共查询到20条相似文献,搜索用时 46 毫秒
1.
V. V. Semenov M. Ya. Ibragimova B. I. Barabanshchikov 《Bulletin of experimental biology and medicine》1998,126(4):1023-1024
Experiments withCrepis capillaris dry seeds show that pretreatment with adrenaline hydrochloride and adrenaline hydrotartrate significantly reduces the number
of aberrations induced by the supermutagen ethylmethane sulfonate. The effective concentration ranges for adrenaline adrenaline
hydrotartrate and hydrochloride are 10−1–10−7 M and 10−3–10−7 M, respectively. Adrenaline hydrochloride is more effective than adrenaline hydrotartrate (79.1vs. 65%, respectively).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10, pp. 427–429, October, 1998 相似文献
2.
G. V. Burlakov 《Bulletin of experimental biology and medicine》1994,118(3):949-952
The effect of lectins (phytohemagglutinin — PHA, concanavalin A — ConA,Pisum sativum lectin — PSL,Ricinus communis lectin — RCL, and pokeweed mitogen — PWM) on the cardiac cholinoceptors is studied in experiments on isolated hearts of maleRana temporaria frogs. The test lectins in concentrations from 10−23 to 10−3 are shown to exhibit cholinomimetic properties.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
9, pp. 252–255, September, 1994
Presented by A. D. Ado, Member of the Russian Academy of Medical Sciences 相似文献
3.
P. V. Sergeev S. A. Chukaev Yu. A. Korovkina 《Bulletin of experimental biology and medicine》1997,124(2):786-788
Effects of estradiol and testosterone and of the antiandrogens cyproterone acetate, niftolide, and antiestrogen tamoxifen
on the activities of human erythrocyte glutathione peroxidase and glutathione reductase were studiedin vitro. In contrast to hormone preperations, antihormones in high concentrations (10−4−5×10−4 M) modified the enzyme activities. Cyproterone acetate and tamoxifen increased the activity of glutathione reductase, while
tamoxifen stimulated glutathione reductase and inhibited glutathione peroxidase. Niftolide inhibited both enzymes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 185–187, August, 1997 相似文献
4.
Ritter U Lechner A Scharl K Kiafard Z Zwirner J Körner H 《Medical microbiology and immunology》2008,197(1):29-37
TNF-negative C57BL/6 (B6.TNF−/−) mice are highly susceptible to Leishmania (L.) major infection and succumb rapidly to fatal leishmaniasis. A T helper type 1 (Th1) cell-mediated immune response is central for protective anti-leishmanial immunity. Therefore, the
observed susceptibility of B6.TNF−/− mice to L. major parasites could be caused by a deficiency in mounting a Th1 response. Analysis of infected footpads revealed, that B6.TNF−/− mice exhibited a substantially diminished formation of DCs at the site of infection. Furthermore, Th1 cytokines such as IFN-γ
were reduced in footpads of infected B6.TNF−/− mice. Cutaneous reconstitution of B6.TNF−/− mice with either bone marrow derived DCs (BM-DCs) or recombinant TNF simultaneous to infection resulted in an increased expression
of cytokines such as IFN-γ and in an enhanced presence of Leishmania-antigen in skin draining lymph nodes. In addition, the individual time of survival was doubled. In conclusion we demonstrate
that the expression of dermal TNF is necessary to provide an environment that initiates a local inflammatory response, but
is not sufficient to induce protective immunity. 相似文献
5.
N. G. Bogdanova T. V. Lelekova N. P. Pal'mina 《Bulletin of experimental biology and medicine》2000,129(1):30-32
Effects of the regulatory peptide thyroliberin on microviscosity of lipid components of endoplasmic reticulum biological membranes
in mouse hepatocytes were studied by electron paramagnetic resonance. Thyroliberin in a concentration of 10−3–10−18 M decreased microviscosity of surface layers of membrane lipids. This decrease was the most pronounced (30%) under effects
of 10−10 and 10−16 M thyroliberin. Physiological effects of thyroliberin corresponded to its influence on the membrane structure.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 38–40, January, 2000 相似文献
6.
