老年轻度认知损害的神经心理特点横断面比较

目的利用神经心理学检查方法对老年人轻度认知损害的神经心理特点进行研究,以便为阿尔茨海默病早期诊断提供依据。方法为横断面比较研究,对50例有轻度认知损害的老年人(MCI组)和54例认知功能正常的老年人(对照组)进行临床记忆量表、词语回忆、画钟表以及词语流畅性测验。结果MCI组临床记忆量表各分测验、词语延迟回忆测验0.48±0.32、画钟表测验3.16±0.87以及词语流畅性测验30.08±6.03的成绩较对照组(0.82±0.19,3.67±0.48,32.54±3.33)均有显著性下降(t=6.37,3.66,2.54,P<0.05),MCI组在简明智力状态检查中计算3.92±0.96、延迟回忆1.34±0.75及视空间技能0.50±0.443个子项目的成绩与对照组(4.48±0.67,2.31±0.77,0.87±0.34)比显著性下降(t=3.64,6.54,5.09,P<0.01)。结论MCI者存在多项认知功能的损害,在短时记忆、视空间功能、执行功能方面表现出与早期阿尔茨海默病相类似的神经心理特点。     

老年轻度认知损害的神经心理特点横断面比较

目的 利用神经心理学检查方法对老年人轻度认知损害的神经心理特点进行研究，以便为阿尔茨海默病早期诊断提供依据。方法 为横断面比较研究，对50例有轻度认知损害的老年人(MCI组)和54例认知功能正常的老年人(对照组)进行临床记忆量表、词语回忆．画钟表以及词语流畅性测验。结果MCI组临床记忆量表各分测验、词语延迟回忆测验0．48&;#177;0．32、画钟表测验3．16&;#177;0．87以及词语流畅性测验30．08&;#177;6．03的成绩较对照组(0．82&;#177;0．19，3．67&;#177;0．48，32．54&;#177;3．33)均有显著性下降(t=6．37，3．66，2．54，P&;lt;0．05)，MCI组在简明智力状态检查中计算3．92&;#177;0．96、延迟回忆1．34&;#177;0．75及视空间技能0．50&;#177;0．443个子项目的成绩与对照组(4．48&;#177;0．67，2．31&;#177;0．77，0．87&;#177;0．34)比显著性下降(t=3．64，6．54，5．09，P&;lt;0．01)。结论 MCI者存在多项认知功能的损害，在短时记忆、视空间功能、执行功能方面表现出与早期阿尔茨海默病相类似的神经心理特点。     

慢性精神分裂症患者认知功能状况及其影响因素研究

目的 探讨慢性精神分裂症患者认知功能状况及其影响因素.方法 将60例住院慢性精神分裂症患者设为研究组,抽取同期慢性精神分裂症恢复期患者57例设为对照组,采用连线测验、数字符号转换测验、言语流畅性测验、数字广度测验和汉密顿抑郁量表进行测评分析.结果 研究组汉密顿抑郁量表、连线测验A和连线测验B评分显著高于对照组(P＜0.01),言语流畅性测验、数字符号转换测验、数字广度测验评分显著低于对照组(P＜0.01).多元逐步线性回归分析显示:年龄增加对数字符号测验、数字广度测验、连线测验A和B的评分有负面影响;汉密顿抑郁量表评分高是数字符号测验成绩偏低的危险因子;文化程度高、脑力劳动及单药治疗对认知功能具有保护作用.结论 慢性精神分裂症患者认知功能损害与多药治疗、抑郁情绪、年龄增加、文化程度低、非脑力劳动等诸多因素有关,其病情的缓解有助于改善认知功能及抑郁情绪.     

