女性生殖道沙眼衣原体和解脲支原体感染与不孕的相关性分析

目的 探讨生殖道沙眼衣原体(CT)和解脲支原体(UU)感染与女性不孕的关系。方法 采用聚合酶链反应技术(PCR)和ELISA间接法，对120例不孕妇女和50例正常妇女生殖道沙眼衣原体(CT)和解脲支原体(UU)及抗精抗体(AsAb)进行检测。结果 不孕组与对照组抗精抗体阳性率分别为40％、4％，CT、UU、CT UU阳性检出率分别为30％、38％、13．6％；抗精抗体阳性组中CT、UU、CT UU阳性检出率分别为52．1％、60．4％、26．7％。结论 生殖道沙眼衣原体(CT)和解脲支原体(UU)感染与女性不孕有相关关系。     

女性不孕与支原体、衣原体感染的关系

目的 探讨女性不孕症与解脲支原体与沙眼衣原体的关系。方法 采用细菌培养及聚合酶链反应技术(PCR0)对178例不孕症妇女进行UU、CT检测并与86例正常生育妇女进行对照。结果 不孕妇女UU和CT阳性率分别为30.1%和26.4%,对照组UU和CT阳性率分别为9.1%和6.9%,两组间均有显著性差异(P<0.01)。生殖道感染(PTI)引起的不孕UU和CT 阳性率高于非感染(非RTI)因素引起的不孕阳性率。两组间存在显著性差异(P<0.01)。结论UU、CT感染是引起不孕因素之一,对不孕夫妇进行UU、CT常规检查并及时治疗非常必要。     

生殖道沙眼衣原体和解脲支原体感染与稽留流产的关系及临床意义

目的探讨生殖道沙眼衣原体(CT)、解脲支原体(UU)与稽留流产的关系及临床意义。方法采用免疫层析法和培养法对176例稽留流产患者和115例人工流产患者的宫颈分泌物进行CT、UU的检测。结果稽留流产组宫颈分泌物CT、UU以及CT和UU复合感染阳性感染率分别为34.7%、39.8%、11.9%,对照组为7.8%、11.3%、2.6%,两组比较差异均有统计学意义(P<0.05)。结论生殖道沙眼衣原体和解脲支原体感染与稽留流产的发生有关,是造成稽留流产的病因之一。对稽留流产患者进行CT和UU的检测并积极治疗对防止不良妊娠结局发生有重要意义。     

解脲支原体和沙眼衣原体感染与女性不孕的相关性分析

目的了解不孕症与解脲支原体(UU)、沙眼衣原体(CT)感染的相关性。方法采用荧光定量聚合酶链反应(PCR)技术对180例女性不孕者(观察组)和180例正常生育者(对照组)的宫颈分泌物进行UU、CT检测后对比分析。结果不孕组UU的阳性率为37.8%,CT阳性率为28.9%,UU+CT阳性率为17.8%;对照组UU阳性率为15.6%,CT阳性率为8.3%,UU+CT阳性率为6.7%。不孕组UU、CT和UU+CT的阳性检出率均明显高于对照组(P<0.01)。原发性不孕UU、CT和UU+CT的阳性率分别为43.9%、22.0%、12.2%,低于继发性不孕(49.0%、26.5%、14.3%),差异无统计学意义(P>0.05)结论生育期女性生殖道感染UU、CT是导致不孕的重要因素,对不孕妇女常规进行UU、CT检测并及时治疗非常必要。     

不孕症患者沙眼衣原体和解脲支原体水平检测的分析

目的比较不孕组(观察组)与正常组(对照组)女性沙眼衣原体(CT)与解脲支原体(Uu)的感染情况,探讨沙眼衣原体、解脲支原体与女性不孕之间的关系。方法对270例女性不孕患者进行CT和Uu的DNA检测,将结果与对照组进行比较分析。结果不孕组的CT、Uu、CT+Uu的检出率分别为15.6%、44.4%、12.2%;对照组CT、Uu、CT+Uu的检出率分别为5.6%、15%、3.8%。结论在众多造成不孕的原因当中,CT和Uu的感染是造成女性不孕的重要原因之一。     

解脲支原体 沙眼衣原体感染与稽留流产的关系探讨

解脲支原体(UU)、沙眼衣原体(CT)是寄居于人体泌尿生殖道的原核细胞型微生物,是引起非淋菌性尿道炎、生殖道感染的病原体,为探讨UU与CT感染和胚胎停止发育的关系,本研究对稽留流产妇女的宫颈分泌物进行解脲支原体与沙眼衣原体的定量聚合酶链反应(PCR)检测,并与正常人工流产妇女进行对比研究,旨在探讨宫颈UU与CT感染和胚胎停止发育的关系.     

