人重复肢体缺血对血压、心率及组织氧饱和度的影响

“远程缺血预适应（remote Isehemie Precondition，HPC）”对远隔脏器缺血／再灌注（Ischemia／Reperfusion，L／R）损伤的保护作用逐渐受到重视。重复肢体缺血（Repetitive Limb Ischemia，Ru）是近年建立人rIPC的方法，其简便易行，具有广阔的临床应用前景。本研究检测重复肢体缺血全过程中健康受试者血压、心率及组织氧饱和度的变化，了解该方法的安全性，     

麻黄汤对正常大鼠血压、心率影响的实验研究

观察麻黄汤对正常大鼠血压、心率的影响,并与麻黄碱的作用进行比较。方法:采用颈总动脉插管法,利用BL-lab 1998智能信号系统观察麻醉大鼠给药前后血压、心率的变化。取32只SD大鼠,雌雄不拘,按拉丁方排序分为四组:正常对照组、麻黄碱组(27mg/kg)、麻黄汤高剂量组、低剂量组(分别为     

佩戴口罩运动对心率、血氧饱和度及呼气末二氧化碳影响的Meta分析

目的：口罩是阻隔病毒最重要的防线之一，然而日常活动或运动时佩戴口罩对呼吸循环功能的影响尚存分歧。文章运用Meta分析方法综合定量评价佩戴口罩运动中的心率、血氧饱和度和呼气末二氧化碳，探讨在不同强度、时间运动中佩戴不同类型的口罩对人体呼吸循环系统的影响。方法：截至2023年2月，以“口罩，面罩，N95，训练，运动，跑步，步行，自行车”为中文检索词，以“Masks,Respiratory Protective Devices,N95 Respirators,Surgical Face Masks,Exercise,Resistance Training,Explosive training,Muscle Stretching Exercises”为英文检索词在中国知网和Web of Science、PubMed、Cochrane Library、万方网络数据库进行检索，收集佩戴口罩运动对血流动力学指标影响的试验研究。结局指标包括运动中心率、血氧饱和度和呼气末二氧化碳，共3个连续性变量，运用Stata 16.0软件对所纳入文献的结局指标进行分析，以PEDro量表作为质量评估的工具，采用漏斗图...     

磁化水对高胆固醇血症大鼠血压及心率的影响

本文对饮用磁化水和非磁化水的两组高胆固醇血症的大鼠进行了血液粘度、血浆粘度、血脂、心电、心率和血压的测试。结果表明,磁化水有明显降低血液粘度和血清总胆固醇和甘油三酯的效应(P<0.05)。心电未见异常,心率明显减慢(P<0.05)。血压有所降低,但无显著意义(P>0.05)。     

富氧机对机体血氧饱和度及行为能力的影响

目的:在模拟高原环境下,探讨自主研制开发基于富氧膜技术的富氧机对机体血氧饱和度(SpO2)以及行为能力的影响。方法:在低压高原模拟舱中分别模拟海拔3000m,4000m,5000m的高原环境,利用PhilipsMP20多参数检测仪监测8名受试对象在每个模拟海拔高度下使用富氧机前后的SpO2。同时,在模拟海拔5000m的高原环境下,对比8名受试对象使用富氧机前后行为能力(包括目标追踪与二维数字搜索两个实验项目)的测量得分。结果:使用富氧机后,受试者SpO2在三个模拟海拔高度下均显著增高(P<0.05);模拟海拔5000m的高原环境下,受试者行为能力得分显著提高(P<0.05)。结论:使用富氧机能显著增加高原环境下机体的SpO2,提高缺氧环境下的作业效能。     

缺血预处置对大鼠肢体缺血再灌注损伤的影响

目的和方法在大鼠肢体缺血再灌注（ＩＲ）损伤模型上观察了缺血预处置（ｐｒｅｃｏｎｄｉｔｉｏｎｉｎｇ，ＰＣ）的影响。结果：发现ＰＣ可以明显减轻ＩＲ引起的血压降低，血浆乳酸脱氢酶、组织蛋白酶Ｄ活性及脂质过氧化产物丙二醛含量的升高；并抑制骨骼肌组织水肿及骨骼肌细胞线粒体钙超载的发生。同时还观察到，ＰＣ对ＩＲ时肢体微血管通透性升高、中性粒细胞浸润及血浆内皮素水平增高均有抑制作用。结论：ＰＣ对大鼠ＩＲ肢体有保护作用，其保护机理之一与其对血管床的保护作用有关。     

