共查询到20条相似文献,搜索用时 93 毫秒
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综述了近年来以物理方法促进多肽和蛋白质药物透皮给药技术研究的进展,包括目前广泛研究的离子导入、电致孔导入和超声导入技术。 相似文献
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综述了近年来以物理方法促进多肽和蛋白质药物透皮给药技术研究的进展,包括目前广泛研究的离子导入、电致孔导入和超声导入技术。 相似文献
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实现蛋白质和多肽类药物的口服给药是药物递送长期追求的目标 ,具有很好的发展前景 ,同时也存在许多问题。渗透性、稳定性及在胃肠内的转运时间等是影响该类药物口服吸收的因素 ,但分子大小一般认为是最主要的障碍。本文主要介绍处方组成、包囊技术、大分子复合物和化学修饰四种改善蛋白质和多肽类药物在胃肠道吸收状况的基本方法。对于吸收促进剂和酶抑制剂已进行了多年的研究。此技术着重于通过改变多肽的渗透性和可消化性来改善其在胃肠道的吸收状况 ,这些组分会改变粘膜表面的完整性 ,甚至会产生全身和局部的副作用。最近开发出一种新的… 相似文献
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《Expert opinion on drug delivery》2013,10(3):533-548
Transdermal delivery has been at the forefront of research addressing the development of non-invasive methods for the systemic administration of peptide and protein therapeutics generated by the biotechnology revolution. Numerous approaches have been suggested for overcoming the skin’s formidable barrier function; whereas certain strategies simply act on the drug formulation or transiently increase the skin permeability, others are designed to bypass or even remove the outermost skin layer. This article reviews the technologies currently under investigation, ranging from those in their early-stage of development, such as laser-assisted delivery to others, where feasibility has already been demonstrated, such as microneedle systems, and finally more mature techniques that have already led to commercialisation (e.g., velocity-based technologies). The principles, mechanisms involved, potential applications, limitations and safety considerations are discussed for each approach, and the most advanced devices in each field are described. 相似文献
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针对近年来多种多肽类药物的透皮给药系统进行综述。通过查阅国内外多种相关期刊文献。将多肽类药物透皮给药方法分为化学促渗剂、多种物理促渗技术,以及透皮肽、微针技术并对其进行论述。反向离子导入技术应用前景广阔,微针给药系统研究逐步深入,出现了胰岛素智能化微针给药系统,透皮肽的研究发展迅速,相信未来多种蛋白质及多肽的透皮给药方式将应用于临床,极大地促进医疗事业的发展。 相似文献
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Takasuga S Yamamoto R Mafune S Sutoh C Kominami K Yoshida Y Ito M Kinoshita M 《The Journal of pharmacy and pharmacology》2011,63(11):1437-1445
Objectives The feasibility of transdermal delivery of tramadol, a centrally acting analgesic, by anodal iontophoresis using Ag/AgCl electrodes was investigated in vitro and in vivo. Methods To examine the effect of species variation and current strength on skin permeability of tramadol, in‐vitro skin permeation studies were performed using porcine ear skin, guinea‐pig abdominal skin and hairless mouse abdominal skin as the membrane. In an in‐vivo pharmacokinetic study, an iontophoretic patch system was applied to the abdominal skin of conscious guinea pigs with a constant current supply (250 µA/cm2) for 6 h. An intravenous injection group to determine the pharmacokinetic parameters for estimation of the transdermal absorption rate in guinea pigs was also included. Key findings The in‐vitro steady‐state skin permeation flux of tramadol current‐dependently increased without significant differences among the three different skin types. In the in‐vivo pharmacokinetic study, plasma concentrations of tramadol steadily increased and reached steady state (336 ng/ml) 3 h after initiation of current supply, and the in‐vivo steady‐state transdermal absorption rate was 499 µg/cm2 per h as calculated by a constrained numeric deconvolution method. Conclusions The present study reveals that anodal iontophoresis provides current‐controlled transdermal delivery of tramadol without significant interspecies differences, and enables the delivery of therapeutic amounts of tramadol. 相似文献
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目的 介绍国内外提高蛋白质与多肽类药物肺部给药系统生物利用度的方法及其作用机制的最新研究进展。方法 对国内外最新发表的相关文献进行分析、整理和综合。结果 吸收促进剂、酶抑制剂及脂质体均可使蛋白质及多肽类药物的肺部吸收明显提高,甚至达到治疗所需的生物利用度。结论 蛋白质及多肽类药物的肺部给药系统具有广阔的应用前景。 相似文献
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《Expert opinion on drug delivery》2013,10(5):645-663