石家庄市老年人遗忘型轻度认知功能障碍患病率及危险因素抽样研究

目的 探讨部分石家庄市老年人的遗忘型轻度认知功能障碍（aMCI）的患病率及危险因素。方法 采取方便抽样的方法，对石家庄市3所社区卫生服务中心和1家老年养护院的1614例60岁以上老人进行调查。采用简易智能精神状态量表（MMSE）、蒙特利尔认知评估量表（MoCA）、听觉词语学习测验量表（AVLT）、数字广度测验量表（DST)、波士顿命名测验量表（BNT）、连线测验量表（TMT）、画钟试验、动物流畅性试验以及日常生活能力量表（ADL）对受试者的整体认知功能，记忆、语言、注意、视觉空间、执行功能等认知领域以及日常活动能力进行评估。计算aMCI的患病率，采用Logistic回归分析aMCI患病的相关危险因素。结果 抽样部分石家庄市老年人aMCI患病率是16.11%，而且不同年龄、性别、职业、教育程度以及婚姻状况的老年人其aMCI患病率差异有统计学意义（P<0.01）。年龄、性别、婚姻状况和教育程度是aMCI的影响因素。结论 高龄、女性、无配偶者以及文化程度低的老年人是aMCI患病的高危人群，应该重点对以上人群做好早期干预。     

应用28通道近红外光谱分析恢复过程中老年期抑郁症患者前额叶的激活特征

目的：认知功能障碍是老年期抑郁症的可逆性症状，试验以认知功能研究为突破口，采用28通道的近红外光谱技术分析处于恢复过程中的老年期抑郁症患者在执行词语流畅性测验时前额叶的激活特点，探讨老年期抑郁症的发病机制。 方法：①分组：患者组为2006～03／12首都医科大学附属北京安定医院收治的12例处于恢复过程中的老年期抑郁症患者，入组时符合DSM-4有关重度和中度抑郁发作或复发的标准诊断，首次发病年龄≥60岁，均服用SSRIs类抗抑郁药物治疗。对照组为12例性别、年龄和教育程度与患者组相匹配的健康志愿者。所有受试者排除脑器质性病变：②试验方法：所有受试者接受近红外光谱测查，在28通道的CW5（TechEnInc．American）NIRS系统上完成。通过近红外光谱系统监测被试者在执行词语流畅性测验任务过程中，前额叶氧合血红蛋白和脱氧血红蛋白浓度的变化，从而反映前额叶认知任务相关的激活效应。采用组块设计的词语流畅性测验作为认知激活任务，任务范式包括词语重复任务和词语流畅性任务两种试验。 结果：24例受试者均进入结果分析。①在健康老年人和处于恢复过程中的老年期抑郁症患者，词语流畅性测验能够激活双侧前额叶．未发现半球单侧化激活效应。②处于恢复过程中的老年期抑郁症患者在词语流畅性测验任务过程中，左侧前额叶激活效应较对照组减弱。③尽管在健康老年人和处于恢复过程中的老年期抑郁症患者，近红外光谱显示了不同的激活模式，但词语流畅性测验的成绩不存在显著性的组间差异（P〉0．05）。 结论：处于恢复过程中的老年期抑郁症患者存在词语流畅性测验相关的功能性左侧前额叶功能减退，微血管功能失调和多巴胺系统异常也许在老年期抑郁症的病理生理学机制中起重要作用。     