高血压合并OSAHS患者治疗前后血清Hcy、CRP、氧饱和度及血压变化及其临床意义

目的分析高血压合并阻塞性呼吸暂停低通气综合征(OSAHS)患者治疗前后血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)、氧饱和度及血压的变化及意义。方法选择医院收治的100例高血压患者,按是否合并OSAHS分为高血压组[n=46,呼吸暂停低通气指数(AHI)<5次/h]与合并组(n=54,AHI≥5次/h),均于治疗前后检测血清Hcy、CRP、血氧饱和度(SaO_2)水平,并检测动态血压变化,分析上述指标与高血压合并OSAHS病情变化的关系。结果合并组Hcy、CRP、AHI高于高血压组,最低SaO_2低于高血压组,其治疗后Hcy、CRP、AHI低于治疗前,SaO_2高于治疗前(P<0.05);合并组随OSAHS病情程度的提升,Hcy、CRP、AHI逐渐升高,最低SaO_2降低(P<0.05),各组治疗后Hcy、CRP、AHI水平均低于治疗前,最低SaO_2高于治疗前(P <0.05);高血压+轻度、中度、重度OSAHS组整体血压昼夜节律变化幅度高于高血压组(P<0. 05),治疗后,除高血压+轻度OSAHS组mSBP、mDBP外,各组血压较治疗前降低(P <0.05);高血压合并OSAHS患者Hcy、CRP与AHI、nSBP均呈正相关,与最低SaO_2呈负相关(P <0.05)。结论高血压合并OSAHS患者随OSAHS程度的上升,Hcy、CRP、AHI水平上升,最低SaO_2降低,且其Hcy、CRP的变化可影响患者通气功能及血压变化节律。     

睡眠呼吸暂停时间对血氧饱和度和心率的影响

目的睡眠呼吸暂停综合征患者发生呼吸暂停时需要及时唤醒,何时唤醒患者需要更多的参考依据。为此,试验研究了睡眠呼吸暂停时间对血氧饱和度和心率的影响,提出通过实时监测血氧饱和度来辅助判断是否发生呼吸暂停。方法选择健康志愿者10例,其中男性3例,女性7例;年龄22～24岁,平均年龄21.7岁;体质量44～85 kg,平均体质量58.35 kg;体质量指数17.3～25.9 kg/m~2,平均体质量指数20.81 kg/m~2;身高155～187 cm,平均身高166.1 cm。受试者通过憋气模拟呼吸暂停事件,利用AFE4490集成模拟前端采集受试者指端脉搏信号,并根据光电容积脉搏波波形计算血氧饱和度和心率值,得到了血氧饱和度和心率随呼吸暂停时长变化的特性曲线。结果血氧饱和度随呼吸暂停时间的增加呈下降趋势;心率随呼吸暂停时间的增加呈上升趋势。血氧饱和度首次代偿到达峰值的时间约为11.2 s,首次代偿结束时间约为18.6 s;心率首次代偿到达峰值的时间约为12.1 s,首次代偿结束时间约为19.4 s。结论患者发生呼吸暂停时,血氧饱和度和心率会出现周期性变化趋势,但与心率相比,血氧饱和度对呼吸暂停时长的变化更为敏感且规律。根据血氧饱和度随呼吸暂停的时间参数为睡眠呼吸暂停综合征患者的唤醒时刻提供了参考数据。     

腹腔镜胆囊切除术中CO2气腹对心率、血压、心电图的影响

目的:探讨腹腔镜胆囊切除术中CO2气腹对患者心率、血压及心电图的影响.方法:选取2020年3月至2021年3月至溆浦县中医医院接受腹腔镜胆囊切除术治疗的患者80例作为研究对象,按其术中建立CO2气腹压力不同分为两组,以压力值12 mmHg为截点,将压力值设定为10～12 mmHg之间的30例患者作为低压组,将压力值设定...     

电针预处理对肢体缺血再灌注大鼠生存、脑损伤及认知功能的影响

 目的：观察电针（EA）预处理对肢体缺血再灌注（LI/R）大鼠生存情况、脑损伤及认知功能的影响,探讨相关机制。方法：清洁级、健康成年雄性SD大鼠132 只,体重255～300 g,采用随机数字表法,将其随机分为3 组：假手术(sham)组、LI/R组和LI/R+EA预处理 (LI/R+EA) 组。LI/R组采用动脉夹夹闭双后肢股动脉3 h,建立LI/R模型;sham组只暴露股动脉,不夹闭;LI/R+EA组于模型制备前14 d行电针治疗,针刺穴位为“百会”、“足三里”及“血海”。观察各组大鼠7 d生存率;于再灌注48 h,用Morris水迷宫方法测试大鼠认知功能的变化;其余大鼠于再灌注48 h后处死取材,用干湿重法测定脑含水量;免疫组织化学法测定小胶质细胞标志物Iba1;采用Western blotting检测cleaved caspase-3的表达水平;原位末端标记(TUNEL)法检测神经细胞凋亡并计算凋亡指数;光镜下观察海马病理结构变化;化学法测定活性氧（ROS）、丙二醛（MDA）含量及髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)活性。结果：与sham组比较,LI/R组及LI/R+EA组大鼠7 d生存率下降,潜伏期和游泳距离增加,穿越平台次数减少,海马Iba1阳性细胞数增加,cleaved caspase-3蛋白表达量增加,凋亡指数明显增加,神经元减少,ROS、MDA含量及MPO活性增加,SOD活性降低(P<0.05或P<0.01);与LI/R组相比,LI/R+EA组上述指标得到明显改善(P<0.05或P<0.01)。结论：电针预处理能提高LI/R大鼠生存率,减轻脑损伤及改善大鼠认知功能障碍,其机制可能与抑制小胶质细胞激活、减轻氧化应激损伤有关。     

