原发性开角型青光眼HRT视盘结构参数与视野缺损相关性研究

目的探讨出现视野缺损与未出现视野缺损的原发性开角型青光眼视盘结构参数的异同及视盘参数与视野平均缺损（MD）的相关性。方法应用海德堡视网膜断层扫描仪（HRT-Ⅱ）和Octopus101视野G2程序对29例（50只眼）原发性开角型青光眼患者进行检查，对出现视野缺损与未出现视野缺损的原发性开角型青光眼视盘结构参数进行比较，检测结果进行t检验；对出现视野缺损的原发性开角型青光眼组的视盘各参数与视野平均缺损进行简单相关分析。结果视野出现缺损组与未出现缺损组的原发性开角型青光眼患者的视盘参数除视盘面积和轮廓线高度变化值外，其余各视盘参数间差异均有显著性（P〈0．01）；对出现视野缺损的原发性开角型青光眼患者HRT视盘各参数与MD进行相关分析显示，盘沿面积与MD间相关性最强（r=0．65，P=0．001）。结论HRT视盘参数能够较准确反映与视野损害相一致的青光眼性视盘改变，盘沿面积在HRT众多参数中最能反映青光眼的视野平均缺损程度。     

倍频视野计检测青光眼性视野缺损能力的研究

目的评估倍频视野计检测青光眼性视野缺损的能力以及与OCTOPUS101全自动视野计检查结果之间的相关性。方法应用倍频视野计的C-20—5筛选程序以及OC—TOPUS101全自动视野计的G2-TOP程序对23例正常对照者、20例早期青光眼患者、35例中晚期青光眼患者、11例高眼压患者及13例疑似青光眼患者进行视野检测。正常对照组、高眼压组及疑似青光眼组随机选择一眼进行测试，青光眼组选择具有较严重视野缺损的一眼进行测试。结果倍频视野计的C-20—5筛选程序在检测青光眼时ROC曲线下面积为0．925（敏感性85％，特异性91％），与OCTOPUS视野指数-平均缺损、偏离缺失之间的Pearson系数分别为0．702与0．429（P〈0．001），倍频视野计与OCTOPUS101视野计检查平均所需时间分别为1．00min与2．33min．2者之间有明显差异（P〈0．001）。结论倍频视野计检测青光眼性视野缺损具有良好的敏感性与特异性，与OCTOPUS101视野计的视野指数之间亦存在理想的相关性，而且前者比后者检测速度更快，使大规模人群筛查成为可能。     

四点阈值视野检查对快速筛查青光眼性视野缺损的诊断价值

目的探讨国产YDS301视野计（简称YDS）四点阈值程序对快速筛查青光眼性视野缺损的诊断价值。方法采用瑞士Octopus101型视野计（简称Octopus）和YDS对67例（75眼）青光眼患者分别进行视野检查。YDS选用四点阈值程序,Octopus选用G1TOP程序,分别在定性、定量和每眼检测时间方面进行对比分析。结果定性诊断：以Octopus为准,YDS敏感性和特异性分别为92.5%和86.4%。定量诊断：YDS与Octopus的平均敏感度和平均缺损的相关系数r分别为0.869和0.865。每眼检测时间分别为48.65s和141.64s（t=26.534,P〈0.01）,YDS比Octopus减少了约2/3时间。结论YDS四点阈值程序在快速筛查青光眼性视野缺损中与Octopus有很高的一致性,而且检测时间是目前国内外现有视野计中最短的。因此,YDS四点阈值程序适用于青光眼的视野筛查。     

