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1.
目的:探讨子痫前期患者血脂及凝血指标变化及其临床价值。方法:选择2011年1月-2013年12月在我院分娩的妊娠妇女96例,分为正常妊娠组44例、轻度子痫前期组20例和重度子痫前期组32例。比较3组血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL),以及凝血酶原时间(PT)、活化的部分凝血酶原时间(APTT)和纤维蛋白原(FIB)等指标。结果:3组血脂及凝血指标存在显著差异(P〈0.05)。其中,重度子痫前期组TC、TG及LDL水平,均显著高于正常妊娠组(P〈0.05);HDL水平显著低于与正常妊娠组(P〈0.05)。轻度子痫前期组TG水平,显著高于正常妊娠组(P〈0.05);TC、HDL及LDL水平两组均差异不显著(P〉0.05)。轻度子痫前期组、重度子痫前期组PT、APTT,均较正常妊娠组显著降低(P〈0.05);FIB较正常妊娠组显著或非常显著升高(P〈0.05,P〈0.01)。结论:血脂及凝血指标变化对于子痫前期早期诊断和防治具有重要临床价值。  相似文献   

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目的分析早发型重度子痫前期非手术治疗时限及妊娠结局。方法65例无严重并发症及合并症的早发型重度子痫前期患者,按其发病孕周分为三组,A组<28周15例,B组28~31+6周28例,C组32~33+6周22例。分析三组孕期治疗时限、孕妇并发症、胎儿及围生儿结局。结果A、B、C组非手术治疗时间分别为(9.5±6.5)、(11.2±7.3)、(9.6±6.3)d,三组比较差异无统计学意义(P>0.05);C组孕妇并发症低于A、B组(P<0.05);胎儿及新生儿死亡率C组明显低于A、B组(P<0.01)。结论早发型重度子痫前期非手术治疗可行,但在治疗中应严密监测,权衡利弊,适时终止妊娠。  相似文献   

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目的:探讨高原地区妊娠早发型重度子痫前期与妊娠并发症危险因素的关系,及其对妊娠结局的影响。方法:采用回顾性调查方法,调查2009年12月—2012年12月青海高原地区早发型重度子痫前期的发生率;比较早发型和晚发型重度子痫前期患者发生并发症的风险、常见并发症的种类和对妊娠结局的影响。结果:通过调查发现,早发型重度子痫前期占在全部妊娠高血压疾病的13.61%;早发型重度子痫前期患者发生并发症的人数为20人,占76.9%;发生并发症的次数为33次,为126.9%,晚发型165人,发生妊娠并发症的人次数为63人,占38.18%;两组发生并发症的发生率经统计学对比有显著性差异(X2=13.65,P=0.000)。早发型重度子痫前期患者26例中,早产13例,占所有并发症的39.4%,列第一位,其他依次是产后出血、胎儿宫内发育迟缓、死胎、胎儿宫内窘迫。晚发型与早发型并发症顺位不同,并发症发生最多的是产后出血,其他依次是胎儿宫内窘迫、胎儿发育迟缓、早产。死胎仅发生于早发型患者中。结论:高原地区妊娠早发型重度子痫前期患者的发生率与全国相似;早发型重度子痫前期并发症的发生率明显高于晚发型重度子痫前期患者;早产是早发型患者最大的威胁;早发型重度子痫前期可能造成妊娠不良结局。  相似文献   

