (first and third week) and between groups CT I and CT IV (third week). If the SAH was extensive in the CT scan, pathological values of MFV > 90 cm/s were observed in ACA, and this was more pronounced in group CT III than in group CT IV. Blood flow velocities obtained via TCD were registered to compare side-to-side differences and particularly high differences were observed in patients with severe SAH. It is concluded that the amount of blood clots in the initial computed tomography after SAH is significantly correlated with cerebral blood flow velocity measurements by TCD. 相似文献
9.
Transcranial Doppler ultrasound for the assessment of intracranial arterial flow velocity--Part 1. Examination technique and normal values 总被引:3,自引:0,他引:3
We present the examination technique and normal values of flow velocity from intracranial basal cerebral arteries for a recently developed pulsed Doppler system operating at 2 MHz emitting frequency. Peak systolic, peak diastolic, and mean flow velocity values are analyzed from fast-Fourier transformed (FFT) Doppler spectra at selected depths for 50 presumed normal subjects ranging in age from 22 to 79 years. Interindividual variation is high for peak flow but moderate for mean flow velocity values, which hence are more likely to discriminate normal from abnormal. Flow velocity values within the posterior cerebral artery (PCA) and the basilar artery (BA) are significantly lower than in the anterior cerebral artery (ACA) and the middle cerebral artery (MCA), which is also unique in showing significantly decreasing values with increasing age: calculated mean flow velocities are 47.3 +/- 13.6 and 45.3 +/- 13.5 cm/sec in the ACA, and 58.4 +/- 8.4 and 44.7 +/- 11.1 cm/sec in the MCA in patients less than 40 years and greater than 60 years, respectively, but 34.2 +/- 7.8 and 29.9 +/- 9.3 (PCA) (patients less than 40 years and patients greater than 60 years), and 34.9 +/- 7.8 and 30.5 +/- 12.4 (BA) (patients less than 40 years and patients greater than 60 years). A new scanning system is introduced, which we suggest will reduce interindividual variations and improve the accurate separation of nearby vessels, which are major causes for the comparatively large standard deviations at present. 相似文献
10.
Transcranial Doppler ultrasound in internal carotid artery and middle cerebral artery disease 总被引:1,自引:0,他引:1
Dr. med. Karen Rosenkranz F.I.C.A. Ruth Langer Michael Cordes Roland Felix 《Neurosurgical review》1992,15(1):37-44
Using noninvasive transcranial Doppler sonography, we studied cerebral collateral patterns in 30 patients with stenosis and/or
occlusion of the extracranial internal carotid artery (ICA). All patients with unilateral ICA stenosis ⩽ 80% had normal transcranial
Doppler findings. 80% of patients with unilateral and 50% of patients with bilateral ICA stenosis of more than 80% including
those with occlusion showed a collateralization via the ipsilateral anterior and/or posterior cerebral artery. 20% of patients
with unilateral and 50% of patients with bilateral ICA stenoses of more than 80% (including occlusion) had two or three collateral
pathways, including the ophthalmic artery.
Another ten patients with stenosis or spasm of the middle cerebral artery (MCA) showed increased flow velocities with turbulence
in the narrow segment. In four patients with severe MCA disease with a systolic peak velocity of more than 200 cm/s, the Doppler
waveform distal to the lesion was damped.
Decreased regional cerebral blood flow (rCBF) measured by99mTc-HMPAO-SPECT was found in two patients with severe MCA stenosis. Another patient with moderate MCA stenosis with a systolic
peak velocity of 140 cm/s showed a normal cerebral perfusion pattern. 相似文献
11.
