老年男性骨代谢相关性激素与年龄和骨密度的相关性

目的探讨老年男性的性激素水平,包括血清睾酮（TTT）、雌二醇（E2）、脱氢表雄酮硫酸酯（DHEAS）随年龄的变化及与多部位骨密度（BMD）之间的关系。方法采用化学发光法测定108例55～92岁男性血清TTT、E2,ELISA法测定血清DHEAS、DEXA测定腰椎正位、股骨颈、大转子、大转子内侧、髋部和Ward＇s三角（Ward＇s）的BMD。根据年龄和BMD诊断标准技血清E2水平的四分位间距分组,年龄分组按每10岁年龄段分为5组,按BMI分为正常组、超重组和肥胖组3组,按T值＞-1．0 s、-2．5 s～-1．0s及≤-2．5 s分为正常骨量组、低骨量组及骨质疏松组,比较各组性激素的差异和BMD的关系。结果（1）各年龄组血清DHEAS水平随增龄而降低（P＜0．05）,与年龄呈负相关（r=-0．596,P＜0．01）,血清E2!、TTT水平与增龄无相关性。（2）正常骨量组、低骨量组、骨质疏松组血清E_1水平逐渐降低（P＜0．05）;股骨上端和腰椎BMD与E2呈正相关（r分别为0．247～0．366,P＜0．05）,与血清TTT和DHEAS水平无相关性,经校正年龄。体质量和BMI后,偏相关分析仍示与血清E1水平相关（r=0．256～0．322,P＜20．05）。各部位的BMD在E2的第1和第2分位间距差异有统计学意义（P＜0．05）,第3和第4分位间距差异无统计学意义。结论（1）老年男性血清DHEAS水平与年龄呈负相关,随增龄而降低;（2）血清E2水平是影响老年男性骨量的一个独立危险因素,动态监测可用于预测老年男性的骨量丢失。     

血脂、性激素水平与胆囊结石关系的研究

目的：探讨血脂、性激素水平与胆囊结石的关系。方法：选取212例确诊为胆囊结石的患者,测定其血脂TC、TG、LDL－ch,HDL-ch,LDL-ch/HDL-ch及T、E2、P、E2／P,并与72例正常对照组比较。结果：除HDL－ch外,血脂TC、TG、LDL－ch,LDL-ch/HDL-ch各项指标均值,胆囊结石组均高于健康对照组（P＜0．05－0．001）。血清T结石组与对照组比较无显著性差异（P＞0．05）。E2、P除育龄期结石组外,绝经期及男性结石组均高于对照组（P＜0．05－0．01）。育龄期结石组血清P高于对照组（P＜0．01）。血清E1虽有升高,但组间比较无显著性差异（P＞0．05）。E2／P结石组明显低于对照组（P＜0．01－0．001）。结论：脂类供谢及雌性激素代谢紊乱与胆囊结石的发生有明显关系。女性脂类代谢异常更是胆囊结石发生的重要原因之一。     

男性肝硬化患者血清雌二醇和睾酮水平变化及其与三联征的关系

目的探讨男性肝硬化患者血清雌二醇（E2）和睾酮（T）水平的变化及其与肝掌、蜘蛛痣和乳房发育三联征发生的关系。方法选择60例男性肝硬化患者和15例健康成年男性,采用放射免疫法检测血清E2和T水平,分析E2、T和E2/T比值与三联征发生的关系。结果男性肝硬化患者血清E2水平与正常对照组比无显著性差异（P〉0．05）,而血清T水平明显降低,Child B和C级患者分别为10．0±8．0和7．5±9．8nmol／L,与正常对照组（26．8±6．3nmol／L）比有显著性差异（P〈0．05）;E2/T比值明显升高,Child A、B、C级分别为4．5±2．8,11．0±8．8,16．7±11．2,与正常对照组（2．3±3．5）比均有显著性差异（P〈0．05）;血清E2水平在有无“三联征”发生的患者之间无显著性差异（P〉0．05）,血清T水平在蜘蛛痣（＋）组和（-）组分别为7．3±6．0nmol,L和17．0±9．2nmol/L,乳房发育（＋）组和（-）组分别为3．7±2．4nmol／L和15．6±8．8nmol／L,两组间比较差异均有显著性（P〈0．01）;E2/T比值在肝掌（＋）组和（-）组分别为13．9±10．5和5．5±3．6,蜘蛛痣（＋）组和（-）组分别为14．7±9．8和4．8±3．5,乳房发育（＋）组和（-）组分别为19．9±9．7和5．7±4．2,两组间比较差异均有显著性（P〈0．01）。结论男性肝硬化患者血清存在不同程度的性激素紊乱,血清T水平和E2/T比值的紊乱程度与肝硬化时肝功能受损程度有明显的关系,“三联征”的发生与血清E2水平无明显相关,而与E2/T比值关系密切。     