眼压降低后原发性慢性青光眼视野的变化

目的了解原发性开角型青光眼（POAG）和原发性慢性闭角型青光眼（PACG）在眼压降低后视野是否发生改变及相关因素分析。方法原发性慢性青光眼32例（44眼）,其中PACG19例（25眼）,POAG13例（19眼）。眼压治疗前及治疗后1个月全部患者均行Humphrey静态自动视野（HFA）24-2全阈值视野检查。比较眼压降低前后视野平均缺损（MD）、模式标准差（PSD）的变化,分析眼压降低幅度、年龄及视神经杯盘比与视野MD改变是否相关。结果治疗前MD为-13．58±9．31,治疗后MD为-12．08±8．37,治疗前后MD比较差异有统计学意义（t=3．35,P=0．002）;治疗前后MD差值与眼压降低幅度呈正相关（r=0．341,P=0．027）。协方差分析结果表明,校正年龄和HRT的杯盘面积比后,治疗前后视野MD的改变与眼压降低幅度呈正相关（F=4．706,P=0．037）。结论原发性慢性青光眼眼压降低后视野有所改善,视野改善的程度与降压幅度有关。     

原发性开角型青光眼和可疑开角型青光眼HRT视盘参数与视野缺损的相关性研究

目的探讨原发性开角型青光眼和可疑性开角型青光眼的视盘参数与视野平均缺损（Mean defect，MD）之间的相关性。方法用海德堡激光眼底扫描仪（HRT—Ⅱ）和自动视野计测定128只原发性开角型青光眼和78只可疑性开角型青光眼患者的视盘参数和静态视网膜光阈值。从视盘参数中选择盘沿面积（rim area，RA）、杯盘面积比（cup／disk area ratio，C/D AR）、视杯面积（cup area，CA）和平均视网膜神经纤维层厚度（mean retinal nerve fibre layer thickness，mRNFLT）与MD作相关分析和多元线性回归分析。结果两组间的视盘参数存在显著性差异（P〈0．001）。在原发性开角型青光眼组，RA、C/D AR和CA与MD之间均显著相关（P〈0．001）。其中盘沿面积每减少1mm^2，MD的绝对值将增加7．291dB；在可疑性开角型青光眼组，RA与MD之间显著相关（P〈0．001）。两组中mRNFLT与MD无明显相关性。结论在HRT-Ⅱ的各项视盘参数中，RA最能反映青光眼的视野平均缺损程度。     

趋势导向蓝黄视野检查青光眼视野损害的评价

目的 对趋势导向蓝黄视野检查（tendency-oriented blue-on-yellow perimetry,TOP/BYP)，常规蓝黄视野检查（normalblue-on-yellow perimetry,N/BYP)及常规白白视野检查（white-on-white perimetry,WWP)结果进行比较，评价TOP/BYP在青光眼视功能检测中的应用价值。方法 利用OCTOPUS101全自动视野计分别对19例（38眼）正常人和27例（54眼）原发性开角型青光眼（primary open-angle glaucoma,POAG)分别进行TOP/BYP、N/BYP及WWP检查，将三种视野检查结果，视野检查指数及视野缺损点数进行比较和分析。结果 TOP/BYP检查的特异性与N/BYP检查的特异性一致（89.47%）；对已确诊的早期POAG，TOP/BYP检查的阳性率为86.49%，明显高于WWP的阳性率（54.05%)，且与N/BYP检查阳性率（89.19%)之间无显性差异；对中期和晚期POAG，TOP/BYP检查与N/BYP和WWP检查的符合率达100%；TOP/BYP和N/BYP检查POAG视野缺损点敷明显大于WWP视野缺损点敷，结论 TOP/BYP检查青光眼视功能损害的敏感性和特异性与N/BYP相当TOP/BYP检测时间短，患不易疲劳，是理想的蓝黄视野检查方法之一。     