The persistent primitive hypoglossal artery (PPHA) is one of the pairs of arterial connections that exist in the human embryo
between the developing anterior and posterior circulation. Normally the PPHA arises from the cervical internal carotid artery
(ICA) and passes through the hypoglossal canal to join the caudal basilar artery (BA). In most cases the vertebral arteries
(VA) are either hypoplastic or aplastic and the posterior communicating arteries (PComA) are absent; thus, the main supply
to the posterior circulation comes from the internal carotid via the PPHA in an antegrade fashion. Atherosclerotic plaques
in the ICA and PPHA present with ischemic symptoms of both the carotid and vertebrobasilar systems. We report a case of a
53-year-old female who presented with a transient episode of left lower extremity numbness and weakness. Work-up with computed
tomography (CT) and magnetic resonance imaging (MRI) showed a small watershed infarct in the right middle cerebral artery
(MCA)/posterior cerebral artery (PCA) territory. Diagnostic angiography revealed severe proximal stenosis of the cervical
ICA and presence of a PPHA just above the stenosis with retrograde filling from the vertebrobasilar junction to the distal
cervical ICA. The patient underwent a carotid endarterectomy with intraoperative EEG monitoring. Intraoperative blood flow
measurements were made before and after endarterectomy showing evidence of reversal of blood flow to a normal antegrade fashion.
The postoperative angiogram showed resolution of the right ICA stenosis and persistence of the PHA. To our knowledge this
is the first case report of a PPHA exhibiting reversal of blood flow from the posterior into the anterior circulation. Awareness
of this embryological anomaly and its interaction with acquired atherosclerotic disease will minimize misinterpretation of
vascular diagnostic studies. 相似文献
12.
Rapid revascularization of tandem extracranial and intracranial acute thromboembolic occlusions can be challenging and can delay restoration of blood flow to the cerebral circulation. Taking advantage of collateral pathways in the circle of Willis for thrombectomy can reduce the occlusion-to-revascularization time significantly, thereby protecting brain tissue from ischemic injury. The authors report using the trans-anterior communicating artery (ACoA) approach by using the Penumbra microcatheter to rapidly restore blood flow to the middle cerebral artery (MCA) territory prior to treating the ipsilateral internal carotid artery (ICA) occlusion. Two patients with acute onset of tandem ipsilateral ICA and MCA occlusions and a competent ACoA underwent rapid revascularization of the MCA using a trans-ACoA approach for pharmaceutical and mechanical thrombolysis with the 0.026-in Penumbra microcatheter. Subsequently, once blood flow was reestablished in the MCA territory via cross-filling from the contralateral ICA, the proximally occluded ICA dissection was revascularized with a stent. Both patients had rapid revascularization of the MCA territory (both Thrombolysis in Myocardial Infarction Grade 3) with the trans-ACoA approach (19 and 36 minutes) followed by treatment of the ipsilateral proximal ICA occlusion. This prevented prolonged MCA ischemia time (72 and 47 minutes for ICA revascularization time saved) that would have otherwise occurred if the dissections were treated prior to revascularization of the MCA. Both patients had improved NIH Stroke Scale scores after the procedure. No adverse events from crossing the ACoA with the Penumbra microcatheter were encountered during the revascularization procedure. The trans-ACoA approach with the Penumbra microcatheter for rapid revascularization of an acutely thrombosed MCA in the setting of a simultaneous ipsilateral proximal ICA occlusion is feasible in patients with a competent ACoA. This technique can significantly minimize ischemic injury by reducing the occlusion-to-revascularization time and allow for MCA perfusion via collateral circulation while treating a proximal occlusion. To the best of the authors' knowledge, this is the first reported trans-ACoA approach with the Penumbra microcatheter and the first to report the utilization of the collateral intracranial circulation to reduce occlusion-to-revascularization time. 相似文献
13.
W. Sorteberg K. -F. Lindegaard K. Rootwelt A. Dahl D. Russell R. Nyberg-Hansen H. Nornes 《Acta neurochirurgica》1989,97(1-2):47-52
Cerebral artery blood velocity and regional blood flow (rCBF) were investigated in 17 normal subjects. Blood velocity was measured with 2 MHz pulsed Doppler ultrasound in the proximal segments of the middle, anterior and posterior cerebral artery (MCA, ACA, and PCA) and in the distal extracranial internal carotid artery (ICA). The rCBF in the regions of interest tentatively corresponding to the perfusion territories of these vessels was estimated using 133Xe inhalation and a rapidly rotating single photon emission computer tomograph. Concomitant capnograph recordings showed that the end-expiratory pCO2 was higher during the rCBF than during the blood velocity examinations. This differences was highly significant. While there was no significant correlation between blood velocity and rCBF when these clear differences in pCO2 were disregarded, we did find significant positive correlations when the data were normalized to a standard pCO2 (5.3 kPa) using accepted formulas. The best correlation was found for the MCA (r = 0.630, p less than 0.001) and the PCA (r = 0.73, p less than 0.001), with a lower correlation in the ACA (r = 0.49, p less than 0.01) and the ICA (r = 0.41, p less than 0.05). The estimated blood velocity (V) given rCBF = 0 was not significantly different from 0. The results support the validity of expressing the relationship between blood velocity (V) and rCBF in defined cerebral artery systems as: V = 1/60 (rCBF) T (A)-1, where A represents the area of the lumen of the vessel segment where the velocity is being measured, and T denotes the size of the brain region being perfused from this artery. 相似文献
14.
