Methods: Two doses of ropivacaine (1.2 and 1.8 mg/kg) and one dose of lidocaine (3 mg/kg) were compared for intravenous regional anesthesia in 15 volunteers. An arm tourniquet was inflated for 30 min after injection and then deflated in two cycles. Sensory block was measured by response to touch, cold, pinprick, and transcutaneous electric stimulation, and motor function was measured by hand grip strength and muscle power. Median, ulnar, radial, and musculocutaneous nerve functions were tested before local anesthetic injection and then at 5-min intervals until blocks resolved. The plasma ropivacaine and lidocaine concentrations were determined from arterial and venous blood samples drawn from the unanesthetized arm.
Results: Sensory and motor blocks were complete within 25 min and 30 min, respectively, in all three treatment groups. However, recovery of sensory and motor block after tourniquet release was slowest in the high-dose ropivacaine group. Anesthesia to pinprick and transcutaneous electric stimulation was sustained in all the volunteers in the high-dose ropivacaine group for 55 min and 85 min, respectively, whereas complete recovery was observed in the lidocaine group (P = 0.008) and partial recovery in the low-dose ropivacaine group (P < 0.05) during the same period. Motor block also was sustained in the high-dose ropivacaine group for 70 min, which was significantly longer than in the lidocaine group (P < 0.05). All volunteers (five of five) given lidocaine and one volunteer given high-dose ropivacaine reported light-headedness and hearing disturbance during tourniquet release when the arterial plasma lidocaine and ropivacaine concentrations were 4.7 +/- 2.1 [micro sign]g/ml (mean) and 2.7 [micro sign]/ml, respectively. 相似文献
Methods: Density of cerebrospinal fluid was measured using a vibrating tube densitometer. Temperature-dependent density data were obtained from all LAs commonly used for spinal anesthesia, at least in triplicate at 5[degrees], 20[degrees], 30[degrees], and 37[degrees]C. The hypothesis was tested by fitting the obtained data into polynomial mathematical models allowing calculations of substance-specific isobaric temperatures.
Results: Cerebrospinal fluid at 37[degrees]C had a density of 1.000646 +/- 0.000086 g/ml. Three groups of local anesthetics with similar temperature (T, [degrees]C)-dependent density ([rho]) characteristics were identified: articaine and mepivacaine, [rho]1(T) = 1.008-5.36 E-06 T2 (heavy LAs, isobaric at body temperature); L-bupivacaine, [rho]2(T) = 1.007-5.46 E-06 T2 (intermediate LA, less hypobaric than saline); bupivacaine, ropivacaine, prilocaine, and lidocaine, [rho]3(T) = 1.0063-5.0 E-06 T2 (light LAs, more hypobaric than saline). Isobaric temperatures ([degrees]C) were as follows: 5 mg/ml bupivacaine, 35.1; 5 mg/ml L-bupivacaine, 37.0; 5 mg/ml ropivacaine, 35.1; 20 mg/ml articaine, 39.4. 相似文献
Methods: Concentrations at which dodecyltrimethylammonium chloride and four local anesthetic (dibucaine, tetracaine, lidocaine, and procaine) molecules exhibit self-aggregation in aqueous solutions were measured using an anesthetic cation-sensitive electrode. Light-scattering measurements in a model membrane solution were also performed at increasing drug concentrations. The concentration at which drugs caused membrane disruption was determined as the point at which scattering intensity decreased. Osmotic pressures of anesthetic agents at these concentrations were also determined.
Results: Concentrations of dodecyltrimethylammonium chloride, dibucaine, tetracaine, lidocaine, and procaine at which aggregation occurred were 0.15, 0.6, 1.1, 5.3, and 7.6%, respectively. Drug concentrations causing membrane disruption were 0.09% (dodecyltrimethylammonium chloride), 0.5% (dibucaine), 1.0% (tetracaine), 5.0% (lidocaine), 10.2% (procaine), and 20% (glucose), and osmotic pressures at these concentrations were 278, 293, 329, 581, 728, and 1,868 mOsm/kg H2O, respectively. 相似文献
Methods: Isometric tension was measured before, during, and after 10 min of hypoxia in the rings of either quiescent or norepinephrine contracted veins, with or without endothelium. Effects of various pharmacologic agents and volatile anesthetics on the responses to hypoxia were examined.