淮安市中老年农村居民记忆能力及相关因素分析

目的：分析淮安市50岁以上不同文化程度农村居民记忆能力的差异及记忆能力与性别、年龄、教育程度和其他非记忆性指标的相关性。方法：调查样本来源于2003-03／2004-02南京医科大学附属淮安医院老年科住院的农村患者(n=44)或患者家属(n=7)以及淮阴区丁集乡宗楼村的健康老人(n=52)，所有受试对象无明显视觉．听觉障碍和语言交流困难．无严重躯体或精神疾病，2剧内无抑郁和／或焦虑情绪、年龄均&;gt;50岁。按照文化程度的不同将116例调查对象分为文盲组．小学组、初中及以上文化组。采用问卷调查的方法，对所有受试对象进行简易智能量表、听觉词语学习测验、图片学习测验及多种非记忆测验。比较不同文化程度调查对象之间的记忆能力差异及记忆能力与性别、年龄、教育程度和其他非记忆性指标的相关性。结果：按实际处理分析，共有103例受试对象(文盲组51例、小学组29例、初中及以上文化组22例)完成所有调查，数据纳入结果分析。①淮安市文化程度高的农村居民在图片即刻回忆、听觉词语即刻回忆2(第2次完整复述语句)、听觉词语即刻回忆3(第3次完整复述语句)及言语流畅性1(1min列举动物名称)方面记忆功能好于文化程度低的农村居民．差异有显著性意义(F=5．91，3．66，4．94，18．53；P&;lt;0．05～0．01）。②所有记忆指标与性别均无相关性(r=-0．144～0．164)：听觉语言忆记、图片再认及言语流畅性1与教育程度呈正相关(r=0．203～0.453，P&;lt;0．05～0．01，其中言语流畅性1与教育程度相关性最大(r=0．453)；除身体部位即刻回忆3(第3次1min内回忆5个身体部位)、身体部位延时回忆、言语流畅性2(1min列举蔬菜名称)外所有记忆指标与简易智能量表评分均呈正相关(r=0．209～0．538，P&;lt;0．05～0．01），其中以听觉词语线索回忆与简易智能量表评分相关性最大(r=0538)；各记忆指标除言语流畅性外均与年龄呈负相关(r=-0．222～-0.030，P&;lt;0．05～0．01)，其中图片再认与年龄相关性最大(r=-0.222)。③记忆性指标和各非记忆指标间有显著相关性(r=-0．206～0．607，P&;lt;0．05～001)，其中相似性与言语流畅性1相关性最大(r=0．607)。结论：淮安市文化程度高的中老年农村居民的记忆能力好于文化程度低的农村居民：记忆能力与性别无关．与受教育程度和智能水平呈正相关，但言语流畅性1与教育程度相关性最大，除此之外的各项记忆指标与年龄呈负相关，身体部位记忆中处龄及受教育程度无关，记忆和非记忆能力有相关性。     

老年原发性高血压患者认知功能的调查分析

目的 研究原发性高血压对老年人认知功能的影响,探讨相应的护理对策.方法 采用听觉词语回忆测验、逻辑记忆测验、连线测验、Rey-Osterrieth复杂图片测验、Stroop色词测验及言语流畅性测验对113例老年高血压患者及98例健康对照组进行认知评定.结果 在记忆测验方面,高血压组患者听觉词语回忆测验及逻辑记忆测验得分低于对照组(P<0.05);非记忆测验方面,高血压组言语流畅性测验得分低于对照组(P<0.05),连线测验-A和连线测验-B耗时数比对照组延长(P<0.05);Stroop色词测验及复杂图片测验得分两组比较没有差异(P>0.05).结论 老年原发性高血压患者存在除视觉构造能力、空间结构记忆、注意力及抗干扰能力外的多项认知功能损害.应及早采取护理干预措施.     

轻度认知功能障碍的神经心理学研究和ApoE基因多态性分析

目的探讨轻度认知功能障碍(MCI)患者神经心理学和ApoE基因多态性与健康老年的差异。方法对23例MCI患者和28例健康对照进行简易精神状态检查表、日常生活行为量表、Preffer门诊患者功能缺损调查表、物体记忆测验、词语流畅性测验、数字广度、逻辑记忆、无意义图形、画钟测验、延迟记忆、临床痴呆量表、总体衰退量表、Hachinski缺血积分量表、流调用自评抑郁量表等神经心理学及ApoE基因检查。结果神经心理学检查显示：MCI患者的记忆、执行功能、视空间能力以及注意力、计算力与健康对照组有显著性差异(P＜0．05～0．001)，尤以记忆(逻辑记忆和语义记忆)最为突出，命名保留，日常生活能力正常；ApoE基因多态性检查显示，McI患者￡4携带率约为健康对照的10倍。结论McI是AD的危险因素，应用神经心理学敏感指标结合其他生物学指标如ApoE基因多态性检测可提高AD早期诊断的敏感性和特异性。     