T. Matsushima M. Fukui K. Kitamura K. Hasuo Y. Kuwabara T. Kurokawa 《Acta neurochirurgica》1990,104(3-4):96-102
Summary Encephalo-duro-arterio-synangiosis (EDAS) was done in 16 Japanese children with Moyamoya disease on 22 sides. The results were evaluated clinically, angiographically, and by positron emission computed tomography (PET). Postoperative external carotid angiograms showed a good collateral circulation through EDAS in 72 percent of the treated sides. Two-thirds of the sides examined by PET showed improvement in cerebral blood circulation, particularly at the surgically-treated cortex. Postoperatively the symptoms disappeared in those with good new collateral formation. TIA, RIND, and/or involuntary movement disappaered in 31 percent and partially so in 44 percent 6 months after EDAS. The TIA in the lower limb and/ or involuntary movement persisted in some children. This surgical approach seems applicable particularly for children with the ischaemic type of Moyamoya disease, however, the procedure also has drawbacks. Development of collateral circulation was insufficient in some cases, and the territories of the anterior cerebral artery (ACA) or posterior cerebral artery (PCA) were often not covered, even in those with a good new collateral formation in the middle cerebral arterial (MCA) area. 相似文献
15.
Kobayashi M Ogasawara K Suzuki T Kuroda H Yamashita T Yoshida K Kubo Y Ogawa A 《Neurologia medico-chirurgica》2012,52(3):161-164
A 74-year-old man with a history of asymptomatic right internal carotid artery (ICA) occlusion experienced amaurosis fugax in the left eye. Angiography showed left cervical ICA stenosis in addition to right cervical ICA occlusion. The right anterior and middle cerebral artery (MCA) territories were perfused from the left ICA via the anterior communicating artery. Brain perfusion single-photon emission computed tomography revealed reduced cerebral blood flow and reduced cerebrovascular reactivity to acetazolamide only in the right cerebral hemisphere. The patient underwent left carotid endarterectomy (CEA). Transcranial Doppler monitoring showed microembolic signals in the left MCA during dissection of the left ICA, but intraoperative monitoring suggested absence of global hypoperfusion or ischemia in the bilateral cerebral hemispheres during left ICA clamping. Transient and slight motor weakness of the left upper extremity was noted on recovery from anesthesia. Diffusion-weighted magnetic resonance imaging demonstrated the development of new spotty ischemic lesions only in the right cerebral hemisphere. The present case suggests that intraoperative cerebral embolism causing postoperative neurological deficits can develop exclusively in the cerebral hemisphere contralateral to CEA if the hemisphere has preoperative hemodynamic impairment and collateral circulation via the anterior communicating artery from the ICA ipsilateral to CEA. 相似文献
16.
Sakamoto S Ohba S Shibukawa M Kiura Y Okazaki T Arita K Kurisu K 《Acta neurochirurgica》2006,148(2):139-143
Summary Background. Arterial bifurcations are sites of maximal hemodynamic stress, where cerebral aneurysms commonly develop. However, in our
experience with endovascular treatment for aneurysms of the internal carotid artery (ICA) bifurcation, we often experienced
that the aneurysmal neck did not necessarily exist only at the ICA bifurcation (ICBi). In this study, we have retrospectively
evaluated characteristics of aneurysms at the ICBi.