标准白色视野与蓝／黄视野检测不同阶段青光眼视野的对比研究

目的比较自动标准白色视野计（white-on-white perimetry,啪w）和蓝／黄视野计（blue-on-bellow perimetry,B/Y）检测不同阶段青光眼视野损害的敏感性。设计横断面调查。研究对象青光眼患者42例（71眼）。方法采用HumphreyⅡ-750型自动视野计对青光眼患者进行B／Y及W｜W检查。根据晚期青光跟治疗研究（Advanced GlaucomaIntervention Study,AGlS）视野评分标准,将青光眼患者分早、中、晚三组,运用青光眼首选治疗研究（collaborative initial glaucoma treatment study,CIGTS）方法,对视野缺损进行评分。比较三组不同时期青光眼应用两种视野计检查,在视野平均缺损（Meandeviation,MD）、模式标准差（Pattern Standard Deviation,PSD）、CIGTS评分方面的差异。主要指标视野的平均缺损、模式标准差、CIGTS评分。结果两种视野计检查MD的均值结果在早、中期青光眼组,B／Y检测的MD（-8．65dB±3．89dB;-14．94dB±3．22dB）较w／W（-3．29dB±2．40dB;-10．04dB±2．73dB）低,t=9．21,P〈0．001及t=-4．89,P〈0．001;在晚期青光眼组,B／Y检测的MD（-22．07dB±2．64dB）较w／w（-25．20dB±5．48dB）高,t=3．93,P〈0．001。两种视野计检查PSD的均值结果,在早期青光眼组,B／Y检测的PSD（4．17dB±1．20dB）较W／W（3．22dB±2．90dB）高,t=2．12,P〈0．05;在中、晚期青光眼组,B／Y检测的PSD较W/W低（t=-3．04,P〈0．01,t=-2．96,P〈0．001）。两种视野计CIGTS评分的均值结果,在早期青光眼组,B／Y的CIGTS评分（5．35±3．83）较W/W（3．36±3．12）高,t=2．67,P〈0．05）;在中、晚期青光眼组,B／Y的CIGTS评分较W/W低,t-4131,P〈0．05及t=-4．02,P〈0．001。结论对于早期青光眼的视野检测,B/Y较W/W敏感,但对于中晚期青光眼,W/W视野较B／Y更敏感。对于早期青光眼及可疑青光眼采用B／Y视野检测较敏感,而对于中晚期青?     

Matrix视野计N-30-F程序与倍频视野计N-30程序检测结果一致性的初步分析

目的 评价Humphery Matrix视野计的N-30-F程序与倍频视野计(frequency-doublingtechnology,FDT)N-30程序的检查结果是否具有一致性.方法 对受检眼32例32只眼(原发性开角型青光眼10例10只眼,可疑青光眼患者13例13只眼,正常人3例3眼,高眼压症6例6只眼)进行上述两种视野程序检查,比较两种检查结果的平均偏差(Mean Deviation,MD)、图型标准偏差(Pattern Standard Deviation,PSD)、总体偏差概率图中概率小于5%的缺损点数以及检查所需时间.结果 MD、PSD及总体偏差概率图中概率小于5%的缺损点数,在两种视野程序检查结果间差异均无有统计学意义(分别为P=0.958,P=0.932,P=0.496),这些参数在这两种程序检查结果有显著相关性(分别为r=0.898,P＜0.01;r=0.559,P＜0.01;r=0.734,P＜0.01),并且两种检测结果有很高的一致性.检查所需时间,Humphery Matrix为3'26",FDT为5'14"(P＜0.01).结论 Humphery Matrix视野计的N-30-F程序与FDTN-30程序的检查结果高度一致,并且前者检查所需时间更短.

Abstract：

Objective To determine the comparability of the N-30-F test with the new Humphrey Matrix instrument to the traditional frequency-doubling technology(FDT)N-30 test.Methods A sample of 32 eyes from 32 patients(3 normal subjects,6 with ocular hypertension,10 with primary open-angle glaucoma (POAG),13 with suspect glaucoma)underwent visual field testing with standard automated perimetry,and with FDT,using the FDT N-30 program,and the Matrix N-30-F program.The plots,mean deviation(MD),pattern standard deviation(PSD),defect locations on the Total Deviation Probability(TDP)and test time were compared.Results No statistically significant differences were found between corresponding parameters of the two tests.High coefficients and the agreement were associated with the MD values,the PSD values and the total number of abnormal test locations on the TDP plot of the two tests.The test time for the Matrix test was significantly shorter.Conclusions The FDT N-30 and Matrix N-30-F tests are comparable in screening for early diagnosis of glaucoma,and the test time for the Matrix test is significantly shorter.     

