抗氧化维生素C、E对急性心肌梗塞患者平均信号心电图的影响

即往研究表明，氧代谢的中间产物、氧自由基和心脏缺血时产生的过氧化氢能导致心肌损害和改变细胞膜电活动。因此自由基导致的损伤可能促使心室晚电位产生。作对随机选择的急性心肌梗塞(AMI)患给予维生素C、E辅助治疗，并与埘照组比较，旨在探讨抗氧化维生素C，E对平均信号心电图影响。     

维生素C、E对氟中毒大鼠不同组织抗氧化酶活性影响的研究

目的探讨氟中毒大鼠肝、肾、脑组织抗氧化酶类及脂质过氧化物的变化以及维生素 C、E 单独和联合干预以及不同剂量干预对高氟状态下大鼠抗氧化酶活性及脂质过氧化物的影响。方法将120只 Wistar 大鼠随机分为9绀,饮水染氟建立氟中毒大鼠模型,并灌胃给予维生素 C 和/或维生素 E;9月后处死大鼠取肝、肾、腑组织测定超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氧酶(CAT)活性和脂质过氧化物丙二醛(MDA)含量。结果染氟组大鼠肝、肾、脑组织 MDA 含量显著增加,肝和腑绀织 SOD、GSH-Px 和 CAT 活性以及肾组织 GSH-Px 活性均显著降低(P<0.05),而肾组织 SOD、CAT 活性无明显变化;维生素 C、E 可不同程度地增强 SOD、GSH-Px 和 CAT 活性,降低 MDA 水平;联合干预维生素 C、E 可明显拮抗氟诱导的脂质过氧化作用,显著增强大鼠肝组织 SOD、GSH-Px 和 CAT活性;维生素 C 低制量干预对肾脏 SOD 和 CAT 以及脑 GSH-Px 和 CAT 具有明显的保护作用;维生素 E 高剂量干预显著增加脑 SOD 活性。结论维生素 C 和维生素 E 在一定剂量范围内可有效拮抗过量氟导敛的脂质过氧化作用,对氟中毒大鼠肝、肾、脑组织有明显的保护作用。     

高血压病患者血浆维生素C和维生素E的测定

采用亚铁嗪显色分光光度法,以60例健康成人为正常对照,观察33例原发性高血压患者的血浆vitC,vitE浓度,结果显示:高血压患者组的血浆vitC,vitE浓度显著低于正常对照组(分别为vitC:43.35±10.19μmol/L vs 54.83±21.76μmol/L,P<0.05;vitE:19.61±6.51μmol/L vs 25.51±10.30μmol/L,P<0.05),同时发现血浆vitC浓度与病程具有负相关趋势(r=-0.304,P=0.08),而血浆vitE浓度与病程具有显著负相关(r=-0.376,P=0.03)。上述结果提示高血压病患者体内存在着vitC,vitE的不足,且与病程相关,这可能与高血压病的发展和并发症的发生有关。     

正常人不宜长期大量服用抗氧化剂维生素E及维生素C

中华高血压杂志编辑部： 近年来不少科普材料，药品、食品广告，大量宣传超氧、氧化应激对身体老化的坏处。临床上不少病人，还有不少健康人看到这些材料，经常向我们索要维生素（Vit）E或Vit C。我们也听过报道Vit E、Vit C对防治心脑血管病的疗效可疑，但说不出道理来，请您们能介绍一下这方面的材料？     

血清维生素A、C、E水平与尿酸水平的相关性

目的 探讨血清维生素A、C、E水平与尿酸水平的关系.方法 采用高效液相法检测100例高尿酸血症患者和100例正常对照组的血清维生素A、C、E水平,利用SPSS16.0统计软件分析尿酸与血清维生素A、C、E水平的关系.结果 高尿酸血症患者血清维生素A水平高于对照组,但维生素C、E水平低于对照组.高尿酸血症患者维生素C、E缺乏高于对照组(P＜0.05).结论 高尿酸血症患者的血清维生素C、E水平降低,可能参与了高尿酸血症的的发生.     