Methods. Ten ICBi aneurysms in 10 consecutive patients were studied retrospectively. The size of the aneurysms, the angles formed
between the ICA and the anterior cerebral artery (ACA) and middle cerebral artery (MCA), and the diameter of the ICA, ACA
and MCA were measured. Furthermore, to study the relationship between the location of the aneurysmal neck and the bifurcation
of the ICA, the distance between the midline of the aneurysmal neck and of the ICA was measured.
Results. The average aneurysm size was 6.3 ± 3.2 mm and the average neck was 3.1 ± 1.2 mm. The average ICA-ACA angle was 57.3 ± 16.5
degrees, and the average ICA-MCA angle was 128.9 ± 24.1 degrees. The average diameters of the ICA, ACA and MCA were 2.9 ±
0.5 mm, 1.9 ± 0.4 mm and 2.5 ± 0.4 mm, respectively. The average distance between the midline of the aneurysmal neck and the
ICA was 1.6 ± 0.6 mm, and all aneurysmal necks of the ICBi arose from the side of the ACA.
Conclusion. ICBi aneurysms were deviated to the side of the A1 segment of the ACA, where the artery might suffer higher hemodynamic
stress. 相似文献
17.
Evaluation of posttraumatic cerebral blood flow velocities by transcranial Doppler ultrasonography 总被引:9,自引:0,他引:9
Thirty-five patients were admitted to the hospital with Glasgow coma scale scores of 4 to 7 after severe, blunt head injury. Blood flow velocities of the middle cerebral artery (MCA) and the ipsilateral internal carotid artery (ICA), high in the neck, were recorded noninvasively by Doppler ultrasonography. Serial examinations were begun within 48 hours of trauma and continued until the patient either died or was discharged. Spasm of the MCA was assumed if the ratio of the velocity of blood flow in the MCA (VMCA) to the velocity of blood flow in the ICA (VICA) exceeded 3 (normal value, 1.7 +/- 0.4). In cases of severe MCA spasm, this ratio is higher because of increased flow velocity in the MCA and reduced flow in the ICA due to increased cerebrovascular resistance. Higher MCA velocities with VMCA/VICA above 3, consistent with MCA spasm, were found in 14 of the 35 patients (40%). The increase began as early as 48 hours after injury, reached a maximum between Days 5 and 7, and lasted until 2 weeks after injury. There was a significant correlation between the occurrence of vasospasm and the quantity of cisternal or intracerebral blood seen on a computed tomographic scan. No correlation was found with the age of the patients, the Glasgow coma scale score at admission, the intracranial pressure, or the functional outcome 6 months after injury. The occurrence of a secondary infarction in a patient with severe MCA spasm suggests that, at least in some cases, spasm may influence the prognosis. 相似文献
18.
Influence of cranioplasty on postural blood flow regulation, cerebrovascular reserve capacity, and cerebral glucose metabolism 总被引:25,自引:0,他引:25
OBJECT: The indications for cranioplasty after decompressive craniectomy are cosmetic repair and, mainly, restoration of cerebral protection. Although neurological improvement after cranioplasty is repeatedly noted, the reasons for this remain unclear. Few observations concerning the impact of cerebrospinal fluid hydrodynamic and/or atmospheric pressure have been published during the last decades. Relevant data concerning the cerebrovascular reserve (CVR) capacity and cerebral glucose metabolism before and after cranioplasty have been lacking until now. To gain further insight, this study was undertaken to investigate the impact of cranioplasty on indices of cerebral blood flow regulation and metabolism. METHODS: Thirteen patients in whom extensive craniectomies had been performed underwent a meticulous study of blood flow velocities in the middle cerebral artery (MCA) and extracranial internal carotid artery (ICA), as assessed by transcranial Doppler ultrasonography during postural maneuvers (supine and sitting positions) and during stimulation with 1 g of acetazolamide for the interpretation of CVR capacity. Twelve patients underwent 18-fluorodeoxyglucose positron emission tomography. These measurements were obtained before and 7 days after cranioplasty. Cranioplasty improved preoperative differences in MCA blood flow velocities when comparing those in the injured with those in the uninjured hemisphere. Similarly, cranioplasty resolved decreases in extracranial ICA blood flow in the injured hemisphere that were induced by postural changes, which was a constant finding prior to this procedure. More strikingly, however, the CVR capacity, which was severely impaired in both hemispheres, increased significantly after the procedure. Metabolic deficits, which were observed in the injured hemisphere, were found to improve after reimplantation of the skull bone flap. CONCLUSIONS: Cranioplasty appears to affect postural blood flow regulation, CVR capacity, and cerebral glucose metabolism markedly. Thus, early cranioplasty is warranted to facilitate rehabilitation in patients after decompressive craniectomy. 相似文献
19.
