A study of Helicobacterium pylori and prevention and treatment of chronic atrophic gastritis.

The rate of detection of helicobacterium pylori (HP) in chronic atrophic gastritis (CAG) is 67%, HP being a slightly aerobic Gram-negative bacterium. Some drugs of traditional Chinese medicine (TCM) for clearing away heat and for removing blood stasis have significant effect on inhibition of HP. The drugs in both the recipe for nourishing yin, clearing away heat and invigorating blood circulation and the recipe for clearing away heat and invigorating blood circulation have inhibitory action on HP in vitro. All patients with CAG have symptoms of damp-heat and blood stasis. Radix et Rhizoma Rhei and Rhizoma Coptidis Decoction for Purging Stomach-Fire ([symbol: see text]) as the basic recipe and "Huo Wei" ([symbol: see text]) No. 2 recipe as the supplementary have good inhibitory effect on HP in inhibition tests. The results show several forms of the medicine all resulted in significant good therapeutic effect.     

The regulatory action of Radix Astragali on M-cholinergic receptor of the brain of senile rats.

The changes in density of M-cholinergic receptors in different areas of senile rats and the regulatory action of Huang Qi ([symbol: see text] Radix Astragali, a drug for warming yang and replenishing qi) were observed by autoradiography. The results showed that the gray scale displayed in brain sections was clear and mainly distributed in the cortex, hippocampus and striate body, while that due to nonspecific combination was negligible. The gray scale in the cortex, hippocampus and striate body of the experimental group was markedly lower than that in the young control rats, decreased respectively by 24.87%, 14.12% and 12.76% (all P < 0.05); but it was obviously higher than those in the senile control rats, increased respectively by 24.15%, 14.38% and 13.47% (P < 0.05). The data indicate that Huang Qi ([symbol: see text]Radix Astragali) may up-regulate the decreased density of M-cholinergic receptors in the brain of senile rats.     

Effects of San Qi on Gastric Secretion and Protective Factors of Gastric Mucosa in the Rat with Precancerous Lesion of Stomach

In the model rat with precancerous lesion of stomach induced by the combined method of insertion of a spring into the pylorus and high salt hot paste, effects of San Qi ([symbol: see text] Radix Notoginseng) on gastric secretion and protective factors of stomach were investigated. The results indicated that gastric secretion, gastric mucosal blood flow (GMBF) and aminohexose content lowered significantly, and malondialdehyde (MDA) increased significantly (P < 0.01) in the model group as compared with the normal group; after treatment with San Qi Powder for 12 weeks, both gastric secresion and GMBF increased, and MDA content decreased as compared with the negative control group (P < 0.01), with no significant increase of aminohexose content. It is suggested that San Qi ([symbol: see text] Radix Notoginseng) may improve gastric secretion, and that increase of GMBF and antagonism against the lesion of oxygen free radicals are possibly one of its mechanisms.     

Treatment of the Localized Neurodermatitis by Plum-blossom Needle Tapping and with the Modified Yangxue Dingfeng Tang——A Clinical Observation of 47 Cases

Since 1993, the authors have successfully treated 47 cases of the localized neurodermatitis by plum-blossom needle tapping and with the modified Yangxue Dingfeng Tang, with quite good therapeutic results reported as follows. Clinical Data The 141 patients…     

Treatment of nonspecific chronic prostatitis with Qian Lie Xian Yan Suppository suppository in 104 cases.

Qian Lie Xian Yan Suppository ([symbol: see text]) was rectally applied to treat 104 patients with nonspecific chronic prostatitis (damp-heat syndrome with blood stasis) in contrast to 30 patients treated with traditional Chinese drug Ye Ju Hua Shuan ([symbol: see text] Suppository of Flos Chrysanthemi Indici). The results show that chronic prostatitis is markedly improved by using Qian Lie Xian Yan suppository, with a short-term cure rate of 23.1% and a total effective rate of 84.6%, superior to that of the control group. The animal experiment indicates that Qian Lie Xian Yan suppository has better anti-inflammatory and analgesic effects, with an action of promoting blood circulation.     