遗忘型轻度认知功能损害与极轻度阿尔茨海默病患者临床和心理学特征的鉴别

目的：通过对遗忘型轻度认知功能损害（简称轻度认知功能损害）和极轻度阿尔茨海默病的人组条件进行严格的量化界定，分析两组受试者的认知功能和临床表现的差异。 方法：所有病例来源于2004-04／12在复旦大学附属华山医院神经内科“记忆障碍”门诊的就诊者，全部在神经心理研究室完成全套评估。根据诊断标准分为轻度认知功能损害组（n=60），极轻度阿尔茨海默病组（n=32）和轻度阿尔茨海默病组（n=32），另有来源于体检和社区离退休的正常老人60例作为对照。分别采用简明精神状态量表、听觉词语记忆测验、逻辑记忆测验、Stroop色词测验、Rey—Osterrich复杂图形测验、连线测验、言语流畅性测验和临床痴呆量表等评定总体认知功能、记忆、语言、注意、视觉空间能力、执行功能和临床特征。结果：所有调查对象全部进入结果分析。①临床痴呆量表记忆项和总分在轻度认知功能损害组与极轻度阿尔茨海默病组之间比较差异有显著性（P〈0．01）；②轻度认知功能损害受试的情景记忆功能全面减退，其听觉词语记忆测验词语记忆变化曲线与极轻度及轻度阿尔茨海默病相类似，而与正常老人组不同；③除了STROOP色词测验卡片C耗时数和连线测验-A耗时数，其余非记忆指标在轻度认知功能损害组与极轻度阿尔茨海默病组之间差异有显著性（P〈0．01-0．05）；反映执行功能的Stroop色词测验卡片C正确数和言语流畅性测验总分尤其明显。结论：轻度认知功能损害是正常衰老与极轻度阿尔茨海默病的连续演变过程的中间环节，临床痴呆量表总分、延迟回忆得分和执行功能测验是鉴别轻度认知功能损害与极轻度阿尔茨海默病患者的有效方法。     

老年男性Ⅱ型糖尿病患者认知功能改变的初步分析及护理

目的 探讨老年男性糖尿病患者认知损伤的特点，为护士制订病人认知功能训练计划提供理论依据。方法 糖尿病患者43例，对照组50例，进行总体认知功能、词语学习、词语记忆、词语再认、视觉记忆、思维判断、空间技能、词语流畅、加工速度、空间执行功能等认知测试。结果 老年男性糖尿病患者简易智力状态检查（MMSE）成绩、学习能力、画钟表测验成绩显著低于正常对照组（P〈0．05）。老年男性糖尿病患者的认知功能成绩与糖尿病病程、发病年龄、伴随的脑梗死、心肌梗死、高血脂、高血压病无关。结论 老年男性糖尿病患者存在以学习和执行功能为主的认知功能减退。认知功能减退与所伴随的脑梗塞、心肌梗塞、高血脂、高血压病无关。     