PURPOSE: Carotid endarterectomy (CEA) has proven to be effective in the prevention of stroke in patients with significant internal carotid artery (ICA) stenosis. However, whether increased cerebral blood flow after CEA improves the cerebral metabolism in patients with asymptomatic ICA flow lesions is unknown. Localized in vivo proton magnetic resonance spectroscopy ((1)H-MRS) has been used to measure the metabolic status of the human brain in a totally noninvasive manner. The aim of this study was to investigate the cerebral metabolism after CEA in patients with asymptomatic ICA flow lesions and no visible infarction on magnetic resonance imaging (MRI). MATERIALS AND METHODS: We designed a prospective study to investigate the metabolic changes in the middle cerebral artery (MCA) territory with (1)H-MRS for 18 consecutive patients with asymptomatic severe stenosis of the ICA (>70% reduction in diameter) and for 16 healthy control subjects. The 18 patients with ICA flow lesion and no visible infarction on MRI who underwent CEA were evaluated before and 7 days after surgery (CEA group). The 16 control subjects had never had a cerebral event, and brain MRI and carotid duplex scan study results were normal in all (control group). RESULTS: Preoperative ICA volume flow was severely decreased to less than 150 mL/min in all 18 patients, in comparison with our laboratory normal value of matched age group of 250 to 300 mL/min. After CEA, ICA volume flow was increased to greater than 300 mL/min in all patients (P =.00). For patients in the CEA group, preoperative N-acetylaspartate/creatine and choline/creatine ratios in the MCA territory were slightly decreased compared with the healthy subjects in the control group but were within normal limits. However, the postoperative values of N-acetylaspartate/creatine and choline/creatine ratios in the ipsilateral MCA territory were significantly increased as compared with the preoperative values (P <.05). In the contralateral side, the postoperative increase of choline/creatine ratio and the decrease of myo-inositol/creatine ratio were statistically significant as compared with the preoperative values (P <.05). CONCLUSION: CEA seems to improve the cerebral metabolic status in patients with asymptomatic ICA flow lesions and no visible infarction on MRI. 相似文献
20.
K. J. van Everdingen C. J. M. Klijn L. J. Kappelle B. C. Eikelboom J. van der Grond 《European journal of vascular and endovascular surgery》2000,20(6):528-535
OBJECTIVES: To study the effect of the severity of internal carotid artery (ICA) lesions on cerebral haemodynamics. DESIGN: Cross-sectional study. MATERIALS AND METHODS: Magnetic resonance (MR) imaging, angiography (MRA) and spectroscopy (MRS) were used to study the prevalence of (border-zone) infarctions, volume flow in the main cerebropetal and middle cerebral arteries (MCA) and metabolic changes in the MCA territories in 170 patients with symptomatic ICA stenoses or occlusions and 25 control subjects. RESULTS: No significant correlation was found between severity of the carotid lesion and the prevalence of border-zone infarctions. Also, no significant correlation was found with changes in the N -acetyl-aspartate/choline ratio nor with the prevalence of cerebral lactate. In patients with at least one severe ICA lesion, flow in the basilar artery was increased. Flow in the MCA on the symptomatic and asymptomatic side was decreased when at least one ICA was occluded. Total cerebropetal flow (flow through the ICAs plus basilar artery) was decreased when at least one ICA was occluded. No significant correlation was found between changes in cerebropetal flow and the N -acetyl-aspartate/choline ratio nor with the prevalence of border-zone infarctions. CONCLUSION: Border-zone infarctions and ischaemic metabolic changes are not directly the result of cerebral hypoperfusion caused by severe ICA lesions. 相似文献