肠易激综合征患者外周血雌孕激素、睾酮激素含量分析

目的检测肠易激综合征（irritable bowel syndrome，IBS）患者外周血中性激素水平，探讨IBS发病与外周血性激素的关系。方法对符合罗马Ⅱ标准的48例IBS患者及30例健康对照者的外周血中雌激素（E2）、孕激素（P）和睾酮激素（T）的水平用放射免疫r计数器测定，并用自动软件分析。结果对于男性IBS患者，其外周血中T含量低于健康对照组（P〈0．05），而E2、P含量与健康对照组差异无显著性（P〉0．05）。对于女性IBS患者，其外周血中E2含量低于健康对照组（P〈0．05），而P、T含量与健康对照组差异无显著性（P〉0．05）。结论男性IBS患者外周血中T含量下降，女性IBS患者外周血中E2含量下降，提示IBS患者的发病可能与体内性激素水平紊乱有关。     

老年男性骨质疏松症与血清雌二醇及睾酮关系的研究

目的探讨老年男性骨质疏松症（OP）与血清雌二醇及睾酮的关系。方法采用双能X线法检测189例老年男性骨密度,分别检测雌二醇（E2）、睾酮（T）、降钙素（CT）、25羟维生素D（25-OH—VitD）、甲状旁腺素（PTH）、钙（Ca）、磷（P）及碱性磷酸酶（ALP）的指标。结果OP组的血清E2、CT及25-OH—VitD水平均低于骨量正常组（P〈0．05）,PTH高于骨量正常组（P〈0．05）,两组的血清T水平差异无统计学意义（P〉0．05）,OP组70～90岁及≥80岁两组的血清E2水平均低于60～69岁组（P〈0．05）,三组的血清T水平呈下降趋势,但差异无统计学意义（P〉0．05）,OP组血清E2水平与骨密度呈正相关（P〈0．05）。结论血清E2水平与老年男性OP密切相关,应重视E2对老年男性OP的预警作用。     

血脂和雌性激素水平与胆囊结石的关系

目的探讨血脂和雌性激素水平与胆囊结石的关系方法选择经B超、手术证实的胆囊结石患者104例（A组）进行血清雌二醇（EZ）、孕酮（P）、总胆固醇（TC）、甘油三酯（TG）测定，并与54例（B组）健康人进行对比分析．结果男性A组E2，P水平明显高于B组（P＜0．05～0．01），女性育龄期E2水平A,B两组相比差异无显著性（P＞0．05），P高于B组（P＜0．01）．绝经期A组E2，P均高于B组（P＜0．01），女性两组E2／P比值A组均显著低于B组（P＜0．01）.而血清TG，TC及TG／TC比值在男女性A组均高于B组（P＜0．01）。结论胆囊结石患者存在雌性激素及脂类代谢紊乱．     