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林笑晗  贲腾  田尧  马林 《转化医学杂志》2022,11(4):233-236+217
目的 探究复方蛋氨酸胆碱结合苦黄注射液在酒精性脂肪肝治疗中的疗效及对肝纤维化的影响。方法 按照随机数字表法将2019年1月至2021年12月海安市人民医院收治并确诊的104例酒精性脂肪肝患者分为对照组和观察组,各52例。对照组给予复方蛋氨酸胆碱治疗,观察组苦黄注射液联合复方蛋氨酸胆碱治疗。两组患者均连续治疗1个月。采用全自动生化分析仪检测两组患者治疗前后血清丙氨酸转移酶(alanine transferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)、总胆固醇(total cholesterol ,TC)、三酰甘油(triacylglycerol,TG)、总胆红素(total bilirubin,TBil)水平;采用放射免疫法检测两组患者治疗前后血清层粘连蛋白(laminin,LN)、透明质酸(hyaluronic acid,HA)、Ⅲ型前胶原N端肽(type III procollagen N-terminal peptide,PC Ⅲ)及Ⅳ型胶原(type IV collagen,Ⅳ-C)水平。比较两组患者的临床症状改善情况、临床疗效、肝功能指标及肝纤维化指标。结果 观察组治疗后的腹胀、肝区不适、黄疸、痞满等症状消失时间分别为(3.9±0.1) d、(9.8±0.2) d、(11.5±0.7)d、(3.8±0.2) d,均短于对照组分别为(7.5±0.3) d、(14.3±0.4) d、(15.6±0.8) d、(7.4±0.3) d(均P<0.05)。观察组临床总有效率高于对照组(94.2% vs 78.9%)(χ2=5.283,P=0.022)。观察组ALT、AST、TC、TG、TBil水平分别为(31.5±5.3) IU/L、(36.4±3.4) IU/L、(4.1±0.2) mmol/L、(1.4±0.3) mmol/L、(12.6±3.1) μmol/L,低于对照组[分别为(57.4±5.6) IU/L、(54.7±3.5) IU/L、(6.4±0.4) mmol/L、(2.6±0.5) mmol/L、(21.2±5.3) μmol/L](均P<0.05)。观察组治疗后LN、HA、PC Ⅲ、Ⅳ-C水平分别为(51.6±9.4) μg/L、(32.5±7.4) μg/L、(7.5±1.8) ng/mL、(32.3±4.2) μg/L,均低于对照组[分别为(80.5±10.3) μg/L、(58.7±12.2) μg/L、(16.5±3.6) ng/mL、(71.2±8.6) μg/L](均P<0.05)。对照组和观察组不良反应发生率分别为7.68%、3.84%,两组比较无明显差异(χ2=0.707,P=0.400)。结论 复方蛋氨酸胆碱结合苦黄注射液在酒精性脂肪肝患者中的治疗疗效显著,可改善患者的临床症状和肝功能,延缓肝纤维化的进程,安全性高。  相似文献   

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【摘要】目的:通过在凶险性前置胎盘伴胎盘植入患者剖宫产手术中应用高、低位球囊导管阻断腹主动脉,对比分析术中出血量及术后对肝肾功能的影响。方法:266例凶险性前置胎盘伴不同程度胎盘植入患者在剖宫产手术前置入球囊导管,133例患者将腹主动脉球囊置于T12-L1椎体之间(高位组),133例患者将球囊置于髂动脉分叉上方、腹主动脉肾动脉下方(低位组),剖宫产术中按手术要求充盈球囊,术后球囊撤出,再拔出鞘管压迫穿刺点,记录剖宫产术中出血量及术后第2天的主要肝肾功能指标。结果:266例患者均顺利经鞘管置入球囊于腹主动脉,术后均顺利拔出,无1例行子宫切除术,高位组、低位组术中出血量分别为(695.5±415.8)mL、(707.5±366.2)mL,术后高位组、低位组的主要肝肾功能指标谷丙转氨酶、谷草转氨酶、白蛋白、肌酐分别为(21.3±12.6)U/L、(14.1±1.2)U/L、(35.4±8.5)g/L、(41.6±15.4)umol/L和(24.7±12.9)U/L、(19.0±1.6)U/L、(35.8±9.5)g/L、(42.4±16.4)umol/L,两组间术中出血量及术后肝肾功能主要指标差异均无统计学意义(P值均>0.05)。结论:高位或低位球囊阻断均可减少术中出血量且术后肝肾功能影响并无明显差异,具有较好的可行性和效果。  相似文献   