Antioxidant properties of thiamine 总被引:1,自引:0,他引:1
P. I. Lukienko N. G. Mel'nichenko I. V. Zverinskii S. V. Zabrodskaya 《Bulletin of experimental biology and medicine》2000,130(3):874-876
Thiamine (10−4–10−6 M) inhibits lipid peroxidation in rat liver microsome and free radical oxidation of oleic acidin vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant
effect of thiamine is probably related to sucessive transfer of 2H+ from the NH2 group of the pyrimidine ring and H+ from the thiazole ring (after its opening) to reactive substrates.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 303–305, September, 2000 相似文献
7.
Lukienko PI Mel'nichenko NG Zverinskii IV Zabrodskaya SV 《Bulletin of experimental biology and medicine》2000,130(9):874-876
Thiamine (10−4–10−6 M) inhibits lipid peroxidation in rat liver microsome and free radical oxidation of oleic acidin vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant
effect of thiamine is probably related to sucessive transfer of 2H+ from the NH2 group of the pyrimidine ring and H+ from the thiazole ring (after its opening) to reactive substrates.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 303–305, September, 2000 相似文献
8.
V. M. Smirnov 《Bulletin of experimental biology and medicine》1997,124(1):635-638
The mechanism by which heart rate is increased upon stimulation of vagal centers is studied using frog heart preparations
perfused with Ringer—Locke solution containing atropine and/or benzohexonium. Atropine stimulates vagus-induced heart-rate
acceleration in dilutions of 10−6 and 10−5 g/ml. In a dilution of 10−4 g/ml both atropine and benzohexonium abolish vagal tachycardia. Rausedyl (3–4 injections, 5 mg/kg, at 18–20-h interval) prevents
tachycardia. Stimulation of both halves of the medulla oblongata increases heart rate to a greater extent than stimulation
of one half.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 16–20, July, 1997 相似文献
9.
The normalised back-scattered intensity (NBI) profiles at various locations on the forearms of ten human subjects were obtained
by moving the multi-probe of a laser reflectometer. The statistical analysis of the NBI data showed that the variation in
the NBI was significantly higher at the ulnar region compared with that at other regions. For determination of the scattering
(μ
s
) and absorption (μ
a
) coefficients and the anisotropy parameter g at each location on the forearm, these profiles were matched with the NBI profiles
simulated by a Monte Carlo procedure (χ
0.99
2
). For the reconstruction of images of variation of these parameters, the averaged values ofμ
a
,μ
s
and g at all locations on the forearms of the subjects were determined. The absorption coefficient had a minimum (1.92 cm−1) and maximum (2.21 cm−1) at the wrist and the lateral region of the forearm, respectively. The scattering coefficient had a maximum (194 cm−1) at the medial side and near the elbow, and a minimum (186 cm−1) at the lateral side of the forearm. Similar changes in the anisotropy parameter were also observed. By interpolation of
the data of each parameter on a 100×100 image matrix and after median filtering, colour-coded images of the variation in the
optical parameters were constructed. These images could be useful for diagnostic and therapeutic applications of lasers. 相似文献
10.
I. G. Rebrov G. N. Kryzhanovskii N. P. Belykh T. F. Shukalova R. N. Glebov 《Bulletin of experimental biology and medicine》1996,122(2):778-781
Effects of picrotoxin and bicuculline on the muscimol-dependent36Cl− entry into synaptoneurosomes of the rat cerebral cortex are examined as well as desensitization of36Cl− entry at muscimol concentrations of 5 and 50 μM. At the 5 μM concentration (which is close to the muscimol IC50), picrotoxin and bicuculline inhibited Cl− entry into synaptoneurosomes and decreased the desensitization. At the 50 μM concentration, muscimol completely abolishes
the bicuculline effects both on Cl− entry and desensitization. Inhibition of Cl− entry by picrotoxin is also abolished by 50 μM muscimol, whereas the picrotoxin-induced decrease in the desensitization rate
is not. It is shown that both bicuculline effects result from inhibition of the GABA receptor, but the action of picrotoxin
on the desensitization of Cl− entry into synaptoneurosomes is not closely related to the functional activity of the GABA receptor/Cl− channel complex.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 8, pp. 144–147, August, 1996 相似文献
11.