老年骨质疏松患者血清瘦素水平与IGF-1等相关因素的研究

目的观察老年骨质疏松患者血清瘦素（LEP）与细胞因子及骨密度的变化及其关联。方法采用放射免疫分析法和生化速率法检测65例老年骨质疏松患者血清LEP、胰岛素样生长因子1（IGF-1）、白细胞介索2（IL-2）、雌二醇（E2）、睾酮（T）和血脂水平，同时行骨密度检测。结果老年女性和男性骨质疏松组LEP水平均较青中年对照组和骨量减少组不同程度增高（P〈0．01，P〈0．05），两组患者IGF-1和IL-2水平均明显低：F青中年对照组（P〈0．05，P〈0．01）；骨密度值亦明显低于青中年对照组（P〈0．01，P〈0．05）。相关实验显示，LEP与E2、T、骨密度均呈显著负相关关系；IGF-1与E2、T、骨密度则呈正相关。结论老年骨质疏松患者LEP与细胞因子的代谢紊乱是造成骨量减少和骨形成障碍的重要因素，LEP、IGF-1、IL-2与其他与骨代谢有关指标对辅助诊断骨质疏松症具有重要临床意义。     

脑还丹胶囊治疗老年痴呆的临床研究

目的：探讨脑还丹胶囊治疗老年痴呆的临床疗效。方法：将符合美国精神病学会《精神障碍诊断与统计手册》（DSM－Ⅳ）诊断标准的老年痴呆患者58例,随机分为脑还丹组30例,脑复康对照组28例,分别采用脑还丹胶囊和脑复康片（吡拉西坦）治疗,疗程3月。采用简易精神状态检查表（MMSE）和日常生活自理能力量表（ADL）积分的变化进行疗效评估,检测患者血清雌二醇（E2）、睾酮（T）、E2／T比值,及血脂、血液流变学等水平变化。结果：脑还丹胶囊能提高E2和T水平,降低E2／T比值（P＜0．05）;能降低血脂,改变血液流变学,脑还丹组总有效率66．7％,对照组60．8％,2组比较差异无显著性（P＞0．05）;MMSE和ADL治疗前后差值比较,脑还丹组均优于对照组（P＜0．05和P＜0．01）。结论：脑还丹胶囊对老年痴呆有较好的防治作用,其机制与提高E2、T水平,降低E2／T比值及调节神经内分泌功能有关。     

血清瘦素与原发性高血压和体脂及血脂的关系研究

目的 探讨血清瘦素浓度与原发性高血压患者血压水平及靶器官损害，性别，肥胖和脂质代谢的关系。方法 用放射免疫法检测68例原发性高血压患者和40例健康自愿者的血清瘦素浓度，同时检测甘油三脂（TG），总胆固水平和靶器官受累程度不同的原发性高血压以及性别，BMI，血脂的关系。结果 高血压组血清瘦素显著高于对照组（P＜0．05），且3级高血压血清瘦素显著高于2级高血压（P＜0．05），2级高血压血清瘦素显著高于1级高血压（P＜0．05），血清瘦素与SBP，DBP均呈直线正相关（P＜0．01，P＜0．05）；血清瘦素浓度与高血压靶器官损害病程度无关；女性瘦素显著高于男性（P＜0．01）；肥胖者血清瘦素显著高于非肥胖者（P＜0．05）；血清瘦素与TG呈直线正相关（P＜0．05），而与TC，HDL－C和HDL－C无关。结论 血清瘦素与血压水平相关，与高血压靶器官受损无相关性，与性别和TG有关，与BMI和TG呈正相关。》     

肝炎后肝硬化的性激素变化及其意义

为了解肝炎后肝硬化的性激素变化及影响性激素改变的有关因素。本文采用放射免疫法对35例男性肝炎后肝硬化进行了血清睾酮（T），雌二醇（E2），催乳素（PRL），黄体生成素（LH）及卵泡刺激素（FSH）的测定。结果发现：肝硬化患者的T及LH平均浓度明显低于正常对照组（P＜0．01），E2及PRL的平均浓度明显高于正常人（P＜0．01），而SH的平均浓度与正常人相比则无明显改变（P＞0．05）。各激素与血清白蛋白，凝血酶原时间及总胆红素之间无明确相关。按Child分级，C级患者的E2水平高于A组和B级患者（P＜0．05），而各组间的T，PRL，LH及FSH浓度无统计学意义。35例肝硬化中，10例发生女性乳房发育，占28．6％。有乳房发育和无乳房发育间各激素浓度无统计学差异。这些结果提示，肝炎后肝硬化存在着性激素的改变，肝细胞功能的损害在性激素紊乱中起着某些作用，但其他因素如门体分流可能起着更重要的作用。     