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目的探讨妊娠早期血清可溶性血管内皮生长因子受体-1(sFlt-1)、促血管生成因子(PIGF)与子痫前期发生的相关性,评价其对子痫前期的预测价值。方法选取辽阳市中心医院自2013年1月至2016年6月进行产检的122例产妇为研究对象。肘静脉采血法留取外周静脉血清进行sFlt-1和PIGF检测,随访记录其妊娠过程。其中,发生重度子痫前期有16例,轻度子痫前期有36例,另取研究对象中无妊娠合并症的正常产妇70例作为正常组。采用Spearman相关性检验sFlt-1与PIGF之间的相关性。结果重度子痫前期组血清sFlt-1水平显著高于正常组及轻度子痫前期组,而重度子痫前期组的PIGF水平显著低于其他两组,差异均有统计学意义(P<0.05)。孕早期产妇血清sFlt-1、PIGF水平呈负相关性(r=-0.570,P<0.05)。结论妊娠早期血清sFlt-1、PIGF指标与子痫前期之间存在相关性,对子痫前期的发生具有预测价值。  相似文献   

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目的分析早发型重度子痫前期的发病机制、诊断及期待治疗对不同孕周母儿结局的影响。方法88例早发型重度子痫前期患者,按孕周分三组:A组〈28w,23例;B组28~31w,30例;C组32~33~,35例。对其临床资料进行回顾性分析。结果3组患者年龄、孕产次、入选时血压、尿蛋白无明显差异;3组并发症的发生率以C组最低,但3组间比较差异无显著性意义(P〉0.05);88例早发型重度子痫前期患者期待治疗时间0~45d,平均11.3d;B组期待时间显著长于C组(P〈0.05),A组与C组及B组比较差异无显著性意义(P〉0.05)。新生儿窒息率A组明显高于B组与C组(P〈0.05),B组与C组间差异无显著性。胎死宫内、新生儿患病率、新生儿死亡率及围产儿死亡率,孕周越小发病率越高,但3组间差异无显著性。结论早发型重度子痫前期严重影响母婴预后,适当期限内的保守治疗有助于改善母儿结局。  相似文献   

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目的观察探讨早发型重度子痫前期期待治疗的临床效果,总结其临床意义。方法选择我院2009年2月~2011年2月收治的早发型重度子痫前期的66例患者,按照人院时的孕周分为A组(孕周≤27周)、B组(孕周在28。31周)和C组(孕周在32~34周),各22例,均给予期待治疗,观察对比3组患者的并发症发生率、期待治疗的平均时间及嗣生儿结局。结果3组患者的并发症发生率对比无显著差异(P〉0.05)。3组患者的同生儿病死率、新生儿病死率会随着孕周的延长及治疗时间的延长而逐渐降低(P〈0.05),具有统计学意义。结论早发型重度子痫对母婴结局有重大的影响.子痫前期适当进行期待治疗,能有效改善母婴预后,减少并发症发生率及嗣生儿死亡率。  相似文献   

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目的 探讨彩色多普勒超声检测子宫动脉血流参数预测妊娠期高血压疾病(HDCP)患者心肾损害程度的临床应用价值。方法 选取我院2016年3月~2017年5月收治的HDCP患者分为妊娠高血压组48例、轻度子痫前期组43例、重度子痫前期组40例,同期入院的50例健康孕妇作为对照组。彩色多普勒超声检测孕妇子宫动脉血流阻力指数(RI)、搏动指数(PI)、收缩期与舒张期流速比(S/D)、心室Tei指数,测定血清Cys C,Hcy水平。分析四组孕妇子宫动脉血流参数、心室Tei指数、血清Cys C,Hcy水平的差异及相关性。结果 妊娠高血压组、轻度子痫前期组、重度子痫前期组子宫动脉RI、PI、S/D、心室Tei指数、血清Cys C,Hcy水平明显高于对照组(P <0.05),轻度子痫前期组、重度子痫前期组明显高于妊娠高血压组(P <0.05),重度子痫前期组又高于轻度子痫前期组(P <0.05);子宫动脉RI、PI、S/D与心室Tei指数、血清Cys C,Hcy水平均呈正相关(P <0.01)。结论 HDCP患者子宫动脉RI、PI、S/D与心肾损害指标随HDCP严重程度的增加而增...  相似文献   