S. A. Gavrilova A. A. Guseva N. A. Medvedeva 《Bulletin of experimental biology and medicine》1997,124(5):1052-1055
The effects of bolus administration and short-term infusion of endothelin 1 in four doses (2×10−16, 2×10−14, 2×10−12, and 2×10−10 mol/kg) on arterial pressure and heart rate were compared in awake rats. Infusion and bolus administration of the two highest
doses increased arterial pressure and provoked bradycardia. Infusion of the two lowest doses increased heart rate without
concomitant changes in arterial pressure, while bolus injection of endothelin 1 in the same doses decreased both arterial
pressure and the heart rate.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 491–494, November, 1997 相似文献
12.
The use of potential-sensitive fluorescent probes allowed us to estimate transmembrane potentials of the plasma (Δφp) and mitochondrial (Δφm) membranes of rat thymocytes, which were −58±3 mV and −169±7 mV, respectively. Dexamethasone-induced apoptosis led to a significant
decrease in Δφp (by 55%) and Δφm (by 17%). This effects of dexamethasone was dose- and time-dependent. Changes in Δφm were greater and preceded those in Δφp.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 117–120, January, 1999 相似文献
13.
Takane H Miyata M Burioka N Shigemasa C Shimizu E Otsubo K Ieiri I 《Journal of human genetics》2006,51(9):822-826
Pravastatin is mainly taken up from the circulation into the liver via organic anion-transporting polypeptide 1B1 (SLCO1B1 gene product). We examined the contribution of genetic variants in the SLCO1B1 gene and other candidate genes to the variability of pravastatin efficacy in 33 hypercholesterolemic patients. In the initial phase of pravastatin treatment (8 weeks), heterozygous carriers of the SLCO1B1*15 allele had poor low-density lipoprotein cholesterol (LDL-C) reduction relative to non-carriers (percent reduction: −14.1 vs −28.9%); however, the genotype-dependent difference in the cholesterol-lowering effect disappeared after 1 year of treatment. Cholesterol 7α-hydroxylase (CYP7A1) and apolipoprotein E (APOE) are known to contribute to lipid metabolism. Homozygous carriers of the CYP7A1 -204C allele or heterozygotes for both CYP7A1 -204C and APOE ε4 alleles showed significantly poorer LDL-C reduction compared to that in other genotypic groups after 1 year of treatment (−24.3 vs −33.1%). These results suggest that the SLCO1B1*15 allele is associated with a slow response to pravastatin therapy, and the combined genotyping of CYP7A1 and APOE genes is a useful index of the lipid-lowering effect of pravastatin. 相似文献
14.
V. V. Alabovskii E. J. Cragow A. A. Vinokurov 《Bulletin of experimental biology and medicine》1999,127(4):363-365
Subtotal 30-min ischemia leads to myoglobin release and increases water content in the heart. Reperfusion partially restores
the developed pressure. Addition of furosemide (a Na+, K+, 2Cl−-sumport blocker) or NMA (inhibitor of Na+/H+-exchange) to perfusate decreases myocardial water content, reduces myoglobin loss, and completely restores myocardial contractile
function. The low-rate perfusion of isolated heart and its reperfusion with solutions containing DIOA (inhibitor of K+, Cl−-co-transport) or IAA-94 (Cl− channel blocker) increases water accumulation and myoglobin release from the myocardium, and deteriorated its contractile
function during reperfusion.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 400–403, April, 1999 相似文献
15.
A. P. Kitaeva Z. D. Tedeeva N. V. Karsanov 《Bulletin of experimental biology and medicine》1999,128(2):814-817
Differential scanning microcalorimetry was used to determine changes in enthalpy, entropy, and free energy of melting of purified
myocardial fibrillar (F) actin from normal dogs and dogs with 2–3-month L-thyroxin-induced and athyreotic cardiomyopathy.