Infusion of epinephrine decreases serum levels of cortisol and 17-hydroxyprogesterone in patients with rheumatoid arthritis

OBJECTIVE: To investigate the pituitary and adrenal hormone response after an intravenous epinephrine challenge in patients with rheumatoid arthritis (RA) and controls. METHODS: Fifteen untreated female patients with RA (age 51.5 +/- 3.2 yrs) and 7 healthy female controls (48.0 +/- 4.3 yrs) were infused with epinephrine (0.05 microg/kg/min) for about 20 min. Plasma levels of adrenocorticotropic hormone (ACTH), and serum levels of cortisol, 17-hydroxyprogesterone (17OHP), and dehydroepiandrosterone sulfate (DHEAS) were analyzed at baseline and shortly after cessation of epinephrine infusion (20 min). RESULTS: At baseline and after epinephrine infusion, serum levels of cortisol (p = 0.045) and 17OHP (p = 0.021) were higher in controls compared to patients with RA. In contrast, at baseline and after epinephrine infusion, plasma levels of ACTH and serum levels of DHEAS were similar in controls and patients. After epinephrine infusion, only the patients with RA had a significant decrease of serum cortisol (p = 0.026) and serum 17OHP (p = 0.026). Plasma levels of ACTH (p = 0.073) and serum levels of DHEAS (p = 0.055) tended to decrease. CONCLUSION: Serum cortisol and 17OHP (cortisol precursor) were lower in patients with RA compared to controls despite similar ACTH levels. Simulation of an adrenomedullary stress response by epinephrine infusion decreased serum cortisol and 17OHP in patients but not in controls. Such a response may play an unfavorable role during a typical stress reaction in patients with RA that may lead to a more proinflammatory situation.     

Association of increased C-peptide serum levels and testosterone in type 2 diabetes

Background: The purpose of our study was to investigate the association of C-peptide and steroid hormones in males and females with type 2 diabetes compared to controls. Methods: In 562 subjects, matched for age and body mass index (BMI), 126 female type 2 diabetic patients (known diabetes duration: 7.8±0.8 years, HbA_1c: 7.6±0.14%), 126 healthy female subjects, 155 male type 2 diabetic patients (known diabetes duration: 6.4±0.6 years, HbA_1c: 7.7±0.11%), and 155 healthy male controls, C-peptide levels and serum levels of steroid hormones (progesterone, cortisol, DHEAS, estradiol, and testosterone) were measured by immunometric assays. Ratios of steroid hormones were calculated to investigate shifts in steroidogenesis. Results: In female patients, testosterone was significantly higher than in controls (1.7±0.1 vs. 1.4±0.2 pmol/l; P<0.05), something that was also demonstrated for the ratio of testosterone/estradiol (P<0.05). In male patients, lower levels of testosterone (11.8±0.5 vs. 14.3±0.5 pmol/l; P<0.05) and higher cortisol levels (257.5±9.9 vs. 228.2±7.9 μmol/l, P<0.01) were found than in controls. The progesterone/DHEAS ratio (P<0.05) and the progesterone/testosterone ratio (P<0.001) were significantly higher and DHEAS/cortisol significantly lower in type 2 diabetic males than in controls. In a multiple linear regression analysis that controlled for age, BMI, C-peptide, HDL-cholesterol, and HbA_1c, testosterone was significantly and positively correlated with C-peptide levels in female (P<0.05) but not in male type 2 diabetic patients. Conclusions: Testosterone levels were higher in female patients than in controls and correlated with C-peptide levels while testosterone levels were lower in male patients than in controls and showed no correlation with C-peptide. A higher ratio of testosterone/estradiol in type 2 diabetic females and of progesterone/DHEAS and progesterone/testosterone in type 2 diabetic males than in controls may indicate gender-dependent shifts in steroidogenesis. Whether the shifts in steroidogenesis contribute to insulin resistance in diabetic patients should be the subject of further studies.     

Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis

Sex hormones have important effects on bone, especially in postmenopausal women. These hormones may be of particular significance in patients with rheumatoid arthritis (RA), who have a high frequency of osteoporosis. To examine this, we measured estrogen and androgen concentrations and bone mineral density (BMD) in 49 postmenopausal women with RA and 49 normal postmenopausal women. Compared with the controls, postmenopausal RA patients had significantly reduced levels of estrone (median 18 pmoles/liter versus 49; P < 0.001), dehydroepiandosterone sulfate (DHEAS) (median 0.3 μmoles/liter versus 2.0; P < 0.001), testosterone (median 0.6 nmoles/liter versus 0.95; P < 0.001), and femoral BMD (mean 0.72 gm/cm² versus 0.80; P < 0.002). Prednisolone therapy in 22 patients (mean dosage 8 mg/day) was associated with reductions in estrone and testosterone levels; however, DHEAS and femoral BMD were also decreased in RA patients who were not receiving corticosteroids. Reduced DHEAS levels in postmenopausal women with RA may increase their risk of osteoporosis.     

A study of serum androgen and cortisol levels in female patients with rheumatoid arthritis. Correlation with disease activity

Summary Androgen status and the role played by androgens in the pathogenesis of rheumatoid arthritis (RA) in female patients are a matter of debate. In the present study serum testosterone (T), DHEAS, sex hormone binding globulin (SHBG) and cortisol levels were determined in 55 RA women, both in pre- and post-menopausal (M) status, and in a group of healthy subjects. Patients were divided into two groups according to disease activity and a correlation analysis of hormonal levels against serum IL1 levels was performed. No significant differences were found in serum T levels between RA patients and controls, both in preM (1.38±0.4 vs 1.35±0.3 nmol/l; p=ns) and in postM status (1.21±0.2 vs 1.10±0.2 nmol/l; p=ns). Serum SHBG levels were lower in RA patients than in control subjects, both in pre and in postM status. DHEAS levels were significantly lower in preM RA patients than in controls (2.34±1.2 vs 5.93±1.6 µmol/l; p<0.001) while cortisol levels were significantly higher in preM active RA patients than in controls (466.2±30.3 vs 411±66.2 nmol/l; p=0.02). IL1 levels were significantly higher in RA patients than in controls both in pre- and postM subjects (70±33.8 vs 23.1±2.9 and 92±27.4 vs 31.9±3.1 fmol/l, p<0.001, respectively).Although androgen status could play a role in the pathogenesis of RA, at present it is not possible to exclude the influence of RA itself on sex hormone profile.     

冠心病患者性激素水平失衡的研究

目的 :研究冠心病患者性激素水平的变化。方法 :选择冠心病患者 5 0例 ,用放射免疫法测定血清雌二醇 （E2 ）、孕酮 （P）、促卵泡刺激素 （FSH）、促黄体生成素 （L H）、睾酮 （T）、泌乳素 （PRL）及生长激素 （GH）的变化 ;采用酶法观测空腹总胆固醇 （TC）、甘油三酯 （TG）、高密度脂蛋白 （HDL）及低密度脂蛋白胆固醇 （L DL- C）的变化。结果 :1男性冠心病组与对照组比 E2 、P均升高 （P<0 .0 5 ） ,T水平亦明显下降 （P<0 .0 1） ;女性冠心病组与对照比 ,P水平均显著升高 （P<0 .0 1） ,E2 水平下降 （P<0 .0 5 ）。 2男性冠心病患者 TC,TG,L DL- C均显著高于对照组 （P<0 .0 1） ,HDL 显著低于对照组 （P<0 .0 1） ;女性冠心病患者 TC,TG,L DL- C均高于对照组 （P<0 .0 5 ） ,HDL 低于对照 （P<0 .0 5 ）。结论 :冠心病患者存在血脂代谢异常。但男性与女性冠心病患者的性激素水平失衡存在差异 :男性 E2 ,P升高 ,T降低 ,女性 P升高 ,E2 降低     

Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones

OBJECTIVE: In patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), low levels of adrenal steroids have been repeatedly demonstrated, but the site of alteration has not been exactly described because measurements of serum pregnenolone and 17-hydroxypregnenolone (17OHPreg) together with other adrenal steroids have never been performed. METHODS: We measured serum levels of adrenal hormones such as pregnenolone, 17OHPreg, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), progesterone (P), 17-hydroxyprogesterone (17OHP), androstenedione (ASD), and cortisol in 24 healthy controls, 24 patients with RA, and 24 patients with SLE. RESULTS: Serum levels of pregnenolone were similar in RA and SLE patients as compared to healthy controls irrespective of prior prednisolone therapy. In all RA and SLE patients (including those with prior prednisolone treatment), serum levels of all measured hormones except pregnenolone were significantly lower as compared to controls. In RA patients without prior prednisolone treatment, serum levels of 17OHPreg, DHEA, cortisol, and ASD were similar to controls, and serum levels of P, 17OHP, and DHEAS were significantly lower as compared to controls. In SLE patients without prior prednisolone treatment, serum levels of 17OHPreg and cortisol were similar, and serum levels of P, 17OHP, ASD, DHEA, and DHEAS were significantly lower as compared to controls. CONCLUSION: The primary hormone of the adrenal steroid cascade, pregnenolone, is almost normal in RA and SLE irrespective of corticosteroid treatment. In patients with RA, we believe that there is a near normal P450scc reaction and a normal double step P450c17 reaction. In SLE patients, the P450scc reaction also seems normal but the second step of the P450c17 reaction seems to be inhibited. In both diseases, cortisol levels remain relatively stable at the expense of other adrenal hormones. This study revealed distinct changes of steroid pathways that are related to the disease entities.     

类风湿关节炎患者NGAL、Lp-PLA2及血脂异常对动脉粥样硬化的预测及在转归中的价值

目的探讨类风湿关节炎(RA)患者中性粒细胞明胶酶相关载脂蛋白(NGAL)、脂蛋白相关磷脂酶(Lp-PLA)2及血脂异常对动脉粥样硬化(AS)的预测及转归中的价值分析。方法选择RA患者100例(缓解期48例和活动期52例)、健康人50例作为对照组。采用动脉彩色多普勒超声诊断仪进行AS检查,比较两组AS患病率及总动脉内中膜厚度(IMT)值;计算血浆致动脉粥样硬化指数(AIP);日立7600全自动生化分析仪测定各组总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);采用半自动免疫比浊法检测血清NGAL、Lp-PLA2水平差异;采用Spearman相关分析指标的关系,采用Logistic回归分析RA合并AS的危险因素。结果与对照组相比,RA患者体内TC、TG、LDL-C、NGAL、Lp-PLA2含量显著升高,斑块面积、斑块厚度和IMT数值显著升高,HDL-C含量显著降低(P<0.05)。与RA缓解期患者相比,RA活动期患者体内NGAL、Lp-PLA2含量,斑块面积、斑块厚度和IMT数值显著升高(P<0.05)。RA组中合并AS患者为41例(死亡组15例,非死亡组26例),RA无AS患者59例。与对照组和RA无AS组相比,RA合并AS组TC、TG、LDL-C含量显著升高,斑块面积、斑块厚度和IMT数值显著升高,HDL-C含量显著降低(P<0.05)。与AS非死亡组相比,AS死亡组TC、TG、LDL-C含量显著升高,斑块面积、斑块厚度和IMT数值显著升高,HDL-C含量显著降低(P<0.05)。RA患者体内TC、TG和LDL-C含量、NGAL、Lp-PLA2含量与患者的疾病程度(活动期、缓解期)、是否合并AS、疾病结局(生存、死亡)、斑块面积、斑块厚度和IMT数值呈明显正相关(P<0.05)。RA患者HDL-C含量与患者的疾病程度(活动期、缓解期)、是否合并AS、疾病结局(生存、死亡)、斑块面积、斑块厚度和IMT数值呈明显负相关(P<0.05)。Logistic回归分析结果显示,RA患者体内TC、TG和LDL-C含量、NGAL、Lp-PLA2含量与患者是否合并AS及生存结局密切相关,是其主要的独立危险因素(P<0.05)。结论RA患者血清NGAL、Lp-PLA2水平升高且血脂异常,对RA患者并发AS的病理过程起到预判作用,利于早期发现RA患者出现AS。     