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芮磊  刘甲兴  庄岳鹏  曾岚 《人民军医》2003,46(9):504-505
目的 :观察慢性心衰病人血清可溶性肿瘤坏死因子受体Ⅱ (sTNFRⅡ )的改变及其临床意义。方法 :sTNFRⅡ采用酶联免疫双抗体夹心法测定。结果 :对照组sTNFRⅡ为 (2 5 9± 0 5 8) μg/L ,观察组sTNFRⅡ为 (8 6 2± 5 32 ) μg/L ,两组间差异非常显著 (P <0 0 1)。观察组中轻度组sTNFRⅡ为 (5 31±1 5 4 ) μg/L ,重度组sTNFRⅡ为 (10 87± 5 78)ug/L ,两组间差异非常显著 (P <0 0 1)。 结论 :心力衰竭病人血清sTNFRⅡ值升高 ,并与心力衰竭的严重程度相关。sTNFRⅡ可以作为判断心力衰竭严重程度的指标之一。  相似文献   

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On December 26, 2004, a tsunami from the Indian Ocean struck the coastal city of Banda Aceh, Sumatra, Indonesia. This case report describes a 24-year-old woman who presented to the Dr. Zainoel Abidin Hospital in Banda Aceh on January 8, 2005, with a tsunami-related illness. The patient was initially treated for tetanus and aspiration pneumonia with a guarded prognosis. Her recovery was complicated by malaria and recurrent pneumonia. Treatment was hampered by a shortage of medication and equipment, damage to the hospital, and a filthy environment. Morphine, diazepam, and ketamine infusions were used to good effect. This case highlights some of the logistical problems of treating multiple tetanus patients in an austere environment.  相似文献   

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Schreiber  MH; Winslade  WJ 《Radiology》1987,163(1):269-270
Traditionally, radiologists report their findings to the referring physician. When a patient who understands the reason for the diagnostic examination asks the radiologist to disclose the results, in most cases the radiologist should not decline but should answer truthfully.  相似文献   

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In order to test the hypothesis that dietary restriction may have a negative influence on physiological and psychological adaptation to a judo competition, we examined the effects of weight loss induced by restricting energy and fluid intake on the physiology, psychology, and physical performance of judo athletes. Twenty male judoka were randomly assigned to one of two groups (Group A: called diet, n = 10; height 174.8 +/- 1.9 cm, body weight 75.9 +/- 3.1 kg; they were asked to lose approximately 5 % of their body weight through self-determined means during the week before the competition; Group B: called control, n = 10; height 176.4 +/- 1.1 cm, body weight 73.3 +/- 6.3 kg maintained their body weight during the week before the competition). A battery of tests was performed during a baseline period (T1), on the morning of a simulated competition (T2) and 10 min after the end of the competition (T3). The test battery included assessment for body composition, performance tests, evaluation of mood, determination of metabolic and hormonal responses. Dietary data were collected using a 7-day diet record. The nutrient analysis indicated that all the athletes followed a low carbohydrate diet whatever the period of the investigation. For the Group A, the food restriction (- 4 MJ per day) resulted in significant decreases of the body weight and altered the mood by increasing Fatigue, Tension and decreasing Vigour. Dietary restriction had also a significant influence on metabolic and endocrine parameters and was associated with poor performance. After the competition, significant decreases of the levels in testosterone, T/C ratio, alkali reserve, and free fatty acid were observed in both groups, whereas the plasma concentrations in insulin, ammonia, urea, and uric acid were increased. In conclusion, our results suggest that the combination of energy restriction and intense exercise training, which causes weight reduction before a competition, adversely affects the physiology and psychology of judo athletes and impairs physical performance before the competition. Our data are the first to demonstrate that a competition including five 5-min bouts induced the same changes of physiological and psychological variables and performance whatever the dietary intake (dietary restriction or not) during the seven days before the competition.  相似文献   

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A study of the 96 gunshot suicides in Victoria, Australia, in 1988 is presented. Only three of the cases were women, all of whom had a psychiatric history. The suicides were commonly associated with physical or mental ill health, the break up of relationships or contact with police. There was often a history of alcohol related problems and 31% showed evidence of drinking before suicide. The suicides tended to occur without witnesses (90%), at home (73%), often in the bedroom (32%). Handguns were used much less commonly than in other countries, although the distribution of entry wounds was similar. The change of gun ownership laws which occurred in 1988 may be expected to alter the incidence of gunshot suicide in future years.  相似文献   

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