TCM Treatment of Bronchial Asthma

Xuan Fei Ding Chuan Wan(宣肺定喘丸 pills for facilitating the flow of the lung-qi to relieve asthma)and Xiao Chuan Gu Ben Wan (哮喘固本丸 pills for treating asthma by consolidating the origin)wereused for treatment of bronchial asthma.The cure rate in the treated group(n=600)was 81.33%,significantly higher(P<0.01)than that in the control group(n=164,with a cure rate of 9.76%).     

Clinical Observation in 86 Cases of Acne Vulgaris Treated with Compound Oldenlandis Mixture

86 cases of acne vulgaris were treated with Fu Fang She She Cao He Ji (复方蛇舌草合剂 CompoundPrepared from Chinese Angelica and Flavescent Sophora Root) as the controls, to observe the therapeuticeffect of the former. The results showed that the cure plus markedly effective rate was 73.26% in thetreatment group, and 47.06% in the control group, with a significant difference in the cure plus markedlyeffective rate between the two groups (P＜0.01), and also in the total effective rate between the two groupssignificant (P＜0.05). It may be concluded that the Compound Oldenlandis Mixture is a better agent for theillness.     

A clinical trial on yu cong tang in treatment of senile dementia.

Yu Cong Tang ([symbol: see text]), a TCM decoction, was used to treat senile dementia. It has the action of invigorating the spleen, reinforcing the kidney, nourishing yin, strengthening yang, improving blood circulation, dredging the channels, removing phlegm and restoring consciousness. CT, EEG, REG, Hb, PaO2, Tch, TG and 17-OHCS were tested, showing significant differences (P < 0.05 or < 0.01) before and after the treatment. Remarkable improvement was found in clinical symptoms, and the effective rate was 94.1%. Significant differences were found between the TCM and western medicine (WM) groups in symptom improvement (P < 0.05-0.01) and therapeutic results (P < 0.001).     

郭淑云从瘀论治慢性胃痛

目的:研究郭淑云教授从瘀论治慢性胃痛的经验及用药规律。方法:收集郭淑云教授从瘀论治慢性胃痛的门诊病案281例,运用"中医传承辅助系统"构建数据库,基于该软件的频次统计、关联规则分析等数据挖掘方法,对郭淑云教授从瘀论治慢性胃痛的经验及用药规律进行总结。结果:郭淑云教授从瘀论治慢性胃痛,分为六型进行辨证施治,以气滞血瘀型最常见。常用的活血化瘀药有延胡索、丹参、莪术、三棱、五灵脂、蒲黄、郁金。常用的药物组合有5对,分别为延胡索-川楝子、丹参-砂仁、三棱-莪术、五灵脂-蒲黄、炒白芍-炙甘草。结论:郭淑云教授擅于从瘀论治慢性胃痛,总结出胃痛瘀血证的6条指征,提出"无形之瘀"理论,临证以治瘀六法从本论治,组方喜用药对。     

Clinical observation of Chinese drugs in prevention of neonatal hyperbilirubinemia.

Observation of the preventive and curative effects of Herba Artemisiae Scopariae [symbol: see text], Fructus Gardeniae [symbol: see text], Radix Scutellariae [symbol: see text] and Radix et Rhizoma Rhei Preparata [symbol: see text] in 30 cases of neonatal hyperbilirubinemia showed that both the peak value of serum total bilirubin and the incidence of hyperbilirubinemia were obviously lower than that in the control group.     

The principle and technique of using Chinese drugs in the treatment of hypertension.

Differential use of Chinese and western drugs, and combination of traditional theory of materia medica with the results of modern pharmacological research can be regarded as a general principle in the treatment of a disease, while combination of lowering blood pressure with preventing and treating complications is a specific method in the treatment of hypertension. As to the use of drugs based on differentiation of diseases and/or symptoms, drugs which have the action of relieving symptoms but also reducing blood pressure should be used as the first choice. For those drugs which have the action of relieving symptoms but can not lower blood pressure should not be used or should be used as less as possible. Drugs with action of raising blood pressure are contraindicated. When patients have the symptoms of hyperactivity of yang resulting from yin deficiency, Huang Bo ([symbol: see text] Cortex Phellodendri) and Zhi Mu ([symbol: see text] Rhizoma Anemarrhenae) are used together to enhance the effects of both nourishing yin to reduce pathogenic fire, and reducing blood pressure. This practice conforms to the TCM theory and also to the modern pharmacological research.     