高通分辨视野检查法对原发性开角型青光眼的早期诊断价值

目的探讨高通分辨视野检查法对青光眼的早期诊断价值。方法参照Ｆｒｉｓéｎ所介绍的方法，利用微型计算机设计适合检测青光眼早期视野缺损的高通分辨视野检查仪。并对２２例（４４只眼）正常人、２７例（４１只眼）自动视野检查异常的原发性开角型青光眼（ｐｒｉｍａｒｙｏｐｅｎａｎｇｌｅｇｌａｕｃｏｍａ，ＰＯＡＧ）及１０例（１３只眼）自动视野检查正常的早期或可疑ＰＯＡＧ进行高通分辨视野测量。结果正常人的平均分辨阈值为右眼３．９６±０．５５ｄＢ，左眼３．９８±０．５５ｄＢ。高通分辨视野检查对检测青光眼视野损害的敏感性高于常规的自动视野计检查，敏感性为９３．７５％，特异性为９７．７％，青光眼早期视野损害可表现为分辨阈值升高。结论高通分辨视野检查法是检测ＰＯＡＧ早期视野损害的敏感方法之一，值得推广应用。     

青少年近视合并高眼压的静态阈值视野改变

目的：探讨合并高眼压青少年近视的静态视野改变的特点及其临床意义。方法：应用Octopus101型全自动视野计对45例(87只眼)青少年近视合并高眼压和36例(72只眼)正常眼压青少年近视进行定量视野测定，并分析其视野缺损形式及视野指数与眼压、屈光度的关系。结果：合并高眼压青少年近视的视野损害发生率明显高于正常眼压青少年近视。视野损害多表现为生理盲点扩大，特征性青光眼视野缺损。与正常眼压青少年近视有显著性差异。平均敏感皮MS值、平均缺损MD值、缺损变异LV值均与正常眼压青少年近视有显著性差异，且在正常眼压青少年近视组中，随着近视度数增加，MS值逐渐下降，MD及LV值逐渐升高。结论：高眼压是青少年近视人群中发展为青光眼性视野损害的一个重要因素。眼压应列为青少年近视的眼科常规检查项目。采用全自动视野计检测是早期发现青少年近视青光眼性视野损害的最敏感最有特异性的检查方法。     

Frequency doubling technique in patients with ocular hypertension and glaucoma: correlation with octopus perimeter indices

PURPOSE: To ascertain whether frequency doubling technique (FDT) (Welch-Allyn, Skaneateles, NY; Zeiss-Humphrey, San Leandro, CA) indices provide results comparable with those of standard Octopus threshold perimeters (Interzeag AG, CH-8952 Schlieren, CH) in patients with glaucoma and in patients suspected of having ocular hypertension, glaucoma, or both. DESIGN: A comparative, consecutive, case series. PARTICIPANTS: Thirty-nine glaucomatous patients and 41 patients with ocular hypertension or suspected glaucoma were recruited consecutively. METHODS: The visual field of the study participants were assessed by FDT program C-20 full threshold and Octopus program dG1X. Only one eye of each participant was selected randomly. Pearson's r correlation coefficient was calculated among the FDT and Octopus indices. MAIN OUTCOME MEASURES: Using Octopus perimeter, mean defect (MD), mean sensitivity (MS), loss variance (LV), and corrected loss variance (CLV) were calculated and used for correlation. For the FDT, mean deviation (FDT-MD) and pattern standard deviation (FDT-PSD) were calculated and used for correlation. Also, the time required to perform the visual field test was considered. RESULTS: In the entire population, a statistically significant correlation (Pearson's r, P<0.001) was found between FDT-MD and both MS (0.77) and MD (-0.80) and between FDT-PSD and both LV (0.50) and CLV (0.45). When the glaucoma group was considered alone, similar significant correlation was found between the indices. In the suspected ocular hypertension and glaucoma suspect group, no significant correlation was found. A significant (P<0.001) difference was found between FDT and Octopus for the time needed to perform the visual field test. CONCLUSIONS: This new technique could be used both to screen populations and to observe glaucomatous visual field progression in early and moderate stages. The FDT is a faster way to analyze the visual field and captures threshold values for each point, but it is important to remember that this is a new technique and its limits are still unknown.     