Results: Hypoxia augmented contractions to norepinephrine and phenylephrine only in endothelium-intact veins. The hypoxic response was inhibited by phentolamine (alpha-adrenoceptor antagonist) and abolished in the absence of extracellular Calcium2+. There were no effects of propranolol (beta-adrenoceptor antagonist), ryanodine (a sarcoplasmic reticulum Calcium2+ depleter), indomethacin (cyclooxygenase inhibitor), or nordihydrogualaretic acid (lipoxygenase inhibitor), L-NAME an inhibitor of nitric oxide synthase) enhanced basal sensitivity of veins to norepinephrine but had no effect on the response to hypoxia. Nicardipine (a blocker of voltage-gated calcium channels) depressed the hypoxic contraction by 86 plus/minus 5%, phosphoramidon (an inhibitor of endothelin-converting enzyme) by 82 plus/minus 8%, and BQ-123 (a specific endothelin-1 receptor antagonist) by 47 + 10%. Volatile anesthetics (1.0 MAC) inhibited responses to hypoxia in the absence as well as presence of L-NAME. 相似文献
Average systolic and diastolic blood pressures were lower during operation in the epidural group than in the other two groups. Statistical analyses failed, however, to show a significant correlation between blood pressures and blood loss in the individual patient. Thus, the ultimate explanation for the diminished bleeding associated with epidural anesthesia is not definitely ascertained. The average postoperative bleeding was not significantly different among the three anesthetic groups. 相似文献
Methods: Eight anesthesia residents in their third year of training with no prior experience using the laryngeal mask airway were observed using the device in 75 pediatric patients each (600 patients in total). Residents were given standardized guidelines for laryngeal mask airway usage in accordance with the manufacturer's recommendations and followed a predetermined protocol for anesthetic management. Induction was achieved with propofol followed by either a propofol infusion or isoflurane and either controlled or spontaneous ventilation as clinically indicated. Predefined major and minor problems were documented during the induction, maintenance, and recovery phases of anesthesia by a randomly selected supervising consultant trained in the study protocol and problem definitions.
Results: The total number of problems was 189 occurring in 121 children. Fifty-five children had one problem, sixty-four children had two problems, and two children had three problems. Of the problems, 77 were major and 112 were minor. The problem rate per patient for overall, major, and minor problems was 31.5%, 12.8%, and 18.7%, respectively. The problem rate comparing the first to last epochs of 15 uses decreased from 62% to 2% for overall problems, 23% to 2% for major problems, and 39 to 1% for minor problems. The residents with the most problems in the final epoch had problem rates of less than 10% after 60 uses. There was a significant decrease in the overall problem rate for induction, maintenance, and recovery (P < 0.05). The major problem rate decreased significantly for induction and maintenance (p < 0.05), but not for recovery. The minor problem rate decreased significantly for induction and recovery (P < 0.05). 相似文献
Methods: Infant, adolescent, and adult rats received blocks with ropivacaine or bupivacaine. Nociceptive, proprioceptive, and motor blockade were assessed. Systemic effects (contralateral leg analgesia, seizures, respiratory distress, apnea) were quantified. Plasma local anesthetic concentrations were measured at terminal apnea.
Results: Nerve blockade for a given absolute dose lasted longer in infants than in older rats for both drugs. Block duration duration from ropivacaine generally was the same as or slightly shorter than bupivacaine. There was no difference in sensory-selectivity between the drugs. Doses required to induce all systemic toxicity indices were inversely related to age (e.g., the lethal dose in 50% of animals [LD50] of ropivacaine in infants is 155 mg/kg; in adults it is 54 mg/kg). All indices of toxicity occurred at higher doses per kilogram for ropivacaine than bupivacaine, at all ages (e.g., the LD50 of bupivacaine in infants is 92 mg/kg; in adults it is 30 mg/kg). Plasma concentrations at terminal apnea were higher for ropivacaine than for bupivacaine at all ages, and were higher in infants than in older rats. 相似文献