One hundred and seven middle-aged and senile cases of coronary heart disease with ventricular premature beat treated by qing xin an shen fang.

The therapeutic principle of clearing away the heart-heat to induce tranquilization was adopted in 107 middle-aged and senile patients with ventricular premature beat of coronary heart disease on the basis of pathogenic features of phlegm, heat, blood stasis and deficiency in this condition. Qing Xin An Shen Fang ([symbol: see text] a formula for clearing away the heart-heat to induce tranquilization) was used in the treatment group and compared with mexiletine and Fu Fang Dan Shen Tablets ([symbol: see text] Compound Salvia Tablets) used in the control group. The results turned to be that the markedly effective rate was 85.1% and the total effective rate 96.3% in the treated group, better than that in the control group, with the former having a good antihypertensive and antihyperlipemic effect and an effect of improving microcirculation and clinical symptoms.     

Clinical Observation on Treatment of Rheumatoid Arthritis with Fengshi Xiandan in 53 Cases

We have successfully developed Fengshi Xiandan ([symbol: see text]) and used it to treat 53 cases of rheumatoid arthritis (RA), with indomethacin used to treat another 53 cases of RA as the controls. The results showed that the rate of cure and obvious effect was 54.7% and the total effective rate was 92.4% in the treatment group, as compared to 26.4% and 66.0% respectively in the control group, with an obvious difference in curative effect between the two groups (P < 0.01). The improvement of all the main clinical symptoms and signs except arthralgia in the treatment group was superior to that in the control group (P < 0.05 or P < 0.01). The improvement of erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C-reaction protein (CRP), immunoglobulin (Ig), T-lymphocyte subgroups, micro-circulation in nail fold, and red blood cell (RBC) and hemoglobin (Hb) of anemia patients in the treatment group was superior to that in the control group (P < 0.05 or P < 0.01). There was an obvious difference (P < 0.05 or P < 0.01) in superoxide dismutase (SOD) of RBC and lipid peroxide (LPO) of plasma before treatment in the two groups as compared to normal group (P < 0.05 or P < 0.01). The level of SOD and LPO after treatment in the treatment group obviously tended to normal as compared to that before treatment (P < 0.05 or P < 0.01). The reduction of LPO in the treatment group was obviously superior to that in the control group (P < 0.01). The result shows that Fengshi Xiandan ([symbol: see text]) with an obvious curative effect on RA can not only control the symptoms of RA but also improve its pathologic damage and prevent its development.     

Seventy-two Cases of Antidiabetic-Induced Hepatopathy Treated by Huatan Yigan Decoction

In order to observe the therapeutic effects of Huatan Yigan Decoction (化痰益肝汤 Decoction for resolving phlegm and replenishing the liver) on antidiabetic-induced hepatopathy, 129 cases were divided into two groups, 72 cases in the treatment group were administrated with Huatan Yigan Decoction and 57 cases in the control group with the liver-protecting drugs. Their liver function, plasma prothrombin time (PT), blood urea nitrogen and symptoms of the patients before and after treatment were observed during the three therapeutic courses. Results: The total effective rate and cured rate of the treatment group manifested an obvious difference in comparison with those of the control group (P＜0.05 or P＜0.01). Even though the liver function, blood urea nitrogen (BUN) and symptoms in both groups were improved markedly, these indicators in the treatment group were improved more markedly than those in control group (P＜0.01). No adverse effect was found during the treatment. Conclusion: Huatan Yigan Decoction shows a repair action on hepatic injury.     

名老中医治疗中风病用药规律分析

[目的]探讨分析张伯礼教授治疗中风病方剂的用药规律.[方法]对351首治疗中风的方剂进行药物名称标准化,通过频数统计、关联规则、聚类分析等数据挖掘的方法进行分析.[结果]张教授治疗中风病中用药频次由高到低的前5味药物依次为丹参、郁金、天麻、桑枝和夏枯草;所选药物以寒、平、温,苦、甘、辛的四气五味为主;归经尤其以肝经为突...