568例心血管患者血清维生素A、E、C水平的初步观察

本文报导568例心血管病患者血清维生素A、E、C水平的调查结果。初步发现心血管病人血清维生素E均低于健康人。而心梗、高血压病、肺心病、风心病人血清维生素A均低于健康人。风心病人血清维生素C高于健康人。其机理尚待进一步研究。     

维生素C和维生素E在根除幽门螺杆菌中作用的研究

目的探讨维生素C和维生素E联合标准三联疗法在H.pylori中的作用。方法将180例H.pylori阳性的非溃疡性消化不良患者按开放性试验随机分为两组。A组60例:阿莫西林(1.0 g bid)+克拉霉素(0.5 g bid)+埃索美拉唑(20 mg bid)+VitC(0.5 g bid)+VitE(200 IU bid);疗程14 d;但VitC和VitE连续服用30 d。B组120例:阿莫西林(1.0 g bid)+克拉霉素(0.5 g bid)+埃索美拉唑(20 mg bid);疗程为14 d。实验结束后停药4~6周行14C呼气试验。试验完成患者均采用ITT和PP分析。结果 A组49例患者H.pylori成功根除,ITT和PP分析根除率分别为81.7%(49/60)和86.0%(49/57)。B组81例患者H.pylori成功根除,ITT和PP分析根除率分别为67.5%(81/120)和70.4%(81/115)。A组根除率明显高于B组,差异具有统计学意义(P0.05)。两组患者组内根除率在性别之间差异无统计学意义(P0.05)。结论在标准三联基础上加用大剂量的维生素C和维生素E可提高H.pylori根除率。     

大剂量维生素C、维生素E治疗新生儿缺氧缺血性脑病123例疗效观察

近年来 ,我院采用大剂量维生素 C、维生素 E联合治疗新生儿缺氧缺血性脑病 12 3例 ,并取得满意效果。现报告如下。临床资料 :本文缺氧缺血性脑病患儿 2 4 3例 ,随机分成两组。治疗组 12 3例 ,男 78例 ,女 4 5例 ;缺血缺氧性脑病轻度 30例 ,中度 5 8例 ,重度 35例。对照组 12 0例 ,男 72例 ,女 4 8例 ;轻度 30例 ,中度 5 6例 ,重度 34例。患儿均符合新生儿缺氧缺血性脑病诊断依据及临床分度标准 ,均在生后 1小时至 2 .5天入院 ,CT检查均有脑实质低密度改变。其中治疗组合并颅内出血 2 9例 ,对照组合并颅内出血 2 6例。两组性别、胎龄、体重…     

从目前的临床试验看维生素E对心血管病的二级预防作用

大量实验证实低密度脂蛋白 (LDL)氧化在动脉粥样硬化的启动和进展中起着重要作用[1,2 ] 。例如 :培养的动脉血管壁细胞发生LDL氧化 ,可被巨噬细胞清道夫受体识别 ;从人和动物动脉粥样斑块分离的LDL有明显的氧化损害的证据 ;脂质氧化产物抗体可检测出动脉粥样硬化损害处的抗原决定簇 ,表明动脉壁存在氧化型低密度脂蛋白 (oxLDL) ,有力地支持LDL脂质和 (或 )蛋白的氧化对动脉粥样硬化的形成起着重要作用。从理论上讲 ,抗氧化剂可降低自由基水平 ,防止LDL过氧化 ,从而减少发生动脉粥样硬化的危险 ,延缓其进展 ,甚至逆转已形成的粥样斑…     

维生素C和维生素E对小鼠化学性肝损伤的预防性保护作用

目的:探讨维生素C(VC)和维生素E(VE)对CCl_4引起化学性肝损伤的预防性保护作用.方法:昆明种小鼠60只随机分5组,设正常对照组、病理模型组、VC保护组、VE保护组、VC VE保护组,饲养10 d,除正常对照组外,其余各组ip 1.5 mL/L CCl_4致小鼠化学性肝损伤,测定小鼠血清中ALT,AST及肝细胞中MDA,GSH,SOD,HE染色光镜下观察肝细胞形态变化.结果:VC和VE保护组能显著降低血清中ALT和AST(2277.12±1187.90,2163.76±1412.11 nkat/L vs 4527.07±1019.37 nkat/L,P<0.01)以及肝细胞中脂质过氧化物MDA的含量(4.37±0.49,3.26±0.71μmol/g vs 9.25±2.74μmol/g,P<0.01).镜下观查肝损伤明显减轻,体外抗氧化实验能显著性的抑制脂质过化物MDA生成,联合应用有协同效应.结论:VC和VE对化学性肝损伤有预防性保护作用.     