Effect of aging on heart rate and blood pressure variabilities in healthy men and women

OBJECT: To clarify the effect of aging and gender on heart rate and blood pressure variability in healthy men and women. SUBJECT AND METHODS: One hundred ninety four healthy subjects aged from 20 to 70(97 men and 97 women) were examined. Heart beat and blood pressure during 5 minutes in the supine and standing positions were measured under a respiration rate of 15/min. Blood pressure and heart were measured with Finapres and Biotop, respectively. Data entry and spectral analysis were carried out by the Fast Fourier Transform(FFT) method with BIMUTAS-II, after correcting 256 data with Hanning window function and resampling at 200 Hz. RESULT AND DISCUSSION: High frequency power(HF: 0.15-0.50 Hz) of heart rate variability decreased with age in both men and women, Low frequency power (LF: 0.05-0.15 Hz) of systolic blood pressure(SBP) variability in the standing posture decreased with age in men. The HF of SBP variability in the standing posture was decreased with age in both men and women. These findings suggest that aging and gender affected heart rate and blood pressure variability.     

Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans

Confusion and controversy exist regarding the cardiovascular effects of dietary supplements containing caffeine and Citrus aurantium (bitter orange) extract. The primary protoalkaloidal ingredient in bitter orange extract is p-synephrine which has some structural similarities to ephedrine and nor-epinephrine, but exhibits markedly different pharmacokinetic and receptor binding properties. The goal of this study was to investigate the cardiovascular effects of a product containing caffeine, bitter orange extract (p-synephrine) and green tea extract in mildly overweight individuals. Fourteen female and nine male subjects (age 24.7 ±7.4 yrs, BMI: 26.6 ±3.8) volunteered in this randomized, placebo-controlled, crossover, double-blind designed study. On day one, subjects entered the laboratory following an overnight fast. Heart rate and blood pressure were recorded at 60 min. Expired air was analyzed for the next 10 min of the session. At each of three meals, subjects ingested one capsule that was either a non-caloric placebo or a dietary supplement that contained 13 mg p-synephrine and 176 mg caffeine. On the following day, the subjects returned and repeated the protocol for data collection beginning 60 min after consuming one capsule of the placebo or the dietary supplement. No effects of the dietary supplement on heart rate, systolic and diastolic blood pressure or mean arterial pressure were observed. No between or within group differences were observed when data were analyzed for gender and caffeine usage. A small but significant decrease in resting respiratory exchange ratio was observed for the low caffeine user group in response to the product containing caffeine and p-synephrine. The results of this study indicate that ingestion of a product containing bitter orange extract, caffeine and green tea extract does not lead to increased cardiovascular stress and that fat oxidation may increase in certain populations.     

Effect of Qi-training on blood pressure, heart rate and respiration rate.

To examine the physiological effects of Korean traditional Qi-training, we investigated the changes in blood pressure, heart and respiratory rates before, during and after ChunDoSunBup (CDSB) Qi-training. Twelve normal healthy CDSB Qi-trainees (19-37 years old; trained for 1.3 +/- 0.2 years; 9 men and 3 women) volunteered to participate in this study. Heart rate, respiratory rate, systolic blood pressure and rate-pressure product were significantly decreased during Qi-training. From these results, we suggest that CDSB Qi-training has physiological effects that indicate stabilization of cardiovascular system.     

Acute effect of decaffeinated coffee on heart rate, blood pressure, and exercise performance in healthy subjects

The effect of decaffeinated coffee on the cardiovascular exercise performance in nine healthy volunteers was evaluated in a double-blind randomized fashion. The heart rate, blood pressure, and duration of exercise were unchanged, and no arrhythmias or ischemic changes were seen on the electrocardiogram after drinking decaffeinated coffee. It was concluded that decaffeinated coffee has no discernible, acute, adverse cardiovascular effects.     