Detection of glaucomatous visual field defect by nonconventional perimetry

PURPOSE: To report the correlations among Humphrey Field Analyzer 750 (HFA), high-pass resolution perimetry (HRP), and frequency-doubling technology (FDT) perimetry in glaucoma patients and ocular hypertensive patients. DESIGN: Cross-sectional study. METHODS: Eighty-two eyes of 82 consecutive patients with primary open-angle glaucoma (POAG) or ocular hypertension were included in this study. One eye of each patient was randomly selected for data analysis. Visual fields were assessed by HFA, HRP, and FDT perimetry. HRP global deviation (HRP-GD), HRP local deviation (HRP-LD), FDT-mean deviation (FDT-MD), and FDT-pattern standard deviation (FDT-PSD) were considered for the analysis. Clinical agreement between HRP and FDT was evaluated. All data were analyzed by Pearson r coefficient when the distribution of the data was normal and by Spearman coefficient correlation when the distribution of the data was not normal. A P <.05 was considered statistically significant. RESULTS: Fifty-two eyes (52 patients) were classified as glaucoma and 30 eyes (30 patients) as ocular hypertension. In the entire group, a significant (P >.001) correlation was found between the HFA indices and those of either HRP or FDT. A significant (P <.001) correlation was found between HRP-GD and FDT-MD as well as between HRP-LD and FDT-PSD. In 14% of the glaucomatous patients and in 33% of the subjects with ocular hypertension, FDT and HRP showed different clinical features. CONCLUSIONS: Our data suggest that FDT and HRP are useful for detection of early glaucomatous visual field damage.     

趋势导向视野检查法与常规阈值视野检查法的对比研究

目的 评价趋势导向视野检查法(tendency-oriented perimetry, TOP)在青光眼视功能检测中的应用价值。 方法 利用Octopus 101全自动视野计分别对20名正常人的20只正常眼、32例原发性开角型青光眼(primary open angle glaucoma, POAG)患者的32只患眼和14例可疑POAG患者的14只眼分别进行常规阈值视野检查(Normal/Normal程序)和TOP视野检查(TOP/Normal程序)。所有受检眼在2周内再次分别进行常规阈值视野检查和TOP视野检查。将两种视野检查的结果、视野检查指数、点对点阈值变异及视野缺损点数进行比较和分析。 结果 TOP视野检查正常人的阴性检出率为90%，POAG的阳性检出率为75%，其中检测中晚期POAG的阳性检出率达100％。2种视野检查的视野指数呈明显正相关，平均敏感度(mean sensitivity, MS)的相关系数为0.9335，平均缺损(mean defect, MD)的相关系数为0.9189，偏离缺失(loss variance, LV)的相关系数为0.9621。点对点阈值变异和视野缺损点数TOP视野检查结果略高于常规阈值视野检查结果，但二者间差异均无显著性的意义(P＝0.2019，P＝0.4448)。 结论 TOP视野检查指数与常规阈值视野检查指数呈明显正相关，其检测中晚期POAG的敏感性及可重复性高。 (中华眼底病杂志, 2002, 18: 169-272)     

Detection of optic neuropathy in glaucomatous eyes with normal standard visual fields using a test battery of short-wavelength automated perimetry and pattern electroretinography