Dehydroepiandrosterone sulfate and bone resorption rates as reflected by serum levels of C-terminal telopeptide of type I collagen: a study in healthy men

Sex steroid hormones contribute to the physiological regulation of bone turnover in males. To address this issue, we investigated serum estradiol (E2), total testosterone (T), and DHEAS concentrations, along with serum levels of carboxy-terminal telopeptide of type I collagen (sCTx), in a sample of 76 healthy men aged 23 to 87. The concentration of sCTx declined with age. Both T and DHEAS, at variance with E2, showed a significant age-related decline. T, DHEAS and sCTx significantly (p<0.01) correlated with each other. DHEAS and T were significantly associated after correcting for age (r=0.35, p=0.002) or body mass index (r=0.65, p<0.0001). DHEAS, but not T, significantly correlated with sCTx after correcting for age (r=0.26, p=0.026, and r=0.20, p=0.08, respectively). Stepwise multiple regression analysis showed that only DHEAS (but not T or E2) was a significant independent predictor of sCTx (p=0.0001). Our results show that adrenal androgens play a crucial role in regulating bone resorption in aging men.     

高原地区男性慢性乙型肝炎患者性激素水平的变化

目的　探讨高原地区男性慢性乙型肝炎 (慢乙肝 )患者性腺激素水平的变化 ,了解不同地区、不同民族性激素的水平。方法　随机选择西藏和沿海地区男性慢性乙型肝炎患者 79例 ,同时选取西藏及沿海地区 61名健康男性作为对照。用放射免疫法测定睾酮 (T)、雌二醇 (E2 )、卵泡刺激素 (FSH)、黄体生成素 (LH)、泌乳素 (PRL)及促性腺激素释放激素 (LHRH)的浓度。结果　慢乙肝患者E2 、PRL和LHRH水平与对照组比较均有显著性差异 (P <0 .0 1、P <0 .0 1、P <0 .0 5 )。西藏地区患者血清T水平高于沿海地区患者 (P <0 .0 5 ) ,藏族患者的E2 水平低于汉族患者 (P <0 .0 5 )。结论　慢乙肝患者性激素水平发生了变化 ,而不同民族、不同地区的患者其性激素水平变化亦有差异 ,表明生活环境及生活习惯可能对慢乙肝患者的性激素水平产生一定的影响     

Sex hormone status in women suffering from rheumatoid arthritis

We studied the sex hormone status of 21 seropositive (IgM-RF) women with rheumatoid arthritis (RA), who were subdivided according to their premenopausal and postmenopausal status. Age matched women with secondary osteoarthritis were used as controls. The hormones evaluated were luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), 17-beta-estradiol (E2), progesterone (Pg), testosterone (T), delta 4-androstenedione (A), dehydrotestosterone (DHT), dehydroepiandrosterone sulphate (DHEAS) and cortisol (C). Normal concentrations of all the hormones considered were found in premenopausal women with RA. Statistically higher concentrations of T (p less than 0.05), A (p less than 0.05) and DHEAS (p less than 0.01) were observed in postmenopausal women with RA when compared to controls, whereas no differences were found for all other hormones studied. Although the significance of observed relative hyperandrogenism in postmenopausal women with RA is not clear, our data seem to indicate that sex hormone levels are altered in patients with RA.