Effect of exercise on systemic blood pressure and heart rate in horses

Summary Carotid loops were prepared in 3 horses several months prior to the experiments. Systemic blood pressure was recorded at rest and during exercise by insertion of a plastic cannula into the carotid artery. The pressure transducer was fixed at the neck of the animal. The blood pressure signal was transmitted by telemetry.When the horses were standing under the rider, the following results were obtained: heart rate 38±5 beats · min^–1, systolic pressure 115±15, disstolic pressure 83±10, mean pressure 97±12, and pulse pressure 32±9 mm Hg. During steady gallop at a mean speed of 548±90 m · min^–1, heart rate rose to 184±23 beats · min^–1, systolic pressure to 205±23, diastolic pressure to 116±12, mean pressure to 160±20 and pulse pressure to 89±19 mm Hg. These values remained stable throughout the exercise period of 5–6 min.When the horses were exercised at stepwise increasing speed from walk through trot to gallop, both the mean arterial blood pressure and the pulse pressure rose in proportion to the running speed.     

Spectral evaluation of aging effects on blood pressure and heart rate variations in healthy subjects

The background to heart rate variability (HRV) and blood pressure variability (BPV), and their determinants and physiological correlates, remain obscure. The impact of age must be taken into account if HRV and BPV are used for predictive purposes in clinical settings. Healthy subjects show wide inter-individual variation in their heart rate behaviour and the factors affecting heart rate dynamics are not well known. This paper has undertaken to evaluate heart rate variability (HRV) and baroreflex sensitivity (BRS) in a random sample of subjects without evidence of heart disease, and to estimate the relation of HRV and BPV behaviour to age. The aim of this study was to analyse the effects of ageing on HRV and BPV for simultaneous recordings of electrocardiograph (ECG) and blood pressure (BP) signals at rest in healthy subjects. We studied eight young (21 – 34 years old) and eight elderly (68 – 85 years old) rigorously screened subjects from the Fantasia Database to make the reproducibility and comparability of the results more extensive. Time- and frequency-domain analysis of HRV and BPV was performed on 5-minute ectopic-free recordings. BRS on the heart was estimated by frequency-domain analysis of spontaneous variability of systolic blood pressure (SBP) and RR interval. It has been observed that compared to young the elderly subjects have (i) diminished HRV; (ii) a shift in the power spectral density and median frequency to low frequency side for HRV and to higher frequency side for BPV; and (iii) increased low-frequency alpha index and decreased high-frequency alpha index of BRS with overall alpha index augmented. The results convey that normal ageing in the absence of disease is associated with lesser parasympathetic regulation of heart rate. Thus it is concluded that the age is an important factor to be considered for prognosis and diagnosis by HRV and BPV. For reliable clinical applications, more research needs to be done on a broad spectrum of subjects. In addition, these observations will prove to be useful for dynamic modelling of cardiovascular regulation for testing the authentication of new techniques for analysis purposes.     

Spectral evaluation of aging effects on blood pressure and heart rate variations in healthy subjects

The background to heart rate variability (HRV) and blood pressure variability (BPV), and their determinants and physiological correlates, remain obscure. The impact of age must be taken into account if HRV and BPV are used for predictive purposes in clinical settings. Healthy subjects show wide inter-individual variation in their heart rate behaviour and the factors affecting heart rate dynamics are not well known. This paper has undertaken to evaluate heart rate variability (HRV) and baroreflex sensitivity (BRS) in a random sample of subjects without evidence of heart disease, and to estimate the relation of HRV and BPV behaviour to age. The aim of this study was to analyse the effects of ageing on HRV and BPV for simultaneous recordings of electrocardiograph (ECG) and blood pressure (BP) signals at rest in healthy subjects. We studied eight young (21-34 years old) and eight elderly (68-85 years old) rigorously screened subjects from the Fantasia Database to make the reproducibility and comparability of the results more extensive. Time- and frequency-domain analysis of HRV and BPV was performed on 5-minute ectopic-free recordings. BRS on the heart was estimated by frequency-domain analysis of spontaneous variability of systolic blood pressure (SBP) and RR interval. It has been observed that compared to young the elderly subjects have (i) diminished HRV; (ii) a shift in the power spectral density and median frequency to low frequency side for HRV and to higher frequency side for BPV; and (iii) increased low-frequency alpha index and decreased high-frequency alpha index of BRS with overall alpha index augmented. The results convey that normal ageing in the absence of disease is associated with lesser parasympathetic regulation of heart rate. Thus it is concluded that the age is an important factor to be considered for prognosis and diagnosis by HRV and BPV. For reliable clinical applications, more research needs to be done on a broad spectrum of subjects. In addition, these observations will prove to be useful for dynamic modelling of cardiovascular regulation for testing the authentication of new techniques for analysis purposes.