PURPOSE: To evaluate the clinical use of a test battery of short-wavelength automated perimetry (SWAP), frequency-doubling technology (FDT) perimetry, and pattern-electroretinography (PERG) in patients with definite primary open-angle glaucoma (POAG) but normal results on standard automated perimetry (SAP). STUDY DESIGN: Prospective, comparative, observational case series. PARTICIPANTS: Thirty-six patients with POAG with standard visual field defects in one eye and normal standard visual fields in the contralateral eye and 36 normal controls were enrolled. MAIN OUTCOME MEASURES: SWAP, PERG, FDT, and SAP were performed in all eyes, and global indices and amplitudes were used for statistical analysis. RESULTS: When contralateral POAG eyes with asymmetric glaucomatous damage was compared, a paired t test showed significant differences in SAP mean deviation (MD) (P < 0.0001), SWAP-MD (P = 0.0003), FDT-MD (P = 0.0008), and PERG amplitudes (P < 0.0001). When comparing between POAG eyes with normal results on SAP and normal controls, Student's t test showed significant differences for SWAP-MD (P < 0.0001), FDT-MD (P = 0.0006), PERG N1P1-amplitude (P = 0.0486) and P1N2-amplitude (P < 0.0001); receiver operating characteristic analysis revealed promising accuracy for SWAP-MD of 73.6% (P < 0.0001). SWAP-MD (P < 0.0001) and FDT-MD (P < 0.0001) correlated significantly with SAP-MD and with each other (range, P < 0.0001 to P = 0.0020). Regression analysis revealed that PERG P1N2-amplitude could improve the power of SWAP-MD from 73.6% to detect early POAG in eyes with normal results on SAP to an accuracy of 81.9%. CONCLUSIONS: A test battery of SWAP-MD and PERG P1N2-amplitude could detect glaucomatous optic neuropathy in POAG eyes with normal standard visual fields, whereas FDT-MD and SWAP-MD significantly correlated with each other and with SAP-MD. All tests were able to detect the eye with the more severe glaucomatous optic neuropathy in patients with asymmetric POAG.     

Comparison of detectability of visual field abnormality by frequency doubling technology in primary open-angle glaucoma and normal-tension glaucoma

PURPOSE: To compare the effectiveness of frequency doubling technology (FDT) in detecting abnormalities in primary open-angle glaucoma (POAG) and in normal-tension glaucoma (NTG). METHODS: Twenty-nine POAG patients (29 eyes) and 27 NTG patients (27 eyes) were studied. All subjects underwent testing with program C-20 of FDT with appropriate corrective lenses. RESULTS: No significant differences were observed between the two groups in mean age, mean deviation (MD), and pattern standard deviation (PSD) measured by the Humphrey Field Analyzer (HFA). The correlation between MD values determined by HFA (x) and FDT (y) is represented by y = 0.60x - 2.7 (r = 0.78, P <.01) in the POAG group and y = 0.59x + 0.6 (r = 0.81, P <.001) in the NTG group. Although the average MD measured by FDT was significantly lower in the POAG group than in the NTG group (P <.05), no significant difference was found in average PSD between the two groups. In early glaucoma cases (MD > or = -5 dB by HFA), a larger proportion of cases in the POAG group than in the NTG group had lower significance level of MD determined by FDT than by HFA (P <.02). At many test points on the temporal periphery in the FDT, the mean sensitivity was lower in the POAG group than in the NTG group; whereas no significant differences among HFA test points were observed. CONCLUSIONS: Frequency doubling technology detected visual field abnormalities in POAG cases more sensitively than in NTG cases. This finding indicates that the pathogenesis of My-cell damage is rather different in POAG and NTG.     

Comparison of detectability of visual field abnormality by frequency doubling technology in primary open-angle glaucoma and normal-tension glaucoma

PURPOSE: To compare the effectiveness of frequency doubling technology(FDT) in detecting abnormalities in primary open-angle glaucoma(POAG) and normal-tension glaucoma(NTG). SUBJECTS AND METHODS: Twenty-nine POAG patients (29 eyes) and 27 NTG-patients(27 eyes) were studied. All subjects underwent testing with program C-20 of FDT with appropriate corrective lenses. RESULTS: No significant differences were observed between the two groups in mean age, mean deviation(MD), and pattern standard deviation(PSD) measured by the Humphrey Field Analyzer(HFA). The correlation between MD values determined by HFA(x) and FDT(y) is represented by y = 0.60x - 2.7 (r = 0.78, p < 0.01) in the POAG group and y = 0.59x + 0.6 (r = 0.81, p < 0.001) in the NTG group. No significant difference was found in the average PSD between the two groups. In early glaucoma cases (MD > or = -5 dB by HFA), a larger proportion of cases in the POAG group than the NTG group had a lower significance level of MD determined by FDT than by HFA (p < 0.02). At many test points on the temporal periphery in FDT the mean sensitivity was lower in the POAG group than in the NTG group; whereas no significant differences among HFA test points were observed. CONCLUSIONS: FDT detected visual field abnormalities in POAG cases more sensitively than in NTG cases. This finding indicates that the pathogenesis of My-cell damage is different in POAG and NTG.     