Introduction: Peptides and proteins are playing an increasingly important role in modern therapy. Their potency and specificity make them excellent therapeutic agents; however, their physicochemical properties and stability requirements almost invariably necessitate their administration by subcutaneous, intramuscular or intravenous injection. Controlled non-invasive administration using more patient-friendly advanced delivery technologies may combine the precision afforded by parenteral administration with improved compliance and the potential for individualized therapy. Areas covered: Transdermal iontophoresis enables hydrophilic charged molecules to be administered through the skin in an effective, non-invasive, patient-friendly manner. This review presents the basic concepts and an analysis of the effect of iontophoretic parameters and molecular properties on electrotransport rates across the skin along with a summary of experimental studies with peptides and proteins. The last section covers other techniques used in conjunction with iontophoresis. Expert opinion: It has long been known that iontophoresis can administer therapeutic amounts of biologically active peptides into the body. More recent studies have shown that it is also capable of delivering structurally intact, functional proteins non-invasively into and across intact human skin. The next step is to develop cost-effective and easy-to-use iontophoretic patch systems that ensure biomolecule stability, optimize delivery efficiency and address unmet therapeutic needs. 相似文献
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Ki-Taek Kim Joon Lee Min-Hwan Kim Ju-Hwan Park Jae-Young Lee Joo-Hyun Song 《Drug delivery》2017,24(1):1204-1215
Topical and transdermal drug delivery has great potential in non-invasive and non-oral administration of poorly bioavailable therapeutic agents. However, due to the barrier function of the stratum corneum, the drugs that can be clinically feasible candidates for topical and transdermal delivery have been limited to small-sized lipophilic molecules. Previously, we fabricated a novel iontophoretic system using reverse electrodialysis (RED) technology (RED system). However, no study has demonstrated its utility in topical and/or transdermal delivery of poorly permeable therapeutic agents. In this study, we report the topical delivery of fluorescein isothiocyanate (FITC)–hyaluronic acid (FITC–HA) and vitamin C and the transdermal delivery of lopinavir using our newly developed RED system in the in vitro hairless mouse skin and in vivo Sprague–Dawley rat models. The RED system significantly enhanced the efficiency of topical HA and vitamin C and transdermal lopinavir delivery. Moreover, the efficiency and safety of transdermal delivery using the RED system were comparable with those of a commercial ketoprofen patch formulation. Thus, the RED system can be a potential topical and transdermal delivery system for various poorly bioavailable pharmaceuticals including HA, vitamin C, and lopinavir. 相似文献
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Y W Chien O Siddiqui W M Shi P Lelawongs J C Liu 《Journal of pharmaceutical sciences》1989,78(5):376-383
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Kevin Ita 《Journal of drug targeting》2016,24(5):386-391
The stratum corneum continues to pose considerable impediment to transdermal drug delivery. One of the effective ways of circumventing this challenge is through the use of iontophoresis. Iontophoresis uses low-level current to drive charged compounds across the skin. This review discusses progress made in the field of iontophoretic transport of small and large molecules. The major obstacles are also touched upon and advances made in the last few decades described. A number of iontophoretic systems approved for clinical use by regulatory authorities is also discussed. 相似文献