Hyperinsulinemia and cognitive decline in a middle-aged cohort

OBJECTIVE: Determining modifiable risks factors for cognitive decline and dementia are a public health priority as we seek to prevent dementia. Type 2 diabetes and related disorders such as hyperinsulinemia increase with aging and are increasing in the U.S. population. Our objective was to determine whether hyperinsulinemia is associated with cognitive decline among middle-aged adults without type 2 diabetes, dementia, or stroke in the Atherosclerosis Risk in Communities (ARIC) cohort. RESEARCH DESIGN AND METHODS: Middle-aged adults (aged 45-64 years at baseline) in the ARIC cohort had fasting insulin and glucose assessed between 1987 and 1989. Subjects with dementia, type 2 diabetes, or stroke at baseline were excluded from analysis. Three tests of cognitive function available at baseline and 6 years later were delayed word recall (DWR), digit symbol subtest (DSS), and first letter word fluency (WF). Cross-sectional comparisons and linear regression models were computed for cognitive tests at baseline and change in cognitive test scores to determine whether cognitive function was associated with two measures of insulin resistance, fasting insulin and homeostasis model assessment (HOMA). Linear regression models controlled for age, sex, race, marital status, education level, smoking status, alcohol use, depression, hypertension, and hyperlipidemia. RESULTS: In unadjusted and adjusted analyses, hyperinsulinemia based on fasting insulin and HOMA at baseline was associated with significantly lower baseline DWR, DSS, and WF scores and a greater decline over 6 years in DWR and WF. CONCLUSIONS: Insulin resistance is a potentially modifiable midlife risk factor for cognitive decline and dementia.     

应用蒙特利尔认知评估量表分析潮汕地区60岁以上老年人脑白质疏松认知障碍特点

目的分析潮汕地区60岁以上老年人群不同程度脑白质疏松（LA）,应用蒙特利尔认知评估量表（MOCA）评估其认知障碍的特点。 方法选择潮汕地区60岁以上老年人不同程度LA患者187例,进行MOCA测评,分析LA程度与认知障碍特点的相关性。 结果MOCA总分与年龄、教育程度、LA级别、脑萎缩、高血压有相关性。重度LA患者认知功能障碍与无LA组比较差异有显著性意义。 结论潮汕地区老年人用MOCA筛查早期认知障碍的危险因素与年龄、教育程度、LA程度、脑萎缩、是否患高血压有关系,其中与年龄、LA程度、脑萎缩呈负相关,与教育程度呈正相关。脑白质疏松认知障碍的特点是Ⅲ~Ⅳ型LA,可以引起认知障碍,影响视空间与执行功能、计算、语言、延迟回忆与定向等方面功能。      

不同严重程度认知障碍组脑内血管周围间隙研究

目的比较不同严重程度认知障碍组别脑内扩张血管周围间隙(enlarged perivascular spaces,EPVS)的差异,分析EPVS与认知功能的相关性。材料与方法纳入48例主观认知下降者(subjective cognitive decline,SCD),43例遗忘型轻度认知障碍者(amnestic mild cognitive impairment,a MCI),44例阿尔茨海默症(Alzheimer disease,AD)者以及43例认知功能正常(normal control,NC)的中老年人,行多项神经心理学测试及3.0 T多模态磁共振检查,在基底节区、半卵圆中心层面对EPVS计数并进行4级评分。用Kruskal-Wallis检验、Kolmogorov-Smirnov Z检验分析整体及组间差异,应用Spearman相关分析及偏相关分析与认知功能的相关性。结果AD组半卵圆中心评分(3.18±0.58)明显高于SCD组评分(2.60±0.64)(P<0.01)、aMCI组评分(2.77±0.81)(P<0.05)、NC组评分(2.56±0.77)(P<0.01)。控制年龄、性别、受教育年限后,偏相关分析结果显示,半卵圆中心EPVS与简明精神状态量表(mini-mental state examination,MMSE)及蒙特利尔认知评估基础量表(montreal cognitive assessment-basic,MoCA-B)评分显著负相关(r=-0.30、-0.37,P=0.000),与华山版听觉词语学习测验(auditory verbal learning test Huashan version,AVLT-H)延迟回忆及再认得分显著负相关(r=-0.241,P=0.002;r=-0.275,P=0.000),与波士顿命名测试(boston namingtest,BNT)评分显著负相关(r=-0.257,P=0.001)。基底节区EPVS与各项神经心理测试评分均无相关性。结论AD患者脑内半卵圆中心EPVS增多,半卵圆中心EPVS与整体认知功能、记忆、语言功能负相关。     