Polymerization of globular (G) actin stabilizes protomer structure in both pathologies. However, the conformational changes
in actin monomer caused by L-thyroxin-induced and, especially, by athyreotic cardiomyopathy decrease the free energy of the
bonds between protomers in the synthesized F-actin. Binding energy between actin protomers modified in athyreotic cardiomyopathy
(−12 kJ/mol) is 4 times below the control value (−48.7 kJ/mol), while in L-thyroxin-induced cardiomyopathy it little differs
from the normal value (−40.8 kJ/mol).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 182–185, August, 1999 相似文献
16.
I. G. Rebrov G. N. Kryzhanovskii N. P. Belykh T. F. Shukalova R. N. Glebov 《Bulletin of experimental biology and medicine》1994,118(2):852-855
A study is performed of the effect of the convulsants picrotoxin and bicuculline, blockers of GABA-dependent Cl−-conductivity, on the rate of desensitization of muscimol-induced36Cl− entry into synaptoneurosomes isolated from rat cortex. Both picrotoxin and bicuculline, despite the difference in the mechanisms
of inhibition of the GABA receptor/Cl− ionophore complex, markedly reduce the rate of desensitization. However, the initial moment of the action of both convulsants
is characterized by inhibition of Cl− transport alone, without a drop of the rate of desensitization.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
8, pp. 160–163, August, 1994 相似文献
17.
H. B. Pratap 《Comparative clinical pathology》2008,17(2):133-136
The haematological response to ambient (10μg Cd l−1) or dietary (10μg Cd fish−1 day−1) cadmium for 2 and 14days was investigated in tilapia (Oreochromis mossambicus) acclimatised to low-calcium (0.2mM Ca2+) and high-calcium water (0.8mMCa2+). Significant reduction of erythrocytes (red blood cells), haemoglobin (Hb), packed cell volume (PCV), mean cell haemoglobin
(MCH) and mean cell volume (MCV) occurred in fish exposed to ambient cadmium in low-calcium water. The anaemic response of
significantly reduced Hb, PCV, MCH and MCV was also evident in fish exposed to dietary cadmium in low-calcium water. Except
for increased mean cell volume of erythrocytes, both ambient and dietary cadmium had no effect on haematological indices in
fish from high-calcium water. This study indicates that high-calcium water has a protective effect on cadmium toxicity. 相似文献
18.
A study is performed of the effect of the phenol antioxidant katavidan on autooxidation of microsomes from rat liver exposed
to visible light. It is shown that katavidan in a concentration of 10−3 M inhibits but in concentrations of 10−5–10−7 M stimulates autooxidation of microsomes. No stimulation is observed under conditions of dark incubation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, № 10, pp. 393–394, October, 1994
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
19.
G. M. Molodavkin E. B. Burlakova L. I. Chernyavskaya T. A. Voronina N. I. Khorseva S. B. Seredenin 《Bulletin of experimental biology and medicine》1996,121(2):151-153
Benzodiazepine tranquilizers, phenazepam and flunitrazepam, administered to random-bred albino male rats in superlow doses
(10−9–10−15 mol/kg), are shown to exert an anxiolytic effect in the conflict test. In contrast to the case with the usual doses, the
above effect is not accompanied by marked myorelaxant or sedative effects.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, № 2, pp. 164–166, February, 1996 相似文献
20.
E. I. Solntseva Yu. V. Bukanova R. U. Ostrovskaya T. A. Gudasheva T. A. Voronina V. G. Skrebitskii 《Bulletin of experimental biology and medicine》1996,121(2):138-142
The effect of two nootropics, piracetam and N-phenylacetyl-L-prolyglycine ethyl ester (GVS-111), is studied by measuring high-threshold
K+ and Ca2+ currents in isolated snail neurons using a two-microelectrode patch-clamp technique. Piracetam and GVS-111 are shown to reduce
the amplitude of both the K+ and the Ca2+ (to a lesser extent) current. The threshold concentrations for GVS-111 and piracetam are 10−9-10−8 M and 1–5×10−4 M, respectively. It is assumed that the antiamnestic effect of the nootropics is partially mediated by a blockade of ion
channels of the neuronal membrane.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 151–155, February, 1996
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献