心脑血管疾病中血清C3的研究进展

补体系统是人体免疫防御的一个重要部分。近来研究发现补体系统参与动脉粥样硬化的形成。血清C3水平在冠状动脉硬化性心脏病及脑梗死等心脑血管疾病中有明显变化,被认为是冠心病的独立危险因素,是心血管疾病一个很好的标志物。现就C3在心脑血管疾病中的研究作一综述。     

硫化氢与心血管系统疾病

硫化氢是一种新发现的内源性气体信号分子,目前已知其对神经系统特别是海马的功能具有调节作用,并可以调节消化道和血管平滑肌的张力,舒张血管和抑制平滑肌的增殖,在呼吸系统及炎症反应中都具有重要调节作用。近几年的基础研究表明,硫化氢参与了心血管系统正常生理功能的调控和病理生理过程,并与多种心血管系统疾病密切相关。     

铁代谢与心血管疾病

铁代谢异常与多种心血管疾病密切相关。慢性心力衰竭、肺动脉高压常与铁缺乏并存,铁超负荷可促进冠心病的发生发展。现简要综述常见心血管疾病中铁代谢异常的表现特征及可能的机制。     

Carvedilol Enhances the Antioxidant Effect of Vitamins E and C in Chronic Chagas Heart Disease

Background

Chagas disease is still an important endemic disease in Brazil, and the cardiac involvement is its more severe manifestation.

Objective

To verify whether the concomitant use of carvedilol will enhance the antioxidant effect of vitamins E and C in reducing the systemic oxidative stress in chronic Chagas heart disease.

Methods

A total of 42 patients with Chagas heart disease were studied. They were divided into four groups according to the modified Los Andes classification: 10 patients in group IA (normal electrocardiogram and echocardiogram; no cardiac involvement); 20 patients in group IB (normal electrocardiogram and abnormal echocardiogram; mild cardiac involvement); eight patients in group II (abnormal electrocardiogram and echocardiogram; no heart failure; moderate cardiac involvement); and four patients in group III (abnormal electrocardiogram and echocardiogram with heart failure; severe cardiac involvement). Blood levels of markers of oxidative stress were determined before and after a six-month period of treatment with carvedilol, and six months after combined therapy of carvedilol with vitamins E and C. The markers analyzed were as follows: activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and reductase, myeloperoxidade and adenosine deaminase; and the levels of reduced glutathione, thiobarbituric-acid reactive substances, protein carbonyls, vitamin E, and nitric oxide.

Results

After treatment with carvedilol, all groups showed significant decrease in protein carbonyls and reduced glutathione levels, whereas nitric oxide levels and adenosine activity increased significantly only in the less severely affected group (IA). In addition, the activity of most of the antioxidant enzymes was decreased in the less severely affected groups (IA and IB). By combining the vitamins with carvedilol, a reduction in protein damage, in glutathione levels, and in the activity of most of the antioxidant enzymes were observed.

Conclusions

The decrease in oxidative stress levels observed by means of the markers tested was more significant when carvedilol was used in combination with the antioxidant vitamins. The findings suggest that both carvedilol alone and in combination with the vitamins were effective in attenuating the systemic oxidative stress in patients with Chagas heart disease, especially those less severely affected, thus suggesting the possibility of synergism between these compounds.     