Cognitive impairment in cancer pain patients receiving opioids: a pilot study

This study aimed to compare cognitive function of cancer pain patients being given opioids during their cancer treatment (n = 14) with that of patients receiving treatment without opioids (n = 12). Correlations between cognitive function, pain intensity, and opioid dose were analyzed. Patients were assessed 3 times in a 1-month period, using the Trail-Making Test, Mini-Mental State Examination, Digit Span, and Brief Cognitive Screening Battery. Opioid use was not associated with clear cognitive impairment. Patients being treated without opioids did perform better in the Digit Span Test reverse-order test (P = .029) and the clock drawing test (P = .023), but the differences arose in just 1 assessment in each case. Pain intensity correlated negatively with scores in the Mini-Mental State Examination (P = .001) and some Brief Cognitive Screening Battery tests (incidental recall, immediate recall, and late recall; P 相似文献   

A biethnic community survey of cognition in participants with type 2 diabetes, impaired glucose tolerance, and normal glucose tolerance: the New Mexico Elder Health Survey

OBJECTIVE: To determine whether elderly individuals with type 2 diabetes or impaired glucose tolerance are at increased risk for cognitive impairment compared with individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS: Elderly Hispanic individuals (n = 414) and non-Hispanic white individuals (n = 469) aged > or =65 years, randomly selected from the Medicare rolls of Bernalillo County (Albuquerque), NM, were recruited for an interview/examination that included an evaluation of glucose tolerance. Information on nine tests of cognitive function and two measures of depression allowed comparisons between diabetic status and these functions. Comparisons also were made between glycosolated hemoglobin concentrations and these cognitive tests in the 188 participants with diabetes. RESULTS: None of the mean scores on the tests of cognitive function was significantly lower in the participants with diabetes compared with those participants with normal glucose tolerance after adjustments for ethnicity, sex, age, level of education, and presence of depression, with or without elimination of those with dementia (Mini-Mental State Exam <18). Interestingly, participants with impaired glucose tolerance tended to score higher than those with normal glucose tolerance. No significant associations were found between glycosolated hemoglobin concentrations and cognitive test scores in participants with diabetes. CONCLUSIONS: We could not show any increased risk for cognitive impairment in participants with diabetes compared with those with normal glucose tolerance after adjustments for ethnicity, sex, age, education, and presence of depression, before or after elimination of dementia in this random sample from a biethnic population of predominantly community-dwelling elders.     

No cognitive deficits in men formerly exposed to lead

OBJECTIVES: The objective of the study was to investigate long-term cognitive effects resulting from low to moderate lead exposure below current threshold values. Executive functions, attention, visuospatial and visuomotor functioning in workers formerly exposed to lead were investigated. METHODS: 48 men formerly exposed to lead and with a mean current blood level (PbB) of 5.4 microg Pb/100 ml were investigated, together with 48 matched controls (PbB, 4.7 microg Pb/100 ml) out of a pool of 61 males. The two groups were matched for age, years spent in education, verbal intelligence and gram alcohol consumption per week. The following neuropsychological tests were used: modified Wisconsin card sorting test, block design test, visual recognition test, simple reaction time, choice reaction and digit-symbol substitution. Lead exposure was assessed using both current and cumulative measurements. RESULTS: There were no significant differences in cognitive parameters between the two groups. When analyzing dose-response relationships, negative correlations were found between PbB and performance in the block design test, and between PbB and scores in the visual recognition and digit-symbol substitution tests. High cumulative exposure (IBL, >5000; duration of exposure, >5 years) correlated only with wrong reactions in the choice reaction test. CONCLUSIONS: The results of our study indicate that cognitive deficits resulting from low-level exposure to lead are reversible. The study was limited to low-level long-term exposure (all PbB values were always below 55 microg Pb/100 ml), and extrapolation of these results to persons heavily exposed to lead is not possible.     