Relationship between optic nerve head microcirculation and visual field loss in glaucoma

PURPOSE: To study the relationship between optic nerve head blood flow velocity and visual field loss in patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). METHODS: This study included 44 eyes of 44 patients with POAG and 44 eyes of 44 patients with NTG. To evaluate optic nerve head blood flow velocity, the square blur rate (SBR) was measured by means of laser speckle flowgraphy. The correlation between SBR and Humphrey visual field indices was evaluated with linear regression analysis. RESULTS: In the NTG group, the average SBR at the superior and inferior temporal neuroretinal rim was positively correlated with mean deviation (MD) (r = 0.349, p = 0.020). The SBR at the superior or inferior temporal neuroretinal rim was positively correlated with the sum of the total deviations in the corresponding hemifields (r = 0.299, p = 0.049; r = 0.354, p = 0.019, respectively). The correlations between SBR and MD did not differ statistically between the NTG and POAG groups; however, no significant correlation between SBR and visual field indices was observed in the POAG group. CONCLUSION: These results suggested that the change in the circulation of the optic nerve head may be related to visual field damage in the NTG group but may be less involved in visual field damage in the POAG group.     

Frequency doubling technology perimetry in open-angle glaucoma eyes with hemifield visual field damage: comparison of high-tension and normal-tension groups

PURPOSE: To evaluate the performance of frequency doubling technology (FDT) perimetry in open-angle glaucoma eyes with hemifield visual field damage and to compare it between open-angle glaucoma with high pressure [high-tension glaucoma (HTG)] and those with normal pressure [normal-tension glaucoma (NTG)] groups. METHODS: FDT perimetry with the N-30 full threshold protocol and standard automated perimetry (SAP) using the Humphrey Field Analyzer with the 30-2 full threshold protocol were performed in 20 eyes of 20 HTG patients and 36 eyes of 36 NTG patients with visual field damage confirmed with SAP in only one hemifield. RESULTS: There was no significant difference in demographics, the Heidelberg Retina Tomography indices, and the Humphrey Field Analyzer indices between HTG and NTG groups. Regarding the FDT perimetry results, mean deviation in the global field (P=0.009) and mean sensitivity in the SAP-spared (P=0.001) and SAP-impaired (P=0.011) hemifields were lower; the numbers of FDT abnormal test points (probability of abnormality <5%) in the SAP-spared hemifield were significantly greater (P=0.005) in HTG than in NTG groups. Eyes in which FDT results of the SAP-spared hemifield were judged as abnormal was more frequent in HTG groups (P=0.007). CONCLUSIONS: The performance of FDT perimetry to detect early or preperimetric glaucomatous functional changes should be different between HTG and NTG eyes.     

早期原发性开角型青光眼倍频视野的改变

目的　探讨早期原发性开角型青光眼(POAG)倍频视野(FDP)的表现。 方法　应用FDP的N 30全阈值程序和HFA视野计(HFA)中心 30 2全阈值程序检查早期青光眼患者 35例 37眼、进展期青光眼患者 36例 43眼、晚期青光眼患者 6例 7眼;正常人 21例 25眼作为对照组。 结果　早期青光眼的FDP主要表现为相对性旁中心暗点和 /或相对性的弓状暗点,上方弓形区(尤其是 10°~20°的视野)和鼻侧视野在青光眼早期最易受到损害。FDP显示的视野损害与HFA的基本一致,但暗点的范围更大,部分早期青光眼病例HFA显示视野正常的部位FDP也可发现局限性暗点。早期青光眼FDP的三个视野指数(FMS、FMD、FPSD)与正常人比较差异有显著性意义,FDP的FMD与HFA的MD有较好的相关性(相关系数r=0 326,P=0 026)。 结论　早期青光眼FDP的改变与HFA有较高的一致性,在POAG早期诊断中FDP可作为一种快速敏感的视功能检测方法。