女性输卵管性不孕与生殖道解脲支原体衣原体感染的相关性分析

目的探讨生殖道解脲支原体、衣原体感染与女性输卵管性不孕的关系。方法68例输卵管因素不孕患者作为观察组,57例非输卵管因素不孕患者作为对照组,取宫颈拭子进行解脲支原体（UU）、衣原体（CT）的培养。结果输卵管性不孕组患者的UU和CT感染高于对照组,有统计学意义;但CT、UU的混合感染差异无统计学意义。结论女性下生殖道CT、UU感染与输卵管性不孕有相关性。     

输卵管妊娠与生殖道解脲支原体和沙眼衣原体感染的关系分析

目的 探讨生殖道解脲支原体和沙眼衣原体感染与输卵管妊娠的关系。方法 采用回顾性分析,选择3年来我院输卵管妊娠患者87例为研究对象,选择同期正常早期妊娠妇女106例为对照组。采用宫颈分泌物分离培养及胶体金方法 分别检测解脲支原体和沙眼衣原体感染情况。结果 病例组87例输卵管妊娠患者中有34例(39.08%)UU感染,其中11例(12.64%)同时感染CT,21例(24.14%)为单纯CT感染。对照组106例患者中有20例(18.87%)UU感染,其中例5例(4.71%)同时感染CT,12例(11.32%)为单纯CT感染。病例组与对照组比较,差异有统计学意义P<0.05。结论 生殖道解脲支原体和沙眼衣原体感染增加输卵管炎及盆腔炎的发生,与输卵管妊娠关系密切。     

420例非淋球菌性生殖道感染患者的解脲支原体和沙眼衣原体感染分析

目的了解本地区非淋球菌性生殖道感染患者的解脲支原体和沙眼衣原体感染状况。方法利用实时荧光聚合酶链反应方法(FQ-PCR)对2010和2011年来院就诊的420例非淋球菌性生殖道感染患者的泌尿生殖道分泌物同时作解脲支原体和沙眼衣原体检测。结果检出阳性病例211例,阳性率50.0%,(211/420):其中解脲支原体,沙眼衣原体和混合感染的阳性检出率分别为31.9%(134/420),11.7%(49/420)和6.7%(28/420),沙眼衣原体和解脲支原体的感染差异有统计学意义,解脲支原体高于沙眼衣原体;不同性别在不同病原体感染中有所不同,总体上女性感染高于男性(P<0.05),在解脲支原体单一感染差异两性差异有统计学意义(P<0.05),且女性高于男性,但在沙眼衣原体单一感染和两种病原体混合感染中两性差异无统计学意义。结论本地区解脲支原体是非淋球菌性生殖道感染患者的主要病原体,女性呈明显高感染状况,实时荧光聚合酶链反应可作为临床检测的解脲支原体和沙眼衣原体的实验方法。     

衣原体解脲支原体感染与流产后子宫异常出血的关系

目的探讨衣原体(CT)、解脲支原体(UU)感染与流产后(人工流产、药物流产)子宫异常出血的关系。方法采用血清衣原体、解脲支原体抗体检测,加宫颈分泌物采用套式聚合酶链反应(PCR)的方法检查CT和UU培养的方法查UU。对82例流产后子宫异常出血者(简称流产后出血组)、流产后无异常出血者152例(简称流产后正常组)和未做流产子宫异常出血者32例,简称未流产出血组、未做流产的正常妇女32例(未流产正常组)。结果流产后出血组宫颈分泌物CT、UU检出率分别为19.5%和30.5%,均明显高于流产后后正常组(P<0.05);流产后出血组CT、UU血清抗体阳性检出率分别为23.2%和37.8%,均明显高于其它各组。结论流产后子宫异常出血与生殖泌尿系CT、UU感染有关。     

Degraded and undegraded carrageenans and experimental gastric and duodenal ulceration

The prevention of histamine-induced gastric and duodenal ulceration in the guinea-pig has been examined using a series of undegraded and degraded carrageenans. Undegraded carrageenans were active at lower doses than degraded carrageenans. The high viscosity of the undegraded carrageenans in solution prevented their use in larger doses. Degradation of carrageenan without serious loss of sulphate, gives a product which allows the dose to be increased to an extent that its effect more than offsets the slight loss in activity caused by the degradation. No single feature of carrageenan structure can be related to anti-ulcer activity although degradation, and hence reduction of molecular size, generally reduces activity. Sulphate contents over 30% have little apparent effect on activity; κ-carrageenans were not consistently different in anti-ulcer activity from Λ-carrageenans. This contrasts with the antipeptic activity of carrageenans where κ-carrageenans are less active than their Λ-counter-parts. As with antipeptic activity, the degree of anti-ulcer activity is probably determined by a combination of structural features which includes molecular size and polyanionic properties.     

Affective and Anxiety Disorders and Alcohol and Drug Dependence:

Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder.     

Alcohol and Substance Use and Abuse in Women and Children

No abstract available for this article.     

Glucosidase and fucosidase inhibitors and Advances in nucleosides and nucleotides.

The American Chemical Society Symposium "Glucosidase and fucosidase inhibitors" took place on 1 April 1998 and was organized by Professors Zbigniew J Witczak (UConn, School of Pharmacy, CT, USA), Kuniaki Tatsuta (Waseda University, Tokyo, Japan) and Waldemar Priebe, MD (Anderson Cancer Center, University of Texas, USA). Professor Witczak provided introductory remarks including the status of existing glucosidase inhibitors, and chaired the morning session, which consisted of six lectures. The symposium was well received, and was particularly attractive for those interested in networking, as attendance was about sixty. In addition, some participants and attendees presented posters on the subject during the regular poster session organized by the Division of Carbohydrate Chemistry.