Disparities in Cardiovascular Disease Risk in the United States

This is a comprehensive narrative review of the literature on the current science and evidence of population-level differences in risk factors for heart disease among different racial and ethnic population in the United States (U.S.). It begins by discussing the importance of population-level risk assessment of heart disease in light of the growth rate of specific minority populations in the U.S. It describes the population-level dynamics for racial and ethnic minorities: a higher overall prevalence of risk factors for coronary artery disease that are unrecognized and therefore not treated, which increases their likelihood of experiencing adverse outcome and, therefore, potentially higher morbidity and mortality. It discusses the rate of Acute Coronary Syndrome (ACS) in minority communities. Minority patients with ACS are at greater risk of myocardial infarction (MI), rehospitalization, and death from ACS. They also are less likely than non-minority patients to receive potentially beneficial treatments such as angiography or percutaneous coronary intervention. This paper looks at the data surrounding the increased rate of heart disease in racial and ethnic minorities, where the risk is related to the prevalence of comorbidities with hypertension or diabetes mellitus, which, in combination with environmental factors, may largely explain CHF disparity. The conclusion is that it is essential that healthcare providers understand these various communities, including nuances in disease presentation, risk factors, and treatment among different racial and ethnic groups. Awareness of these communities’ attributes, as well as differences in incidence, risk factor burdens, prognosis and treatment are necessary to mitigate racial and ethnic disparities in heart disease.     

Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer

OBJECTIVE: To evaluate the evidence of the supplements vitamin C and vitamin E for treatment and prevention of cancer. METHODS: Systematic review of trials and meta-analysis. DATA SOURCES AND MAIN RESULTS: Thirty-eight studies showed scant evidence that vitamin C or vitamin E beneficially affects survival. In the ATBC Cancer Prevention Study Group, no statistically significant effect of treatment was seen for any cancer individually, and our pooled relative risk (regardless of tumor type) for alpha-tocopherol alone was 0.91 (95% confidence interval [CI]: 0.74, 1.12). All cause mortality was not significant. In the Linxian General Population Trial, the relative risks for cancer death for vitamin C (combined with molybdenum) was 1.06 (95% CI: 0.92, 1.21) and for vitamin E (combined with beta-carotene and selenium) was 0.87 (95% CI: 0.76, 1.00). We identified only 3 studies that reported statistically significant beneficial results: vitamin C (in combination with BCG) was found to be beneficial in a single trial of bladder cancer and vitamin E (in combination with omega-3 fatty acid) increased survival in patients with advanced cancer. In the ATBC trial, in analyses of 6 individual cancers, the prevention of prostate cancer in subjects treated with alpha-tocopherol was statistically significant (RR=0.64, 95% CI: 0.44, 0.94). CONCLUSIONS: The systematic review of the literature does not support the hypothesis that the use of supplements of vitamin C or vitamin E in the doses tested helps prevent and/or treat cancer in the populations tested. There were isolated findings of benefit, which require confirmation.     

血清胆红素与冠心病关系的研究进展

胆红素是体内一种天然抗氧化剂 ,其抗氧化活性具有防止低密度脂蛋白胆固醇 (LDL C)的氧化修饰继而防止动脉粥样硬化形成的作用。流行病学研究已证实 ,血清总胆红素水平与冠心病发病率呈负相关关系。在冠心病防治方面 ,临床上尚无提高胆红素水平以防治冠心病的报道 ,在这些方面进行研究 ,有望对冠心病的防治提供一个新的突破点。     

载脂蛋白E等位基因多态性与冠心病相关性的研究

对103例冠心病患者和100例正常对照者提取外周血白细胞DNA,采用PCR方法扩增apo E基因片段,经Hha I酶切,聚丙烯酰胺电泳分离,测得天津地区汉人apo R等位基分布,E4/3、E4/2、E3/3、E3/2在冠心病组和对照组基因频率分别为:0.068、0.019、0.854、0.058和0.060、0.010、0.800、0.130.E4/3基因型携带者胆固醇平均水平较高,E3/2基因型携带者甘油三酯平均水平较高.apo E基因多态性与冠脉受累数目无关.     

胱抑素C与冠状动脉粥样硬化性心脏病危险因素的研究进展

胱抑素C是半胱氨酸蛋白酶抑制剂家族中的一员,参与机体许多生理与病理过程。以往的研究发现它是一种理想的反映肾小球滤过率变化的内源性标志物,而新近的研究发现,胱抑素C还与冠状动脉粥样硬化性心脏病的危险因素有关,现对其进展做一概述。     

抑郁障碍与心血管疾病的关系

抑郁障碍与躯体疾病共存于慢性疾病中,并具有较高的发病率、致残率和致死率。现有研究发现,抑郁障碍可能成为诱发冠状动脉性心脏病、高血压病、心力衰竭的新的危险因素。同时,心血管疾病又可能引起或加重抑郁障碍,从而使患者住院时间延长,并发症增加。