Cortical thickness correlates of specific cognitive performance accounted for by the general factor of intelligence in healthy children aged 6 to 18

Prevailing psychometric theories of intelligence posit that individual differences in cognitive performance are attributable to three main sources of variance: the general factor of intelligence (g), cognitive ability domains, and specific test requirements and idiosyncrasies. Cortical thickness has been previously associated with g. In the present study, we systematically analyzed associations between cortical thickness and cognitive performance with and without adjusting for the effects of g in a representative sample of children and adolescents (N=207, Mean age=11.8; SD=3.5; Range=6 to 18.3 years). Seven cognitive tests were included in a measurement model that identified three first-order factors (representing cognitive ability domains) and one second-order factor representing g. Residuals of the cognitive ability domain scores were computed to represent g-independent variance for the three domains and seven tests. Cognitive domain and individual test scores as well as residualized scores were regressed against cortical thickness, adjusting for age, gender and a proxy measure of brain volume. g and cognitive domain scores were positively correlated with cortical thickness in very similar areas across the brain. Adjusting for the effects of g eliminated associations of domain and test scores with cortical thickness. Within a psychometric framework, cortical thickness correlates of cognitive performance on complex tasks are well captured by g in this demographically representative sample.     

MIGRAINE EPIDEMIOLOGY AND CLINICAL FEATURES

Objective: To investigate the cognitive functioning of migraineurs versus nonmigraineurs in a large population-based sample of middle-aged twins where headache diagnoses were established by neurologists.
Methods: Twins identified through the population-based Danish Twin Registry participated in face-to-face structured interviews, which included cognitive tests and two previously validated questions screening for migraine. Twins who screened positive for migraine and their cotwins were invited to participate in a telephone-based interview conducted by neurologists, who established headache diagnoses according to the International Headache Society criteria. Cognitive scores on fluency, digit span, delayed word recall, and symbol digit substitution test were compared between migraineurs and nonmigraineurs. Comparisons within monozygotic and dizygotic same sex twin pairs discordant for migraine were also performed.
Results: Of the 1789 twins who were eligible for inclusion in the present study, 1393 (77.8%) were interviewed. A diagnosis of migraine was established in 536 twins (migraine without aura n = 347; migraine with aura n = 157). Average scores on cognitive tests in twins with migraine or one of the migraine subtypes did not differ from those of nonmigraineurs in any of the tests. Comparisons within twin pairs discordant for migraine produced highly comparable results. Adjustment for possible confounders and stratification by cumulated number of lifetime attacks did not influence the results.
Conclusions: A lifetime diagnosis of migraine was not associated with cognitive deficits in middle-aged subjects.
And there is an accompanying editorial, excerpted below:     

影响原发性癫痫患者发生认知功能障碍的危险因素分析

目的:分析影响原发性癫痫患者发生认知功能障碍的危险因素。方法:采用韦氏成人智力量表(WAIS-RC)对研究组100例原发性癫痫患者与对照组50例健康体检者进行认知功能测验,同时对影响认知功能的相关因素进行单因素分析与多元线性逐步回归分析。结果:研究组患者认知功能测验中知识、领悟、算术等11个分测量指标得分均显著低于对照组(P<0.001);研究组言语智商(VIQ)、操作智商(PIQ)及全量表智商(FIQ)得分显著低于对照组(P<0.001);相关性分析结果显示FIQ与学历、抗癫痫药物数量、发作时间及病程显著相关(R=0.611),VIQ与学历、抗癫痫药物数量显著相关(R=0.619),PIQ与发作时间、年龄、抗癫痫药物数量及学历显著相关(R=0.571)。结论:原发性癫痫患者认知功能障碍的发生与学历、年龄、病程、抗癫痫药物数量、发作持续时间等因素显著相关。     

轻度认知功能障碍患者的神经心理学特点初步探讨

目的 通过比较遗忘型轻度认知障碍(amnestic mild cognitive impairment,aMCI)和血管性认知障碍非痴呆型(vascular cognitive impairment-no dementia,VCFND)患者及正常老年人群在简易智能精神状态检查量表(mini mental state e...